TissGeneSummary for FAM46D |
Gene summary |
Basic gene information | Gene symbol | FAM46D |
Gene name | family with sequence similarity 46, member D | |
Synonyms | CT1.26|CT112 | |
Cytomap | UCSC genome browser: Xq21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001170574.1, NM_152630.4, | |
Description | cancer/testis antigen 112protein FAM46D | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000174016 | ||
HPRD : 06643 | ||
Vega : OTTHUMG00000021902 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM46D | |
BioGPS: 169966 | ||
Pathway | NCI Pathway Interaction Database: FAM46D | |
KEGG: FAM46D | ||
REACTOME: FAM46D | ||
Pathway Commons: FAM46D | ||
Context | iHOP: FAM46D | |
ligand binding site mutation search in PubMed: FAM46D | ||
UCL Cancer Institute: FAM46D | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FAM46D | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FAM46D |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.307767341 | -0.273243341 | -1.034524 | 2.87E-06 | 9.98E-06 |
KIRC | -1.566748953 | -0.248971175 | -1.317777778 | 1.87E-22 | 1.76E-21 |
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TissGene-miRNA for FAM46D |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM46D |
TissGeneSNV for FAM46D |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S69R | STAD | 4 |
p.P200S | SKCM | 2 |
p.Q350* | SKCM | 2 |
p.F169L | HNSC | 2 |
p.D82N | SKCM | 2 |
p.E335* | UCEC | 2 |
p.S172I | LUAD | 1 |
p.R360W | GBM | 1 |
p.D18V | LUAD | 1 |
p.R383C | LUAD | 1 |
p.D102Y | COAD | 1 |
p.C138Y | LIHC | 1 |
p.A61T | ESCA | 1 |
p.Q13* | BLCA | 1 |
p.H220Q | LUAD | 1 |
p.K278N | READ | 1 |
p.V201F | LUAD | 1 |
p.N64S | THYM | 1 |
p.S69G | STAD | 1 |
p.R383C | BLCA | 1 |
p.E95K | UCEC | 1 |
p.P369S | LGG | 1 |
p.D124E | COAD | 1 |
p.P113S | LIHC | 1 |
p.D12N | SKCM | 1 |
p.D115N | COAD | 1 |
p.D128Y | READ | 1 |
p.K196I | SKCM | 1 |
p.E274* | CESC | 1 |
p.N286S | UCEC | 1 |
p.G53R | LUAD | 1 |
p.S175F | SKCM | 1 |
p.E119K | HNSC | 1 |
p.S198Y | HNSC | 1 |
p.W144L | HNSC | 1 |
p.F266L | UCEC | 1 |
p.F186L | COAD | 1 |
p.Q350X | SKCM | 1 |
p.I321T | SARC | 1 |
p.P379S | LIHC | 1 |
p.P362H | LUAD | 1 |
p.L91H | STAD | 1 |
p.S2Y | UCEC | 1 |
p.L322I | UCEC | 1 |
p.T346N | SARC | 1 |
p.V372I | COAD | 1 |
p.G387D | SKCM | 1 |
p.S148F | SKCM | 1 |
p.A61P | HNSC | 1 |
p.P271S | SKCM | 1 |
p.V201L | LUSC | 1 |
p.P113Q | ESCA | 1 |
p.A68S | STAD | 1 |
p.L105P | HNSC | 1 |
p.P113S | SKCM | 1 |
p.V173E | LUAD | 1 |
p.E308K | PCPG | 1 |
p.L302F | SKCM | 1 |
p.E308K | SKCM | 1 |
p.H28N | LUAD | 1 |
p.Y187* | LUAD | 1 |
p.S389I | UCEC | 1 |
p.D115N | UCEC | 1 |
p.V99I | UCEC | 1 |
p.L63F | THYM | 1 |
p.F211V | LUAD | 1 |
p.M328I | LUAD | 1 |
p.I147S | ESCA | 1 |
p.L108I | LUAD | 1 |
p.P200L | SKCM | 1 |
p.H287Y | SKCM | 1 |
p.K256R | LUAD | 1 |
p.I125F | KIRC | 1 |
p.E95K | SKCM | 1 |
p.N32I | LIHC | 1 |
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TissGeneCNV for FAM46D |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM46D |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FAM46D |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM46D |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM46D |
TissGeneDrug for FAM46D |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM46D |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |