TissGeneSummary for RBM46 |
Gene summary |
Basic gene information | Gene symbol | RBM46 |
Gene name | RNA binding motif protein 46 | |
Synonyms | CT68 | |
Cytomap | UCSC genome browser: 4q32.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001277171.1, NM_001277173.1,NM_144979.4, | |
Description | RNA-binding motif protein 46cancer/testis antigen 68probable RNA-binding protein 46 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000151962 | ||
HPRD : 14517 | ||
Vega : OTTHUMG00000161543 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RBM46 | |
BioGPS: 166863 | ||
Pathway | NCI Pathway Interaction Database: RBM46 | |
KEGG: RBM46 | ||
REACTOME: RBM46 | ||
Pathway Commons: RBM46 | ||
Context | iHOP: RBM46 | |
ligand binding site mutation search in PubMed: RBM46 | ||
UCL Cancer Institute: RBM46 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of RBM46 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for RBM46 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -1.281633356 | 0.308929356 | -1.590562712 | 4.65E-09 | 2.43E-08 |
KIRC | -0.007331473 | -1.723553695 | 1.716222222 | 3.58E-16 | 1.97E-15 |
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TissGene-miRNA for RBM46 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for RBM46 |
TissGeneSNV for RBM46 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R91* | SKCM | 3 |
p.Y273C | LGG | 2 |
p.E151K | SKCM | 2 |
p.E74K | SKCM | 1 |
p.R184C | SKCM | 1 |
p.K44I | SKCM | 1 |
p.R127X | LGG | 1 |
p.L158X | SKCM | 1 |
p.F131V | STAD | 1 |
p.H340Y | ACC | 1 |
p.N242T | COAD | 1 |
p.I6T | UCEC | 1 |
p.P206S | SKCM | 1 |
p.S487F | SKCM | 1 |
p.Q529E | BLCA | 1 |
p.C402Y | UCEC | 1 |
p.Q217* | SKCM | 1 |
p.Y239* | UCEC | 1 |
p.K258T | STAD | 1 |
p.R127* | LGG | 1 |
p.A104G | HNSC | 1 |
p.P48S | SKCM | 1 |
p.P362S | SKCM | 1 |
p.K153N | PAAD | 1 |
p.R127Q | SKCM | 1 |
p.W407R | STAD | 1 |
p.G505D | BLCA | 1 |
p.K404N | STAD | 1 |
p.R127* | SKCM | 1 |
p.S509P | PAAD | 1 |
p.D71H | LIHC | 1 |
p.R281Q | SKCM | 1 |
p.Y273C | COAD | 1 |
p.D159V | SKCM | 1 |
p.F256L | LUAD | 1 |
p.A274G | OV | 1 |
p.F105C | UCEC | 1 |
p.E224D | LUAD | 1 |
p.L158* | SKCM | 1 |
p.P128S | COAD | 1 |
p.R473H | UCEC | 1 |
p.K152N | STAD | 1 |
p.P55L | HNSC | 1 |
p.F275S | GBM | 1 |
p.A436T | COAD | 1 |
p.S483N | COAD | 1 |
p.D272Y | READ | 1 |
p.E190* | CESC | 1 |
p.K180E | KIRC | 1 |
p.E39K | SKCM | 1 |
p.E337K | SKCM | 1 |
p.E156* | SKCM | 1 |
p.R271K | SKCM | 1 |
p.P351S | SKCM | 1 |
p.R127* | GBM | 1 |
p.Y73F | BRCA | 1 |
p.R91Q | READ | 1 |
p.G66E | SKCM | 1 |
p.Y88H | BLCA | 1 |
p.K14N | STAD | 1 |
p.Y191D | PRAD | 1 |
p.E282K | LUSC | 1 |
p.T485A | STAD | 1 |
p.V15L | LUAD | 1 |
p.R316K | SKCM | 1 |
p.R473L | ESCA | 1 |
p.L452S | STAD | 1 |
p.P507H | STAD | 1 |
p.G129R | SKCM | 1 |
p.K307T | SKCM | 1 |
p.D272N | SKCM | 1 |
p.E457K | STAD | 1 |
p.S488Y | COAD | 1 |
p.R119K | UCEC | 1 |
p.V164A | COAD | 1 |
p.A274V | SKCM | 1 |
p.I118M | LUAD | 1 |
p.E338* | LUAD | 1 |
p.L467V | UCEC | 1 |
p.G489E | SKCM | 1 |
p.I126M | COAD | 1 |
p.P308L | LUAD | 1 |
p.R91X | SKCM | 1 |
p.P50S | SKCM | 1 |
p.R266L | STAD | 1 |
p.C141F | UCEC | 1 |
p.R101* | UCEC | 1 |
p.E113G | LIHC | 1 |
p.R367I | UCEC | 1 |
p.L121F | SKCM | 1 |
p.E156X | SKCM | 1 |
p.S441C | OV | 1 |
p.P374L | LUAD | 1 |
p.G41R | SKCM | 1 |
p.A284T | HNSC | 1 |
p.S385Y | UCEC | 1 |
p.S289F | UCEC | 1 |
p.G185A | UCEC | 1 |
p.V427G | SKCM | 1 |
p.F105S | BLCA | 1 |
p.E250K | SKCM | 1 |
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TissGeneCNV for RBM46 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for RBM46 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for RBM46 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for RBM46 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for RBM46 |
TissGeneDrug for RBM46 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for RBM46 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0001925 | Albuminuria | 1 | GAD |