TissGeneSummary for NLRP7 |
Gene summary |
Basic gene information | Gene symbol | NLRP7 |
Gene name | NLR family, pyrin domain containing 7 | |
Synonyms | CLR19.4|HYDM|NALP7|NOD12|PAN7|PYPAF3 | |
Cytomap | UCSC genome browser: 19q13.42 | |
Type of gene | protein-coding | |
RefGenes | NM_001127255.1, NM_139176.3,NM_206828.3, | |
Description | NACHT, LRR and PYD containing protein 7NACHT, LRR and PYD domains-containing protein 7NACHT, leucine rich repeat and PYD containing 7PYRIN-containing Apaf1-like protein 3nucleotide-binding oligomerization domain protein 12nucleotide-binding oligomeri | |
Modification date | 20141207 | |
dbXrefs | MIM : 609661 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167634 | ||
HPRD : 10112 | ||
Vega : OTTHUMG00000180428 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NLRP7 | |
BioGPS: 199713 | ||
Pathway | NCI Pathway Interaction Database: NLRP7 | |
KEGG: NLRP7 | ||
REACTOME: NLRP7 | ||
Pathway Commons: NLRP7 | ||
Context | iHOP: NLRP7 | |
ligand binding site mutation search in PubMed: NLRP7 | ||
UCL Cancer Institute: NLRP7 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of NLRP7 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for NLRP7 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -0.998913786 | 0.603951599 | -1.602865385 | 2.90E-07 | 1.85E-06 |
KICH | -1.809191632 | -0.732459632 | -1.076732 | 0.00567 | 0.010754458 |
LUSC | 0.484026486 | -0.722297043 | 1.206323529 | 0.00186 | 0.003324381 |
HNSC | 1.037348647 | -0.516644376 | 1.553993023 | 0.000876 | 0.00302765 |
Top |
TissGene-miRNA for NLRP7 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for NLRP7 |
TissGeneSNV for NLRP7 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E593K | SKCM | 3 |
p.M634I | SKCM | 2 |
p.E261K | SKCM | 2 |
p.H787Y | SKCM | 2 |
p.E1013* | UCEC | 2 |
p.R247I | UCEC | 2 |
p.M662I | SKCM | 2 |
p.S361L | SKCM | 2 |
p.E621K | SKCM | 2 |
p.R446C | BLCA | 2 |
p.D308N | SKCM | 2 |
p.W123X | SKCM | 2 |
p.E776K | SKCM | 2 |
p.R958I | COAD | 2 |
p.E631D | UCEC | 2 |
p.G141E | SKCM | 2 |
p.Q342* | LUSC | 1 |
p.R413Q | SKCM | 1 |
p.E671* | UCS | 1 |
p.R801C | SKCM | 1 |
p.S730N | HNSC | 1 |
p.K259R | PAAD | 1 |
p.A108T | LIHC | 1 |
p.W8R | LUAD | 1 |
p.A420T | COAD | 1 |
p.K620N | LUAD | 1 |
p.R474C | HNSC | 1 |
p.W495X | SKCM | 1 |
p.E581X | SKCM | 1 |
p.A767E | SKCM | 1 |
p.A477T | UCEC | 1 |
p.E485D | COAD | 1 |
p.P220H | LUAD | 1 |
p.S216G | STAD | 1 |
p.S91L | SKCM | 1 |
p.D542N | ESCA | 1 |
p.R302W | MESO | 1 |
p.W151* | SKCM | 1 |
p.Q11E | LIHC | 1 |
p.G524D | SKCM | 1 |
p.K592N | LUAD | 1 |
p.I596F | LUAD | 1 |
p.V178I | LGG | 1 |
p.D444N | UCEC | 1 |
p.E528K | COAD | 1 |
p.E536K | SKCM | 1 |
p.L922F | BLCA | 1 |
p.P651S | SKCM | 1 |
p.R746C | LUAD | 1 |
p.R659H | UCEC | 1 |
p.T201M | CESC | 1 |
p.E643X | UCS | 1 |
p.E897D | LUSC | 1 |
p.A343S | PAAD | 1 |
p.D149N | UCEC | 1 |
p.K855N | UCEC | 1 |
p.A447V | SKCM | 1 |
p.L938M | LUAD | 1 |
p.V46M | LUAD | 1 |
p.K120R | THYM | 1 |
p.L568Q | KIRP | 1 |
