TissGeneSummary for ARMC3 |
Gene summary |
Basic gene information | Gene symbol | ARMC3 |
Gene name | armadillo repeat containing 3 | |
Synonyms | CT81|KU-CT-1 | |
Cytomap | UCSC genome browser: 10p12.31 | |
Type of gene | protein-coding | |
RefGenes | NM_001282745.1, NM_001282746.1,NM_001282747.1,NM_173081.4, | |
Description | armadillo repeat-containing protein 3beta-catenin-like proteincancer/testis antigen 81 | |
Modification date | 20141207 | |
dbXrefs | MIM : 611226 | |
HGNC : HGNC | ||
Ensembl : ENSG00000165309 | ||
HPRD : 12487 | ||
Vega : OTTHUMG00000017811 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ARMC3 | |
BioGPS: 219681 | ||
Pathway | NCI Pathway Interaction Database: ARMC3 | |
KEGG: ARMC3 | ||
REACTOME: ARMC3 | ||
Pathway Commons: ARMC3 | ||
Context | iHOP: ARMC3 | |
ligand binding site mutation search in PubMed: ARMC3 | ||
UCL Cancer Institute: ARMC3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ARMC3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ARMC3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.948082143 | 0.353005857 | -3.301088 | 1.98E-17 | 8.39E-16 |
BRCA | 0.060195366 | -1.714885336 | 1.775080702 | 1.02E-11 | 4.30E-11 |
LUSC | -1.2747503 | 2.558896759 | -3.833647059 | 2.52E-12 | 1.13E-11 |
THCA | -2.863531024 | -0.971886956 | -1.891644068 | 1.15E-12 | 1.00E-11 |
LUAD | 1.502310823 | 2.681848754 | -1.179537931 | 0.00734 | 0.013483718 |
STAD | -1.126186268 | -2.685426893 | 1.559240625 | 7.93E-05 | 0.000625774 |
PRAD | -1.073848527 | -2.206998527 | 1.13315 | 0.000112 | 0.000465662 |
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TissGene-miRNA for ARMC3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ARMC3 |
TissGeneSNV for ARMC3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A138T | UCEC | 2 |
p.G836R | SKCM | 2 |
p.E714* | UCEC | 2 |
p.R817C | PAAD | 1 |
p.D99E | HNSC | 1 |
p.R432C | STAD | 1 |
p.R626* | PAAD | 1 |
p.S606I | LUAD | 1 |
p.E471K | SKCM | 1 |
p.K51T | COAD | 1 |
p.L177* | LUAD | 1 |
p.K641N | UCEC | 1 |
p.K660R | GBM | 1 |
p.A514T | TGCT | 1 |
p.E658* | UCEC | 1 |
p.P37A | LUAD | 1 |
p.P37E | LUAD | 1 |
p.S112Y | UCEC | 1 |
p.R817C | STAD | 1 |
p.G788* | UCEC | 1 |
p.D524H | LIHC | 1 |
p.F723L | UCEC | 1 |
p.E127G | UCEC | 1 |
p.A462T | COAD | 1 |
p.K277* | STAD | 1 |
p.L858M | LUAD | 1 |
p.V123L | LGG | 1 |
p.K498T | COAD | 1 |
p.Q116E | PCPG | 1 |
p.L747Q | LUAD | 1 |
p.E223V | STAD | 1 |
p.G581S | UCEC | 1 |
p.E528K | OV | 1 |
p.R599W | STAD | 1 |
p.A675T | UCEC | 1 |
p.W715* | SKCM | 1 |
p.A118P | LUSC | 1 |
p.A752T | PAAD | 1 |
p.T73N | LUAD | 1 |
p.A419G | PAAD | 1 |
p.V529F | LUAD | 1 |
p.F353L | HNSC | 1 |
p.R817C | READ | 1 |
p.D618Y | UCEC | 1 |
p.P37Q | LUAD | 1 |
p.Y50N | SKCM | 1 |
p.G326A | COAD | 1 |
p.A393T | PAAD | 1 |
p.P195S | SKCM | 1 |
p.K55T | STAD | 1 |
p.E316K | BRCA | 1 |
p.F128L | LUAD | 1 |
p.G348V | LUAD | 1 |
p.R798* | BLCA | 1 |
p.P402L | LUAD | 1 |
p.K60E | LIHC | 1 |
p.K277X | STAD | 1 |
p.Q338H | LUAD | 1 |
p.P656T | COAD | 1 |
p.E371V | CESC | 1 |
p.G480C | COAD | 1 |
p.L805V | LUAD | 1 |
p.G233R | GBM | 1 |
p.N515D | BLCA | 1 |
p.R184X | READ | 1 |
p.Q182* | SKCM | 1 |
p.E770Q | KIRC | 1 |
p.L448M | STAD | 1 |
p.V455M | GBM | 1 |
p.L482F | LUAD | 1 |
p.G756D | STAD | 1 |
p.K835N | SKCM | 1 |
p.S814C | BLCA | 1 |
p.N545S | THCA | 1 |
p.R432H | COAD | 1 |
p.A799S | GBM | 1 |
p.S349C | LUAD | 1 |
p.I196M | BRCA | 1 |
p.T73S | LUSC | 1 |
p.A465T | CESC | 1 |
p.E189* | BLCA | 1 |
p.L861F | BLCA | 1 |
p.R599W | UCEC | 1 |
p.R449H | STAD | 1 |
p.A467V | SARC | 1 |
p.G680R | SKCM | 1 |
p.R225Q | STAD | 1 |
p.R798Q | COAD | 1 |
p.P19T | LUAD | 1 |
p.S347* | LUAD | 1 |
p.E528X | READ | 1 |
p.F312I | LUAD | 1 |
p.L800F | LUAD | 1 |
p.A462D | PAAD | 1 |
p.H250Y | BLCA | 1 |
p.D305H | BLCA | 1 |
p.R535W | ESCA | 1 |
p.L261I | LUAD | 1 |
p.R817C | BLCA | 1 |
p.P19Q | LUAD | 1 |
p.G840S | SKCM | 1 |
p.Y175F | STAD | 1 |
p.K546T | STAD | 1 |
p.G92E | SKCM | 1 |
p.A253V | UCEC | 1 |
p.H313Y | SKCM | 1 |
p.S665C | HNSC | 1 |
p.A43D | LUAD | 1 |
p.E528K | UCEC | 1 |
p.R798* | SKCM | 1 |
p.C507S | LUAD | 1 |
p.E245* | UCEC | 1 |
p.R808I | LUAD | 1 |
p.A823V | LIHC | 1 |
p.R626Q | COAD | 1 |
p.P430T | LGG | 1 |
p.D230N | PAAD | 1 |
p.Y573C | LUAD | 1 |
p.S606N | SKCM | 1 |
p.E845D | CESC | 1 |
p.W715X | SKCM | 1 |
p.M343I | ACC | 1 |
p.S655T | LUAD | 1 |
p.E8X | THYM | 1 |
p.L66R | STAD | 1 |
p.R432H | THYM | 1 |
p.P205L | SKCM | 1 |
p.P842S | LGG | 1 |
p.K143N | UCEC | 1 |
p.T73S | BLCA | 1 |
p.L489P | HNSC | 1 |
p.R798Q | BLCA | 1 |
p.R449H | MESO | 1 |
p.L598V | CESC | 1 |
p.E845K | SKCM | 1 |
p.S627N | UCEC | 1 |
p.A379V | READ | 1 |
p.R373Q | TGCT | 1 |
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TissGeneCNV for ARMC3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ARMC3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | UCS | TCGA-NA-A5I1-01A | CD81-ARMC3 | Out-of-Frame | chr11:2398845 | chr10:23321789 |
Chimerdb3.0 | FusionScan | LUAD | TCGA-38-4630-01A | USP6NL-ARMC3 | Out-of-Frame | chr10:11531100 | chr10:23297743 |
Chimerdb3.0 | TopHat-Fusion | UCS | TCGA-NA-A5I1-01A | ARMC3-CD81-AS1 | Out-of-Frame | chr10:23321789 | chr11:2398844 |
Chimerdb3.0 | TopHat-Fusion | UCS | TCGA-NA-A5I1-01A | ARMC3-CD81-AS1 | Out-of-Frame | chr10:23326198 | chr11:2398844 |
TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A1EW-01A | PARD3-ARMC3 | CDS-5UTR | Chr10:34558585 | Chr10:23220925 |
TCGAfusionPortal | PRADA | LUAD | TCGA-38-4630-01A | USP6NL-ARMC3 | Out-of-frame | Chr10:11531101 | Chr10:23297744 |
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TissGeneNet for ARMC3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ARMC3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ARMC3 |
TissGeneDrug for ARMC3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ARMC3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
umls:C0014170 | Endometrial Neoplasms | 1 | LHGDN |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |