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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PRSS55
check button Gene summary
Basic gene informationGene symbolPRSS55
Gene nameprotease, serine, 55
SynonymsCT153|T-SP1|TSP1|UNQ9391
CytomapUCSC genome browser: 8p23.1
Type of geneprotein-coding
RefGenesNM_001197020.1,
NM_198464.3,
Descriptionprobable serine protease UNQ9391/PRO34284serine protease 55testis serine protease 1tryptophan/serine protease
Modification date20141207
dbXrefs MIM : 615144
HGNC : HGNC
Ensembl : ENSG00000184647
HPRD : 07162
Vega : OTTHUMG00000129345
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PRSS55
BioGPS: 203074
PathwayNCI Pathway Interaction Database: PRSS55
KEGG: PRSS55
REACTOME: PRSS55
Pathway Commons: PRSS55
ContextiHOP: PRSS55
ligand binding site mutation search in PubMed: PRSS55
UCL Cancer Institute: PRSS55
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of PRSS55
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for PRSS55

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for PRSS55

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for PRSS55
TissGeneSNV for PRSS55

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G61RSKCM2
p.L293IREAD1
p.Q82KLUAD1
p.T179RLUAD1
p.A236VGBM1
p.L337VLUAD1
p.L342MKIRP1
p.G95SLGG1
p.G71ESKCM1
p.P174HUCEC1
p.R334KLIHC1
p.S287LSKCM1
p.A74VREAD1
p.V50ASTAD1
p.T286ALUAD1
p.A140GCOAD1
p.S332ILUAD1
p.L337PLUAD1
p.P80LGBM1
p.E329KSKCM1
p.M153ISKCM1
p.R40HLGG1
p.G19SPAAD1
p.P328TCOAD1
p.G283ESKCM1
p.K239MSKCM1
p.G321DKIRP1
p.F306LCOAD1
p.W219*KIRP1
p.L144FHNSC1
p.L293IUCEC1
p.S164LSTAD1
p.E114KSKCM1
p.E75QLUAD1
p.E188KSKCM1
p.E329DESCA1
p.I136TPRAD1
p.W272*SKCM1
p.P323LSTAD1
p.V6MLUSC1
p.A199GACC1
p.P25SSKCM1
p.E221QLUAD1
p.P227SSKCM1
p.D156GSTAD1
p.G33DLUAD1
p.P43SSTAD1
p.E90*LUAD1
p.P80LUCEC1
p.R56KSKCM1
p.G15ESKCM1
p.P181RKIRP1
p.S287LUCEC1
p.W219XKIRP1
p.P49TSARC1
p.E302KCESC1
p.M210ISKCM1
p.S89TUCEC1
p.E113KSKCM1
p.V205LSKCM1
p.S314YREAD1
p.P25LSKCM1
p.R21QSTAD1
p.Q86HOV1


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TissGeneCNV for PRSS55

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for PRSS55

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for PRSS55

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for PRSS55

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for PRSS55
TissGeneDrug for PRSS55

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for PRSS55

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0025202melanoma5BeFree
umls:C0699791Stomach Carcinoma4BeFree
umls:C0007102Malignant tumor of colon3BeFree
umls:C0007137Squamous cell carcinoma3BeFree
umls:C0028754Obesity3BeFree
umls:C0376358Malignant neoplasm of prostate3BeFree
umls:C0600139Prostate carcinoma3BeFree
umls:C0699790Colon Carcinoma3BeFree
umls:C1519670Tumor Angiogenesis3BeFree
umls:C0001430Adenoma2BeFree
umls:C0003873Rheumatoid Arthritis2BeFree
umls:C0006142Malignant neoplasm of breast2BeFree
umls:C0007103Malignant neoplasm of endometrium2BeFree
umls:C0007134Renal Cell Carcinoma2BeFree
umls:C0017601Glaucoma2BeFree
umls:C0017638Glioma2BeFree
umls:C0018801Heart failure2BeFree
umls:C0018802Congestive heart failure2BeFree
umls:C0022116Ischemia2BeFree
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0178874Tumor Progression2BeFree
umls:C0476089Endometrial Carcinoma2BeFree
umls:C0678222Breast Carcinoma2BeFree
umls:C1883486Uterine Corpus Cancer2BeFree
umls:C2931822Nasopharyngeal carcinoma2BeFree
umls:C0003857Congenital arteriovenous malformation1BeFree
umls:C0003864Arthritis1BeFree
umls:C0004114Astrocytoma1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007222Cardiovascular Diseases1BeFree
umls:C0007847Malignant tumor of cervix1BeFree
umls:C0011644Scleroderma1BeFree
umls:C0011881Diabetic Nephropathy1BeFree
umls:C0017075Ganglioneuroma1BeFree
umls:C0018889Helminthiasis1BeFree
umls:C0021051Immunologic Deficiency Syndromes1BeFree
umls:C0023652Lichen Sclerosus et Atrophicus1BeFree
umls:C0025149Medulloblastoma1BeFree
umls:C0026764Multiple Myeloma1BeFree
umls:C0027819Neuroblastoma1BeFree
umls:C0028945oligodendroglioma1BeFree
umls:C0029408Degenerative polyarthritis1BeFree
umls:C0029928Ovarian Diseases1BeFree
umls:C0033578Prostatic Neoplasms1BeFree
umls:C0034155Purpura, Thrombotic Thrombocytopenic1BeFree
umls:C0036421Systemic Scleroderma1BeFree
umls:C0038356Stomach Neoplasms1BeFree
umls:C0152013Adenocarcinoma of lung (disorder)1BeFree
umls:C0156259Hypertrophy of kidney1BeFree
umls:C0206708Cervical Intraepithelial Neoplasia1BeFree
umls:C0238190Inclusion Body Myositis (disorder)1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0271650Impaired glucose tolerance1BeFree
umls:C0278883Metastatic melanoma1BeFree
umls:C0302592Cervix carcinoma1BeFree
umls:C0334590Anaplastic Oligodendroglioma1BeFree
umls:C0595936Aqueous Humor Disorders1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0751396Well Differentiated Oligodendroglioma1BeFree
umls:C0751713Inclusion Body Myopathy, Sporadic1BeFree
umls:C0812413Malignant Pleural Mesothelioma1BeFree
umls:C1140680Malignant neoplasm of ovary1BeFree
umls:C1318485Liver regeneration disorder1BeFree
umls:C1335110Oligodendroglial Neoplasm1BeFree
umls:C1378703Renal carcinoma1BeFree
umls:C1510885Angiogenic Switch1BeFree
umls:C1704436Peripheral Arterial Diseases1BeFree
umls:C2584778Thrombotic thrombocytopenic purpura, acquired1BeFree