p.E19D | UCEC | 1 |
p.P413S | SKCM | 1 |
p.P1030H | BLCA | 1 |
p.L454F | KICH | 1 |
p.R659C | SKCM | 1 |
p.R815L | LUAD | 1 |
p.R307G | GBM | 1 |
p.W301L | STAD | 1 |
p.K846N | UCEC | 1 |
p.I915L | BLCA | 1 |
p.R446C | HNSC | 1 |
p.L417F | PRAD | 1 |
p.I678L | UCS | 1 |
p.P651L | GBM | 1 |
p.Y206* | LUAD | 1 |
p.D657N | SKCM | 1 |
p.E464G | KIRC | 1 |
p.G490D | LIHC | 1 |
p.W495* | SKCM | 1 |
p.D142Y | UCEC | 1 |
p.E709K | SKCM | 1 |
p.A382T | PRAD | 1 |
p.P202L | COAD | 1 |
p.G729V | LUSC | 1 |
p.R746H | LUAD | 1 |
p.V1011G | SKCM | 1 |
p.A526T | UCEC | 1 |
p.E549K | SKCM | 1 |
p.E533Q | BLCA | 1 |
p.A55T | BLCA | 1 |
p.R662C | BRCA | 1 |
p.P845S | SKCM | 1 |
p.L334V | LUAD | 1 |
p.E381K | SKCM | 1 |
p.A481T | COAD | 1 |
p.D452H | SKCM | 1 |
p.E748K | SKCM | 1 |
p.A411V | COAD | 1 |
p.T186M | HNSC | 1 |
p.D661N | SKCM | 1 |
p.K808E | OV | 1 |
p.W911X | SKCM | 1 |
p.P945L | SKCM | 1 |
p.E609* | SKCM | 1 |
p.G770D | STAD | 1 |
p.R986I | UCEC | 1 |
p.W123L | ACC | 1 |
p.S702N | HNSC | 1 |
p.L193M | KIRC | 1 |
p.L543Q | HNSC | 1 |
p.P803T | HNSC | 1 |
p.V500I | HNSC | 1 |
p.P316L | SKCM | 1 |
p.P385S | SKCM | 1 |
p.V714A | HNSC | 1 |
p.C994S | OV | 1 |
p.R373H | LUAD | 1 |
p.P403T | LUAD | 1 |
p.A87T | PAAD | 1 |
p.T61S | HNSC | 1 |
p.Q579H | KIRC | 1 |
p.L723V | LUAD | 1 |
p.A612V | LUAD | 1 |
p.Q310R | DLBC | 1 |
p.A371S | PAAD | 1 |
p.I594F | COAD | 1 |
p.D253N | LGG | 1 |
p.K85T | COAD | 1 |
p.S713G | BLCA | 1 |
p.A425V | BRCA | 1 |
p.G169E | SKCM | 1 |
p.R541Q | UCEC | 1 |
p.D336N | SKCM | 1 |
p.T731S | KIRP | 1 |
p.P917L | SKCM | 1 |
p.S697F | SKCM | 1 |
p.L773F | COAD | 1 |
p.P803T | LUAD | 1 |
p.N101D | CESC | 1 |
p.K619T | SKCM | 1 |
p.R815C | LUAD | 1 |
p.E508X | CHOL | 1 |
p.S673* | UCEC | 1 |
p.A584V | LUAD | 1 |
p.W920* | SKCM | 1 |
p.W43* | LUSC | 1 |
p.S957R | THYM | 1 |
p.G487E | COAD | 1 |
p.G451R | SKCM | 1 |
p.E860K | LGG | 1 |
p.S62F | SKCM | 1 |
p.Y508* | LUAD | 1 |
p.V182M | READ | 1 |
p.V528I | HNSC | 1 |
p.P816Q | LUAD | 1 |
p.E76K | LGG | 1 |
p.P572S | SKCM | 1 |
p.V500I | COAD | 1 |
p.L557F | BLCA | 1 |
p.D754E | KIRP | 1 |
p.R774H | LUAD | 1 |
p.L362P | SKCM | 1 |
p.R909C | COAD | 1 |
p.Q517P | HNSC | 1 |
p.P844Q | LUAD | 1 |
p.R541Q | STAD | 1 |
p.K461Q | STAD | 1 |
p.Q545* | SARC | 1 |
p.R746C | STAD | 1 |
p.R857C | SKCM | 1 |
p.Q607H | KIRC | 1 |
p.S669F | SKCM | 1 |
p.R662C | STAD | 1 |
p.M192L | DLBC | 1 |
p.S914F | SKCM | 1 |
p.R432Q | SKCM | 1 |
p.D689N | SKCM | 1 |
p.G834R | COAD | 1 |
p.E508* | CHOL | 1 |
p.A354T | PRAD | 1 |
p.G450D | SKCM | 1 |
p.R687C | SKCM | 1 |
p.G247S | BLCA | 1 |
p.S416R | LUAD | 1 |
p.G439W | LUSC | 1 |
p.G1003D | SKCM | 1 |
p.R843C | LUAD | 1 |
p.H970Y | HNSC | 1 |
p.P973H | BLCA | 1 |
p.A526T | READ | 1 |
p.P1059S | SKCM | 1 |
p.L515Q | HNSC | 1 |
p.A235V | LUAD | 1 |
p.S3L | LIHC | 1 |
p.I276T | BLCA | 1 |
p.R289K | MESO | 1 |
p.L265P | STAD | 1 |
p.G467R | SARC | 1 |
p.E1031K | SKCM | 1 |
p.G462D | LIHC | 1 |
p.P191L | SKCM | 1 |
p.W231L | BLCA | 1 |
p.D514N | ESCA | 1 |
p.D268N | SKCM | 1 |
p.E637* | LUAD | 1 |
p.D237N | BLCA | 1 |
p.A188P | UCEC | 1 |
p.S602F | COAD | 1 |
p.R432X | STAD | 1 |
p.R396L | BRCA | 1 |
p.F893I | SKCM | 1 |
p.E508K | SKCM | 1 |
p.S970F | SKCM | 1 |
p.E643* | UCS | 1 |
p.P61S | SKCM | 1 |
p.A691T | READ | 1 |
p.C732G | HNSC | 1 |
p.A833T | SKCM | 1 |
p.M350I | BLCA | 1 |
p.P679S | SKCM | 1 |
p.E528D | READ | 1 |
p.E322K | SKCM | 1 |
p.C852S | LUAD | 1 |
p.S953C | BLCA | 1 |
p.R396H | GBM | 1 |
p.I650L | UCS | 1 |
p.E561Q | BLCA | 1 |
p.E233K | SKCM | 1 |
p.E641* | UCEC | 1 |
p.D977Y | LUSC | 1 |
p.D142Y | COAD | 1 |
p.A481G | LUAD | 1 |
p.W967* | SKCM | 1 |
p.H24Y | BLCA | 1 |
p.D230Y | READ | 1 |
p.Q552X | ESCA | 1 |
p.A419D | SKCM | 1 |
p.D689Y | UCEC | 1 |
p.P873S | SKCM | 1 |
p.E409K | SKCM | 1 |
p.H468Y | HNSC | 1 |
p.Q39E | LIHC | 1 |
p.A264V | COAD | 1 |
p.R455H | BRCA | 1 |
p.T173M | CESC | 1 |
p.G254C | LUAD | 1 |
p.P775T | HNSC | 1 |
p.E436G | KIRC | 1 |
p.V150I | LGG | 1 |
p.A805T | SKCM | 1 |
p.L522S | LUAD | 1 |
p.E327K | UCEC | 1 |
p.R396C | BRCA | 1 |
p.L311I | DLBC | 1 |
p.E653K | SKCM | 1 |
p.W273L | STAD | 1 |
p.R857H | MESO | 1 |
p.D514N | STAD | 1 |
p.E483* | LUSC | 1 |
p.D444N | ESCA | 1 |
p.G254S | SKCM | 1 |
p.L851M | STAD | 1 |
p.K287R | PAAD | 1 |
p.V182M | GBM | 1 |
p.R432* | STAD | 1 |
p.G141R | SKCM | 1 |
p.F837I | SKCM | 1 |
p.A59S | LUAD | 1 |
p.W123* | SKCM | 1 |
p.D336N | UCS | 1 |
p.D144E | UCEC | 1 |
p.D308N | UCS | 1 |
p.F333L | LUAD | 1 |
p.E985K | READ | 1 |
p.R665L | SKCM | 1 |
p.R693Q | STAD | 1 |
p.T703S | KIRP | 1 |
p.L905I | HNSC | 1 |
p.G118R | LUAD | 1 |
p.Y234* | LUAD | 1 |
p.A425V | STAD | 1 |
p.W36R | LUAD | 1 |
Top |
TissGeneCNV for NLRP7 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for NLRP7 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DA412352 | RNF11-NLRP7 | chr1:51738009 | chr19:55476712 |
Top |
TissGeneNet for NLRP7 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for NLRP7 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for NLRP7 |
TissGeneDrug for NLRP7 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for NLRP7 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020217 | Hydatidiform Mole | 23 | BeFree,CTD_human,LHGDN |
umls:C3463897 | HYDATIDIFORM MOLE, RECURRENT, 1 | 11 | BeFree,UNIPROT |
umls:C0027960 | Nevus | 5 | BeFree |
umls:C0027962 | Melanocytic nevus | 5 | BeFree |
umls:C0678213 | Complete hydatidiform mole | 5 | BeFree,ORPHANET |
umls:C1456781 | Benign melanocytic nevus | 5 | BeFree |
umls:C0206659 | Embryonal Carcinoma | 2 | BeFree |
umls:C0333693 | Triploidy syndrome | 2 | BeFree |
umls:C0004903 | Beckwith-Wiedemann Syndrome | 1 | BeFree |
umls:C0008497 | Choriocarcinoma | 1 | BeFree |
umls:C0010346 | Crohn Disease | 1 | GAD |
umls:C0032962 | Pregnancy Complications | 1 | BeFree |
umls:C0036631 | Seminoma | 1 | BeFree,LHGDN |
umls:C0205851 | Germ cell tumor | 1 | BeFree |
umls:C0334529 | Hydatidiform Mole, Partial | 0 | ORPHANET |
umls:C2931618 | Gestational trophoblastic disease | 0 | CLINVAR |