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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for NLRP7
check button Gene summary
Basic gene informationGene symbolNLRP7
Gene nameNLR family, pyrin domain containing 7
SynonymsCLR19.4|HYDM|NALP7|NOD12|PAN7|PYPAF3
CytomapUCSC genome browser: 19q13.42
Type of geneprotein-coding
RefGenesNM_001127255.1,
NM_139176.3,NM_206828.3,
DescriptionNACHT, LRR and PYD containing protein 7NACHT, LRR and PYD domains-containing protein 7NACHT, leucine rich repeat and PYD containing 7PYRIN-containing Apaf1-like protein 3nucleotide-binding oligomerization domain protein 12nucleotide-binding oligomeri
Modification date20141207
dbXrefs MIM : 609661
HGNC : HGNC
Ensembl : ENSG00000167634
HPRD : 10112
Vega : OTTHUMG00000180428
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NLRP7
BioGPS: 199713
PathwayNCI Pathway Interaction Database: NLRP7
KEGG: NLRP7
REACTOME: NLRP7
Pathway Commons: NLRP7
ContextiHOP: NLRP7
ligand binding site mutation search in PubMed: NLRP7
UCL Cancer Institute: NLRP7
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of NLRP7
Description by TissGene annotationsTissgsKTS
CNV lost TissGeneKTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for NLRP7

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
COAD-0.9989137860.603951599-1.6028653852.90E-071.85E-06
KICH-1.809191632-0.732459632-1.0767320.005670.010754458
LUSC0.484026486-0.7222970431.2063235290.001860.003324381
HNSC1.037348647-0.5166443761.5539930230.0008760.00302765


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TissGene-miRNA for NLRP7

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for NLRP7
TissGeneSNV for NLRP7

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E593KSKCM3
p.M634ISKCM2
p.E261KSKCM2
p.H787YSKCM2
p.E1013*UCEC2
p.R247IUCEC2
p.M662ISKCM2
p.S361LSKCM2
p.E621KSKCM2
p.R446CBLCA2
p.D308NSKCM2
p.W123XSKCM2
p.E776KSKCM2
p.R958ICOAD2
p.E631DUCEC2
p.G141ESKCM2
p.Q342*LUSC1
p.R413QSKCM1
p.E671*UCS1
p.R801CSKCM1
p.S730NHNSC1
p.K259RPAAD1
p.A108TLIHC1
p.W8RLUAD1
p.A420TCOAD1
p.K620NLUAD1
p.R474CHNSC1
p.W495XSKCM1
p.E581XSKCM1
p.A767ESKCM1
p.A477TUCEC1
p.E485DCOAD1
p.P220HLUAD1
p.S216GSTAD1
p.S91LSKCM1
p.D542NESCA1
p.R302WMESO1
p.W151*SKCM1
p.Q11ELIHC1
p.G524DSKCM1
p.K592NLUAD1
p.I596FLUAD1
p.V178ILGG1
p.D444NUCEC1
p.E528KCOAD1
p.E536KSKCM1
p.L922FBLCA1
p.P651SSKCM1
p.R746CLUAD1
p.R659HUCEC1
p.T201MCESC1
p.E643XUCS1
p.E897DLUSC1
p.A343SPAAD1
p.D149NUCEC1
p.K855NUCEC1
p.A447VSKCM1
p.L938MLUAD1
p.V46MLUAD1
p.K120RTHYM1
p.L568QKIRP1
p.E19DUCEC1
p.P413SSKCM1
p.P1030HBLCA1
p.L454FKICH1
p.R659CSKCM1
p.R815LLUAD1
p.R307GGBM1
p.W301LSTAD1
p.K846NUCEC1
p.I915LBLCA1
p.R446CHNSC1
p.L417FPRAD1
p.I678LUCS1
p.P651LGBM1
p.Y206*LUAD1
p.D657NSKCM1
p.E464GKIRC1
p.G490DLIHC1
p.W495*SKCM1
p.D142YUCEC1
p.E709KSKCM1
p.A382TPRAD1
p.P202LCOAD1
p.G729VLUSC1
p.R746HLUAD1
p.V1011GSKCM1
p.A526TUCEC1
p.E549KSKCM1
p.E533QBLCA1
p.A55TBLCA1
p.R662CBRCA1
p.P845SSKCM1
p.L334VLUAD1
p.E381KSKCM1
p.A481TCOAD1
p.D452HSKCM1
p.E748KSKCM1
p.A411VCOAD1
p.T186MHNSC1
p.D661NSKCM1
p.K808EOV1
p.W911XSKCM1
p.P945LSKCM1
p.E609*SKCM1
p.G770DSTAD1
p.R986IUCEC1
p.W123LACC1
p.S702NHNSC1
p.L193MKIRC1
p.L543QHNSC1
p.P803THNSC1
p.V500IHNSC1
p.P316LSKCM1
p.P385SSKCM1
p.V714AHNSC1
p.C994SOV1
p.R373HLUAD1
p.P403TLUAD1
p.A87TPAAD1
p.T61SHNSC1
p.Q579HKIRC1
p.L723VLUAD1
p.A612VLUAD1
p.Q310RDLBC1
p.A371SPAAD1
p.I594FCOAD1
p.D253NLGG1
p.K85TCOAD1
p.S713GBLCA1
p.A425VBRCA1
p.G169ESKCM1
p.R541QUCEC1
p.D336NSKCM1
p.T731SKIRP1
p.P917LSKCM1
p.S697FSKCM1
p.L773FCOAD1
p.P803TLUAD1
p.N101DCESC1
p.K619TSKCM1
p.R815CLUAD1
p.E508XCHOL1
p.S673*UCEC1
p.A584VLUAD1
p.W920*SKCM1
p.W43*LUSC1
p.S957RTHYM1
p.G487ECOAD1
p.G451RSKCM1
p.E860KLGG1
p.S62FSKCM1
p.Y508*LUAD1
p.V182MREAD1
p.V528IHNSC1
p.P816QLUAD1
p.E76KLGG1
p.P572SSKCM1
p.V500ICOAD1
p.L557FBLCA1
p.D754EKIRP1
p.R774HLUAD1
p.L362PSKCM1
p.R909CCOAD1
p.Q517PHNSC1
p.P844QLUAD1
p.R541QSTAD1
p.K461QSTAD1
p.Q545*SARC1
p.R746CSTAD1
p.R857CSKCM1
p.Q607HKIRC1
p.S669FSKCM1
p.R662CSTAD1
p.M192LDLBC1
p.S914FSKCM1
p.R432QSKCM1
p.D689NSKCM1
p.G834RCOAD1
p.E508*CHOL1
p.A354TPRAD1
p.G450DSKCM1
p.R687CSKCM1
p.G247SBLCA1
p.S416RLUAD1
p.G439WLUSC1
p.G1003DSKCM1
p.R843CLUAD1
p.H970YHNSC1
p.P973HBLCA1
p.A526TREAD1
p.P1059SSKCM1
p.L515QHNSC1
p.A235VLUAD1
p.S3LLIHC1
p.I276TBLCA1
p.R289KMESO1
p.L265PSTAD1
p.G467RSARC1
p.E1031KSKCM1
p.G462DLIHC1
p.P191LSKCM1
p.W231LBLCA1
p.D514NESCA1
p.D268NSKCM1
p.E637*LUAD1
p.D237NBLCA1
p.A188PUCEC1
p.S602FCOAD1
p.R432XSTAD1
p.R396LBRCA1
p.F893ISKCM1
p.E508KSKCM1
p.S970FSKCM1
p.E643*UCS1
p.P61SSKCM1
p.A691TREAD1
p.C732GHNSC1
p.A833TSKCM1
p.M350IBLCA1
p.P679SSKCM1
p.E528DREAD1
p.E322KSKCM1
p.C852SLUAD1
p.S953CBLCA1
p.R396HGBM1
p.I650LUCS1
p.E561QBLCA1
p.E233KSKCM1
p.E641*UCEC1
p.D977YLUSC1
p.D142YCOAD1
p.A481GLUAD1
p.W967*SKCM1
p.H24YBLCA1
p.D230YREAD1
p.Q552XESCA1
p.A419DSKCM1
p.D689YUCEC1
p.P873SSKCM1
p.E409KSKCM1
p.H468YHNSC1
p.Q39ELIHC1
p.A264VCOAD1
p.R455HBRCA1
p.T173MCESC1
p.G254CLUAD1
p.P775THNSC1
p.E436GKIRC1
p.V150ILGG1
p.A805TSKCM1
p.L522SLUAD1
p.E327KUCEC1
p.R396CBRCA1
p.L311IDLBC1
p.E653KSKCM1
p.W273LSTAD1
p.R857HMESO1
p.D514NSTAD1
p.E483*LUSC1
p.D444NESCA1
p.G254SSKCM1
p.L851MSTAD1
p.K287RPAAD1
p.V182MGBM1
p.R432*STAD1
p.G141RSKCM1
p.F837ISKCM1
p.A59SLUAD1
p.W123*SKCM1
p.D336NUCS1
p.D144EUCEC1
p.D308NUCS1
p.F333LLUAD1
p.E985KREAD1
p.R665LSKCM1
p.R693QSTAD1
p.T703SKIRP1
p.L905IHNSC1
p.G118RLUAD1
p.Y234*LUAD1
p.A425VSTAD1
p.W36RLUAD1


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TissGeneCNV for NLRP7

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for NLRP7

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNADA412352RNF11-NLRP7chr1:51738009chr19:55476712


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TissGeneNet for NLRP7

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
NLRP7, CASP1, FAF1, IL1B (tumor)NLRP7, CASP1, FAF1, IL1B (normal)
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COAD (tumor)COAD (normal)
NLRP7, CASP1, FAF1, IL1B (tumor)NLRP7, CASP1, FAF1, IL1B (normal)
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HNSC (tumor)HNSC (normal)
NLRP7, CASP1, FAF1, IL1B (tumor)NLRP7, CASP1, FAF1, IL1B (normal)
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KICH (tumor)KICH (normal)
NLRP7, CASP1, FAF1, IL1B (tumor)NLRP7, CASP1, FAF1, IL1B (normal)
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KIRC (tumor)KIRC (normal)
NLRP7, CASP1, FAF1, IL1B (tumor)NLRP7, CASP1, FAF1, IL1B (normal)
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KIRP (tumor)KIRP (normal)
NLRP7, CASP1, FAF1, IL1B (tumor)NLRP7, CASP1, FAF1, IL1B (normal)
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LIHC (tumor)LIHC (normal)
NLRP7, CASP1, FAF1, IL1B (tumor)NLRP7, CASP1, FAF1, IL1B (normal)
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LUAD (tumor)LUAD (normal)
NLRP7, CASP1, FAF1, IL1B (tumor)NLRP7, CASP1, FAF1, IL1B (normal)
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LUSC (tumor)LUSC (normal)
NLRP7, CASP1, FAF1, IL1B (tumor)NLRP7, CASP1, FAF1, IL1B (normal)
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PRAD (tumor)PRAD (normal)
NLRP7, CASP1, FAF1, IL1B (tumor)NLRP7, CASP1, FAF1, IL1B (normal)
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STAD (tumor)STAD (normal)
NLRP7, CASP1, FAF1, IL1B (tumor)NLRP7, CASP1, FAF1, IL1B (normal)
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THCA (tumor)THCA (normal)
NLRP7, CASP1, FAF1, IL1B (tumor)NLRP7, CASP1, FAF1, IL1B (normal)
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TissGeneProg for NLRP7

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for NLRP7
TissGeneDrug for NLRP7

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for NLRP7

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0020217Hydatidiform Mole23BeFree,CTD_human,LHGDN
umls:C3463897HYDATIDIFORM MOLE, RECURRENT, 111BeFree,UNIPROT
umls:C0027960Nevus5BeFree
umls:C0027962Melanocytic nevus5BeFree
umls:C0678213Complete hydatidiform mole5BeFree,ORPHANET
umls:C1456781Benign melanocytic nevus5BeFree
umls:C0206659Embryonal Carcinoma2BeFree
umls:C0333693Triploidy syndrome2BeFree
umls:C0004903Beckwith-Wiedemann Syndrome1BeFree
umls:C0008497Choriocarcinoma1BeFree
umls:C0010346Crohn Disease1GAD
umls:C0032962Pregnancy Complications1BeFree
umls:C0036631Seminoma1BeFree,LHGDN
umls:C0205851Germ cell tumor1BeFree
umls:C0334529Hydatidiform Mole, Partial0ORPHANET
umls:C2931618Gestational trophoblastic disease0CLINVAR