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| TissGeneSummary for OAF |
 Gene summary |
| Basic gene information | Gene symbol | OAF |
| Gene name | OAF homolog (Drosophila) | |
| Synonyms | NS5ATP13TP2 | |
| Cytomap | UCSC genome browser: 11q23.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_178507.2, | |
| Description | HCV NS5A-transactivated protein 13 target protein 2out at first protein homolog | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| HPRD : 17646 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_OAF | |
| BioGPS: 220323 | ||
| Pathway | NCI Pathway Interaction Database: OAF | |
| KEGG: OAF | ||
| REACTOME: OAF | ||
| Pathway Commons: OAF | ||
| Context | iHOP: OAF | |
| ligand binding site mutation search in PubMed: OAF | ||
| UCL Cancer Institute: OAF | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of OAF | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for OAF |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | 0.105222979 | 1.114779997 | -1.009557018 | 2.48E-19 | 1.68E-18 |
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| TissGene-miRNA for OAF |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for OAF |
| TissGeneSNV for OAF |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E45G | BLCA | 1 |
| p.Q49* | STAD | 1 |
| p.Q49X | STAD | 1 |
| p.E110Q | BLCA | 1 |
| p.A168V | STAD | 1 |
| p.G88W | PRAD | 1 |
| p.R172H | PAAD | 1 |
| p.E91Q | BLCA | 1 |
| p.H141Q | KIRP | 1 |
| p.E115X | KIRC | 1 |
| p.R235H | LUAD | 1 |
| p.P202L | ESCA | 1 |
| p.R126W | COAD | 1 |
| p.I112V | STAD | 1 |
| p.E45K | BLCA | 1 |
| p.V258G | SKCM | 1 |
| p.E115* | KIRC | 1 |
| p.G151W | STAD | 1 |
| p.A199V | HNSC | 1 |
| p.H108Q | LUAD | 1 |
| p.P270S | SKCM | 1 |
| p.Q182H | LUAD | 1 |
| p.P156A | LGG | 1 |
| p.E110G | LIHC | 1 |
| p.H141P | KIRP | 1 |
| p.A116V | STAD | 1 |
| p.R121Q | STAD | 1 |
| p.R172H | UCS | 1 |
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| TissGeneCNV for OAF |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for OAF |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | R99623 | AUTS2-OAF | chr7:70002755 | chr11:120100537 | |
| Chimerdb3.0 | ChiTaRs | NA | R99080 | OAF-AUTS2 | chr11:120100650 | chr7:70002535 | |
| Chimerdb3.0 | ChiTaRs | NA | AI248504 | OAF-AUTS2 | chr11:120100650 | chr7:70002569 | |
| Chimerdb3.0 | ChiTaRs | NA | BQ345738 | OAF-CDK19 | chr11:120099714 | chr6:110942314 | |
| Chimerdb3.0 | ChiTaRs | NA | BQ373966 | OAF-ARHGEF1 | chr11:120097629 | chr19:42421352 | |
| TCGAfusionPortal | PRADA | HNSC | TCGA-CV-5443-01A | SLC26A11-OAF | In-frame | Chr17:78211393 | Chr11:120099577 |
| TCGAfusionPortal | PRADA | HNSC | TCGA-CV-5443-01A | OAF-SLC26A11 | In-frame | Chr11:120097705 | Chr17:78215570 |
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| TissGeneNet for OAF |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for OAF |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for OAF |
| TissGeneDrug for OAF |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for OAF |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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