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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CCDC171
check button Gene summary
Basic gene informationGene symbolCCDC171
Gene namecoiled-coil domain containing 171
SynonymsC9orf93|bA536D16.1|bA778P13.1
CytomapUCSC genome browser: 9p22.3
Type of geneprotein-coding
RefGenesNM_173550.2,
Descriptioncoiled-coil domain-containing protein 171myosin tail domain containing protein
Modification date20141207
dbXrefs HGNC : HGNC
HPRD : 10805
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CCDC171
BioGPS: 203238
PathwayNCI Pathway Interaction Database: CCDC171
KEGG: CCDC171
REACTOME: CCDC171
Pathway Commons: CCDC171
ContextiHOP: CCDC171
ligand binding site mutation search in PubMed: CCDC171
UCL Cancer Institute: CCDC171
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)SkinTestis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)SKCMTGCT
Reference showing the relevant tissue of CCDC171
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for CCDC171

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for CCDC171

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
ACChsa-miR-221-3pMIMAT00002780.017-0.2778
ACChsa-miR-186-5pMIMAT00004560.044-0.2778
ACChsa-miR-221-3pMIMAT00002780.017-0.2778
ACChsa-miR-186-5pMIMAT00004560.044-0.2778
ACChsa-miR-23b-3pMIMAT00004180.017-0.2978
ACChsa-miR-23b-3pMIMAT00004180.017-0.2978


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TissGeneMut for CCDC171
TissGeneSNV for CCDC171

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.N495DHNSC2
p.E423XCOAD2
p.G1085AHNSC1
p.E352DKIRP1
p.S434LKICH1
p.V1197ASTAD1
p.Q466HLUAD1
p.M158LLUAD1
p.E1183DSTAD1
p.L738XCOAD1
p.R903ILUSC1
p.E131KBLCA1
p.H245QSTAD1
p.S777XESCA1
p.E131QHNSC1
p.A732VLGG1
p.E1203KUCEC1
p.E423*LUAD1
p.H1227YHNSC1
p.L1234FBLCA1
p.R309LLUAD1
p.D753YCOAD1
p.Y391CSTAD1
p.I383VPRAD1
p.L1042RLUAD1
p.Q1160HLUAD1
p.I1217MBLCA1
p.L667PKIRP1
p.R164QSTAD1
p.T1174IESCA1
p.R802QSKCM1
p.R859HDLBC1
p.H492DSKCM1
p.R81LESCA1
p.P1280QLUAD1
p.E1041XREAD1
p.A898TUCEC1
p.L1249SSKCM1
p.V886ICOAD1
p.A558PKIRP1
p.E402KSTAD1
p.E943*LUSC1
p.K240NCOAD1
p.L675PKIRP1
p.E195QSKCM1
p.R279KCOAD1
p.E509DACC1
p.S439LSKCM1
p.Q221KSTAD1
p.E373XSTAD1
p.V421MLGG1
p.R1099KSARC1
p.S894FSKCM1
p.K782XLIHC1
p.E456*LUAD1
p.E85KSKCM1
p.D1271NLUAD1
p.Q436KHNSC1
p.E1041XCHOL1
p.R1244CESCA1
p.S971XLIHC1
p.Q553EBLCA1
p.K55RCOAD1
p.L70PSTAD1
p.K1243RLUSC1
p.K664NKIRC1
p.G1274VHNSC1
p.R520QREAD1
p.P1269LSTAD1
p.L1047FLUAD1
p.L864ISTAD1
p.E1151KBLCA1
p.R937SLUSC1
p.N368IPAAD1
p.R307QCOAD1
p.M742ILUSC1
p.E346KCOAD1
p.L1281SPRAD1
p.F713LBLCA1
p.L241ISTAD1
p.A478TKIRC1
p.L708FSKCM1
p.A954PSKCM1
p.P1194SSTAD1
p.T243RBLCA1
p.F299LREAD1
p.K115QREAD1
p.K16NSTAD1
p.A747TSTAD1
p.R744QCOAD1
p.S262NUCEC1
p.G978*HNSC1
p.R1244HSTAD1
p.T998ISTAD1
p.D608HCESC1
p.C922RSTAD1
p.D1139NREAD1
p.D613YLUAD1
p.E476XESCA1
p.R990CSTAD1
p.E258XCOAD1
p.D151NSKCM1
p.N495HPAAD1
p.L1175RDLBC1
p.R929GKIRC1
p.K855TLUAD1
p.S894CBLCA1
p.S777*ESCA1
p.E1221KHNSC1
p.D613GCESC1


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TissGeneCNV for CCDC171

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CCDC171

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABF378126CCDC171-SARSchr9:15764404chr1:109780357
Chimerdb3.0FusionScanBRCATCGA-BH-A1FM-01ACCNK-CCDC171Out-of-Framechr14:99969981chr9:15920267


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TissGeneNet for CCDC171

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for CCDC171

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.

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TissGeneClin for CCDC171
TissGeneDrug for CCDC171

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CCDC171

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0007273Carotid Artery Diseases1GAD
umls:C0040336Tobacco Use Disorder1GAD