TissGeneSummary for ADAM32 |
Gene summary |
Basic gene information | Gene symbol | ADAM32 |
Gene name | ADAM metallopeptidase domain 32 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 8p11.22 | |
Type of gene | protein-coding | |
RefGenes | NM_145004.5, | |
Description | ADAM 32a disintegrin and metalloprotease domain 32a disintegrin and metalloproteinase domain 32disintegrin and metalloproteinase domain-containing protein 32metalloproteinase 12-like protein | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000197140 | ||
HPRD : 16475 | ||
Vega : OTTHUMG00000164071 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADAM32 | |
BioGPS: 203102 | ||
Pathway | NCI Pathway Interaction Database: ADAM32 | |
KEGG: ADAM32 | ||
REACTOME: ADAM32 | ||
Pathway Commons: ADAM32 | ||
Context | iHOP: ADAM32 | |
ligand binding site mutation search in PubMed: ADAM32 | ||
UCL Cancer Institute: ADAM32 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ADAM32 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ADAM32 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.221738533 | -1.98207971 | 1.760341176 | 1.76E-09 | 5.90E-09 |
LUAD | -1.127514362 | -2.16114712 | 1.033632759 | 1.31E-05 | 3.79E-05 |
BRCA | 0.507554604 | 1.572996709 | -1.065442105 | 5.54E-07 | 1.54E-06 |
KICH | -0.349759396 | -1.572631396 | 1.222872 | 0.0103 | 0.018516476 |
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TissGene-miRNA for ADAM32 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ADAM32 |
TissGeneSNV for ADAM32 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R611C | SKCM | 5 |
p.R298C | SKCM | 2 |
p.E215K | COAD | 2 |
p.E242K | SKCM | 2 |
p.M294I | LUAD | 1 |
p.W544X | SKCM | 1 |
p.F171S | LUAD | 1 |
p.S264F | SKCM | 1 |
p.E215K | UCEC | 1 |
p.D420N | SKCM | 1 |
p.D534N | UCEC | 1 |
p.I478S | KIRP | 1 |
p.R559Q | COAD | 1 |
p.A621V | BLCA | 1 |
p.H455Q | CESC | 1 |
p.S724L | SKCM | 1 |
p.S417R | BLCA | 1 |
p.P390L | SKCM | 1 |
p.E57D | READ | 1 |
p.T197P | ESCA | 1 |
p.G429R | SKCM | 1 |
p.M280I | SKCM | 1 |
p.C413Y | COAD | 1 |
p.G659E | UCEC | 1 |
p.P692L | PRAD | 1 |
p.L685I | CHOL | 1 |
p.R501H | GBM | 1 |
p.Q94E | BLCA | 1 |
p.C458Y | HNSC | 1 |
p.F258S | LIHC | 1 |
p.S657F | SKCM | 1 |
p.W544* | SKCM | 1 |
p.G659E | SKCM | 1 |
p.A461T | HNSC | 1 |
p.S736G | LGG | 1 |
p.T743A | UCEC | 1 |
p.K147N | READ | 1 |
p.P54L | SKCM | 1 |
p.G99E | CESC | 1 |
p.T758I | THCA | 1 |
p.S776L | SKCM | 1 |
p.T225I | HNSC | 1 |
p.E680K | HNSC | 1 |
p.R501H | STAD | 1 |
p.D56G | ESCA | 1 |
p.Y306C | STAD | 1 |
p.E470* | UCEC | 1 |
p.E714K | SKCM | 1 |
p.E253D | LIHC | 1 |
p.L379F | SKCM | 1 |
p.S727N | SKCM | 1 |
p.S724L | BLCA | 1 |
p.R588Q | DLBC | 1 |
p.E309K | SKCM | 1 |
p.G493E | SKCM | 1 |
p.R639K | SKCM | 1 |
p.V614L | BRCA | 1 |
p.S645L | UCEC | 1 |
p.I521M | UCEC | 1 |
p.D272N | HNSC | 1 |
p.G543R | SKCM | 1 |
p.G739C | SKCM | 1 |
p.K431R | COAD | 1 |
p.R559Q | SKCM | 1 |
p.R588Q | READ | 1 |
p.E57D | OV | 1 |
p.G401E | SKCM | 1 |
p.S482L | SKCM | 1 |
p.E313D | KIRP | 1 |
p.A7T | LIHC | 1 |
p.F515L | LUSC | 1 |
p.P646T | BLCA | 1 |
p.E250D | COAD | 1 |
p.D333Y | LUAD | 1 |
p.L688H | ESCA | 1 |
p.Q755E | CESC | 1 |
p.P651S | SKCM | 1 |
p.I208L | STAD | 1 |
p.R575Q | SKCM | 1 |
p.T743R | STAD | 1 |
p.Q94L | ESCA | 1 |
p.R422Q | UCEC | 1 |
p.H191R | LIHC | 1 |
p.S204F | SKCM | 1 |
p.V701G | ESCA | 1 |
p.D494N | SKCM | 1 |
p.S645L | PAAD | 1 |
p.C602R | UCEC | 1 |
p.I170T | HNSC | 1 |
p.L161P | KIRC | 1 |
p.S645L | GBM | 1 |
p.K387N | UCEC | 1 |
p.P692S | SKCM | 1 |
p.K244N | HNSC | 1 |
p.Q384X | KIRP | 1 |
p.E131K | BLCA | 1 |
p.S600P | LIHC | 1 |
p.S360R | COAD | 1 |
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TissGeneCNV for ADAM32 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ADAM32 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A18J-11A | AGPAT6-ADAM32 | In-Frame | chr8:41456823 | chr8:39079128 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-EW-A1PH-01A | WHSC1L1-ADAM32 | Out-of-Frame | chr8:38138984 | chr8:39131830 |
Chimerdb3.0 | FusionScan | LUSC | TCGA-43-6770-01A | RPAP3-ADAM32 | In-Frame | chr12:48073275 | chr8:39141104 |
Chimerdb3.0 | FusionScan | LUSC | TCGA-43-6770-01A | RPAP3-ADAM32 | Out-of-Frame | chr12:48073486 | chr8:39141104 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-A8-A09K-01A | ZNF703-ADAM32 | 3'UTR-CDS | chr8:37556515 | chr8:39129223 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-EW-A1PH-01A | WHSC1L1-ADAM32 | Out-of-Frame | chr8:38138984 | chr8:39131830 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0EX-01A | FBXO16-ADAM32 | Out-of-frame | Chr8:28304688 | Chr8:39131831 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AN-A0FX-01A | ADAM32-ZNF251 | Out-of-frame | Chr8:39009067 | Chr8:145948767 |
TCGAfusionPortal | PRADA | BRCA | TCGA-EW-A1PH-01A | WHSC1L1-ADAM32 | Out-of-frame | Chr8:38138985 | Chr8:39131831 |
TCGAfusionPortal | PRADA | LUSC | TCGA-43-6770-01A | RPAP3-ADAM32 | Out-of-frame | Chr12:48073276 | Chr8:39141105 |
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TissGeneNet for ADAM32 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ADAM32 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ADAM32 |
TissGeneDrug for ADAM32 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ADAM32 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |