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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for AK4
check button Gene summary
Basic gene informationGene symbolAK4
Gene nameadenylate kinase 4
SynonymsAK 4|AK3|AK3L1|AK3L2
CytomapUCSC genome browser: 1p31.3
Type of geneprotein-coding
RefGenesNM_001005353.2,
NM_013410.3,NM_203464.2,
DescriptionAK 4ATP-AMP transphosphorylaseGTP:AMP phosphotransferase AK4, mitochondrialadenylate kinase 3-like 1adenylate kinase 4, mitochondrialadenylate kinase isoenzyme 4, mitochondrialmitochondrial adenylate kinase-3nucleoside-triphosphate-adenylate kinase
Modification date20141207
dbXrefs MIM : 103030
HGNC : HGNC
Ensembl : ENSG00000162433
HPRD : 00048
Vega : OTTHUMG00000009033
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AK4
BioGPS: 205
PathwayNCI Pathway Interaction Database: AK4
KEGG: AK4
REACTOME: AK4
Pathway Commons: AK4
ContextiHOP: AK4
ligand binding site mutation search in PubMed: AK4
UCL Cancer Institute: AK4
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Kidney
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICH
Reference showing the relevant tissue of AK4
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006165nucleoside diphosphate phosphorylation23416111
GO:0009142nucleoside triphosphate biosynthetic process23416111
GO:0046033AMP metabolic process19766732
GO:0046034ATP metabolic process19766732
GO:0046039GTP metabolic process19766732
GO:0006165nucleoside diphosphate phosphorylation23416111
GO:0009142nucleoside triphosphate biosynthetic process23416111
GO:0046033AMP metabolic process19766732
GO:0046034ATP metabolic process19766732
GO:0046039GTP metabolic process19766732


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TissGeneExp for AK4

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for AK4

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for AK4
TissGeneSNV for AK4

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.P131SSKCM1
p.P91SSKCM1
p.G189EHNSC1
p.G196EHNSC1
p.S187NREAD1
p.E59QBLCA1
p.V206IUCEC1
p.T93IHNSC1
p.V135AUCEC1
p.R188QBLCA1
p.V151IESCA1
p.D161YESCA1
p.R170SREAD1
p.P142SSKCM1
p.V177ALIHC1
p.D88YTHYM1


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TissGeneCNV for AK4

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for AK4

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanESCATCGA-L5-A8NE-01AAK4-TMEM48Out-of-Framechr1:65656512chr1:54291609
Chimerdb3.0FusionScanESCATCGA-L5-A8NE-01AAK4-TMEM48In-Framechr1:65656512chr1:54293846


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TissGeneNet for AK4

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for AK4

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.

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TissGeneClin for AK4
TissGeneDrug for AK4

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for AK4

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0002736Amyotrophic Lateral Sclerosis1BeFree
umls:C0022672Acute Kidney Tubular Necrosis1RGD
umls:C0025517Metabolic Diseases1BeFree
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0029408Degenerative polyarthritis1CTD_human
umls:C0040336Tobacco Use Disorder1GAD
umls:C0152013Adenocarcinoma of lung (disorder)1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0342783Deficiency of butyryl-CoA dehydrogenase1BeFree
umls:C0524851Neurodegenerative Disorders1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0860207Drug-Induced Liver Injury1RGD
umls:C1861172Venous Thromboembolism1GWASCAT