TissGeneSummary for TMEM92 |
Gene summary |
Basic gene information | Gene symbol | TMEM92 |
Gene name | transmembrane protein 92 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 17q21.33 | |
Type of gene | protein-coding | |
RefGenes | NM_001168215.1, NM_153229.2, | |
Description | - | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000167105 | ||
HPRD : 08743 | ||
Vega : OTTHUMG00000162060 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TMEM92 | |
BioGPS: 162461 | ||
Pathway | NCI Pathway Interaction Database: TMEM92 | |
KEGG: TMEM92 | ||
REACTOME: TMEM92 | ||
Pathway Commons: TMEM92 | ||
Context | iHOP: TMEM92 | |
ligand binding site mutation search in PubMed: TMEM92 | ||
UCL Cancer Institute: TMEM92 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonStomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADSTAD | |
Reference showing the relevant tissue of TMEM92 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for TMEM92 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -4.910940768 | -1.821508768 | -3.089432 | 1.02E-08 | 5.44E-08 |
BRCA | -1.850602312 | -3.59980582 | 1.749203509 | 5.23E-21 | 4.02E-20 |
KIRC | 0.800841621 | -2.350775046 | 3.151616667 | 6.19E-13 | 2.70E-12 |
HNSC | 0.722201279 | -1.460431279 | 2.182632558 | 1.72E-09 | 2.58E-08 |
THCA | -0.457055954 | -4.703432225 | 4.246376271 | 1.16E-15 | 1.69E-14 |
LUSC | 0.582801507 | 1.838466213 | -1.255664706 | 4.72E-06 | 1.11E-05 |
KIRP | -0.894537893 | -2.803403518 | 1.908865625 | 0.00183 | 0.004699725 |
LIHC | 0.707547232 | 2.356541232 | -1.648994 | 0.00171 | 0.004431634 |
Top |
TissGene-miRNA for TMEM92 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for TMEM92 |
TissGeneSNV for TMEM92 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P55S | SKCM | 1 |
p.P55L | SKCM | 1 |
p.T134P | UCEC | 1 |
p.G8S | KIRC | 1 |
p.C94S | KIRC | 1 |
p.P138T | PRAD | 1 |
p.P133T | SKCM | 1 |
p.R95W | PRAD | 1 |
p.E135K | HNSC | 1 |
p.K126M | LIHC | 1 |
p.G96E | SKCM | 1 |
p.G8D | LIHC | 1 |
p.R108K | SKCM | 1 |
p.A4T | COAD | 1 |
p.F159L | CESC | 1 |
p.D150N | SKCM | 1 |
p.P157Q | PRAD | 1 |
p.E107D | BLCA | 1 |
Top |
TissGeneCNV for TMEM92 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for TMEM92 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AK026449 | TMEM92-TMEM92 | chr17:48355023 | chr17:48351967 |
Top |
TissGeneNet for TMEM92 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for TMEM92 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for TMEM92 |
TissGeneDrug for TMEM92 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for TMEM92 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1963137 | Hydrocephalus Adverse Event | 0 | CLINVAR |