TissGeneSummary for PRSS55 |
Gene summary |
Basic gene information | Gene symbol | PRSS55 |
Gene name | protease, serine, 55 | |
Synonyms | CT153|T-SP1|TSP1|UNQ9391 | |
Cytomap | UCSC genome browser: 8p23.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001197020.1, NM_198464.3, | |
Description | probable serine protease UNQ9391/PRO34284serine protease 55testis serine protease 1tryptophan/serine protease | |
Modification date | 20141207 | |
dbXrefs | MIM : 615144 | |
HGNC : HGNC | ||
Ensembl : ENSG00000184647 | ||
HPRD : 07162 | ||
Vega : OTTHUMG00000129345 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PRSS55 | |
BioGPS: 203074 | ||
Pathway | NCI Pathway Interaction Database: PRSS55 | |
KEGG: PRSS55 | ||
REACTOME: PRSS55 | ||
Pathway Commons: PRSS55 | ||
Context | iHOP: PRSS55 | |
ligand binding site mutation search in PubMed: PRSS55 | ||
UCL Cancer Institute: PRSS55 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of PRSS55 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PRSS55 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for PRSS55 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PRSS55 |
TissGeneSNV for PRSS55 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G61R | SKCM | 2 |
p.L293I | READ | 1 |
p.Q82K | LUAD | 1 |
p.T179R | LUAD | 1 |
p.A236V | GBM | 1 |
p.L337V | LUAD | 1 |
p.L342M | KIRP | 1 |
p.G95S | LGG | 1 |
p.G71E | SKCM | 1 |
p.P174H | UCEC | 1 |
p.R334K | LIHC | 1 |
p.S287L | SKCM | 1 |
p.A74V | READ | 1 |
p.V50A | STAD | 1 |
p.T286A | LUAD | 1 |
p.A140G | COAD | 1 |
p.S332I | LUAD | 1 |
p.L337P | LUAD | 1 |
p.P80L | GBM | 1 |
p.E329K | SKCM | 1 |
p.M153I | SKCM | 1 |
p.R40H | LGG | 1 |
p.G19S | PAAD | 1 |
p.P328T | COAD | 1 |
p.G283E | SKCM | 1 |
p.K239M | SKCM | 1 |
p.G321D | KIRP | 1 |
p.F306L | COAD | 1 |
p.W219* | KIRP | 1 |
p.L144F | HNSC | 1 |
p.L293I | UCEC | 1 |
p.S164L | STAD | 1 |
p.E114K | SKCM | 1 |
p.E75Q | LUAD | 1 |
p.E188K | SKCM | 1 |
p.E329D | ESCA | 1 |
p.I136T | PRAD | 1 |
p.W272* | SKCM | 1 |
p.P323L | STAD | 1 |
p.V6M | LUSC | 1 |
p.A199G | ACC | 1 |
p.P25S | SKCM | 1 |
p.E221Q | LUAD | 1 |
p.P227S | SKCM | 1 |
p.D156G | STAD | 1 |
p.G33D | LUAD | 1 |
p.P43S | STAD | 1 |
p.E90* | LUAD | 1 |
p.P80L | UCEC | 1 |
p.R56K | SKCM | 1 |
p.G15E | SKCM | 1 |
p.P181R | KIRP | 1 |
p.S287L | UCEC | 1 |
p.W219X | KIRP | 1 |
p.P49T | SARC | 1 |
p.E302K | CESC | 1 |
p.M210I | SKCM | 1 |
p.S89T | UCEC | 1 |
p.E113K | SKCM | 1 |
p.V205L | SKCM | 1 |
p.S314Y | READ | 1 |
p.P25L | SKCM | 1 |
p.R21Q | STAD | 1 |
p.Q86H | OV | 1 |
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TissGeneCNV for PRSS55 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PRSS55 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for PRSS55 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PRSS55 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PRSS55 |
TissGeneDrug for PRSS55 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PRSS55 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0025202 | melanoma | 5 | BeFree |
umls:C0699791 | Stomach Carcinoma | 4 | BeFree |
umls:C0007102 | Malignant tumor of colon | 3 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 3 | BeFree |
umls:C0028754 | Obesity | 3 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
umls:C0600139 | Prostate carcinoma | 3 | BeFree |
umls:C0699790 | Colon Carcinoma | 3 | BeFree |
umls:C1519670 | Tumor Angiogenesis | 3 | BeFree |
umls:C0001430 | Adenoma | 2 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
umls:C0007103 | Malignant neoplasm of endometrium | 2 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
umls:C0017601 | Glaucoma | 2 | BeFree |
umls:C0017638 | Glioma | 2 | BeFree |
umls:C0018801 | Heart failure | 2 | BeFree |
umls:C0018802 | Congestive heart failure | 2 | BeFree |
umls:C0022116 | Ischemia | 2 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
umls:C0178874 | Tumor Progression | 2 | BeFree |
umls:C0476089 | Endometrial Carcinoma | 2 | BeFree |
umls:C0678222 | Breast Carcinoma | 2 | BeFree |
umls:C1883486 | Uterine Corpus Cancer | 2 | BeFree |
umls:C2931822 | Nasopharyngeal carcinoma | 2 | BeFree |
umls:C0003857 | Congenital arteriovenous malformation | 1 | BeFree |
umls:C0003864 | Arthritis | 1 | BeFree |
umls:C0004114 | Astrocytoma | 1 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0011644 | Scleroderma | 1 | BeFree |
umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
umls:C0017075 | Ganglioneuroma | 1 | BeFree |
umls:C0018889 | Helminthiasis | 1 | BeFree |
umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
umls:C0023652 | Lichen Sclerosus et Atrophicus | 1 | BeFree |
umls:C0025149 | Medulloblastoma | 1 | BeFree |
umls:C0026764 | Multiple Myeloma | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0028945 | oligodendroglioma | 1 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
umls:C0029928 | Ovarian Diseases | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
umls:C0034155 | Purpura, Thrombotic Thrombocytopenic | 1 | BeFree |
umls:C0036421 | Systemic Scleroderma | 1 | BeFree |
umls:C0038356 | Stomach Neoplasms | 1 | BeFree |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
umls:C0156259 | Hypertrophy of kidney | 1 | BeFree |
umls:C0206708 | Cervical Intraepithelial Neoplasia | 1 | BeFree |
umls:C0238190 | Inclusion Body Myositis (disorder) | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0271650 | Impaired glucose tolerance | 1 | BeFree |
umls:C0278883 | Metastatic melanoma | 1 | BeFree |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0334590 | Anaplastic Oligodendroglioma | 1 | BeFree |
umls:C0595936 | Aqueous Humor Disorders | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C0751396 | Well Differentiated Oligodendroglioma | 1 | BeFree |
umls:C0751713 | Inclusion Body Myopathy, Sporadic | 1 | BeFree |
umls:C0812413 | Malignant Pleural Mesothelioma | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1318485 | Liver regeneration disorder | 1 | BeFree |
umls:C1335110 | Oligodendroglial Neoplasm | 1 | BeFree |
umls:C1378703 | Renal carcinoma | 1 | BeFree |
umls:C1510885 | Angiogenic Switch | 1 | BeFree |
umls:C1704436 | Peripheral Arterial Diseases | 1 | BeFree |
umls:C2584778 | Thrombotic thrombocytopenic purpura, acquired | 1 | BeFree |