TissGeneSummary for AK4 |
Gene summary |
Basic gene information | Gene symbol | AK4 |
Gene name | adenylate kinase 4 | |
Synonyms | AK 4|AK3|AK3L1|AK3L2 | |
Cytomap | UCSC genome browser: 1p31.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001005353.2, NM_013410.3,NM_203464.2, | |
Description | AK 4ATP-AMP transphosphorylaseGTP:AMP phosphotransferase AK4, mitochondrialadenylate kinase 3-like 1adenylate kinase 4, mitochondrialadenylate kinase isoenzyme 4, mitochondrialmitochondrial adenylate kinase-3nucleoside-triphosphate-adenylate kinase | |
Modification date | 20141207 | |
dbXrefs | MIM : 103030 | |
HGNC : HGNC | ||
Ensembl : ENSG00000162433 | ||
HPRD : 00048 | ||
Vega : OTTHUMG00000009033 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AK4 | |
BioGPS: 205 | ||
Pathway | NCI Pathway Interaction Database: AK4 | |
KEGG: AK4 | ||
REACTOME: AK4 | ||
Pathway Commons: AK4 | ||
Context | iHOP: AK4 | |
ligand binding site mutation search in PubMed: AK4 | ||
UCL Cancer Institute: AK4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of AK4 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006165 | nucleoside diphosphate phosphorylation | 23416111 | GO:0009142 | nucleoside triphosphate biosynthetic process | 23416111 | GO:0046033 | AMP metabolic process | 19766732 | GO:0046034 | ATP metabolic process | 19766732 | GO:0046039 | GTP metabolic process | 19766732 | GO:0006165 | nucleoside diphosphate phosphorylation | 23416111 | GO:0009142 | nucleoside triphosphate biosynthetic process | 23416111 | GO:0046033 | AMP metabolic process | 19766732 | GO:0046034 | ATP metabolic process | 19766732 | GO:0046039 | GTP metabolic process | 19766732 |
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TissGeneExp for AK4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for AK4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for AK4 |
TissGeneSNV for AK4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P131S | SKCM | 1 |
p.P91S | SKCM | 1 |
p.G189E | HNSC | 1 |
p.G196E | HNSC | 1 |
p.S187N | READ | 1 |
p.E59Q | BLCA | 1 |
p.V206I | UCEC | 1 |
p.T93I | HNSC | 1 |
p.V135A | UCEC | 1 |
p.R188Q | BLCA | 1 |
p.V151I | ESCA | 1 |
p.D161Y | ESCA | 1 |
p.R170S | READ | 1 |
p.P142S | SKCM | 1 |
p.V177A | LIHC | 1 |
p.D88Y | THYM | 1 |
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TissGeneCNV for AK4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for AK4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A8NE-01A | AK4-TMEM48 | Out-of-Frame | chr1:65656512 | chr1:54291609 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A8NE-01A | AK4-TMEM48 | In-Frame | chr1:65656512 | chr1:54293846 |
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TissGeneNet for AK4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for AK4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for AK4 |
TissGeneDrug for AK4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for AK4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
umls:C0022672 | Acute Kidney Tubular Necrosis | 1 | RGD |
umls:C0025517 | Metabolic Diseases | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 1 | CTD_human |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0342783 | Deficiency of butyryl-CoA dehydrogenase | 1 | BeFree |
umls:C0524851 | Neurodegenerative Disorders | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0860207 | Drug-Induced Liver Injury | 1 | RGD |
umls:C1861172 | Venous Thromboembolism | 1 | GWASCAT |