TissGeneSummary for KRT78 |
Gene summary |
Basic gene information | Gene symbol | KRT78 |
Gene name | keratin 78 | |
Synonyms | CK-78|K5B|K78|Kb40 | |
Cytomap | UCSC genome browser: 12q13.13 | |
Type of gene | protein-coding | |
RefGenes | NM_001300814.1, NM_173352.3, | |
Description | cytokeratin-78keratin, type II cytoskeletal 78keratin-5btype-II keratin Kb40 | |
Modification date | 20141207 | |
dbXrefs | MIM : 611159 | |
HGNC : HGNC | ||
Ensembl : ENSG00000170423 | ||
HPRD : 17171 | ||
Vega : OTTHUMG00000169880 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KRT78 | |
BioGPS: 196374 | ||
Pathway | NCI Pathway Interaction Database: KRT78 | |
KEGG: KRT78 | ||
REACTOME: KRT78 | ||
Pathway Commons: KRT78 | ||
Context | iHOP: KRT78 | |
ligand binding site mutation search in PubMed: KRT78 | ||
UCL Cancer Institute: KRT78 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Esophagus | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCA | |
Reference showing the relevant tissue of KRT78 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KRT78 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 0.968178046 | -2.452445483 | 3.420623529 | 4.19E-12 | 1.83E-11 |
HNSC | 4.350147677 | 8.824912793 | -4.474765116 | 1.33E-07 | 1.27E-06 |
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TissGene-miRNA for KRT78 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KRT78 |
TissGeneSNV for KRT78 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S43F | SKCM | 2 |
p.E180K | SKCM | 2 |
p.E290K | SKCM | 2 |
p.L201F | SKCM | 1 |
p.G63E | SKCM | 1 |
p.Q149H | UCEC | 1 |
p.N136K | PCPG | 1 |
p.E291* | OV | 1 |
p.G60V | THYM | 1 |
p.P102L | SKCM | 1 |
p.D375N | ACC | 1 |
p.G254E | SKCM | 1 |
p.R180Q | SKCM | 1 |
p.R15H | STAD | 1 |
p.T402M | STAD | 1 |
p.L311F | SKCM | 1 |
p.A355T | SKCM | 1 |
p.S22L | BLCA | 1 |
p.P102S | SKCM | 1 |
p.D167H | HNSC | 1 |
p.S401N | STAD | 1 |
p.S204F | BLCA | 1 |
p.T264M | PRAD | 1 |
p.V138I | HNSC | 1 |
p.E99K | SKCM | 1 |
p.H333N | THYM | 1 |
p.T400M | COAD | 1 |
p.A17T | STAD | 1 |
p.K197Q | PRAD | 1 |
p.R65W | PRAD | 1 |
p.R180L | BLCA | 1 |
p.D214N | SKCM | 1 |
p.R70Q | SKCM | 1 |
p.R288Q | UCEC | 1 |
p.R52C | SKCM | 1 |
p.D57N | SKCM | 1 |
p.T154M | PRAD | 1 |
p.L77M | SKCM | 1 |
p.D485N | ACC | 1 |
p.G47D | SKCM | 1 |
p.D192Y | OV | 1 |
p.T112I | OV | 1 |
p.D161N | SKCM | 1 |
p.P95Q | LUAD | 1 |
p.T215M | HNSC | 1 |
p.P95K | LUAD | 1 |
p.D277H | HNSC | 1 |
p.V51L | SKCM | 1 |
p.P95T | LUAD | 1 |
p.K307Q | PRAD | 1 |
p.G335R | SKCM | 1 |
p.E291K | SKCM | 1 |
p.A245T | SKCM | 1 |
p.Q121R | LGG | 1 |
p.V225I | COAD | 1 |
p.R21H | PAAD | 1 |
p.L389M | HNSC | 1 |
p.L187M | SKCM | 1 |
p.C284F | HNSC | 1 |
p.E267K | SKCM | 1 |
p.Q9* | LIHC | 1 |
p.D113N | SKCM | 1 |
p.D104N | SKCM | 1 |
p.S220C | BLCA | 1 |
p.Q90K | LUAD | 1 |
p.E131K | HNSC | 1 |
p.Q258P | LIHC | 1 |
p.L136M | SKCM | 1 |
p.T109M | DLBC | 1 |
p.A355V | UCEC | 1 |
p.R70L | BLCA | 1 |
p.T402M | HNSC | 1 |
p.S280I | UCEC | 1 |
p.D101N | SKCM | 1 |
p.S204F | PRAD | 1 |
p.E241K | HNSC | 1 |
p.Q202* | SKCM | 1 |
p.V28I | HNSC | 1 |
p.R414H | PAAD | 1 |
p.L279M | HNSC | 1 |
p.V161L | SKCM | 1 |
p.L118F | SKCM | 1 |
p.S51C | ESCA | 1 |
p.E181K | SKCM | 1 |
p.Q227R | LUAD | 1 |
p.Q227E | BLCA | 1 |
p.K403T | UCEC | 1 |
p.E141K | SKCM | 1 |
p.R52H | LGG | 1 |
p.N26K | PCPG | 1 |
p.T292M | HNSC | 1 |
p.H208L | SARC | 1 |
p.G419S | BRCA | 1 |
p.L75F | SKCM | 1 |
p.C80F | LUAD | 1 |
p.E344D | READ | 1 |
p.D375N | SKCM | 1 |
p.T325M | HNSC | 1 |
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TissGeneCNV for KRT78 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KRT78 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | TopHat-Fusion | HNSC | TCGA-CV-7177-11A | KRT78-KRT13 | Out-of-Frame | chr12:53233149 | chr17:39659355 |
TCGAfusionPortal | PRADA | BLCA | TCGA-CF-A3MI-01A | NRG1-KRT78 | Out-of-frame | Chr8:32406344 | Chr12:53233768 |
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TissGeneNet for KRT78 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KRT78 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KRT78 |
TissGeneDrug for KRT78 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KRT78 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0033578 | Prostatic Neoplasms | 1 | GAD |