TissGeneSummary for CCDC83 |
Gene summary |
Basic gene information | Gene symbol | CCDC83 |
Gene name | coiled-coil domain containing 83 | |
Synonyms | CT148 | |
Cytomap | UCSC genome browser: 11q14.1-q14.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001286159.1, NM_173556.4, | |
Description | coiled-coil domain-containing protein 83 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000150676 | ||
HPRD : 14586 | ||
Vega : OTTHUMG00000166978 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC83 | |
BioGPS: 220047 | ||
Pathway | NCI Pathway Interaction Database: CCDC83 | |
KEGG: CCDC83 | ||
REACTOME: CCDC83 | ||
Pathway Commons: CCDC83 | ||
Context | iHOP: CCDC83 | |
ligand binding site mutation search in PubMed: CCDC83 | ||
UCL Cancer Institute: CCDC83 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CCDC83 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for CCDC83 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
PRAD | 1.339114295 | 0.12777391 | 1.211340385 | 9.49E-11 | 2.09E-09 |
Top |
TissGene-miRNA for CCDC83 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for CCDC83 |
TissGeneSNV for CCDC83 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E187K | SKCM | 2 |
p.E197K | SKCM | 2 |
p.G397C | LUSC | 1 |
p.Q68H | BLCA | 1 |
p.M404I | ESCA | 1 |
p.D251V | STAD | 1 |
p.E417Q | LUAD | 1 |
p.L79P | STAD | 1 |
p.S291Y | UCEC | 1 |
p.K36* | LUSC | 1 |
p.G210C | THYM | 1 |
p.L350F | UCEC | 1 |
p.W70C | LUAD | 1 |
p.G371D | READ | 1 |
p.I185L | BRCA | 1 |
p.P277S | BRCA | 1 |
p.V401E | CHOL | 1 |
p.W103X | SKCM | 1 |
p.V162F | ESCA | 1 |
p.P398T | LUAD | 1 |
p.A304V | UCEC | 1 |
p.M379I | SKCM | 1 |
p.A244S | LGG | 1 |
p.D14E | LUSC | 1 |
p.Q329E | LUSC | 1 |
p.G305R | SKCM | 1 |
p.A39V | LUAD | 1 |
p.E311D | STAD | 1 |
p.K195N | UCEC | 1 |
p.G375R | SKCM | 1 |
p.E167D | UCEC | 1 |
p.P431S | SKCM | 1 |
p.W103* | SKCM | 1 |
p.G15E | SKCM | 1 |
p.R117L | LUSC | 1 |
p.W198* | SKCM | 1 |
p.E82D | UCEC | 1 |
p.E357K | CESC | 1 |
p.H270N | SKCM | 1 |
p.W198X | SKCM | 1 |
p.H228Y | LUAD | 1 |
p.E280D | STAD | 1 |
p.V162A | SKCM | 1 |
p.P367T | LUAD | 1 |
p.E96K | LUAD | 1 |
p.R73Q | STAD | 1 |
p.R117H | HNSC | 1 |
p.E67* | SKCM | 1 |
p.G371S | SKCM | 1 |
p.E234X | READ | 1 |
p.D337N | READ | 1 |
p.L365V | STAD | 1 |
p.E37K | SKCM | 1 |
p.L283P | STAD | 1 |
p.E78K | SKCM | 1 |
p.T320I | LUAD | 1 |
p.K441T | SKCM | 1 |
p.L396V | STAD | 1 |
p.R117H | UCEC | 1 |
p.Q109K | LUAD | 1 |
p.T289I | LUAD | 1 |
p.K380R | LIHC | 1 |
p.R336I | UCEC | 1 |
p.E327K | CESC | 1 |
p.M411L | UCEC | 1 |
p.E146K | UCEC | 1 |
p.K262N | BLCA | 1 |
p.H71Y | BLCA | 1 |
p.M118I | ACC | 1 |
p.S345N | LUAD | 1 |
p.S314N | LUAD | 1 |
p.R107K | SKCM | 1 |
p.E19K | SKCM | 1 |
p.H352R | LUSC | 1 |
p.S442Y | UCEC | 1 |
p.R117L | CHOL | 1 |
p.E373X | THYM | 1 |
Top |
TissGeneCNV for CCDC83 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for CCDC83 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A1XZ-01A | NELL1-CCDC83 | CDS-5UTR | Chr11:20982106 | Chr11:85576139 |
Top |
TissGeneNet for CCDC83 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CCDC83 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for CCDC83 |
TissGeneDrug for CCDC83 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CCDC83 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |