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| TissGeneSummary for PSORS1C1 |
 Gene summary |
| Basic gene information | Gene symbol | PSORS1C1 |
| Gene name | psoriasis susceptibility 1 candidate 1 | |
| Synonyms | C6orf16|SEEK1 | |
| Cytomap | UCSC genome browser: 6p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014068.2, | |
| Description | psoriasis susceptibility 1 candidate gene 1 protein | |
| Modification date | 20141217 | |
| dbXrefs | MIM : 613525 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000204540 | ||
| HPRD : 17920 | ||
| Vega : OTTHUMG00000031077 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PSORS1C1 | |
| BioGPS: 170679 | ||
| Pathway | NCI Pathway Interaction Database: PSORS1C1 | |
| KEGG: PSORS1C1 | ||
| REACTOME: PSORS1C1 | ||
| Pathway Commons: PSORS1C1 | ||
| Context | iHOP: PSORS1C1 | |
| ligand binding site mutation search in PubMed: PSORS1C1 | ||
| UCL Cancer Institute: PSORS1C1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of PSORS1C1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PSORS1C1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 0.938074019 | -2.086359314 | 3.024433333 | 2.32E-31 | 5.05E-30 |
| KIRP | 1.317000061 | -1.987524939 | 3.304525 | 5.59E-14 | 1.17E-12 |
| LIHC | -2.225527814 | -3.273901814 | 1.048374 | 0.000483 | 0.001415228 |
| HNSC | -0.396981117 | -1.775434605 | 1.378453488 | 0.000217 | 0.000881318 |
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| TissGene-miRNA for PSORS1C1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for PSORS1C1 |
| TissGeneSNV for PSORS1C1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T18I | STAD | 1 |
| p.S92C | BLCA | 1 |
| p.C47R | GBM | 1 |
| p.P90S | SKCM | 1 |
| p.E34K | DLBC | 1 |
| p.L111F | ESCA | 1 |
| p.M64I | SKCM | 1 |
| p.P105S | SKCM | 1 |
| p.R45Q | READ | 1 |
| p.D86G | SKCM | 1 |
| p.P24T | COAD | 1 |
| p.S91Y | COAD | 1 |
| p.L26F | COAD | 1 |
| p.E35K | BLCA | 1 |
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| TissGeneCNV for PSORS1C1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PSORS1C1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for PSORS1C1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for PSORS1C1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PSORS1C1 |
| TissGeneDrug for PSORS1C1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PSORS1C1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0033860 | Psoriasis | 5 | BeFree,GAD,LHGDN |
| umls:C0004943 | Behcet Syndrome | 3 | CTD_human,GAD,GWASCAT |
| umls:C0024141 | Lupus Erythematosus, Systemic | 2 | GAD |
| umls:C0036421 | Systemic Scleroderma | 2 | BeFree,CTD_human,GWASCAT |
| umls:C0001175 | Acquired Immunodeficiency Syndrome | 1 | GAD |
| umls:C0003872 | Arthritis, Psoriatic | 1 | BeFree,GAD |
| umls:C0010051 | Coronary Aneurysm | 1 | GAD |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GWASCAT |
| umls:C0026691 | Mucocutaneous Lymph Node Syndrome | 1 | GAD |
| umls:C0026764 | Multiple Myeloma | 1 | GWASCAT |
| umls:C0026769 | Multiple Sclerosis | 1 | GAD |
| umls:C0036429 | Sclerosis | 1 | GAD |
| umls:C0038325 | Stevens-Johnson Syndrome | 1 | GAD |
| umls:C0086445 | Idiopathic Membranous Glomerulonephritis | 1 | GWASCAT |
| umls:C0406317 | Chronic small plaque psoriasis | 1 | BeFree |
| umls:C0497169 | hiv-infection/aids | 1 | BeFree |
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