TissGeneSummary for CCER1 |
Gene summary |
Basic gene information | Gene symbol | CCER1 |
Gene name | coiled-coil glutamate-rich protein 1 | |
Synonyms | C12orf12 | |
Cytomap | UCSC genome browser: 12q21.33 | |
Type of gene | protein-coding | |
RefGenes | NM_152638.2, | |
Description | coiled-coil domain-containing glutamate-rich protein 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000197651 | ||
HPRD : 14505 | ||
Vega : OTTHUMG00000170070 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCER1 | |
BioGPS: 196477 | ||
Pathway | NCI Pathway Interaction Database: CCER1 | |
KEGG: CCER1 | ||
REACTOME: CCER1 | ||
Pathway Commons: CCER1 | ||
Context | iHOP: CCER1 | |
ligand binding site mutation search in PubMed: CCER1 | ||
UCL Cancer Institute: CCER1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CCER1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for CCER1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
Top |
TissGene-miRNA for CCER1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for CCER1 |
TissGeneSNV for CCER1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P391S | SKCM | 2 |
p.G331E | SKCM | 2 |
p.G182A | STAD | 1 |
p.G89X | STAD | 1 |
p.P386S | SKCM | 1 |
p.E315K | SKCM | 1 |
p.G144D | SKCM | 1 |
p.Q402H | HNSC | 1 |
p.P394L | LUAD | 1 |
p.R145C | STAD | 1 |
p.G252S | SKCM | 1 |
p.R145C | LUAD | 1 |
p.E177D | LGG | 1 |
p.A401V | LIHC | 1 |
p.R40* | SKCM | 1 |
p.E351D | LUAD | 1 |
p.A45P | ESCA | 1 |
p.R151H | DLBC | 1 |
p.Q70K | HNSC | 1 |
p.P159Q | LUAD | 1 |
p.S380N | SKCM | 1 |
p.R110Q | STAD | 1 |
p.E319K | SKCM | 1 |
p.P172L | LGG | 1 |
p.E332D | LUAD | 1 |
p.P67S | SKCM | 1 |
p.P386T | LUAD | 1 |
p.R209H | PRAD | 1 |
p.D309E | KIRP | 1 |
p.S380R | UCS | 1 |
p.P273T | PRAD | 1 |
p.E315K | PAAD | 1 |
p.P227Q | LUAD | 1 |
p.M201I | SKCM | 1 |
p.C124R | LUAD | 1 |
p.R40X | SKCM | 1 |
p.Y290S | LUAD | 1 |
p.W85* | SKCM | 1 |
p.N350K | LUAD | 1 |
p.W85C | LUAD | 1 |
p.W100* | SKCM | 1 |
p.S36L | PAAD | 1 |
p.G138D | STAD | 1 |
p.R110W | SKCM | 1 |
p.P51L | UVM | 1 |
p.F261L | LGG | 1 |
p.E376D | STAD | 1 |
p.H52Q | LUAD | 1 |
p.P73Q | LUAD | 1 |
p.W85X | SKCM | 1 |
p.E318K | HNSC | 1 |
p.E348* | LUAD | 1 |
p.E351K | SKCM | 1 |
p.L271F | SKCM | 1 |
p.E177* | LUAD | 1 |
p.G245E | SKCM | 1 |
p.E326K | BLCA | 1 |
p.W26* | LIHC | 1 |
p.P172L | SKCM | 1 |
p.R142C | STAD | 1 |
p.S366L | ACC | 1 |
p.V294M | SKCM | 1 |
p.Q217H | BLCA | 1 |
p.R64K | LUAD | 1 |
p.E318K | SKCM | 1 |
p.E248K | SKCM | 1 |
p.E224K | SKCM | 1 |
p.P73T | LUAD | 1 |
p.W35R | HNSC | 1 |
p.G90W | HNSC | 1 |
p.R142H | LIHC | 1 |
p.R148S | LUAD | 1 |
p.A164V | HNSC | 1 |
p.E308G | PAAD | 1 |
p.Y112H | PRAD | 1 |
p.E224* | BLCA | 1 |
p.W26C | ESCA | 1 |
p.W26X | LIHC | 1 |
p.H115Q | LUAD | 1 |
p.N385S | SKCM | 1 |
p.S33R | LUAD | 1 |
p.G61R | SKCM | 1 |
Top |
TissGeneCNV for CCER1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for CCER1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for CCER1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CCER1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for CCER1 |
TissGeneDrug for CCER1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CCER1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |