TissGeneSummary for ELAVL2 |
Gene summary |
Basic gene information | Gene symbol | ELAVL2 |
Gene name | ELAV like neuron-specific RNA binding protein 2 | |
Synonyms | HEL-N1|HELN1|HUB | |
Cytomap | UCSC genome browser: 9p21 | |
Type of gene | protein-coding | |
RefGenes | NM_001171195.1, NM_001171197.1,NM_004432.3, | |
Description | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)ELAV-like neuronal protein 1 isoform Hel-N2ELAV-like protein 2hu-antigen Bnervous system-specific RNA-binding protein Hel-N1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601673 | |
HGNC : HGNC | ||
Ensembl : ENSG00000107105 | ||
HPRD : 03396 | ||
Vega : OTTHUMG00000019700 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ELAVL2 | |
BioGPS: 1993 | ||
Pathway | NCI Pathway Interaction Database: ELAVL2 | |
KEGG: ELAVL2 | ||
REACTOME: ELAVL2 | ||
Pathway Commons: ELAVL2 | ||
Context | iHOP: ELAVL2 | |
ligand binding site mutation search in PubMed: ELAVL2 | ||
UCL Cancer Institute: ELAVL2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ELAVL2 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ELAVL2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -0.06689611 | -1.743613351 | 1.676717241 | 2.03E-07 | 7.59E-07 |
LUSC | -0.101723392 | -1.771415549 | 1.669692157 | 2.80E-05 | 6.13E-05 |
PRAD | 2.248365296 | 0.317644142 | 1.930721154 | 5.69E-07 | 4.31E-06 |
BRCA | 2.176474338 | 0.20756118 | 1.968913158 | 5.77E-18 | 3.56E-17 |
KICH | 4.595684373 | 0.402604373 | 4.19308 | 4.71E-08 | 2.28E-07 |
LIHC | -1.543635627 | -2.564109627 | 1.020474 | 3.46E-07 | 2.10E-06 |
HNSC | 1.874025582 | 0.54611628 | 1.327909302 | 0.00694 | 0.018010381 |
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TissGene-miRNA for ELAVL2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
THYM | hsa-miR-892c-3p | MIMAT0025858 | 0.0067 | -0.29 | 122 |
UCS | hsa-miR-501-3p | MIMAT0004774 | 0.028 | -0.3 | 56 |
UCS | hsa-miR-148a-3p | MIMAT0000243 | 0.02 | -0.31 | 56 |
UCS | hsa-miR-502-3p | MIMAT0004775 | 0.011 | -0.34 | 56 |
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TissGeneMut for ELAVL2 |
TissGeneSNV for ELAVL2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R155C | SKCM | 3 |
p.S146L | SKCM | 2 |
p.E2K | SKCM | 2 |
p.S26L | SKCM | 2 |
p.D344H | LUAD | 1 |
p.C25W | UCS | 1 |
p.G213D | CESC | 1 |
p.E53K | SKCM | 1 |
p.M30I | HNSC | 1 |
p.S16L | SKCM | 1 |
p.T10A | KIRP | 1 |
p.Y45X | STAD | 1 |
p.E94D | BLCA | 1 |
p.A320V | COAD | 1 |
p.G169W | LUAD | 1 |
p.R236G | LUSC | 1 |
p.D124N | SKCM | 1 |
p.Y45C | UCEC | 1 |
p.I122T | LIHC | 1 |
p.R224K | BLCA | 1 |
p.G17A | COAD | 1 |
p.I156V | LUAD | 1 |
p.R236C | PAAD | 1 |
p.V280L | SKCM | 1 |
p.L105R | BLCA | 1 |
p.G343E | HNSC | 1 |
p.M260I | SKCM | 1 |
p.A287S | LUAD | 1 |
p.G259R | STAD | 1 |
p.C316Y | PAAD | 1 |
p.K38R | STAD | 1 |
p.Q76* | CESC | 1 |
p.S121C | SKCM | 1 |
p.E64K | SKCM | 1 |
p.G77A | PRAD | 1 |
p.D89G | LIHC | 1 |
p.G169R | SKCM | 1 |
p.W17* | SARC | 1 |
p.P90L | SKCM | 1 |
p.G81E | SKCM | 1 |
p.G273E | SKCM | 1 |
p.W276* | SKCM | 1 |
p.A333V | UCS | 1 |
p.W22* | HNSC | 1 |
p.E289Q | LUAD | 1 |
p.N98I | STAD | 1 |
p.S337F | SKCM | 1 |
p.D258E | BLCA | 1 |
p.I122V | COAD | 1 |
p.S26L | READ | 1 |
p.S165L | SKCM | 1 |
p.N33K | THYM | 1 |
p.L263F | LUAD | 1 |
p.D159H | HNSC | 1 |
p.G149E | UCEC | 1 |
p.V29A | HNSC | 1 |
p.I198M | STAD | 1 |
p.A182V | LUAD | 1 |
p.K139N | SKCM | 1 |
p.R166M | STAD | 1 |
p.G169V | LUAD | 1 |
p.T14A | LIHC | 1 |
p.G297E | STAD | 1 |
p.T210I | SKCM | 1 |
p.M1I | HNSC | 1 |
p.R172* | SKCM | 1 |
p.P90H | LUAD | 1 |
p.G167C | GBM | 1 |
p.A115D | MESO | 1 |
p.I177S | COAD | 1 |
p.R176* | LGG | 1 |
p.N223D | PRAD | 1 |
p.T10I | STAD | 1 |
p.P47S | SKCM | 1 |
p.T34K | LUSC | 1 |
p.L157R | ESCA | 1 |
p.R176X | LGG | 1 |
p.R150C | KIRC | 1 |
p.Q160* | LUAD | 1 |
p.R116H | STAD | 1 |
p.G273R | LUSC | 1 |
p.G273E | ESCA | 1 |
p.L46P | STAD | 1 |
p.S61G | KICH | 1 |
p.S350F | SKCM | 1 |
p.L80M | HNSC | 1 |
p.N314K | PAAD | 1 |
p.Y45* | STAD | 1 |
p.I211M | CESC | 1 |
p.A231D | LUAD | 1 |
p.K38T | STAD | 1 |
p.R150C | STAD | 1 |
p.R13K | SKCM | 1 |
p.V346E | OV | 1 |
p.R150P | HNSC | 1 |
p.Q52X | DLBC | 1 |
p.S113F | SKCM | 1 |
p.T325S | LUAD | 1 |
p.M50V | STAD | 1 |
p.L46I | KIRP | 1 |
p.D89G | BLCA | 1 |
p.Y87X | ESCA | 1 |
p.G248R | LUAD | 1 |
p.R172Q | SKCM | 1 |
p.A301D | UCEC | 1 |
p.V267L | SKCM | 1 |
p.G102E | SKCM | 1 |
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TissGeneCNV for ELAVL2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ELAVL2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | HNSC | TCGA-DQ-7589-01A | ZDHHC21-ELAVL2 | 5UTR-CDS | Chr9:14690335 | Chr9:23731123 |
TCGAfusionPortal | PRADA | PRAD | TCGA-YL-A8HM-01A | ELAVL2-CFTR | 5UTR-CDS | Chr9:23821603 | Chr7:117304742 |
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TissGeneNet for ELAVL2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ELAVL2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ELAVL2 |
TissGeneDrug for ELAVL2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ELAVL2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0149925 | Small cell carcinoma of lung | 8 | BeFree,CTD_human,LHGDN |
umls:C0006142 | Malignant neoplasm of breast | 5 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 5 | BeFree |
umls:C0678222 | Breast Carcinoma | 5 | BeFree |
umls:C0684249 | Carcinoma of lung | 5 | BeFree |
umls:C0699885 | Carcinoma of bladder | 5 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 4 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 3 | BeFree |
umls:C0036341 | Schizophrenia | 3 | BeFree |
umls:C0699791 | Stomach Carcinoma | 3 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | BeFree |
umls:C0017638 | Glioma | 2 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree |
umls:C0025202 | melanoma | 2 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0400966 | Non-alcoholic Fatty Liver Disease | 2 | BeFree |
umls:C0596263 | Carcinogenesis | 2 | BeFree |
umls:C0751912 | Paraneoplastic Encephalomyelitis | 2 | BeFree |
umls:C1956346 | Coronary Artery Disease | 2 | BeFree,GAD |
umls:C2239176 | Liver carcinoma | 2 | BeFree |
umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | GAD |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | GAD |
umls:C0004096 | Asthma | 1 | GAD |
umls:C0004936 | Mental disorders | 1 | BeFree |
umls:C0005586 | Bipolar Disorder | 1 | BeFree |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | BeFree |
umls:C0026499 | Monosomy | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0031099 | Periodontitis | 1 | BeFree |
umls:C0038436 | Post-Traumatic Stress Disorder | 1 | BeFree |
umls:C0206664 | Teratocarcinoma | 1 | BeFree |
umls:C0235031 | Neurologic Symptoms | 1 | BeFree |
umls:C0242647 | Mucosa-Associated Lymphoid Tissue Lymphoma | 1 | BeFree |
umls:C0264408 | Childhood asthma | 1 | BeFree |
umls:C0338451 | Frontotemporal dementia | 1 | BeFree |
umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
umls:C0494463 | Alzheimer Disease, Late Onset | 1 | BeFree |
umls:C0518014 | Hematocrit level | 1 | GAD |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C3241937 | Nonalcoholic Steatohepatitis | 1 | BeFree |