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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for EGF
check button Gene summary
Basic gene informationGene symbolEGF
Gene nameepidermal growth factor
SynonymsHOMG4|URG
CytomapUCSC genome browser: 4q25
Type of geneprotein-coding
RefGenesNM_001178130.1,
NM_001178131.1,NM_001963.4,
Descriptionbeta-urogastronepro-epidermal growth factor
Modification date20141222
dbXrefs MIM : 131530
HGNC : HGNC
Ensembl : ENSG00000138798
HPRD : 00578
Vega : OTTHUMG00000132044
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_EGF
BioGPS: 1950
PathwayNCI Pathway Interaction Database: EGF
KEGG: EGF
REACTOME: EGF
Pathway Commons: EGF
ContextiHOP: EGF
ligand binding site mutation search in PubMed: EGF
UCL Cancer Institute: EGF
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Kidney
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICH
Reference showing the relevant tissue of EGFTissue-specific effects of castration and ovariectomy on murine epidermal growth factor and its mRNA. Pascall JC, Saunders J, Blakeley DM, Laurie MS, Brown KD. J Endocrinol. 1989 Jun;121(3):501-6. (pmid:2787828)
go to article
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0001525angiogenesis15611079
GO:0008284positive regulation of cell proliferation15611079
GO:0010800positive regulation of peptidyl-threonine phosphorylation16314496
GO:0035413positive regulation of catenin import into nucleus20302655
GO:0042327positive regulation of phosphorylation15611079
GO:0043406positive regulation of MAP kinase activity15611079
GO:0045741positive regulation of epidermal growth factor-activated receptor activity15611079
GO:0045840positive regulation of mitosis15611079
GO:0045893positive regulation of transcription, DNA-templated16314496
GO:0051048negative regulation of secretion10559227
GO:0070371ERK1 and ERK2 cascade16314496
GO:0090279regulation of calcium ion import19996314
GO:1900127positive regulation of hyaluronan biosynthetic process17324121
GO:2000008regulation of protein localization to cell surface19996314
GO:0001525angiogenesis15611079
GO:0008284positive regulation of cell proliferation15611079
GO:0010800positive regulation of peptidyl-threonine phosphorylation16314496
GO:0035413positive regulation of catenin import into nucleus20302655
GO:0042327positive regulation of phosphorylation15611079
GO:0043406positive regulation of MAP kinase activity15611079
GO:0045741positive regulation of epidermal growth factor-activated receptor activity15611079
GO:0045840positive regulation of mitosis15611079
GO:0045893positive regulation of transcription, DNA-templated16314496
GO:0051048negative regulation of secretion10559227
GO:0070371ERK1 and ERK2 cascade16314496
GO:0090279regulation of calcium ion import19996314
GO:1900127positive regulation of hyaluronan biosynthetic process17324121
GO:2000008regulation of protein localization to cell surface19996314


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TissGeneExp for EGF

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BRCA1.2712445292.665513827-1.3942692983.22E-057.54E-05
LUAD1.397028135-0.4396097961.8366379311.06E-084.76E-08
KIRC1.2823936527.202699208-5.9203055568.57E-372.70E-35
KIRP0.9271561527.181362402-6.254206252.96E-212.14E-19
THCA-1.040008890.559531788-1.5995406782.11E-121.76E-11
PRAD2.7302994211.2017224981.5285769231.84E-071.60E-06
HNSC-0.332644720.93923435-1.271879070.009510.023748613
KICH5.5042196527.409327652-1.9051080.003520.006871639
COAD-2.031217886-0.154790963-1.8764269230.0003520.001124245
LIHC-2.920412348-4.6169263481.6965140.0003130.000956221


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TissGene-miRNA for EGF

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for EGF
TissGeneSNV for EGF

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G147ESKCM2
p.R943CUCEC2
p.S1075RLUAD2
p.E1103*UCEC2
p.Q856RSTAD1
p.D654NSARC1
p.S119YUCS1
p.G385ESKCM1
p.N220SSKCM1
p.E115DUCEC1
p.L918VCESC1
p.R87ISTAD1
p.E624KSARC1
p.G370ESTAD1
p.V142GPRAD1
p.I666FLIHC1
p.A661VPAAD1
p.P300SSKCM1
p.E1204*BLCA1
p.T381SUCEC1
p.G646EUCEC1
p.K1065EBRCA1
p.K594NLUAD1
p.D864NSKCM1
p.W90GHNSC1
p.T1206SHNSC1
p.S626CBLCA1
p.A185SUCEC1
p.R588HLGG1
p.D542NSKCM1
p.C929YESCA1
p.R898PLUAD1
p.Y983CLUAD1
p.F651LSTAD1
p.S1064LSKCM1
p.E851QBLCA1
p.Q629*UCEC1
p.D211HLUSC1
p.S224CKIRP1
p.R282TBLCA1
p.E624KBLCA1
p.V130ILUSC1
p.D640NBLCA1
p.D784YLUAD1
p.R394*SKCM1
p.L254FSKCM1
p.G1009VLUAD1
p.D211NSKCM1
p.H365YSKCM1
p.L823IESCA1
p.P736LSKCM1
p.E1087XLIHC1
p.R394QSKCM1
p.P1113LESCA1
p.E94DKIRC1
p.F173CUCEC1
p.R1023HLGG1
p.Q1207EBLCA1
p.Q397XSKCM1
p.E667QSARC1
p.A477TLGG1
p.S1187*LGG1
p.E200DREAD1
p.W571*UCEC1
p.K757RBRCA1
p.A691TBRCA1
p.K576NUCEC1
p.R588CLGG1
p.R709ITHYM1
p.P160SSKCM1
p.W658*SARC1
p.R1163QBLCA1
p.G235ELUSC1
p.P300LSKCM1
p.K14QUCEC1
p.P44SSKCM1
p.R100KSKCM1
p.F289YHNSC1
p.V428MUCEC1
p.R1132KSKCM1
p.L187IUCS1
p.L153FSKCM1
p.G1089WESCA1
p.P1070HSTAD1
p.D492YUCEC1
p.C395YBLCA1
p.G277ESKCM1
p.E624*UCEC1
p.G323ESKCM1
p.G512RLIHC1
p.R943CLUAD1
p.D234NSKCM1
p.G907ESKCM1
p.G902SSKCM1
p.V111GPRAD1
p.M772ISKCM1
p.D518VSTAD1
p.W264*SKCM1
p.P705SSKCM1
p.S377YGBM1
p.Q599HGBM1
p.L985FHNSC1
p.A346GPAAD1
p.D660YLUAD1
p.R961MLGG1
p.I152TUCEC1
p.N890SUCEC1
p.G741ESKCM1
p.E343QBLCA1
p.S577YBLCA1
p.V357ILUAD1
p.E1072GLIHC1
p.R403CBLCA1
p.P456SUCEC1
p.R622QREAD1
p.C874YSTAD1
p.S377FSKCM1
p.E552*HNSC1
p.E537DBLCA1
p.W459*HNSC1
p.N798DLIHC1
p.Q218XKIRC1
p.L347QSKCM1
p.V1040LSTAD1
p.E1087*LIHC1
p.M708ICOAD1
p.W264SSKCM1
p.C423SGBM1
p.D973ALIHC1
p.V989LLUSC1
p.D701GESCA1
p.R494QUCEC1
p.R1163QUCEC1
p.L227PSKCM1
p.R213QSTAD1
p.G438RLUAD1
p.E624XESCA1
p.R258CSTAD1
p.D573GUCEC1
p.E473KSKCM1
p.S625RPRAD1
p.G905ESKCM1
p.S150FPAAD1
p.V880MPAAD1
p.G138ESKCM1
p.G632DLUAD1
p.E67XTHYM1
p.A34TUCEC1
p.V969IHNSC1
p.Q1060*BLCA1
p.E115QBLCA1
p.A853VCOAD1
p.P456QBLCA1
p.M252KTHYM1
p.E1180KLGG1
p.S638CLUSC1
p.S21LHNSC1


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TissGeneCNV for EGF

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for EGF

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABF806633EGF-NEAT1chr4:110909761chr11:65192917
TCGAfusionPortalPRADAPRADTCGA-VP-A87K-01AAL359075.1-EGFOut-of-frameChr1:177927267Chr4:110914403


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TissGeneNet for EGF

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (tumor)EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (normal)
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COAD (tumor)COAD (normal)
EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (tumor)EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (normal)
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HNSC (tumor)HNSC (normal)
EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (tumor)EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (normal)
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KICH (tumor)KICH (normal)
EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (tumor)EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (normal)
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KIRC (tumor)KIRC (normal)
EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (tumor)EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (normal)
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KIRP (tumor)KIRP (normal)
EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (tumor)EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (normal)
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LIHC (tumor)LIHC (normal)
EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (tumor)EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (normal)
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LUAD (tumor)LUAD (normal)
EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (tumor)EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (normal)
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LUSC (tumor)LUSC (normal)
EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (tumor)EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (normal)
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PRAD (tumor)PRAD (normal)
EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (tumor)EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (normal)
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STAD (tumor)STAD (normal)
EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (tumor)EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (normal)
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THCA (tumor)THCA (normal)
EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (tumor)EGF, GRB2, ERBB2, SCN9A, HDAC6, ADAM12, ADRBK1, EGFR, PIK3R2, ERBB3, VTN, S100A4, LMNA, FNBP1, DUSP3, CPM (normal)
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TissGeneProg for EGF

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for EGF
TissGeneDrug for EGF

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for EGF

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0006142Malignant neoplasm of breast192BeFree,GAD
umls:C0678222Breast Carcinoma184BeFree
umls:C0007131Non-Small Cell Lung Carcinoma100BeFree,GAD
umls:C0007137Squamous cell carcinoma71BeFree,GAD
umls:C0027627Neoplasm Metastasis70BeFree,CTD_human
umls:C0596263Carcinogenesis66BeFree
umls:C0242379Malignant neoplasm of lung65BeFree,GAD
umls:C0017636Glioblastoma61BeFree,CTD_human,GAD
umls:C0376358Malignant neoplasm of prostate60BeFree,GAD
umls:C0600139Prostate carcinoma58BeFree
umls:C0684249Carcinoma of lung56BeFree
umls:C2239176Liver carcinoma55BeFree,CTD_human,GAD,LHGDN
umls:C0017638Glioma54BeFree,GAD,LHGDN
umls:C0029925Ovarian Carcinoma51BeFree
umls:C0699791Stomach Carcinoma45BeFree
umls:C0235974Pancreatic carcinoma44BeFree
umls:C1140680Malignant neoplasm of ovary43BeFree,GAD
umls:C0009402Colorectal Carcinoma40BeFree
umls:C1527249Colorectal Cancer40BeFree,GAD
umls:C0024623Malignant neoplasm of stomach35BeFree,GAD
umls:C0699790Colon Carcinoma35BeFree
umls:C0346647Malignant neoplasm of pancreas34BeFree
umls:C0007102Malignant tumor of colon30BeFree
umls:C0001418Adenocarcinoma28BeFree,CTD_human,GAD,LHGDN
umls:C0178874Tumor Progression27BeFree
umls:C0025202melanoma26BeFree,GAD
umls:C1458155Mammary Neoplasms26BeFree,CTD_human,LHGDN
umls:C0007134Renal Cell Carcinoma22BeFree,GAD
umls:C0004114Astrocytoma19BeFree
umls:C0005684Malignant neoplasm of urinary bladder17BeFree,GAD
umls:C0033578Prostatic Neoplasms16BeFree,CTD_human,LHGDN
umls:C0152013Adenocarcinoma of lung (disorder)16BeFree
umls:C0677886Epithelial ovarian cancer16BeFree,GAD
umls:C0699885Carcinoma of bladder16BeFree
umls:C0023903Liver neoplasms15BeFree,GAD
umls:C1168401Squamous cell carcinoma of the head and neck15BeFree
umls:C0302592Cervix carcinoma14BeFree
umls:C0006118Brain Neoplasms13BeFree,GAD
umls:C0476089Endometrial Carcinoma13BeFree
umls:C0012546Diphtheria12BeFree
umls:C0014859Esophageal Neoplasms12BeFree,GAD,LHGDN
umls:C0549473Thyroid carcinoma12BeFree
umls:C0751587CADASIL Syndrome12BeFree
umls:C0032002Pituitary Diseases11BeFree
umls:C0152018Esophageal carcinoma11BeFree
umls:C0007847Malignant tumor of cervix10BeFree
umls:C0008497Choriocarcinoma9BeFree
umls:C0024121Lung Neoplasms9BeFree,LHGDN
umls:C0033860Psoriasis9BeFree
umls:C0036341Schizophrenia9BeFree,GAD
umls:C0149925Small cell carcinoma of lung9BeFree
umls:C0279626Squamous cell carcinoma of esophagus9BeFree
umls:C0546837Malignant neoplasm of esophagus9BeFree,GAD
umls:C0555198Malignant Glioma9BeFree
umls:C1257930Mammary Carcinoma, Human9BeFree
umls:C0023890Liver Cirrhosis8BeFree,GAD,LHGDN
umls:C0030297Pancreatic Neoplasm8BeFree,GAD,LHGDN
umls:C0280100Solid tumour8BeFree
umls:C0948380Colorectal cancer metastatic8BeFree
umls:C0007103Malignant neoplasm of endometrium7BeFree
umls:C0007115Malignant neoplasm of thyroid7BeFree
umls:C0023267Fibroid Tumor7BeFree,LHGDN
umls:C0024796Marfan Syndrome7BeFree
umls:C0025286Meningioma7BeFree,GAD
umls:C0027819Neuroblastoma7BeFree,LHGDN
umls:C0272138Erythroblastosis7BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma7BeFree
umls:C1623038Cirrhosis7BeFree
umls:C1883486Uterine Corpus Cancer7BeFree
umls:C0001430Adenoma6BeFree
umls:C0009404Colorectal Neoplasms6BeFree,LHGDN
umls:C0032019Pituitary Neoplasms6BeFree
umls:C0042133Uterine Fibroids6BeFree
umls:C0520459Necrotizing Enterocolitis6BeFree,LHGDN,RGD
umls:C0686619Secondary malignant neoplasm of lymph node6BeFree
umls:C0700095Central neuroblastoma6BeFree
umls:C1621958Glioblastoma Multiforme6BeFree,GAD
umls:C3539878Triple Negative Breast Neoplasms6BeFree
umls:C0019163Hepatitis B5BeFree
umls:C0020445Hypercholesterolemia, Familial5BeFree
umls:C0029463Osteosarcoma5BeFree
umls:C0153633Malignant neoplasm of brain5BeFree,GAD
umls:C0220650Metastatic malignant neoplasm to brain5BeFree
umls:C0278996Cancer of Head and Neck5BeFree
umls:C0279628Adenocarcinoma Of Esophagus5BeFree
umls:C0585442Osteosarcoma of bone5BeFree
umls:C0919267ovarian neoplasm5BeFree,LHGDN
umls:C1368683Epithelioma5BeFree
umls:C1512409Hepatocarcinogenesis5BeFree
umls:C1654637androgen independent prostate cancer5BeFree
umls:C2931822Nasopharyngeal carcinoma5BeFree
umls:C0004096Asthma4BeFree
umls:C0008354Cholera4BeFree
umls:C0008533Hemophilia B4BeFree
umls:C0011881Diabetic Nephropathy4BeFree
umls:C0014175Endometriosis4BeFree
umls:C0017168Gastroesophageal reflux disease4BeFree,GAD
umls:C0022658Kidney Diseases4BeFree,CTD_human
umls:C0040136Thyroid Neoplasm4BeFree,LHGDN
umls:C0085413Polycystic Kidney, Autosomal Dominant4BeFree
umls:C0239946Fibrosis, Liver4BeFree
umls:C0263641Epithelial hyperplasia of skin4BeFree
umls:C0265341Rieger syndrome4BeFree
umls:C0279000Liver and Intrahepatic Biliary Tract Carcinoma4BeFree
umls:C0345904Malignant neoplasm of liver4BeFree
umls:C0751690Malignant Peripheral Nerve Sheath Tumor4BeFree
umls:C0858252Breast adenocarcinoma4BeFree
umls:C1762616Meningioma, benign, no ICD-O subtype4BeFree
umls:C3495488Axenfeld-Rieger syndrome4BeFree
umls:C3495489Rieger eye malformation sequence4BeFree
umls:C0002793Anaplasia3BeFree
umls:C0003873Rheumatoid Arthritis3BeFree
umls:C0009375Colonic Neoplasms3BeFree
umls:C0017185Gastrointestinal Neoplasms3BeFree
umls:C0019196Hepatitis C3BeFree,GAD
umls:C0020542Pulmonary Hypertension3BeFree
umls:C0023467Leukemia, Myelocytic, Acute3BeFree,LHGDN
umls:C0023473Myeloid Leukemia, Chronic3BeFree
umls:C0024299Lymphoma3BeFree
umls:C0026764Multiple Myeloma3BeFree
umls:C0027626Neoplasm Invasiveness3CTD_human
umls:C0027830neurofibroma3BeFree
umls:C0032927Precancerous Conditions3BeFree,CTD_human,GAD
umls:C0035412Rhabdomyosarcoma3BeFree
umls:C0037286Skin Neoplasms3BeFree,GAD
umls:C0085548Autosomal Recessive Polycystic Kidney Disease3BeFree
umls:C0151779Cutaneous Melanoma3BeFree
umls:C0155490Middle Ear Cholesteatoma3BeFree
umls:C0206682Follicular thyroid carcinoma3BeFree
umls:C0206686Adrenocortical carcinoma3BeFree
umls:C0206698Cholangiocarcinoma3BeFree
umls:C0220641Lip and Oral Cavity Carcinoma3BeFree
umls:C0238462Medullary carcinoma of thyroid3BeFree
umls:C0238463Papillary thyroid carcinoma3BeFree
umls:C0242852Proliferative vitreoretinopathy3BeFree
umls:C0278488Carcinoma breast stage IV3BeFree
umls:C0278601Inflammatory Breast Carcinoma3BeFree
umls:C0338106Adenocarcinoma of colon3BeFree
umls:C0345967Malignant mesothelioma3BeFree
umls:C0524910Hepatitis C, Chronic3BeFree
umls:C0598935Tumor Initiation3BeFree
umls:C1261473Sarcoma3BeFree
umls:C1319315Adenocarcinoma of large intestine3BeFree
umls:C1378703Renal carcinoma3BeFree
umls:C1709246Non-Neoplastic Disorder3BeFree
umls:C0001486Adenovirus Infections2BeFree
umls:C0001973Alcoholic Intoxication, Chronic2GAD
umls:C0007133Carcinoma, Papillary2BeFree
umls:C0007621Neoplastic Cell Transformation2CTD_human
umls:C0008373Cholesteatoma2BeFree
umls:C0009319Colitis2BeFree
umls:C0010278Craniosynostosis2BeFree
umls:C0010709Cyst2BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent2BeFree
umls:C0013537Eclampsia2BeFree
umls:C0013581Ectopia Lentis2BeFree
umls:C0015230Exanthema2BeFree
umls:C0017152Gastritis2BeFree
umls:C0018206granulosa cell tumor2BeFree
umls:C0019348Herpes Simplex Infections2BeFree
umls:C0020295Hydronephrosis2BeFree,LHGDN
umls:C0020538Hypertensive disease2BeFree,GAD
umls:C0021670insulinoma2BeFree
umls:C0022116Ischemia2BeFree
umls:C0022661Kidney Failure, Chronic2BeFree,LHGDN
umls:C0022665Kidney Neoplasm2BeFree,GAD
umls:C0022679Cystic kidney2BeFree
umls:C0022680Polycystic Kidney Diseases2BeFree
umls:C0023895Liver diseases2BeFree
umls:C0024115Lung diseases2BeFree
umls:C0024232Lymphatic Metastasis2BeFree,GAD
umls:C0024530Malaria2BeFree
umls:C0027643Neoplasm Recurrence, Local2GAD
umls:C0027809Neurilemmoma2BeFree,GAD
umls:C0027831Neurofibromatosis 12BeFree
umls:C0028754Obesity2BeFree
umls:C0028960Oligospermia2BeFree
umls:C0030354Papilloma2BeFree
umls:C0033999Pterygium2BeFree
umls:C0034067Pulmonary Emphysema2BeFree
umls:C0036421Systemic Scleroderma2BeFree
umls:C0038358Gastric ulcer2CTD_human
umls:C0038454Cerebrovascular accident2BeFree
umls:C0041341Tuberous Sclerosis2BeFree
umls:C0041696Unipolar Depression2BeFree
umls:C0041956Ureteral obstruction2BeFree
umls:C0042769Virus Diseases2BeFree
umls:C0079218Fibromatosis, Aggressive2BeFree
umls:C0085695Chronic gastritis2BeFree
umls:C0086692Benign Neoplasm2BeFree
umls:C0086942Rous Sarcoma2BeFree
umls:C0149521Pancreatitis, Chronic2BeFree
umls:C0151546Oral Cavity Carcinoma2BeFree
umls:C0153381Malignant neoplasm of mouth2BeFree
umls:C0153392Malignant neoplasm of nasopharynx2BeFree
umls:C0153690Secondary malignant neoplasm of bone2BeFree
umls:C0162810Cicatrix, Hypertrophic2BeFree
umls:C0206664Teratocarcinoma2BeFree
umls:C0206701Cystadenocarcinoma, Serous2BeFree
umls:C0206727Nerve Sheath Tumors2BeFree
umls:C0206754Neuroendocrine Tumors2BeFree
umls:C0220633Uveal melanoma2BeFree
umls:C0238301Cancer of Nasopharynx2BeFree
umls:C0241961Angiomyolipoma of kidney2BeFree
umls:C0279672Cervical Adenocarcinoma2BeFree
umls:C0333516Tumor necrosis2BeFree
umls:C0334463Malignant Fibrous Histiocytoma2BeFree
umls:C0338656Impaired cognition2BeFree
umls:C0494165Secondary malignant neoplasm of liver2BeFree
umls:C0521158Recurrent tumor2BeFree
umls:C0553723Squamous cell carcinoma of skin2BeFree
umls:C0677944Sentinel node (disorder)2BeFree
umls:C0685938Malignant neoplasm of gastrointestinal tract2BeFree
umls:C0740391Middle Cerebral Artery Occlusion2BeFree
umls:C0751688Malignant Squamous Cell Neoplasm2BeFree
umls:C0812413Malignant Pleural Mesothelioma2BeFree
umls:C0850666Helicobacter pylori infection2BeFree
umls:C1269683Major Depressive Disorder2BeFree
umls:C1516170Cancer Cell Growth2BeFree
umls:C1704272Benign Prostatic Hyperplasia2BeFree
umls:C1800706Idiopathic Pulmonary Fibrosis2BeFree
umls:C3665419Intracranial glioma2BeFree
umls:C0000786Spontaneous abortion1GAD
umls:C0001622Adrenal Gland Hyperfunction1BeFree
umls:C0002448Ameloblastoma1BeFree
umls:C0002736Amyotrophic Lateral Sclerosis1BeFree
umls:C0002874Aplastic Anemia1BeFree
umls:C0003811Cardiac Arrhythmia1GAD
umls:C0003850Arteriosclerosis1BeFree
umls:C0003872Arthritis, Psoriatic1BeFree,GAD
umls:C0004153Atherosclerosis1BeFree
umls:C0004352Autistic Disorder1BeFree,CTD_human
umls:C0004364Autoimmune Diseases1BeFree
umls:C0004763Barrett Esophagus1GAD
umls:C0005411Biliary Atresia1BeFree
umls:C0005818Blood Platelet Disorders1BeFree
umls:C0006079Bowen's Disease1BeFree
umls:C0006840Candidiasis1BeFree
umls:C0007095Carcinoid Tumor1BeFree
umls:C0007104Female Breast Carcinoma1BeFree
umls:C0007112Adenocarcinoma of prostate1BeFree
umls:C0007113Rectal Carcinoma1BeFree
umls:C0007138Carcinoma, Transitional Cell1BeFree
umls:C0007140Carcinosarcoma1BeFree
umls:C0007222Cardiovascular Diseases1GAD
umls:C0007282Carotid Stenosis1BeFree
umls:C0007570Celiac Disease1BeFree
umls:C0008073Developmental Disabilities1BeFree
umls:C0008493Hydatidiform Mole, Invasive1BeFree
umls:C0008677Bronchitis, Chronic1BeFree
umls:C0008925Cleft Palate1CTD_human
umls:C0010276Craniopharyngioma1BeFree
umls:C0010674Cystic Fibrosis1LHGDN
umls:C0010823Cytomegalovirus Infections1LHGDN
umls:C0011265Presenile dementia1BeFree
umls:C0011269Dementia, Vascular1BeFree
umls:C0011603Dermatitis1BeFree
umls:C0011615Dermatitis, Atopic1BeFree
umls:C0011644Scleroderma1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1GAD
umls:C0012754Distemper1BeFree
umls:C0013295Duodenal Ulcer1BeFree
umls:C0013312Dupuytren Contracture1LHGDN
umls:C0013595Eczema1BeFree
umls:C0014474Ependymoma1BeFree
umls:C0015302External exotoses1BeFree
umls:C0015393Eye Abnormalities1BeFree
umls:C0016978gallbladder neoplasm1LHGDN
umls:C0017150Gastrinoma1BeFree
umls:C0017661IGA Glomerulonephritis1BeFree
umls:C0018021Goiter1BeFree
umls:C0018553Hamartoma Syndrome, Multiple1BeFree
umls:C0018671Head and Neck Neoplasms1LHGDN
umls:C0018817Atrial Septal Defects1BeFree
umls:C0018889Helminthiasis1BeFree
umls:C0020217Hydatidiform Mole1BeFree
umls:C0020503Hyperparathyroidism, Secondary1GAD
umls:C0020608Hypodontia1BeFree
umls:C0021051Immunologic Deficiency Syndromes1BeFree
umls:C0021368Inflammation1LHGDN
umls:C0021390Inflammatory Bowel Diseases1BeFree
umls:C0021846Intestinal Polyps1BeFree
umls:C0023434Chronic Lymphocytic Leukemia1GAD
umls:C0023449Acute lymphocytic leukemia1BeFree
umls:C0024117Chronic Obstructive Airway Disease1GAD
umls:C0025269Multiple Endocrine Neoplasia Type 2b1BeFree
umls:C0025500Mesothelioma1BeFree
umls:C0025568Metaplasia1CTD_human
umls:C0026393Molluscum Contagiosum1BeFree
umls:C0026499Monosomy1BeFree
umls:C0026703Mucopolysaccharidoses1BeFree
umls:C0026847Spinal Muscular Atrophy1BeFree
umls:C0027686Pathologic Neovascularization1GAD
umls:C0027766Nervous System Neoplasms1BeFree,GAD
umls:C0027832Neurofibromatosis 21BeFree
umls:C0027960Nevus1BeFree
umls:C0027962Melanocytic nevus1BeFree
umls:C0029408Degenerative polyarthritis1BeFree
umls:C0029927Ovarian Cysts1BeFree
umls:C0030567Parkinson Disease1BeFree
umls:C0031099Periodontitis1GAD
umls:C0031117Peripheral Neuropathy1CTD_human
umls:C0031511Pheochromocytoma1BeFree
umls:C0031941Pineal Gland Neoplasm1BeFree
umls:C0032000Pituitary Adenoma1BeFree
umls:C0032584polyps1BeFree
umls:C0032914Pre-Eclampsia1GAD
umls:C0033575Prostatic Diseases1BeFree
umls:C0033839Pseudorabies1BeFree
umls:C0034069Pulmonary Fibrosis1CTD_human
umls:C0034885Rectal Neoplasms1GAD
umls:C0035078Kidney Failure1BeFree
umls:C0035126Reperfusion Injury1CTD_human
umls:C0035222Respiratory Distress Syndrome, Adult1BeFree,GAD
umls:C0038356Stomach Neoplasms1LHGDN
umls:C0039590Testicular Neoplasms1BeFree
umls:C0039685Tetralogy of Fallot1BeFree
umls:C0040336Tobacco Use Disorder1GAD
umls:C0041107Trisomy1BeFree
umls:C0041182Trophoblastic Neoplasms1BeFree
umls:C0079474Hallopeau-Siemens Disease1BeFree
umls:C0079588Ichthyosis, X-Linked1BeFree
umls:C0085109Corneal Neovascularization1BeFree
umls:C0085400Neurofibrillary degeneration (morphologic abnormality)1BeFree
umls:C0086543Cataract1BeFree
umls:C0149939Obstructive nephropathy1BeFree
umls:C0152171Idiopathic pulmonary hypertension1BeFree
umls:C0152451Chronic glomerulonephritis1BeFree
umls:C0153601Malignant neoplasm of penis1BeFree
umls:C0153676Secondary malignant neoplasm of lung1BeFree
umls:C0155552Hearing Loss, Mixed Conductive-Sensorineural1BeFree
umls:C0162359Christ-Siemens-Touraine syndrome1BeFree
umls:C0175693Russell-Silver syndrome1BeFree
umls:C0175704LEOPARD Syndrome1BeFree
umls:C0206062Lung Diseases, Interstitial1BeFree
umls:C0206638Giant Cell Tumor of Bone1BeFree
umls:C0206659Embryonal Carcinoma1BeFree
umls:C0206669Hepatocellular Adenoma1BeFree
umls:C0206681Adenocarcinoma, Clear Cell1BeFree
umls:C0206693Medullary carcinoma1BeFree
umls:C0206695Carcinoma, Neuroendocrine1BeFree
umls:C0206699Cystadenocarcinoma, Mucinous1BeFree
umls:C0206720Squamous Cell Neoplasms1BeFree
umls:C0206726gliosarcoma1BeFree
umls:C0221228Comedone1BeFree
umls:C0221239Rapidly progressive glomerulonephritis1BeFree
umls:C0221406Pituitary-dependent Cushing's disease1BeFree
umls:C0235394Wasting1BeFree
umls:C0236053Mucosal ulcer1BeFree
umls:C0238394Female Pseudohermaphroditism1BeFree
umls:C0240035Interstitial fibrosis1BeFree
umls:C0242383Age related macular degeneration1BeFree
umls:C0242647Mucosa-Associated Lymphoid Tissue Lymphoma1BeFree
umls:C0242656Disease Progression1CTD_human
umls:C0242666Protein S Deficiency1BeFree
umls:C0262655Recurrent urinary tract infection1BeFree
umls:C0263454Chloracne1BeFree
umls:C0265268Adams Oliver syndrome1BeFree
umls:C0265344Donohue Syndrome1BeFree
umls:C0267952Fibrosis of pancreas1BeFree
umls:C0268225Aspartylglucosaminuria1BeFree
umls:C0270075Perinatal disorder1BeFree
umls:C0271568Laron Syndrome1BeFree
umls:C0271844Parathyroid hyperplasia1BeFree
umls:C0276623Chronic viral hepatitis1BeFree
umls:C0278701Gastric Adenocarcinoma1BeFree
umls:C0279637Anal carcinoma1BeFree
umls:C0279680Transitional cell carcinoma of bladder1BeFree
umls:C0279702Conventional (Clear Cell) Renal Cell Carcinoma1BeFree
umls:C0280232stage, cervical cancer1BeFree
umls:C0280280stage, prostate cancer1BeFree
umls:C0280321Squamous cell carcinoma of the hypopharynx1BeFree
umls:C0282488Interstitial Cystitis1LHGDN
umls:C0333186Restenosis1BeFree
umls:C0333983Hyperplastic Polyp1BeFree
umls:C0334108Multiple polyps1BeFree
umls:C0334274Papillary transitional cell carcinoma1BeFree
umls:C0334294Multiple adenomatous polyps1BeFree
umls:C0334299Carcinoid tumor no ICD-O subtype1BeFree
umls:C0334588Giant Cell Glioblastoma1BeFree
umls:C0338831Manic1BeFree
umls:C0339508Hereditary macular dystrophy1BeFree
umls:C0346109Malignant Mesothelioma of Peritoneum1BeFree
umls:C0346163Endometrioid carcinoma ovary1BeFree
umls:C0349534Carcinoma of anal margin1BeFree
umls:C0349566Squamous cell carcinoma of tongue1BeFree
umls:C0393559Troyer syndrome1BeFree
umls:C0403592Chronic rejection of renal transplant1BeFree
umls:C0497327Dementia1BeFree
umls:C0521707Bilateral cataracts (disorder)1BeFree
umls:C0524909Hepatitis B, Chronic1BeFree
umls:C0587248Costello syndrome (disorder)1BeFree
umls:C0677055CARCINOMA OF VULVA1BeFree
umls:C0730292Macular dystrophy1BeFree
umls:C0740457Malignant neoplasm of kidney1BeFree
umls:C0744310gastritis h pylori1BeFree
umls:C0751674Lymphangioleiomyomatosis1BeFree
umls:C0751689Peripheral Nerve Sheath Neoplasm1BeFree
umls:C0853105Penis carcinoma1BeFree
umls:C0853879Invasive breast carcinoma1BeFree
umls:C0854917Rhabdoid Tumor of the Kidney1BeFree
umls:C0856747Aneurysm of ascending aorta1BeFree
umls:C0936223Metastatic Prostate Carcinoma1BeFree
umls:C1153706Endometrial adenocarcinoma1BeFree
umls:C1167791Skin toxicity1BeFree
umls:C1260954Morphologically altered structure1BeFree
umls:C1266184Atypical teratoid/rhabdoid tumor1BeFree
umls:C1332271Perianal Squamous Intraepithelial Neoplasia1BeFree
umls:C1334274Invasive Carcinoma1BeFree
umls:C1368404Hypopharyngeal Carcinoma1BeFree
umls:C1456781Benign melanocytic nevus1BeFree
umls:C1519670Tumor Angiogenesis1BeFree
umls:C1519689Tumor Promotion1BeFree
umls:C1812607Aortic aneurysm and dissection1BeFree
umls:C1827820Fast acetylator due to N-acetyltransferase enzyme variant1BeFree
umls:C1853195Prostate Cancer, Hereditary, 71BeFree
umls:C1956089Osteophyte1BeFree
umls:C1970109AROMATASE EXCESS SYNDROME1BeFree
umls:C2145472Urothelial Carcinoma1BeFree
umls:C2239120eyelids (symptom)1BeFree
umls:C2609414Acute kidney injury1RGD
umls:C2673648Hypomagnesemia 4, Renal1CLINVAR,CTD_human,UNIPROT
umls:C2937421Prostatic Hyperplasia1LHGDN
umls:C2973725Pulmonary arterial hypertension1BeFree
umls:C3463897HYDATIDIFORM MOLE, RECURRENT, 11BeFree
umls:C3495559Juvenile arthritis1CTD_human
umls:C3665593Melanocytic nevus of skin1BeFree
umls:C3669246Mammary adenocarcinoma1BeFree
umls:C3714534dowling-degos disease1BeFree
umls:C3714844Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia1BeFree
umls:C3714873Axenfeld-Rieger Syndrome, Type 11BeFree
umls:C3828416Radiation Damage1BeFree
umls:C3829122Mesenchymal Glioblastoma1BeFree