TissGeneSummary for MUC20 |
Gene summary |
Basic gene information | Gene symbol | MUC20 |
Gene name | mucin 20, cell surface associated | |
Synonyms | MUC-20 | |
Cytomap | UCSC genome browser: 3q29 | |
Type of gene | protein-coding | |
RefGenes | NM_001282506.1, NM_001291833.1,NM_020790.1,NM_152673.3,NM_001098516.1, | |
Description | mucin-20transmembrane mucin MUC20S | |
Modification date | 20141207 | |
dbXrefs | MIM : 610360 | |
HGNC : HGNC | ||
Ensembl : ENSG00000176945 | ||
HPRD : 17615 | ||
Vega : OTTHUMG00000155823 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MUC20 | |
BioGPS: 200958 | ||
Pathway | NCI Pathway Interaction Database: MUC20 | |
KEGG: MUC20 | ||
REACTOME: MUC20 | ||
Pathway Commons: MUC20 | ||
Context | iHOP: MUC20 | |
ligand binding site mutation search in PubMed: MUC20 | ||
UCL Cancer Institute: MUC20 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of MUC20 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0051260 | protein homooligomerization | 15314156 | GO:0051260 | protein homooligomerization | 15314156 |
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TissGeneExp for MUC20 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 1.685718932 | 3.785399487 | -2.099680556 | 1.84E-14 | 8.93E-14 |
KIRP | 0.209678307 | 3.924697057 | -3.71501875 | 3.37E-14 | 7.56E-13 |
THCA | 1.788531432 | 0.765050076 | 1.023481356 | 1.54E-08 | 7.51E-08 |
HNSC | 0.466040734 | 2.772680269 | -2.306639535 | 5.10E-06 | 3.14E-05 |
LUAD | 2.928553846 | 1.492688328 | 1.435865517 | 5.63E-08 | 2.29E-07 |
KICH | 6.451047432 | 4.265171432 | 2.185876 | 0.000668 | 0.001490154 |
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TissGene-miRNA for MUC20 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MUC20 |
TissGeneSNV for MUC20 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P392L | BRCA | 4 |
p.P380L | SKCM | 2 |
p.P437S | SKCM | 2 |
p.R448Q | BLCA | 2 |
p.R448X | PCPG | 2 |
p.T276M | BRCA | 2 |
p.P380S | SKCM | 2 |
p.P185A | BLCA | 1 |
p.T425I | SKCM | 1 |
p.S247L | COAD | 1 |
p.A523T | BRCA | 1 |
p.R448X | ACC | 1 |
p.P10S | COAD | 1 |
p.R448X | STAD | 1 |
p.L11F | SKCM | 1 |
p.K462E | BRCA | 1 |
p.V339L | ESCA | 1 |
p.P185S | SKCM | 1 |
p.A350V | OV | 1 |
p.R527K | CESC | 1 |
p.S174* | HNSC | 1 |
p.H524Q | UCEC | 1 |
p.S367F | SKCM | 1 |
p.R356S | BLCA | 1 |
p.S465C | COAD | 1 |
p.A408V | SKCM | 1 |
p.G201C | SARC | 1 |
p.A307V | BLCA | 1 |
p.T471M | UCEC | 1 |
p.S402F | SKCM | 1 |
p.T471A | SKCM | 1 |
p.P479L | STAD | 1 |
p.P231L | DLBC | 1 |
p.T346A | KIRP | 1 |
p.R356S | LUAD | 1 |
p.P345S | SKCM | 1 |
p.A389T | COAD | 1 |
p.S577L | CESC | 1 |
p.R413X | ACC | 1 |
p.A409T | STAD | 1 |
p.A378E | STAD | 1 |
p.P430T | LIHC | 1 |
p.G391S | BRCA | 1 |
p.D146N | SKCM | 1 |
p.S285Y | CHOL | 1 |
p.G620R | CESC | 1 |
p.R534H | PAAD | 1 |
p.S253L | CESC | 1 |
p.R534C | UCEC | 1 |
p.R448* | LUSC | 1 |
p.P205L | CESC | 1 |
p.G449R | SARC | 1 |
p.A8G | PRAD | 1 |
p.G548V | CESC | 1 |
p.L273P | OV | 1 |
p.R495W | PCPG | 1 |
p.A409T | UCS | 1 |
p.R460W | COAD | 1 |
p.P328S | STAD | 1 |
p.S446N | UCEC | 1 |
p.P288L | STAD | 1 |
p.A8G | HNSC | 1 |
p.P384L | COAD | 1 |
p.D146A | BLCA | 1 |
p.E361* | LGG | 1 |
p.L496P | KIRP | 1 |
p.G6V | KIRC | 1 |
p.T324S | LIHC | 1 |
p.L496P | GBM | 1 |
p.G201S | MESO | 1 |
p.R478S | OV | 1 |
p.A475V | STAD | 1 |
p.A299T | COAD | 1 |
p.A8T | KIRP | 1 |
p.P428R | THCA | 1 |
p.D322H | BRCA | 1 |
p.V375I | LUSC | 1 |
p.T300I | COAD | 1 |
p.K456N | LUSC | 1 |
p.P295H | COAD | 1 |
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TissGeneCNV for MUC20 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MUC20 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for MUC20 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MUC20 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MUC20 |
TissGeneDrug for MUC20 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MUC20 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0017661 | IGA Glomerulonephritis | 3 | BeFree,GAD |
umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
umls:C0023067 | Laryngitis | 1 | LHGDN |
umls:C0024143 | Lupus Nephritis | 1 | BeFree |
umls:C0041956 | Ureteral obstruction | 1 | BeFree |
umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |