TissGeneSummary for CEP112 |
Gene summary |
Basic gene information | Gene symbol | CEP112 |
Gene name | centrosomal protein 112kDa | |
Synonyms | CCDC46|MACOCO | |
Cytomap | UCSC genome browser: 17q24.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001037325.2, NM_001199165.2,NM_001302891.1,NR_126542.1,NM_145036.3, | |
Description | centrosomal protein of 112 kDacoiled-coil domain-containing protein 46 | |
Modification date | 20141212 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000154240 | ||
HPRD : 11336 | ||
Vega : OTTHUMG00000179474 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CEP112 | |
BioGPS: 201134 | ||
Pathway | NCI Pathway Interaction Database: CEP112 | |
KEGG: CEP112 | ||
REACTOME: CEP112 | ||
Pathway Commons: CEP112 | ||
Context | iHOP: CEP112 | |
ligand binding site mutation search in PubMed: CEP112 | ||
UCL Cancer Institute: CEP112 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CEP112 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CEP112 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CEP112 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CEP112 |
TissGeneSNV for CEP112 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P218S | SKCM | 2 |
p.D18H | SARC | 1 |
p.V328D | KIRC | 1 |
p.E736* | UCEC | 1 |
p.I343T | HNSC | 1 |
p.K786N | HNSC | 1 |
p.E265V | UCEC | 1 |
p.E709K | SKCM | 1 |
p.R527I | UCEC | 1 |
p.N217Y | STAD | 1 |
p.P174Q | LIHC | 1 |
p.R744L | LUAD | 1 |
p.M395I | BLCA | 1 |
p.S4F | COAD | 1 |
p.E583K | KIRC | 1 |
p.P174L | HNSC | 1 |
p.D387G | LUAD | 1 |
p.R219X | PAAD | 1 |
p.E559* | UCEC | 1 |
p.R904Q | SKCM | 1 |
p.S801R | LUSC | 1 |
p.R110X | STAD | 1 |
p.E663* | LUAD | 1 |
p.L578F | CESC | 1 |
p.H247D | HNSC | 1 |
p.W138* | SKCM | 1 |
p.P108Q | ESCA | 1 |
p.R702H | LGG | 1 |
p.E316Q | BLCA | 1 |
p.N27S | HNSC | 1 |
p.I712T | HNSC | 1 |
p.R904L | LUAD | 1 |
p.W122C | LUAD | 1 |
p.E695K | LUSC | 1 |
p.S350Y | UCEC | 1 |
p.R443I | UCEC | 1 |
p.L751I | UCEC | 1 |
p.S498L | CESC | 1 |
p.L516F | SKCM | 1 |
p.M231I | LUAD | 1 |
p.W138X | SKCM | 1 |
p.Q746P | BLCA | 1 |
p.E310* | UCEC | 1 |
p.E667Q | LUSC | 1 |
p.E331D | HNSC | 1 |
p.R883* | UCEC | 1 |
p.I252T | LUSC | 1 |
p.W355X | THYM | 1 |
p.L516* | BLCA | 1 |
p.K478N | UCEC | 1 |
p.Q481H | STAD | 1 |
p.R459H | LUAD | 1 |
p.A15S | LUSC | 1 |
p.R904Q | READ | 1 |
p.N27T | COAD | 1 |
p.T153A | PAAD | 1 |
p.R692Q | SKCM | 1 |
p.D200N | SKCM | 1 |
p.K456N | COAD | 1 |
p.L95I | UCEC | 1 |
p.K570R | UCS | 1 |
p.Q805L | LUAD | 1 |
p.R253C | STAD | 1 |
p.R219* | PAAD | 1 |
p.I21V | COAD | 1 |
p.E698K | SKCM | 1 |
p.E922D | LUAD | 1 |
p.E783V | LUAD | 1 |
p.L911V | UCEC | 1 |
p.V870A | SKCM | 1 |
p.R459C | UCEC | 1 |
p.R459H | READ | 1 |
p.E14K | SKCM | 1 |
p.K224N | PAAD | 1 |
p.K433I | SKCM | 1 |
p.E893X | STAD | 1 |
p.E349K | SKCM | 1 |
p.E494* | UCEC | 1 |
p.K234E | UCEC | 1 |
p.P185S | SKCM | 1 |
p.L497V | ESCA | 1 |
p.M23I | LUAD | 1 |
p.E423* | UCEC | 1 |
p.K357N | HNSC | 1 |
p.E412* | UCEC | 1 |
p.M780I | SKCM | 1 |
p.E16* | UCEC | 1 |
p.E437K | STAD | 1 |
p.S141C | BLCA | 1 |
p.K581I | STAD | 1 |
p.R207S | SKCM | 1 |
p.E383K | COAD | 1 |
p.D387N | SKCM | 1 |
p.A815S | LUAD | 1 |
p.Q446K | ESCA | 1 |
p.R883X | STAD | 1 |
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TissGeneCNV for CEP112 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CEP112 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CR627301 | CEP112-LRBA | chr17:64188221 | chr4:151185814 | |
Chimerdb3.0 | ChiTaRs | NA | BM696908 | CEP112-CCDC109B | chr17:63684796 | chr4:110580157 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-A8-A08J-01A | PSMD11-CEP112 | CDS-5'UTR | chr17:30774064 | chr17:64179425 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-AO-A0JM-01A | NME2-CEP112 | 5'UTR-CDS | chr17:49243042 | chr17:63637183 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-D8-A140-01A | OLFM2-CEP112 | In-Frame | chr19:10046979 | chr17:63685336 |
Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-78-7146-01A | CUEDC1-CEP112 | 3'UTR-CDS | chr17:55940142 | chr17:63799117 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-A8-A08J-01A | PSMD11-CEP112 | CDS-5'UTR | chr17:30774063 | chr17:64179424 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-A8-A08J-01A | ASIC2-CEP112 | Out-of-Frame | chr17:31749746 | chr17:64125863 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-AO-A0JM-01A | NME1-NME2-CEP112 | 3'UTR-3'UTR | chr17:49243041 | chr17:63637182 |
TCGAfusionPortal | PRADA | BLCA | TCGA-CU-A3KJ-01A | HELZ-CEP112 | Out-of-frame | Chr17:65116521 | Chr17:63685336 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A076-01A | MED24-CEP112 | Out-of-frame | Chr17:38209551 | Chr17:63957716 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A08J-01A | PSMD11-CEP112 | CDS-5UTR | Chr17:30774064 | Chr17:64179425 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A09Q-01A | C21orf63-CEP112 | Out-of-frame | Chr21:33840156 | Chr17:63923807 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A09Q-01A | ARSG-CEP112 | Out-of-frame | Chr17:66303852 | Chr17:64092750 |
TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A140-01A | OLFM2-CEP112 | In-frame | Chr19:10046980 | Chr17:63685336 |
TCGAfusionPortal | PRADA | BRCA | TCGA-E9-A1NA-01A | CEP112-OTOA | In-frame | Chr17:64092369 | Chr16:21730454 |
TCGAfusionPortal | PRADA | LUSC | TCGA-33-6738-01A | GNA13-CEP112 | In-frame | Chr17:63049620 | Chr17:63637183 |
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TissGeneNet for CEP112 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CEP112 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CEP112 |
TissGeneDrug for CEP112 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CEP112 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0026769 | Multiple Sclerosis | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C1263846 | Attention deficit hyperactivity disorder | 1 | GAD,GWASCAT |