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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for F2
check button Gene summary
Basic gene informationGene symbolF2
Gene namecoagulation factor II (thrombin)
SynonymsPT|RPRGL2|THPH1
CytomapUCSC genome browser: 11p11
Type of geneprotein-coding
RefGenesNM_000506.3,
Descriptionprepro-coagulation factor IIprothrombinprothrombin B-chainserine protease
Modification date20141222
dbXrefs MIM : 176930
HGNC : HGNC
Ensembl : ENSG00000180210
HPRD : 01488
Vega : OTTHUMG00000150344
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_F2
BioGPS: 2147
PathwayNCI Pathway Interaction Database: F2
KEGG: F2
REACTOME: F2
Pathway Commons: F2
ContextiHOP: F2
ligand binding site mutation search in PubMed: F2
UCL Cancer Institute: F2
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of F2
Description by TissGene annotationsCancer gene
TissgsKTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0001934positive regulation of protein phosphorylation7559487
GO:0007166cell surface receptor signaling pathway1672265
GO:0009611response to wounding9639571
GO:0030168platelet activation9038223
GO:0030194positive regulation of blood coagulation9038223
GO:0032967positive regulation of collagen biosynthetic process9639571
GO:0042730fibrinolysis12855810
GO:0045861negative regulation of proteolysis1695900
GO:0048712negative regulation of astrocyte differentiation1691280
GO:0051281positive regulation of release of sequestered calcium ion into cytosol1672265
GO:0051480cytosolic calcium ion homeostasis19052258
GO:1900738positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway20164183
GO:2000379positive regulation of reactive oxygen species metabolic process17275676
GO:0001934positive regulation of protein phosphorylation7559487
GO:0007166cell surface receptor signaling pathway1672265
GO:0009611response to wounding9639571
GO:0030168platelet activation9038223
GO:0030194positive regulation of blood coagulation9038223
GO:0032967positive regulation of collagen biosynthetic process9639571
GO:0042730fibrinolysis12855810
GO:0045861negative regulation of proteolysis1695900
GO:0048712negative regulation of astrocyte differentiation1691280
GO:0051281positive regulation of release of sequestered calcium ion into cytosol1672265
GO:0051480cytosolic calcium ion homeostasis19052258
GO:1900738positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway20164183
GO:2000379positive regulation of reactive oxygen species metabolic process17275676


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TissGeneExp for F2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LIHC13.4078343614.84791636-1.4400821.32E-055.38E-05
KIRC2.148108696-0.335970472.4840791671.53E-074.21E-07
COAD0.146131132-0.8786957911.0248269230.003560.008883781


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TissGene-miRNA for F2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for F2
TissGeneSNV for F2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.A405SESCA1
p.A79TLGG1
p.E352QBLCA1
p.R52CSTAD1
p.R35GBRCA1
p.D349YLUAD1
p.P471AGBM1
p.E312KCOAD1
p.Q130KLUAD1
p.T164ISKCM1
p.T164SUCEC1
p.S144PLIHC1
p.R158CSTAD1
p.N260YSTAD1
p.S199FSKCM1
p.Q130HLUAD1
p.R217WBLCA1
p.D287NSKCM1
p.P480HPRAD1
p.P577SLGG1
p.V4IKIRP1
p.G373DLUAD1
p.K469NUCEC1
p.W612*SKCM1
p.W590*SKCM1
p.R135HUCEC1
p.A240SSTAD1
p.E296KHNSC1
p.G267ESKCM1
p.A405TUCEC1
p.G499RSKCM1
p.A150SBRCA1
p.V176MCOAD1
p.R363CLUAD1
p.R135CUCEC1
p.G569EGBM1
p.L493FCOAD1
p.R135HPRAD1
p.R436QESCA1
p.V193ESKCM1
p.I438FLUAD1
p.R425HSTAD1
p.E110KLUAD1
p.T95MKIRC1
p.R135HCOAD1
p.R178KSKCM1
p.K440NCOAD1
p.E4*UCEC1
p.V525AESCA1
p.G503ASTAD1
p.G201CSTAD1
p.N252SKIRC1
p.R198LLUAD1
p.Q8KLUAD1
p.N289SLIHC1
p.P471SSKCM1
p.G496ESKCM1
p.R456QSTAD1
p.P376LSKCM1
p.D268NHNSC1
p.D597GREAD1
p.F578CSTAD1
p.A464SBRCA1
p.F83LUCEC1
p.R217WSKCM1
p.D306NUCEC1
p.A85TUCEC1
p.P471SOV1
p.R198COV1
p.A277PLGG1
p.R436QCOAD1
p.T351ISKCM1
p.E211KLGG1
p.Y290CSTAD1
p.R217QUCEC1
p.R97GBLCA1
p.V214LKIRP1
p.R543HSTAD1
p.E305KHNSC1
p.G231ESKCM1
p.G201DSKCM1
p.E270KSKCM1
p.R133MCOAD1


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TissGeneCNV for F2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for F2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
TCGAfusionPortalPRADALUADTCGA-69-7979-01AC11orf49-F2Out-of-frameChr11:47008861Chr11:46747409
TCGAfusionPortalPRADAOVTCGA-13-0760-01ALPP-F25UTR-CDSChr3:188059507Chr11:46741252


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TissGeneNet for F2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
F2, HNF4A, GP5, F2RL1, PLAT, HNF1A, F13A1, F5, IGFBP5, ST13, KNG1, THBD, IGFBP3, F11, GGCX, ITGA2B, PROZ, FOXA2, SERPINC1, HGFAC, SERPINE2 (tumor)F2, HNF4A, SPP1, PLAU, DDIT3, HNF1A, CPB2, FGA, KNG1, F11, PROC, AMBP, ITGA2B, PROZ, SERPIND1, FOXA2, SERPINC1, HGFAC, F9, AANAT, F2RL3 (normal)
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COAD (tumor)COAD (normal)
F2, HNF4A, SPP1, PLAU, DDIT3, F2RL1, CPB2, IGFBP5, FGA, SERPINB8, C6, FGG, IGFBP3, GGCX, AMBP, ITGA2B, FGB, SERPIND1, SERPINC1, F9, F2RL3 (tumor)F2, HNF4A, PLAU, HNF1A, SERPINB6, CPB2, FGA, KNG1, SERPINB8, C6, FGG, F11, PROC, AMBP, FGB, SERPIND1, FOXA2, AKR7A2, SERPING1, SERPINE2, AANAT (normal)
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HNSC (tumor)HNSC (normal)
F2, HNF4A, GP1BA, PLAU, F2RL1, CPB2, IGFBP5, FGA, KNG1, FGG, IGFBP3, F11, PROC, AMBP, FGB, SERPIND1, FOXA2, SERPINC1, F8, SERPINE2, F9 (tumor)F2, HNF4A, HNF1A, SERPINB6, CPB2, F5, FGA, ST13, KNG1, THBD, FGG, IGFBP3, AMBP, PROZ, FGB, SERPINC1, HGFAC, AKR7A2, SERPING1, SERPINE2, F9 (normal)
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KICH (tumor)KICH (normal)
F2, HNF4A, GP1BA, GP5, PLAU, PITX3, HNF1A, F13A1, SERPINB6, ST13, PROS1, IGFBP3, PROC, AMBP, ITGA2B, PROZ, FOXA2, SERPINC1, AKR7A2, AANAT, F2RL3 (tumor)F2, PLAU, THBS1, DDIT3, CPB2, IGFBP5, FGA, FGG, IGFBP3, F11, PROC, AMBP, ITGA2B, PROZ, SERPINC1, HGFAC, AKR7A2, F8, SERPINE2, AANAT, F2RL3 (normal)
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KIRC (tumor)KIRC (normal)
F2, HNF4A, GP5, PLAU, PITX3, PLAT, HNF1A, F13A1, CPB2, FGA, ST13, KNG1, PROS1, FGG, F2R, FGB, SERPIND1, FOXA2, SERPINC1, F8, SERPINE2 (tumor)F2, HNF4A, SPP1, SERPINE1, PLAU, PLAT, CPB2, SERPINA5, FGA, PROS1, SERPINB8, FGG, GGCX, FGB, SERPIND1, FOXA2, SERPINC1, SERPING1, SERPINE2, F9, F2RL3 (normal)
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KIRP (tumor)KIRP (normal)
F2, HNF4A, GP1BA, GP5, PLAU, PITX3, HNF1A, F13A1, IGFBP5, ST13, PROS1, IGFBP3, GGCX, F2R, PROC, ITGA2B, PROZ, FGB, SERPINC1, HGFAC, AKR7A2 (tumor)F2, GP1BA, SERPINE1, DDIT3, F2RL1, CPB2, FGA, ST13, KNG1, PROS1, THBD, C6, FGG, AMBP, PROZ, FGB, SERPIND1, SERPINC1, HGFAC, F2RL2, F9 (normal)
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LIHC (tumor)LIHC (normal)
F2, PLAU, F2RL1, F13A1, CPB2, ST13, KNG1, PROS1, SERPINB8, C6, F11, F2R, PROC, AMBP, PROZ, FOXA2, SERPINC1, HGFAC, AKR7A2, SERPING1, F9 (tumor)F2, HNF4A, PLAU, HNF1A, CPB2, F5, SERPINA5, FGA, KNG1, FGG, F11, GGCX, PROC, AMBP, PROZ, FGB, SERPIND1, FOXA2, SERPINC1, SERPING1, F9 (normal)
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LUAD (tumor)LUAD (normal)
F2, HNF4A, GP5, THBS1, PITX3, F2RL1, CPB2, F5, IGFBP5, FGA, KNG1, PROS1, THBD, SERPINB8, FGG, GGCX, FGB, FOXA2, SERPINC1, SERPING1, F8 (tumor)F2, HNF4A, PLAU, THBS1, PITX3, PLAT, HNF1A, F13A1, CPB2, F5, SERPINA5, FGA, KNG1, FGG, PROC, AMBP, PROZ, FGB, SERPIND1, F8, F9 (normal)
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LUSC (tumor)LUSC (normal)
F2, GP5, SERPINE1, PLAU, DDIT3, F2RL1, F13A1, SERPINB6, F5, KNG1, PROS1, THBD, IGFBP3, F2R, AMBP, FGB, FOXA2, SERPINC1, F2RL2, F9, F2RL3 (tumor)F2, HNF4A, SPP1, PLAU, PLAT, HNF1A, F13A1, CPB2, SERPINA5, FGA, KNG1, THBD, FGG, PROC, AMBP, PROZ, FGB, FOXA2, SERPINC1, HGFAC, F9 (normal)
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PRAD (tumor)PRAD (normal)
F2, HNF4A, GP1BA, GP5, PLAU, DDIT3, PLAT, SERPINB6, F5, FGA, KNG1, FGG, F11, ITGA2B, PROZ, SERPIND1, HGFAC, F2RL2, AKR7A2, F8, F2RL3 (tumor)F2, HNF4A, DDIT3, F13A1, SERPINB6, CPB2, F5, FGA, KNG1, FGG, F11, AMBP, ITGA2B, PROZ, FGB, SERPIND1, SERPINC1, HGFAC, AKR7A2, F8, F9 (normal)
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STAD (tumor)STAD (normal)
F2, SPP1, PLAU, THBS1, DDIT3, PLAT, CPB2, IGFBP5, FGA, ST13, KNG1, PROS1, SERPINB8, FGG, ITGA2B, FGB, SERPINC1, HGFAC, F2RL2, SERPING1, F8 (tumor)F2, HNF4A, HNF1A, SERPINB6, CPB2, F5, SERPINA5, FGA, KNG1, SERPINB8, FGG, F11, GGCX, PROC, AMBP, ITGA2B, PROZ, FGB, SERPIND1, FOXA2, SERPINC1 (normal)
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THCA (tumor)THCA (normal)
F2, HNF4A, SPP1, GP5, SERPINE1, PITX3, F13A1, CPB2, F5, SERPINA5, ST13, C6, FGG, PROC, ITGA2B, FGB, SERPIND1, FOXA2, AKR7A2, SERPING1, AANAT (tumor)F2, HNF4A, HNF1A, SERPINB6, CPB2, SERPINA5, FGA, KNG1, PROS1, SERPINB8, FGG, F11, AMBP, PROZ, FGB, SERPIND1, SERPINC1, HGFAC, AKR7A2, F9, AANAT (normal)
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TissGeneProg for F2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for F2
TissGeneDrug for F2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00001LepirudinInhibitorBiotechApproved
DB00100Coagulation Factor IX (Recombinant)BiotechApproved
DB01123ProflavineOther/unknownSmall moleculeApproved
DB04786SuraminInhibitorSmall moleculeApproved
DB06695Dabigatran etexilateInhibitorSmall moleculeApproved
DB00006BivalirudinInhibitorSmall moleculeApproved|Investigational
DB00278ArgatrobanInhibitorSmall moleculeApproved|Investigational
DB05777Thrombomodulin AlfaInhibitorBiotechApproved|Investigational
DB00055Drotrecogin alfaBiotechApproved|Investigational|Withdrawn
DB04898XimelagatranInhibitorSmall moleculeApproved|Investigational|Withdrawn


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TissGeneDisease for F2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0398623Thrombophilia245BeFree,CLINVAR,CTD_human,GAD,RGD
umls:C0584960Factor V Leiden mutation165BeFree,GAD
umls:C0040038Thromboembolism108BeFree,CTD_human,GAD,LHGDN
umls:C0042487Venous Thrombosis106CTD_human,GAD,LHGDN,RGD
umls:C0040053Thrombosis83CTD_human,GAD,LHGDN,RGD
umls:C0149871Deep Vein Thrombosis63BeFree,GAD
umls:C0038454Cerebrovascular accident61BeFree,CTD_human,GAD,LHGDN
umls:C0600433Activated Protein C Resistance53BeFree,GAD
umls:C0027051Myocardial Infarction46BeFree,CTD_human,GAD,LHGDN
umls:C0034065Pulmonary Embolism38BeFree,GAD
umls:C1861172Venous Thromboembolism29CTD_human,GAD,GWASCAT,LHGDN
umls:C0598608Hyperhomocysteinemia28BeFree,GAD,LHGDN
umls:C1861171THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder)28BeFree
umls:C0948008Ischemic stroke27BeFree,GAD
umls:C0020640Inherited Factor II deficiency26BeFree,CLINVAR,CTD_human,GAD,LHGDN,ORPHANET,UNIPROT
umls:C0007786Brain Ischemia24CTD_human,GAD,LHGDN
umls:C0000809Abortion, Habitual23GAD,LHGDN
umls:C0005779Blood Coagulation Disorders23BeFree,CTD_human,GAD
umls:C0010068Coronary heart disease23BeFree,GAD
umls:C0032914Pre-Eclampsia23GAD,LHGDN
umls:C0242666Protein S Deficiency23BeFree,GAD
umls:C2239176Liver carcinoma23BeFree,CTD_human,GAD,LHGDN
umls:C0020538Hypertensive disease20BeFree,GAD
umls:C0032964Pregnancy Complications, Hematologic20GAD
umls:C0340708Deep vein thrombosis of lower limb20BeFree
umls:C0398625Protein C Deficiency19BeFree,GAD,LHGDN
umls:C1956346Coronary Artery Disease19BeFree,GAD,LHGDN
umls:C3272363Ischemic Cerebrovascular Accident19BeFree,GAD
umls:C3495426Homocysteinemia18BeFree
umls:C0007222Cardiovascular Diseases17BeFree,GAD
umls:C0010054Coronary Arteriosclerosis16BeFree,GAD
umls:C0019069Hemophilia A16BeFree,GAD,LHGDN
umls:C0151945Thrombosis of cerebral veins15BeFree,GAD
umls:C0151950Deep thrombophlebitis15BeFree
umls:C0004943Behcet Syndrome14BeFree,GAD,LHGDN
umls:C0023890Liver Cirrhosis14BeFree,CTD_human,GAD
umls:C0151942Arterial thrombosis14BeFree,GAD
umls:C0004153Atherosclerosis13BeFree,GAD,LHGDN,RGD
umls:C0000832Abruptio Placentae12GAD
umls:C0015934Fetal Growth Retardation12GAD
umls:C0085278Antiphospholipid Syndrome12BeFree,GAD
umls:C0272375Antithrombin III Deficiency12BeFree,GAD
umls:C3203356Factor II deficiency12BeFree
umls:C0002895Anemia, Sickle Cell11BeFree,GAD
umls:C0035328Retinal Vein Occlusion11BeFree,GAD
umls:C0687675Pregnancy loss11GAD
umls:C0037198Sinus Thrombosis, Intracranial10BeFree,CTD_human,GAD,LHGDN
umls:C0155773Portal vein thrombosis10BeFree
umls:C0272317Hereditary factor II deficiency disease10BeFree,CLINVAR
umls:C2584620Thrombophilia, hereditary10BeFree
umls:C0000786Spontaneous abortion9GAD
umls:C0028754Obesity9BeFree,CTD_human,GAD,RGD
umls:C0032962Pregnancy Complications9BeFree,GAD,LHGDN
umls:C0085096Peripheral Vascular Diseases9BeFree,GAD,LHGDN
umls:C0684275Hemophilia, NOS9BeFree
umls:C2584409Prothrombin G20210A mutation9BeFree
umls:C0007785Cerebral Infarction8BeFree,CTD_human,GAD
umls:C0019080Hemorrhage8CTD_human,GAD,RGD
umls:C0021390Inflammatory Bowel Diseases8BeFree,GAD
umls:C0032963Pregnancy Complications, Cardiovascular8GAD
umls:C0151744Myocardial Ischemia8BeFree,GAD
umls:C0311370Lupus anticoagulant disorder8BeFree
umls:C0752143Intracranial Thrombosis8GAD
umls:C0852077Blood Coagulation Disorders, Inherited8BeFree,GAD
umls:C0856761Budd-Chiari Syndrome8BeFree,GAD
umls:C0011849Diabetes Mellitus7BeFree,GAD
umls:C0024141Lupus Erythematosus, Systemic7BeFree,GAD
umls:C0042373Vascular Diseases7BeFree,GAD
umls:C0151526Premature Birth7GAD
umls:C0003850Arteriosclerosis6BeFree,GAD
umls:C0007787Transient Ischemic Attack6BeFree,GAD,LHGDN
umls:C0018784Sensorineural Hearing Loss (disorder)6BeFree,GAD
umls:C0019154Hepatic Vein Thrombosis6BeFree
umls:C0154841Central retinal vein occlusion6BeFree
umls:C0155626Acute myocardial infarction6BeFree
umls:C0267412Mesenteric Venous Thrombosis6BeFree
umls:C0338573Cerebral venous sinus thrombosis6BeFree
umls:C0524702Pulmonary Thromboembolisms6BeFree,GAD
umls:C0852949Arteriopathic disease6BeFree
umls:C1623038Cirrhosis6BeFree
umls:C0003838Arterial Occlusive Diseases5BeFree,GAD
umls:C0005283beta Thalassemia5GAD
umls:C0006142Malignant neoplasm of breast5BeFree,GAD
umls:C0016522Foramen Ovale, Patent5BeFree,GAD
umls:C0018799Heart Diseases5BeFree,GAD
umls:C0019163Hepatitis B5BeFree
umls:C0029445Bone necrosis5GAD
umls:C0032787Postoperative Complications5GAD
umls:C0034040Puerperal Disorders5GAD
umls:C0085409Polyendocrinopathies, Autoimmune5BeFree
umls:C0162739HELLP Syndrome5BeFree,GAD
umls:C1260403prothrombin gene mutation5BeFree
umls:C0007789Cerebral Palsy4GAD
umls:C0011057Hearing Loss, Sudden4GAD
umls:C0012739Disseminated Intravascular Coagulation4BeFree,CTD_human,RGD
umls:C0015927Fetal Death4GAD
umls:C0020443Hypercholesterolemia4GAD
umls:C0020473Hyperlipidemia4GAD
umls:C0021368Inflammation4GAD,LHGDN
umls:C0022116Ischemia4BeFree,GAD
umls:C0023895Liver diseases4BeFree
umls:C0035302Retinal Artery Occlusion4BeFree,GAD
umls:C0035326Retinal vascular occlusion4BeFree,GAD
umls:C0040028Thrombocythemia, Essential4BeFree,GAD
umls:C0042345Varicosity4GAD
umls:C0267797Acute hepatitis4BeFree
umls:C0917798Cerebral Ischemia4BeFree
umls:C1704436Peripheral Arterial Diseases4BeFree,GAD
umls:C0002395Alzheimer's Disease3BeFree,CTD_human,GAD
umls:C0002875Cooley's anemia3BeFree,GAD
umls:C0007820Cerebrovascular Disorders3GAD
umls:C0008533Hemophilia B3BeFree,GAD
umls:C0009324Ulcerative Colitis3BeFree,GAD
umls:C0010346Crohn Disease3BeFree,GAD,LHGDN
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent3BeFree,GAD
umls:C0015503Factor VII Deficiency3BeFree
umls:C0015519Factor X Deficiency3BeFree
umls:C0018817Atrial Septal Defects3GAD
umls:C0019061Hemolytic-Uremic Syndrome3GAD
umls:C0019087Hemorrhagic Disorders3BeFree,GAD
umls:C0022650Kidney Calculi3BeFree,GAD
umls:C0042344Varicose Ulcer3GAD
umls:C0085083Ovarian Hyperstimulation Syndrome3BeFree
umls:C0085584Encephalopathies3BeFree
umls:C0085605Liver Failure3BeFree,CTD_human
umls:C0149931Migraine Disorders3BeFree,GAD
umls:C0155668Old myocardial infarction3BeFree
umls:C0242383Age related macular degeneration3GAD
umls:C0243026Sepsis3BeFree,RGD
umls:C0302809Fulminant hepatitis3BeFree
umls:C0342257Complications of Diabetes Mellitus3GAD
umls:C0376618Endotoxemia3RGD
umls:C0409980Primary antiphospholipid syndrome3BeFree
umls:C0678222Breast Carcinoma3BeFree
umls:C0745744End Stage Liver Disease3BeFree
umls:C0852036Pregnancy associated hypertension3GAD
umls:C0948089Acute Coronary Syndrome3BeFree,GAD
umls:C1527249Colorectal Cancer3BeFree,GAD
umls:C1867596Hyperprothrombinemia3BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma3BeFree,GAD
umls:C3714514Infection3GAD
umls:C0000768Congenital Abnormality2BeFree
umls:C0002965Angina, Unstable2BeFree
umls:C0004238Atrial Fibrillation2GAD
umls:C0007282Carotid Stenosis2GAD,LHGDN
umls:C0009402Colorectal Carcinoma2BeFree
umls:C0011847Diabetes2BeFree
umls:C0013537Eclampsia2BeFree
umls:C0014544Epilepsy2BeFree,GAD
umls:C0015499Factor V Deficiency2BeFree,GAD
umls:C0015814Femur Head Necrosis2GAD
umls:C0015929Fetal Diseases2GAD
umls:C0017181Gastrointestinal Hemorrhage2GAD
umls:C0017205Gaucher Disease2GAD
umls:C0017638Glioma2LHGDN,RGD
umls:C0018798Congenital Heart Defects2GAD
umls:C0018995Hemochromatosis2BeFree,GAD
umls:C0019151Hepatic Encephalopathy2BeFree
umls:C0019158Hepatitis2BeFree
umls:C0019159Hepatitis A2BeFree
umls:C0020445Hypercholesterolemia, Familial2GAD
umls:C0020542Pulmonary Hypertension2GAD,LHGDN
umls:C0021361Female infertility2GAD
umls:C0022658Kidney Diseases2BeFree,GAD
umls:C0022661Kidney Failure, Chronic2GAD,RGD
umls:C0022876Premature Obstetric Labor2GAD
umls:C0023234Legg-Calve-Perthes Disease2GAD
umls:C0023449Acute lymphocytic leukemia2BeFree
umls:C0023903Liver neoplasms2BeFree
umls:C0024623Malignant neoplasm of stomach2BeFree
umls:C0027022Myeloproliferative disease2GAD
umls:C0032045Placenta Disorders2GAD
umls:C0032460Polycystic Ovary Syndrome2BeFree,GAD
umls:C0032463Polycythemia Vera2BeFree,GAD
umls:C0033626Protein Deficiency2BeFree,GAD
umls:C0036572Seizures2BeFree,GAD
umls:C0036690Septicemia2BeFree
umls:C0042974von Willebrand Disease2BeFree,GAD
umls:C0079102Cerebral Thrombosis2BeFree,GAD
umls:C0085650Purpura Fulminans2BeFree
umls:C0085762Alcohol abuse2BeFree
umls:C0155305Optic Neuropathy, Ischemic2GAD
umls:C0232197Fibrillation2BeFree
umls:C0265099Basilar artery thrombosis2BeFree
umls:C0282193Iron Overload2BeFree,GAD
umls:C0339505Venous retinal branch occlusion2BeFree,GAD
umls:C0341439Chronic liver disease2BeFree
umls:C0524620Metabolic Syndrome X2BeFree,GAD
umls:C0553681Hypofibrinogenemia2BeFree
umls:C0553692Brain hemorrhage2GAD
umls:C0584984Heterozygous Factor V Leiden mutation2BeFree
umls:C0600518Choroidal Neovascularization2GAD
umls:C0699791Stomach Carcinoma2BeFree
umls:C0745497Thrombosis of internal jugular vein2BeFree
umls:C0747845early pregnancy2BeFree
umls:C0751956Acute Cerebrovascular Accidents2BeFree
umls:C0752155Central Nervous System Vascular Malformations2GAD,LHGDN
umls:C1559271Non-Malignant Ascites Adverse Event2BeFree
umls:C2717961Thrombotic Microangiopathies2BeFree
umls:C2919828Chronic ulcerative colitis2GAD
umls:C3241945Melena due to gastrointestinal hemorrhage2BeFree
umls:C0001925Albuminuria1GAD
umls:C0001973Alcoholic Intoxication, Chronic1GAD
umls:C0002736Amyotrophic Lateral Sclerosis1GAD
umls:C0002962Angina Pectoris1GAD
umls:C0003130Anoxia1GAD
umls:C0003578Apnea1GAD
umls:C0003873Rheumatoid Arthritis1CTD_human
umls:C0004626Pneumonia, Bacterial1RGD
umls:C0005129Bernard-Soulier Syndrome1BeFree
umls:C0005818Blood Platelet Disorders1GAD
umls:C0006111Brain Diseases1GAD
umls:C0007134Renal Cell Carcinoma1BeFree
umls:C0007193Cardiomyopathy, Dilated1GAD
umls:C0007772Intracranial Arteriovenous Malformation1GAD
umls:C0007781Intracranial Embolism and Thrombosis1GAD
umls:C0008495Chorioamnionitis1GAD
umls:C0009782Connective Tissue Diseases1GAD
umls:C0011071Sudden death1GAD
umls:C0013922Embolism1GAD,LHGDN
umls:C0014175Endometriosis1LHGDN
umls:C0014591Epistaxis1GAD
umls:C0014836Escherichia coli Infections1GAD
umls:C0014849Esophageal and Gastric Varices1GAD
umls:C0015397Disorder of eye1GAD
umls:C0015695Fatty Liver1CTD_human
umls:C0015944Fetal Membranes, Premature Rupture1GAD
umls:C0018991Hemiplegia1GAD
umls:C0019189Hepatitis, Chronic1BeFree
umls:C0019880Homocystinuria1BeFree
umls:C0020615Hypoglycemia1BeFree
umls:C0021296Infant, Small for Gestational Age1BeFree,GAD
umls:C0021359Infertility1GAD
umls:C0021943Chromosome inversion1GAD
umls:C0022104Irritable Bowel Syndrome1BeFree
umls:C0022672Acute Kidney Tubular Necrosis1BeFree
umls:C0022865Obstetric Labor Complications1GAD
umls:C0023223Leg Ulcer1BeFree,LHGDN
umls:C0024115Lung diseases1LHGDN
umls:C0024131Lupus Vulgaris1BeFree
umls:C0024138Lupus Erythematosus, Discoid1BeFree
umls:C0024314Lymphoproliferative Disorders1GAD
umls:C0025202melanoma1BeFree
umls:C0025472Mesenteric Vascular Occlusion1GAD
umls:C0026827Muscle hypotonia1GAD
umls:C0026857Musculoskeletal Diseases1GAD
umls:C0027627Neoplasm Metastasis1BeFree,LHGDN
umls:C0027720Nephrosis1CTD_human,RGD
umls:C0027746Nerve Degeneration1CTD_human
umls:C0027765nervous system disorder1GAD
umls:C0030524Paratuberculosis1CTD_human
umls:C0031069Familial Mediterranean Fever1GAD
umls:C0031542Phlebitis1GAD
umls:C0032461Polycythemia1GAD
umls:C0032797Postpartum Hemorrhage1GAD
umls:C0034069Pulmonary Fibrosis1LHGDN
umls:C0034152Henoch-Schoenlein Purpura1GAD
umls:C0034155Purpura, Thrombotic Thrombocytopenic1GAD
umls:C0034341Pyruvate Carboxylase Deficiency Disease1BeFree
umls:C0035126Reperfusion Injury1RGD
umls:C0036421Systemic Scleroderma1GAD
umls:C0036982Shock, Hemorrhagic1RGD
umls:C0037054Sickle Cell Trait1BeFree,GAD
umls:C0037274Dermatologic disorders1GAD
umls:C0038002Splenomegaly1GAD
umls:C0038356Stomach Neoplasms1GAD
umls:C0040015Thrombasthenia1GAD
umls:C0040021Thromboangiitis Obliterans1BeFree,GAD
umls:C0040034Thrombocytopenia1GAD
umls:C0041408Turner Syndrome1GAD
umls:C0042075Urologic Diseases1BeFree
umls:C0085298Sudden Cardiac Death1GAD
umls:C0085669Acute leukemia1BeFree
umls:C0151699Intracranial Hemorrhages1GAD
umls:C0154723Migraine with Aura1GAD
umls:C0162819Skin Diseases, Vascular1CTD_human
umls:C0206624Hepatoblastoma1BeFree
umls:C0220810Congenital defects1BeFree
umls:C0221505Lesion of brain1BeFree
umls:C0238096Embolism, Paradoxical1GAD,LHGDN
umls:C0242231Coronary Stenosis1GAD
umls:C0242488Acute Lung Injury1RGD
umls:C0242526Gonadal Dysgenesis, 45,X1GAD
umls:C0243038Carcinoma, Lewis Lung1BeFree,LHGDN
umls:C0259744dysproteinemia1BeFree
umls:C0265706Gastroschisis1BeFree,GAD
umls:C0270853Myoclonic Epilepsy, Juvenile1BeFree
umls:C0277919Postthrombotic Syndrome1GAD
umls:C0333186Restenosis1GAD
umls:C0338586Vertebral Artery Dissection1GAD
umls:C0340293Anterior myocardial infarction1BeFree
umls:C0376545Hematologic Neoplasms1GAD
umls:C0392106Hepatic artery thrombosis1GAD
umls:C0392525Nephrolithiasis1RGD
umls:C0400966Non-alcoholic Fatty Liver Disease1CTD_human
umls:C0409974Lupus Erythematosus1BeFree
umls:C0524909Hepatitis B, Chronic1BeFree
umls:C0524910Hepatitis C, Chronic1GAD
umls:C0567312Menopause present (finding)1GAD
umls:C0574002Edema of foot (finding)1BeFree
umls:C0600503Coagulation Protein Disorders1GAD
umls:C0677886Epithelial ovarian cancer1GAD
umls:C0683381inflammatory joint disease1BeFree
umls:C0749087Thrombosis of subclavian vein1BeFree
umls:C0751202Cystathionine beta-Synthase Deficiency Disease1BeFree
umls:C0751530Subarachnoid Hemorrhage, Aneurysmal1GAD
umls:C0752138Intracranial Arterial Diseases1GAD
umls:C0752351Embryo Loss1GAD
umls:C0860207Drug-Induced Liver Injury1RGD
umls:C0917805Transient Cerebral Ischemia1BeFree
umls:C0948441Venoocclusive disease1BeFree
umls:C0948480Coronary Restenosis1GAD
umls:C0971858Arthritis, Collagen-Induced1BeFree
umls:C1175175Severe Acute Respiratory Syndrome1GAD
umls:C1261287Stenosis1GAD
umls:C1273976First myocardial infarction1BeFree
umls:C1334928Necrotic changes (finding)1GAD
umls:C1412000Mesenteric vascular insufficiency1BeFree
umls:C1519670Tumor Angiogenesis1BeFree
umls:C1527311Brain Edema1RGD
umls:C1559093Bruising in the Absence of Grade 3 or Grade 4 Thrombocytopenia Adverse Event1BeFree
umls:C1842372ASPIRIN RESISTANCE1GAD
umls:C1857941Brooke-Spiegler syndrome1BeFree
umls:C1959635Parvovirus B19 (disease)1BeFree
umls:C2314994Infarction of spinal cord1BeFree
umls:C2585350Hereditary hyperhomocysteinemia1BeFree
umls:C2608079WARFARIN SENSITIVITY (disorder)1GAD
umls:C2717899Upper Extremity Deep Vein Thrombosis1GAD
umls:C2919032Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified1GAD
umls:C2921106Recurrent pregnancy loss1GAD
umls:C2939465Deficiency of glucose-6-phosphate dehydrogenase1GAD
umls:C2945695Limb ischemia1BeFree
umls:C3495801Granulomatosis with polyangiitis1GAD
umls:C4022560Splanchnic vein thrombosis1GAD
umls:C3280672PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 20CLINVAR