TissGeneSummary for IMMP1L |
Gene summary |
Basic gene information | Gene symbol | IMMP1L |
Gene name | IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) | |
Synonyms | IMP1|IMP1-LIKE | |
Cytomap | UCSC genome browser: 11p13 | |
Type of gene | protein-coding | |
RefGenes | NM_144981.1, | |
Description | mitochondrial inner membrane protease subunit 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 612323 | |
HGNC : HGNC | ||
Ensembl : ENSG00000148950 | ||
HPRD : 08048 | ||
Vega : OTTHUMG00000166226 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IMMP1L | |
BioGPS: 196294 | ||
Pathway | NCI Pathway Interaction Database: IMMP1L | |
KEGG: IMMP1L | ||
REACTOME: IMMP1L | ||
Pathway Commons: IMMP1L | ||
Context | iHOP: IMMP1L | |
ligand binding site mutation search in PubMed: IMMP1L | ||
UCL Cancer Institute: IMMP1L | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHTGCT | |
Reference showing the relevant tissue of IMMP1L | ||
Description by TissGene annotations | Risk TissGene in OS Risk TissGene in RFS TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for IMMP1L |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for IMMP1L |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for IMMP1L |
TissGeneSNV for IMMP1L |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R140* | UCEC | 1 |
p.G130V | BLCA | 1 |
p.S48L | SKCM | 1 |
p.S97I | STAD | 1 |
p.K8R | HNSC | 1 |
p.M41V | DLBC | 1 |
p.I86V | STAD | 1 |
p.W146L | STAD | 1 |
p.R140Q | UCEC | 1 |
p.R11Q | UCEC | 1 |
p.D49N | CESC | 1 |
p.H59R | KIRP | 1 |
p.D150Y | HNSC | 1 |
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TissGeneCNV for IMMP1L |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for IMMP1L |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BG433771 | IMMP1L-ELP4 | chr11:31531125 | chr11:31541601 | |
Chimerdb3.0 | FusionScan | HNSC | TCGA-BB-4228-01A | IMMP1L-ELP4 | 5'UTR-CDS | chr11:31531065 | chr11:31669288 |
Chimerdb3.0 | FusionScan | LGG | TCGA-QH-A65Z-01A | IMMP1L-ELP4 | 5'UTR-CDS | chr11:31531065 | chr11:31648656 |
Chimerdb3.0 | FusionScan | LGG | TCGA-S9-A6WN-01A | IMMP1L-ELP4 | 5'UTR-CDS | chr11:31531065 | chr11:31653763 |
Chimerdb3.0 | FusionScan | LGG | TCGA-FG-5965-01B | IMMP1L-ELP4 | 5'UTR-CDS | chr11:31531065 | chr11:31541602 |
Chimerdb3.0 | FusionScan | LGG | TCGA-DU-6401-01A | IMMP1L-ELP4 | 5'UTR-CDS | chr11:31531065 | chr11:31804940 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-IG-A4QS-01A | IMMP1L-ELP4 | Out-of-Frame | chr11:31484718 | chr11:31541602 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A9FO-01A | IMMP1L-ELP4 | 5'UTR-CDS | chr11:31531065 | chr11:31669288 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A8NR-01A | IMMP1L-ELP4 | 5'UTR-CDS | chr11:31531065 | chr11:31616316 |
Chimerdb3.0 | FusionScan | COAD | TCGA-CK-5912-01A | IMMP1L-ELP4 | 5'UTR-CDS | chr11:31531065 | chr11:31616316 |
Chimerdb3.0 | FusionScan | UCEC | TCGA-EY-A54A-01A | IMMP1L-ELP4 | 5'UTR-CDS | chr11:31531065 | chr11:31616316 |
Chimerdb3.0 | FusionScan | KIRC | TCGA-CW-5585-11A | IMMP1L-SCIN | 5'UTR-5'UTR | chr11:31531065 | chr7:12644138 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-JY-A93E-01A | IMMP1L-DCDC1 | 5'UTR-CDS | chr11:31531065 | chr11:31329455 |
Chimerdb3.0 | FusionScan | LUSC | TCGA-21-5783-01A | IMMP1L-ELP4 | 5'UTR-CDS | chr11:31531065 | chr11:31648656 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-ZR-A9CJ-01B | DNAJC24-IMMP1L | In-Frame | chr11:31392406 | chr11:31455117 |
Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-MP-A4T4-01A | IMMP1L-ELP4 | Out-of-Frame | chr11:31484718 | chr11:31543278 |
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TissGeneNet for IMMP1L |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for IMMP1L |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for IMMP1L |
TissGeneDrug for IMMP1L |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for IMMP1L |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0008497 | Choriocarcinoma | 1 | BeFree |
umls:C0017601 | Glaucoma | 1 | GWASCAT |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0040558 | Toxoplasmosis | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |