TissGeneSummary for C17orf74 |
Gene summary |
Basic gene information | Gene symbol | C17orf74 |
Gene name | chromosome 17 open reading frame 74 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 17p13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_175734.4, | |
Description | uncharacterized protein C17orf74 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000184560 | ||
HPRD : 14128 | ||
Vega : OTTHUMG00000178190 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C17orf74 | |
BioGPS: 201243 | ||
Pathway | NCI Pathway Interaction Database: C17orf74 | |
KEGG: C17orf74 | ||
REACTOME: C17orf74 | ||
Pathway Commons: C17orf74 | ||
Context | iHOP: C17orf74 | |
ligand binding site mutation search in PubMed: C17orf74 | ||
UCL Cancer Institute: C17orf74 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C17orf74 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C17orf74 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for C17orf74 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C17orf74 |
TissGeneSNV for C17orf74 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R129H | STAD | 3 |
p.Q208* | SKCM | 2 |
p.H131R | STAD | 2 |
p.E186K | SKCM | 1 |
p.R246C | STAD | 1 |
p.M167I | COAD | 1 |
p.G304S | LGG | 1 |
p.E272K | SKCM | 1 |
p.G114S | SKCM | 1 |
p.A210V | UCEC | 1 |
p.P78L | SKCM | 1 |
p.F206V | KICH | 1 |
p.R129H | ESCA | 1 |
p.R125C | SKCM | 1 |
p.R144W | UCEC | 1 |
p.L240M | LUAD | 1 |
p.P440S | SKCM | 1 |
p.H131R | MESO | 1 |
p.R314W | LUAD | 1 |
p.E187* | SKCM | 1 |
p.R130H | STAD | 1 |
p.P161L | LUAD | 1 |
p.R126C | SKCM | 1 |
p.N331S | STAD | 1 |
p.R414W | UCEC | 1 |
p.M1T | LUAD | 1 |
p.R266* | STAD | 1 |
p.P294H | UCEC | 1 |
p.S367F | SKCM | 1 |
p.R333W | DLBC | 1 |
p.D189G | LIHC | 1 |
p.F112L | SKCM | 1 |
p.Q83E | HNSC | 1 |
p.R125L | KIRC | 1 |
p.R266X | STAD | 1 |
p.R330Q | LUAD | 1 |
p.R316H | STAD | 1 |
p.L185P | PRAD | 1 |
p.G211D | SKCM | 1 |
p.F112L | STAD | 1 |
p.R330W | HNSC | 1 |
p.P294S | THYM | 1 |
p.N451Y | HNSC | 1 |
p.E67K | SKCM | 1 |
p.S426F | SKCM | 1 |
p.D22N | COAD | 1 |
p.R125C | COAD | 1 |
p.R260H | UCEC | 1 |
p.R163H | UCEC | 1 |
p.P429S | HNSC | 1 |
p.L120F | UCEC | 1 |
p.P299T | HNSC | 1 |
p.W6* | HNSC | 1 |
p.N42I | UCEC | 1 |
p.Q350* | UCEC | 1 |
p.E187X | SKCM | 1 |
p.S479L | HNSC | 1 |
p.I87T | STAD | 1 |
p.D80E | OV | 1 |
p.E24K | COAD | 1 |
p.G304C | LUAD | 1 |
p.Q313* | SKCM | 1 |
p.P442L | GBM | 1 |
p.R122H | STAD | 1 |
p.V433I | LUSC | 1 |
p.A402V | KIRC | 1 |
p.E188* | BLCA | 1 |
p.M167V | KIRC | 1 |
p.Q150X | READ | 1 |
p.W276C | PRAD | 1 |
p.E369X | ESCA | 1 |
p.Q103H | PRAD | 1 |
p.Y184C | STAD | 1 |
p.P490L | SKCM | 1 |
p.V82I | CESC | 1 |
p.R323H | SARC | 1 |
p.Q376R | DLBC | 1 |
p.P294T | LUAD | 1 |
p.P99L | SKCM | 1 |
p.P192L | HNSC | 1 |
p.R330W | SKCM | 1 |
p.N3K | MESO | 1 |
p.S263F | SKCM | 1 |
p.E274Q | LUAD | 1 |
p.R127H | STAD | 1 |
p.R396H | COAD | 1 |
p.P325H | BLCA | 1 |
p.A410P | HNSC | 1 |
p.R201C | SKCM | 1 |
p.W311* | HNSC | 1 |
p.S214F | LUAD | 1 |
p.R241C | PAAD | 1 |
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TissGeneCNV for C17orf74 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C17orf74 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for C17orf74 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C17orf74 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C17orf74 |
TissGeneDrug for C17orf74 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C17orf74 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |