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| TissGeneSummary for FANCG |
 Gene summary |
| Basic gene information | Gene symbol | FANCG |
| Gene name | Fanconi anemia, complementation group G | |
| Synonyms | FAG|XRCC9 | |
| Cytomap | UCSC genome browser: 9p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004629.1, | |
| Description | DNA repair protein XRCC9Fanconi anemia group G proteinX-ray repair complementing defective repair in Chinese hamster cells 9X-ray repair, complementing defective, in Chinese hamster, 9 | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 602956 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000221829 | ||
| HPRD : 04262 | ||
| Vega : OTTHUMG00000019850 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FANCG | |
| BioGPS: 2189 | ||
| Pathway | NCI Pathway Interaction Database: FANCG | |
| KEGG: FANCG | ||
| REACTOME: FANCG | ||
| Pathway Commons: FANCG | ||
| Context | iHOP: FANCG | |
| ligand binding site mutation search in PubMed: FANCG | ||
| UCL Cancer Institute: FANCG | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
| Reference showing the relevant tissue of FANCG | ||
| Description by TissGene annotations | Cancer gene TissgsLTS Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for FANCG |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | -0.383934915 | -1.625362915 | 1.241428 | 2.68E-13 | 6.20E-12 |
| LUAD | 0.236753154 | -0.854984777 | 1.091737931 | 2.21E-20 | 4.86E-19 |
| BLCA | 1.205614769 | -0.11761681 | 1.323231579 | 8.48E-07 | 2.90E-05 |
| LUSC | 1.051195987 | -0.701786366 | 1.752982353 | 1.61E-21 | 2.32E-20 |
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| TissGene-miRNA for FANCG |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FANCG |
| TissGeneSNV for FANCG |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E285G | COAD | 1 |
| p.C544F | LUAD | 1 |
| p.W451R | UCEC | 1 |
| p.V471E | OV | 1 |
| p.P590T | COAD | 1 |
| p.R214H | ESCA | 1 |
| p.H339N | LUAD | 1 |
| p.R242Q | LUAD | 1 |
| p.P590L | SKCM | 1 |
| p.L80V | CESC | 1 |
| p.S7T | LUSC | 1 |
| p.P187T | ESCA | 1 |
| p.L310F | LUSC | 1 |
| p.A496T | COAD | 1 |
| p.M259I | SKCM | 1 |
| p.R155C | STAD | 1 |
| p.G238S | SKCM | 1 |
| p.E481K | UCEC | 1 |
| p.R242Q | DLBC | 1 |
| p.R3C | SKCM | 1 |
| p.K274* | LUAD | 1 |
| p.L208M | UCEC | 1 |
| p.R353S | PRAD | 1 |
| p.R214H | UCEC | 1 |
| p.K504* | LUAD | 1 |
| p.A200V | THYM | 1 |
| p.D205G | UCEC | 1 |
| p.A468T | UCEC | 1 |
| p.E219Q | BLCA | 1 |
| p.S7F | BLCA | 1 |
| p.S11N | UCS | 1 |
| p.L161M | KIRC | 1 |
| p.V541L | LUAD | 1 |
| p.S519T | KIRC | 1 |
| p.S603T | SKCM | 1 |
| p.R613Q | THYM | 1 |
| p.A514T | PAAD | 1 |
| p.R98Q | STAD | 1 |
| p.E324Q | BLCA | 1 |
| p.H55Y | SKCM | 1 |
| p.G276R | UCEC | 1 |
| p.S7A | STAD | 1 |
| p.L156V | BRCA | 1 |
| p.V248A | KIRP | 1 |
| p.R605C | UCEC | 1 |
| p.K175N | UCEC | 1 |
| p.R520C | KIRC | 1 |
| p.R214H | STAD | 1 |
| p.W16* | THCA | 1 |
| p.S237* | BLCA | 1 |
| p.S7F | LUSC | 1 |
| p.S33C | HNSC | 1 |
| p.R605C | SKCM | 1 |
| p.P68L | SKCM | 1 |
| p.S540N | UCEC | 1 |
| p.I323T | LUAD | 1 |
| p.D604N | HNSC | 1 |
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| TissGeneCNV for FANCG |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FANCG |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BQ224571 | FANCG-FANCG | chr9:35078230 | chr9:35078674 |
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| TissGeneNet for FANCG |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FANCG, KRT19, FANCL, FTSJ3, FANCF, CYP19A1, HES1, FANCA, CAPN1, TOP3A, FANCD2, FANCC, ANTXR2, STRA13, PRDX3, C19orf40, C17orf70, APITD1, CYP2E1, ERCC1, XRCC3 (tumor) | FANCG, CDK1, RPA1, ERCC4, BLM, FANCL, FANCA, TOP3A, FANCD2, FSCN1, FANCC, ANTXR2, FANCE, POLN, STRA13, C19orf40, C17orf70, APITD1, XRCC3, FANCB, RTN2 (normal) |
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| COAD (tumor) | COAD (normal) |
| FANCG, UBC, CDK1, GABPB1, BRCA2, BLM, FANCL, FANCF, CYP19A1, FANCA, TOP3A, FANCD2, FANCM, ANTXR2, FANCE, STRA13, PRDX3, C19orf40, APITD1, XRCC3, FANCB (tumor) | FANCG, UBC, PSMB1, CDK1, RPA1, GABPB1, BLM, FANCL, FANCA, TOP3A, FANCD2, FANCM, FANCC, ANTXR2, FANCE, STRA13, PRDX3, C17orf70, APITD1, XRCC3, FANCB (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FANCG, ZBED1, CDK1, BRCA2, FANCF, USHBP1, FANCA, CAPN1, FANCD2, FANCC, ANTXR2, FANCE, POLN, STRA13, PRDX3, C19orf40, APITD1, CYP2E1, XRCC3, FANCB, RTN2 (tumor) | FANCG, CDK1, RPA1, BRCA2, BLM, FANCL, FTSJ3, FANCA, TOP3A, FANCD2, FSCN1, FANCM, FANCC, ANTXR2, FANCE, STRA13, C19orf40, APITD1, XRCC3, FANCB, SAMD3 (normal) |
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| KICH (tumor) | KICH (normal) |
| FANCG, ZBED1, CDK1, GABPB1, BRCA2, KRT19, ERCC4, BLM, FANCL, FTSJ3, USHBP1, CAPN1, TOP3A, FANCD2, FANCM, FANCE, C19orf40, APITD1, XRCC3, FANCB, RTN2 (tumor) | FANCG, UBC, CDK1, RPA1, BLM, FANCL, USHBP1, FANCA, TOP3A, FANCD2, FSCN1, FANCC, FANCE, POLN, STRA13, C19orf40, C17orf70, ERCC1, XRCC3, FANCB, RTN2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| FANCG, UBC, CDK1, RPA1, KRT19, BLM, FANCL, HES1, CAPN1, FANCD2, FSCN1, FANCC, FANCE, C19orf40, APITD1, CYP2E1, ERCC1, XRCC3, FANCB, SAMD3, RTN2 (tumor) | FANCG, UBC, PSMB1, CDK1, RPA1, ERCC4, BLM, FANCL, FANCA, TOP3A, FANCD2, FSCN1, FANCE, STRA13, C19orf40, C17orf70, CYP2E1, ERCC1, XRCC3, FANCB, RTN2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FANCG, CDK1, RPA1, KRT19, ERCC4, BLM, FANCL, FTSJ3, FANCF, HES1, CAPN1, FANCD2, FANCC, FANCE, PRDX3, C19orf40, C17orf70, APITD1, XRCC3, FANCB, RTN2 (tumor) | FANCG, CDK1, SPTAN1, KRT19, ERCC4, BLM, FANCL, USHBP1, HES1, FANCA, TOP3A, FANCD2, FSCN1, FANCE, STRA13, PRDX3, C17orf70, CYP2E1, XRCC3, FANCB, RTN2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FANCG, CDK1, RPA1, GABPB1, BRCA2, KRT19, BLM, FANCL, USHBP1, FANCA, CAPN1, FANCD2, FSCN1, FANCC, POLN, STRA13, C19orf40, ERCC1, XRCC3, FANCB, SAMD3 (tumor) | FANCG, CDK1, RPA1, BRCA2, BLM, FANCL, FTSJ3, USHBP1, FANCA, FANCD2, FANCM, FANCC, ANTXR2, FANCE, POLN, PRDX3, C19orf40, APITD1, CYP2E1, XRCC3, FANCB (normal) |
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| LUAD (tumor) | LUAD (normal) |
| FANCG, UBC, PSMB1, CDK1, SPTAN1, RPA1, BLM, FANCL, FANCF, FANCA, CAPN1, FANCD2, FANCE, STRA13, PRDX3, C19orf40, C17orf70, ERCC1, XRCC3, FANCB, RTN2 (tumor) | FANCG, PSMB1, CDK1, RPA1, GABPB1, BRCA2, BLM, FANCL, USHBP1, FANCA, TOP3A, FANCD2, FSCN1, FANCM, FANCC, ANTXR2, FANCE, STRA13, C19orf40, XRCC3, FANCB (normal) |
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| LUSC (tumor) | LUSC (normal) |
| FANCG, UBC, CDK1, RPA1, GABPB1, BRCA2, KRT19, BLM, FANCL, FANCF, FANCA, FANCD2, FSCN1, FANCM, FANCE, POLN, PRDX3, C19orf40, XRCC3, FANCB, RTN2 (tumor) | FANCG, PSMB1, CDK1, SPTAN1, RPA1, BRCA2, BLM, FANCL, USHBP1, FANCA, FANCD2, FANCM, FANCC, ANTXR2, FANCE, STRA13, C19orf40, APITD1, XRCC3, FANCB, RTN2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| FANCG, PSMB1, ZBED1, SPTAN1, GABPB1, BRCA2, ERCC4, BLM, FANCL, CYP19A1, USHBP1, HES1, FANCA, FANCD2, FANCC, STRA13, C19orf40, C17orf70, CYP2E1, ERCC1, XRCC3 (tumor) | FANCG, PSMB1, ZBED1, CDK1, ERCC4, BLM, FANCL, FANCF, CYP19A1, FANCA, TOP3A, FANCD2, FANCC, ANTXR2, FANCE, STRA13, C17orf70, APITD1, ERCC1, XRCC3, FANCB (normal) |
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| STAD (tumor) | STAD (normal) |
| FANCG, CDK1, SPTAN1, GABPB1, BRCA2, KRT19, ERCC4, BLM, FANCF, FANCA, CAPN1, FANCD2, FSCN1, FANCC, ANTXR2, FANCE, STRA13, C19orf40, XRCC3, FANCB, SAMD3 (tumor) | FANCG, CDK1, RPA1, BRCA2, BLM, FTSJ3, FANCF, USHBP1, FANCA, TOP3A, FANCD2, FANCM, FANCC, ANTXR2, FANCE, STRA13, C19orf40, C17orf70, APITD1, XRCC3, FANCB (normal) |
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| THCA (tumor) | THCA (normal) |
| FANCG, PSMB1, CDK1, SPTAN1, GABPB1, ERCC4, BLM, FANCL, FANCA, FANCD2, FSCN1, FANCE, STRA13, PRDX3, C19orf40, C17orf70, ERCC1, XRCC3, FANCB, SAMD3, RTN2 (tumor) | FANCG, CDK1, KRT19, ERCC4, BLM, FANCL, FTSJ3, FANCA, CAPN1, FANCD2, FANCC, FANCE, POLN, PRDX3, C19orf40, C17orf70, CYP2E1, ERCC1, XRCC3, T, RTN2 (normal) |
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| TissGeneProg for FANCG |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FANCG |
| TissGeneDrug for FANCG |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FANCG |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0015625 | Fanconi Anemia | 28 | BeFree,CLINVAR,CTD_human,LHGDN,ORPHANET |
| umls:C3469521 | FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 24 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 6 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 6 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | GAD |
| umls:C0008626 | Congenital chromosomal disease | 2 | BeFree |
| umls:C3469527 | fanconi anemia complementation group g | 2 | BeFree,UNIPROT |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | GAD |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | GAD |
| umls:C0014859 | Esophageal Neoplasms | 1 | GAD |
| umls:C0016514 | Foot-and-Mouth Disease | 1 | BeFree |
| umls:C0018671 | Head and Neck Neoplasms | 1 | GAD |
| umls:C0023055 | Laryngeal neoplasm | 1 | GAD |
| umls:C0023470 | Myeloid Leukemia | 1 | BeFree |
| umls:C0026636 | Mouth Diseases | 1 | CTD_human |
| umls:C0026640 | Mouth Neoplasms | 1 | GAD |
| umls:C0030297 | Pancreatic Neoplasm | 1 | BeFree |
| umls:C0030312 | Pancytopenia | 1 | BeFree |
| umls:C0031347 | Pharyngeal Neoplasms | 1 | GAD |
| umls:C0242379 | Malignant neoplasm of lung | 1 | GAD |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | GAD |
| umls:C0677886 | Epithelial ovarian cancer | 1 | GAD |
| umls:C0917796 | Optic Atrophy, Hereditary, Leber | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | GAD |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2931038 | Pancreatic carcinoma, familial | 1 | BeFree |
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