TissGeneSummary for GBP6 |
Gene summary |
Basic gene information | Gene symbol | GBP6 |
Gene name | guanylate binding protein family, member 6 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 1p22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_198460.2, | |
Description | GBP-6GTP-binding protein 6guanine nucleotide-binding protein 6guanylate-binding protein 6 | |
Modification date | 20141207 | |
dbXrefs | MIM : 612467 | |
HGNC : HGNC | ||
Ensembl : ENSG00000183347 | ||
HPRD : 13572 | ||
Vega : OTTHUMG00000010123 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GBP6 | |
BioGPS: 163351 | ||
Pathway | NCI Pathway Interaction Database: GBP6 | |
KEGG: GBP6 | ||
REACTOME: GBP6 | ||
Pathway Commons: GBP6 | ||
Context | iHOP: GBP6 | |
ligand binding site mutation search in PubMed: GBP6 | ||
UCL Cancer Institute: GBP6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Esophagus | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCA | |
Reference showing the relevant tissue of GBP6 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GBP6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 4.678718778 | 0.272367798 | 4.40635098 | 1.01E-12 | 4.63E-12 |
KIRC | -2.238898052 | -3.333371663 | 1.094473611 | 1.16E-10 | 4.10E-10 |
PRAD | -2.961753394 | -1.411803394 | -1.54995 | 4.63E-12 | 1.75E-10 |
HNSC | 6.565886767 | 8.007221651 | -1.441334884 | 0.0186 | 0.041724826 |
BLCA | 2.611718468 | -0.632365742 | 3.244084211 | 0.00453 | 0.024632567 |
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TissGene-miRNA for GBP6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GBP6 |
TissGeneSNV for GBP6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R538K | SKCM | 2 |
p.V252M | LUAD | 1 |
p.N18K | OV | 1 |
p.P86T | LUAD | 1 |
p.I421V | LUAD | 1 |
p.L22F | LUAD | 1 |
p.P193S | LUAD | 1 |
p.L31F | READ | 1 |
p.K51R | UCEC | 1 |
p.S402Y | UCEC | 1 |
p.N24S | SKCM | 1 |
p.Q262* | LUAD | 1 |
p.R159M | UCEC | 1 |
p.Q36* | BLCA | 1 |
p.E2K | SKCM | 1 |
p.H432R | LIHC | 1 |
p.F426V | READ | 1 |
p.E458Q | BLCA | 1 |
p.G191S | COAD | 1 |
p.A339T | STAD | 1 |
p.E222K | SKCM | 1 |
p.M384T | COAD | 1 |
p.V252A | BLCA | 1 |
p.K533T | ESCA | 1 |
p.D445N | SKCM | 1 |
p.P345L | SKCM | 1 |
p.R226H | STAD | 1 |
p.L410R | STAD | 1 |
p.G191S | SKCM | 1 |
p.E99K | DLBC | 1 |
p.Q61H | UCEC | 1 |
p.R181W | UCEC | 1 |
p.E2* | HNSC | 1 |
p.P220L | HNSC | 1 |
p.E150X | ESCA | 1 |
p.V327M | COAD | 1 |
p.G284R | SKCM | 1 |
p.G293E | SKCM | 1 |
p.T552M | COAD | 1 |
p.R225S | LUAD | 1 |
p.Q61H | THYM | 1 |
p.F234S | STAD | 1 |
p.E263* | UCEC | 1 |
p.P309S | LUAD | 1 |
p.F234L | THYM | 1 |
p.L475F | LUAD | 1 |
p.K33T | READ | 1 |
p.S425I | LUAD | 1 |
p.Q141K | STAD | 1 |
p.S166F | PRAD | 1 |
p.K627N | SKCM | 1 |
p.T348M | STAD | 1 |
p.Q448* | UCEC | 1 |
p.W114C | BRCA | 1 |
p.A117S | SKCM | 1 |
p.V300I | LUAD | 1 |
p.N202S | STAD | 1 |
p.P193S | SKCM | 1 |
p.F633S | SKCM | 1 |
p.N211T | BLCA | 1 |
p.E150* | UCEC | 1 |
p.I224F | LUSC | 1 |
p.T590A | BRCA | 1 |
p.K33N | LUAD | 1 |
p.K255N | UCEC | 1 |
p.R231W | UCEC | 1 |
p.T98N | OV | 1 |
p.Q337L | LUAD | 1 |
p.H192Q | BRCA | 1 |
p.D354N | KIRC | 1 |
p.A117T | LUAD | 1 |
p.H356Y | STAD | 1 |
p.V23L | LUSC | 1 |
p.F176Y | LUAD | 1 |
p.K433T | STAD | 1 |
p.E74K | SKCM | 1 |
p.D347N | LUAD | 1 |
p.G453R | SKCM | 1 |
p.L189F | CESC | 1 |
p.R538T | HNSC | 1 |
p.G618S | SKCM | 1 |
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TissGeneCNV for GBP6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GBP6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-AN-A0FZ-01A | HS2ST1-GBP6 | CDS-5UTR | Chr1:87380843 | Chr1:89834088 |
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TissGeneNet for GBP6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GBP6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GBP6 |
TissGeneDrug for GBP6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GBP6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0003873 | Rheumatoid Arthritis | 1 | GAD |