TissGeneSummary for CCDC171 |
Gene summary |
Basic gene information | Gene symbol | CCDC171 |
Gene name | coiled-coil domain containing 171 | |
Synonyms | C9orf93|bA536D16.1|bA778P13.1 | |
Cytomap | UCSC genome browser: 9p22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_173550.2, | |
Description | coiled-coil domain-containing protein 171myosin tail domain containing protein | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
HPRD : 10805 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC171 | |
BioGPS: 203238 | ||
Pathway | NCI Pathway Interaction Database: CCDC171 | |
KEGG: CCDC171 | ||
REACTOME: CCDC171 | ||
Pathway Commons: CCDC171 | ||
Context | iHOP: CCDC171 | |
ligand binding site mutation search in PubMed: CCDC171 | ||
UCL Cancer Institute: CCDC171 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMTGCT | |
Reference showing the relevant tissue of CCDC171 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for CCDC171 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
Top |
TissGene-miRNA for CCDC171 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-221-3p | MIMAT0000278 | 0.017 | -0.27 | 78 |
ACC | hsa-miR-186-5p | MIMAT0000456 | 0.044 | -0.27 | 78 |
ACC | hsa-miR-221-3p | MIMAT0000278 | 0.017 | -0.27 | 78 |
ACC | hsa-miR-186-5p | MIMAT0000456 | 0.044 | -0.27 | 78 |
ACC | hsa-miR-23b-3p | MIMAT0000418 | 0.017 | -0.29 | 78 |
ACC | hsa-miR-23b-3p | MIMAT0000418 | 0.017 | -0.29 | 78 |
Top |
TissGeneMut for CCDC171 |
TissGeneSNV for CCDC171 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.N495D | HNSC | 2 |
p.E423X | COAD | 2 |
p.G1085A | HNSC | 1 |
p.E352D | KIRP | 1 |
p.S434L | KICH | 1 |
p.V1197A | STAD | 1 |
p.Q466H | LUAD | 1 |
p.M158L | LUAD | 1 |
p.E1183D | STAD | 1 |
p.L738X | COAD | 1 |
p.R903I | LUSC | 1 |
p.E131K | BLCA | 1 |
p.H245Q | STAD | 1 |
p.S777X | ESCA | 1 |
p.E131Q | HNSC | 1 |
p.A732V | LGG | 1 |
p.E1203K | UCEC | 1 |
p.E423* | LUAD | 1 |
p.H1227Y | HNSC | 1 |
p.L1234F | BLCA | 1 |
p.R309L | LUAD | 1 |
p.D753Y | COAD | 1 |
p.Y391C | STAD | 1 |
p.I383V | PRAD | 1 |
p.L1042R | LUAD | 1 |
p.Q1160H | LUAD | 1 |
p.I1217M | BLCA | 1 |
p.L667P | KIRP | 1 |
p.R164Q | STAD | 1 |
p.T1174I | ESCA | 1 |
p.R802Q | SKCM | 1 |
p.R859H | DLBC | 1 |
p.H492D | SKCM | 1 |
p.R81L | ESCA | 1 |
p.P1280Q | LUAD | 1 |
p.E1041X | READ | 1 |
p.A898T | UCEC | 1 |
p.L1249S | SKCM | 1 |
p.V886I | COAD | 1 |
p.A558P | KIRP | 1 |
p.E402K | STAD | 1 |
p.E943* | LUSC | 1 |
p.K240N | COAD | 1 |
p.L675P | KIRP | 1 |
p.E195Q | SKCM | 1 |
p.R279K | COAD | 1 |
p.E509D | ACC | 1 |
p.S439L | SKCM | 1 |
p.Q221K | STAD | 1 |
p.E373X | STAD | 1 |
p.V421M | LGG | 1 |
p.R1099K | SARC | 1 |
p.S894F | SKCM | 1 |
p.K782X | LIHC | 1 |
p.E456* | LUAD | 1 |
p.E85K | SKCM | 1 |
p.D1271N | LUAD | 1 |
p.Q436K | HNSC | 1 |
p.E1041X | CHOL | 1 |
p.R1244C | ESCA | 1 |
p.S971X | LIHC | 1 |
p.Q553E | BLCA | 1 |
p.K55R | COAD | 1 |
p.L70P | STAD | 1 |
p.K1243R | LUSC | 1 |
p.K664N | KIRC | 1 |
p.G1274V | HNSC | 1 |
p.R520Q | READ | 1 |
p.P1269L | STAD | 1 |
p.L1047F | LUAD | 1 |
p.L864I | STAD | 1 |
p.E1151K | BLCA | 1 |
p.R937S | LUSC | 1 |
p.N368I | PAAD | 1 |
p.R307Q | COAD | 1 |
p.M742I | LUSC | 1 |
p.E346K | COAD | 1 |
p.L1281S | PRAD | 1 |
p.F713L | BLCA | 1 |
p.L241I | STAD | 1 |
p.A478T | KIRC | 1 |
p.L708F | SKCM | 1 |
p.A954P | SKCM | 1 |
p.P1194S | STAD | 1 |
p.T243R | BLCA | 1 |
p.F299L | READ | 1 |
p.K115Q | READ | 1 |
p.K16N | STAD | 1 |
p.A747T | STAD | 1 |
p.R744Q | COAD | 1 |
p.S262N | UCEC | 1 |
p.G978* | HNSC | 1 |
p.R1244H | STAD | 1 |
p.T998I | STAD | 1 |
p.D608H | CESC | 1 |
p.C922R | STAD | 1 |
p.D1139N | READ | 1 |
p.D613Y | LUAD | 1 |
p.E476X | ESCA | 1 |
p.R990C | STAD | 1 |
p.E258X | COAD | 1 |
p.D151N | SKCM | 1 |
p.N495H | PAAD | 1 |
p.L1175R | DLBC | 1 |
p.R929G | KIRC | 1 |
p.K855T | LUAD | 1 |
p.S894C | BLCA | 1 |
p.S777* | ESCA | 1 |
p.E1221K | HNSC | 1 |
p.D613G | CESC | 1 |
Top |
TissGeneCNV for CCDC171 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for CCDC171 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF378126 | CCDC171-SARS | chr9:15764404 | chr1:109780357 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A1FM-01A | CCNK-CCDC171 | Out-of-Frame | chr14:99969981 | chr9:15920267 |
Top |
TissGeneNet for CCDC171 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CCDC171 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for CCDC171 |
TissGeneDrug for CCDC171 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CCDC171 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007273 | Carotid Artery Diseases | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |