TissGeneSummary for TDRD6 |
Gene summary |
Basic gene information | Gene symbol | TDRD6 |
Gene name | tudor domain containing 6 | |
Synonyms | CT41.2|NY-CO-45|SPATA36|TDR2|bA446F17.4 | |
Cytomap | UCSC genome browser: 6p12.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001010870.2, NM_001168359.1, | |
Description | antigen NY-CO-45cancer/testis antigen 41.2spermatogenesis associated 36tudor domain-containing protein 6tudor repeat 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 611200 | |
HGNC : HGNC | ||
Ensembl : ENSG00000180113 | ||
HPRD : 18172 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TDRD6 | |
BioGPS: 221400 | ||
Pathway | NCI Pathway Interaction Database: TDRD6 | |
KEGG: TDRD6 | ||
REACTOME: TDRD6 | ||
Pathway Commons: TDRD6 | ||
Context | iHOP: TDRD6 | |
ligand binding site mutation search in PubMed: TDRD6 | ||
UCL Cancer Institute: TDRD6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ProstateTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRADTGCT | |
Reference showing the relevant tissue of TDRD6 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TDRD6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -2.157474568 | -0.940935353 | -1.216539216 | 5.47E-09 | 1.76E-08 |
BRCA | -2.107063474 | -0.074521369 | -2.032542105 | 5.23E-38 | 1.31E-36 |
THCA | -0.595952368 | 0.866428988 | -1.462381356 | 1.05E-13 | 1.09E-12 |
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TissGene-miRNA for TDRD6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TDRD6 |
TissGeneSNV for TDRD6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.L1414S | LGG | 2 |
p.E1997* | HNSC | 2 |
p.S1989L | READ | 2 |
p.E501Q | BLCA | 2 |
p.P262H | ESCA | 1 |
p.E281K | SKCM | 1 |
p.I1152M | CESC | 1 |
p.E1660D | STAD | 1 |
p.D202N | SKCM | 1 |
p.S1384P | UCEC | 1 |
p.K667E | STAD | 1 |
p.K1043T | DLBC | 1 |
p.V372E | LUSC | 1 |
p.G425E | CESC | 1 |
p.A1990T | MESO | 1 |
p.E1110* | UCS | 1 |
p.P225L | SKCM | 1 |
p.W60C | LIHC | 1 |
p.E1825* | UCEC | 1 |
p.Q889K | UCEC | 1 |
p.K1306* | LUAD | 1 |
p.S1196R | STAD | 1 |
p.D562Y | LUAD | 1 |
p.D1464A | STAD | 1 |
p.D1789N | LUAD | 1 |
p.L918I | UCEC | 1 |
p.R1337G | LGG | 1 |
p.K1043R | STAD | 1 |
p.N754Y | COAD | 1 |
p.K799N | LIHC | 1 |
p.M1920I | SKCM | 1 |
p.P1628A | BLCA | 1 |
p.L751F | UCEC | 1 |
p.D1046E | GBM | 1 |
p.P1412L | UCEC | 1 |
p.E1140K | LUAD | 1 |
p.H417R | BRCA | 1 |
p.R958I | STAD | 1 |
p.R433H | STAD | 1 |
p.C1936Y | TGCT | 1 |
p.G1762E | COAD | 1 |
p.H1436R | LGG | 1 |
p.S1948Y | UCEC | 1 |
p.D1581Y | CESC | 1 |
p.G34E | SARC | 1 |
p.V847G | UCEC | 1 |
p.R572X | STAD | 1 |
p.L506F | CESC | 1 |
p.L1226P | COAD | 1 |
p.R572* | UCEC | 1 |
p.S867* | THCA | 1 |
p.R1577G | SARC | 1 |
p.T812A | UCEC | 1 |
p.K964Q | PRAD | 1 |
p.P1915S | KICH | 1 |
p.T1526A | LIHC | 1 |
p.L1141P | LUAD | 1 |
p.A710T | LIHC | 1 |
p.Q904X | STAD | 1 |
p.A1478V | SKCM | 1 |
p.C755F | LUSC | 1 |
p.V900G | UCEC | 1 |
p.P1910H | HNSC | 1 |
p.E919* | BLCA | 1 |
p.L176H | THYM | 1 |
p.R1164K | SKCM | 1 |
p.H1960L | KIRC | 1 |
p.S779C | GBM | 1 |
p.E1656X | STAD | 1 |
p.F1251L | STAD | 1 |
p.K546N | OV | 1 |
p.K916N | UCEC | 1 |
p.R1941X | LIHC | 1 |
p.H682R | UCEC | 1 |
p.E1013K | CESC | 1 |
p.S2037* | BLCA | 1 |
p.P1252S | SKCM | 1 |
p.R368* | UCEC | 1 |
p.P1412A | LUAD | 1 |
p.E1806Q | BLCA | 1 |
p.F1979Y | PAAD | 1 |
p.P1633L | SKCM | 1 |
p.S1859Y | READ | 1 |
p.L1684F | BLCA | 1 |
p.Y348C | LGG | 1 |
p.R178C | SKCM | 1 |
p.S414T | BRCA | 1 |
p.I841M | OV | 1 |
p.M859I | SARC | 1 |
p.R336W | COAD | 1 |
p.Q904* | STAD | 1 |
p.G321S | SKCM | 1 |
p.F976L | OV | 1 |
p.R264L | LUSC | 1 |
p.K741E | HNSC | 1 |
p.I1208M | COAD | 1 |
p.R572X | ESCA | 1 |
p.E705G | CHOL | 1 |
p.G324* | LUSC | 1 |
p.L1720I | UCEC | 1 |
p.P375L | SKCM | 1 |
p.S575L | SKCM | 1 |
p.V170I | STAD | 1 |
p.E472D | SARC | 1 |
p.D635H | LUSC | 1 |
p.E1825G | UCEC | 1 |
p.E1643Q | HNSC | 1 |
p.F495C | UCEC | 1 |
p.S1840A | SKCM | 1 |
p.G1571R | HNSC | 1 |
p.R95H | DLBC | 1 |
p.M520L | OV | 1 |
p.T1541M | COAD | 1 |
p.A1706D | PRAD | 1 |
p.G294R | KIRC | 1 |
p.Q1648E | BLCA | 1 |
p.S618F | SKCM | 1 |
p.Y748F | SKCM | 1 |
p.L646I | UCEC | 1 |
p.M1302I | UCEC | 1 |
p.R518M | KIRC | 1 |
p.R572* | LGG | 1 |
p.T623S | SKCM | 1 |
p.T4M | THCA | 1 |
p.P1266L | SKCM | 1 |
p.R206H | SARC | 1 |
p.C1017Y | DLBC | 1 |
p.N574Y | SKCM | 1 |
p.R479K | SKCM | 1 |
p.D490N | SKCM | 1 |
p.D561G | ACC | 1 |
p.W503C | LUAD | 1 |
p.A1150V | BRCA | 1 |
p.M752L | ACC | 1 |
p.S1845* | BLCA | 1 |
p.R103H | COAD | 1 |
p.K1125Q | STAD | 1 |
p.L2059F | BLCA | 1 |
p.E1260* | SKCM | 1 |
p.R572Q | ESCA | 1 |
p.E2095* | LUSC | 1 |
p.Q1857* | UCEC | 1 |
p.N917K | SKCM | 1 |
p.L1124V | SARC | 1 |
p.E2054K | COAD | 1 |
p.F1848L | READ | 1 |
p.Y1811C | UCEC | 1 |
p.V130M | HNSC | 1 |
p.Y1584F | BRCA | 1 |
p.A152T | COAD | 1 |
p.Q1116* | SKCM | 1 |
p.G1282R | TGCT | 1 |
p.F1387C | UCEC | 1 |
p.E1656K | BLCA | 1 |
p.F205L | COAD | 1 |
p.R827Q | BLCA | 1 |
p.T291M | GBM | 1 |
p.R1561T | KIRP | 1 |
p.S1499F | SKCM | 1 |
p.V250M | BLCA | 1 |
p.F1251C | UCEC | 1 |
p.A597V | STAD | 1 |
p.W503* | HNSC | 1 |
p.E193* | LUSC | 1 |
p.R1457T | BLCA | 1 |
p.S355G | STAD | 1 |
p.D186H | BLCA | 1 |
p.D1676N | SKCM | 1 |
p.D911N | HNSC | 1 |
p.R955I | THYM | 1 |
p.K1983N | STAD | 1 |
p.K916Q | KIRC | 1 |
p.D1132H | LUAD | 1 |
p.G223E | SKCM | 1 |
p.W388C | HNSC | 1 |
p.D804N | BLCA | 1 |
p.R433H | LUAD | 1 |
p.R368Q | LUAD | 1 |
p.E352K | ESCA | 1 |
p.E275* | KIRC | 1 |
p.G384S | STAD | 1 |
p.D1652H | BLCA | 1 |
p.E1825G | LIHC | 1 |
p.P375S | SKCM | 1 |
p.P1841L | STAD | 1 |
p.K1043N | STAD | 1 |
p.Q592E | KIRC | 1 |
p.R1271I | ESCA | 1 |
p.R584T | HNSC | 1 |
p.N1035S | HNSC | 1 |
p.D295N | SKCM | 1 |
p.A825P | STAD | 1 |
p.R572* | STAD | 1 |
p.K863R | LUSC | 1 |
p.T1231S | LUAD | 1 |
p.P1215S | HNSC | 1 |
p.E365Q | CESC | 1 |
p.N1218I | LUAD | 1 |
p.L1869V | BLCA | 1 |
p.T993M | GBM | 1 |
p.E1693D | BLCA | 1 |
p.I1760F | LUAD | 1 |
p.A1706V | COAD | 1 |
p.Q1455* | SKCM | 1 |
p.P5S | KIRP | 1 |
p.T993M | STAD | 1 |
p.S839G | STAD | 1 |
p.E1656* | STAD | 1 |
p.I1667R | READ | 1 |
p.E467* | THYM | 1 |
p.Q1557H | UCEC | 1 |
p.E871K | BLCA | 1 |
p.S861Y | UCEC | 1 |
p.A1559E | HNSC | 1 |
p.R1671K | BLCA | 1 |
p.S525F | SKCM | 1 |
p.E648K | STAD | 1 |
p.T993R | LUAD | 1 |
p.E1211K | UCEC | 1 |
p.N510S | UCEC | 1 |
p.V938L | COAD | 1 |
p.H1822R | STAD | 1 |
p.P1678L | SKCM | 1 |
p.Q1455X | SKCM | 1 |
p.S1647Y | UCS | 1 |
p.E2054* | LUAD | 1 |
p.M1358I | BLCA | 1 |
p.E1110X | UCS | 1 |
p.Q878R | STAD | 1 |
p.D1288Y | COAD | 1 |
p.N794K | KIRP | 1 |
p.G1402C | COAD | 1 |
p.R339C | LGG | 1 |
p.A879V | SKCM | 1 |
p.R1953H | STAD | 1 |
p.E1450* | HNSC | 1 |
p.A1409T | CESC | 1 |
p.P1252L | SKCM | 1 |
p.Q662R | MESO | 1 |
p.R198W | CESC | 1 |
p.K515E | STAD | 1 |
p.E628* | UCEC | 1 |
p.I631S | BRCA | 1 |
p.S1149C | LUAD | 1 |
p.S1494T | BLCA | 1 |
p.P1568H | SKCM | 1 |
p.T800S | ESCA | 1 |
p.D1540N | SKCM | 1 |
p.E1981Q | CESC | 1 |
p.A141E | LUAD | 1 |
p.R1769C | UCEC | 1 |
p.R955K | LUAD | 1 |
p.D1842H | CESC | 1 |
p.V774A | LUAD | 1 |
p.S929L | SKCM | 1 |
p.I1410L | PRAD | 1 |
p.T773I | LUAD | 1 |
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TissGeneCNV for TDRD6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TDRD6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TDRD6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TDRD6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TDRD6 |
TissGeneDrug for TDRD6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TDRD6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |