TissGeneSummary for DUSP4 |
Gene summary |
Basic gene information | Gene symbol | DUSP4 |
Gene name | dual specificity phosphatase 4 | |
Synonyms | HVH2|MKP-2|MKP2|TYP | |
Cytomap | UCSC genome browser: 8p12-p11 | |
Type of gene | protein-coding | |
RefGenes | NM_001394.6, NM_057158.3, | |
Description | MAP kinase phosphatase 2VH1 homologous phosphatase 2dual specificity protein phosphatase 4dual specificity protein phosphatase hVH2mitogen-activated protein kinase phosphatase 2serine/threonine specific protein phosphatase | |
Modification date | 20141222 | |
dbXrefs | MIM : 602747 | |
HGNC : HGNC | ||
Ensembl : ENSG00000120875 | ||
HPRD : 04123 | ||
Vega : OTTHUMG00000133395 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DUSP4 | |
BioGPS: 1846 | ||
Pathway | NCI Pathway Interaction Database: DUSP4 | |
KEGG: DUSP4 | ||
REACTOME: DUSP4 | ||
Pathway Commons: DUSP4 | ||
Context | iHOP: DUSP4 | |
ligand binding site mutation search in PubMed: DUSP4 | ||
UCL Cancer Institute: DUSP4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinStomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMSTAD | |
Reference showing the relevant tissue of DUSP4 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DUSP4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | 0.316604118 | -2.381684343 | 2.698288462 | 9.32E-07 | 5.30E-06 |
LUAD | 1.243241121 | -0.520491638 | 1.763732759 | 3.35E-11 | 2.17E-10 |
KIRC | -0.97432569 | -2.694434023 | 1.720108333 | 3.52E-17 | 2.12E-16 |
THCA | 0.589616048 | -1.82902124 | 2.418637288 | 7.03E-18 | 1.60E-16 |
STAD | 2.42554931 | 0.71910556 | 1.70644375 | 0.000544 | 0.003236656 |
PRAD | -0.49433819 | 0.633748349 | -1.128086538 | 0.000538 | 0.001866344 |
KICH | -0.48195419 | -2.10079019 | 1.618836 | 0.00039 | 0.000909587 |
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TissGene-miRNA for DUSP4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-let-7f-5p | MIMAT0000067 | 0.021 | -0.26 | 78 |
ACC | hsa-let-7f-5p | MIMAT0000067 | 0.021 | -0.26 | 78 |
ACC | hsa-miR-665 | MIMAT0004952 | 0.032 | -0.27 | 78 |
ACC | hsa-miR-665 | MIMAT0004952 | 0.032 | -0.27 | 78 |
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TissGeneMut for DUSP4 |
TissGeneSNV for DUSP4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D249N | COAD | 1 |
p.P170L | DLBC | 1 |
p.S371F | SKCM | 1 |
p.R300L | STAD | 1 |
p.S386N | UCEC | 1 |
p.S315R | LUSC | 1 |
p.A268V | SKCM | 1 |
p.R353Q | SKCM | 1 |
p.A208P | BLCA | 1 |
p.E331X | ESCA | 1 |
p.K252M | LIHC | 1 |
p.E308G | LUAD | 1 |
p.A219T | COAD | 1 |
p.R3S | STAD | 1 |
p.S33G | STAD | 1 |
p.R21Q | COAD | 1 |
p.C244X | ESCA | 1 |
p.G221V | COAD | 1 |
p.M260I | SKCM | 1 |
p.G35D | DLBC | 1 |
p.S159C | BLCA | 1 |
p.R8L | PRAD | 1 |
p.I106V | SKCM | 1 |
p.G30D | LUSC | 1 |
p.R21K | SKCM | 1 |
p.A219V | SKCM | 1 |
p.P168L | SKCM | 1 |
p.A35S | BLCA | 1 |
p.R3K | THYM | 1 |
p.P155S | LGG | 1 |
p.R275C | COAD | 1 |
p.A135V | HNSC | 1 |
p.G221C | LUAD | 1 |
p.A282V | LGG | 1 |
p.R30X | COAD | 1 |
p.S338F | SKCM | 1 |
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TissGeneCNV for DUSP4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DUSP4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF802699 | DUSP4-SRSF5 | chr8:29191260 | chr14:70238017 | |
Chimerdb3.0 | FusionScan | OV | TCGA-3P-A9WA-01A | DUSP4-RBPMS | CDS-3'UTR | chr8:29197614 | chr8:30428153 |
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TissGeneNet for DUSP4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DUSP4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DUSP4 |
TissGeneDrug for DUSP4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DUSP4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 7 | BeFree |
umls:C0678222 | Breast Carcinoma | 6 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
umls:C1527249 | Colorectal Cancer | 3 | BeFree |
umls:C0017638 | Glioma | 2 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree |
umls:C0684249 | Carcinoma of lung | 2 | BeFree |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0079731 | B-Cell Lymphomas | 1 | BeFree |
umls:C0079744 | Diffuse Large B-Cell Lymphoma | 1 | BeFree |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
umls:C0334579 | Anaplastic astrocytoma | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0878544 | Cardiomyopathies | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
umls:C1514422 | Primary Glioblastoma | 1 | BeFree |
umls:C3495559 | Juvenile arthritis | 1 | CTD_human |
umls:C3539878 | Triple Negative Breast Neoplasms | 1 | BeFree |
umls:C3809768 | IMMUNODEFICIENCY 13 | 1 | BeFree |