TissGeneSummary for HIST1H2AA |
Gene summary |
Basic gene information | Gene symbol | HIST1H2AA |
Gene name | histone cluster 1, H2aa | |
Synonyms | H2AA|H2AFR|bA317E16.2 | |
Cytomap | UCSC genome browser: 6p22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_170745.3, | |
Description | H2A histone family, member Rhistone 1, H2aahistone H2A type 1-Ahistone H2A/r | |
Modification date | 20141207 | |
dbXrefs | MIM : 613499 | |
HGNC : HGNC | ||
HPRD : 13653 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HIST1H2AA | |
BioGPS: 221613 | ||
Pathway | NCI Pathway Interaction Database: HIST1H2AA | |
KEGG: HIST1H2AA | ||
REACTOME: HIST1H2AA | ||
Pathway Commons: HIST1H2AA | ||
Context | iHOP: HIST1H2AA | |
ligand binding site mutation search in PubMed: HIST1H2AA | ||
UCL Cancer Institute: HIST1H2AA | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of HIST1H2AA | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for HIST1H2AA |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for HIST1H2AA |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for HIST1H2AA |
TissGeneSNV for HIST1H2AA |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R4Q | SKCM | 4 |
p.R36C | SKCM | 2 |
p.R78C | UCEC | 2 |
p.A70E | LUAD | 1 |
p.E93K | PAAD | 1 |
p.R72H | READ | 1 |
p.A22V | UCEC | 1 |
p.A48T | HNSC | 1 |
p.G3R | SKCM | 1 |
p.L64I | UCEC | 1 |
p.T102I | LUAD | 1 |
p.V28I | SKCM | 1 |
p.R18H | STAD | 1 |
p.G9E | SKCM | 1 |
p.G100S | HNSC | 1 |
p.R78C | SKCM | 1 |
p.G107R | SKCM | 1 |
p.Q7H | HNSC | 1 |
p.L64F | SKCM | 1 |
p.G107E | SKCM | 1 |
p.R12P | LUSC | 1 |
p.A70G | SKCM | 1 |
p.R4* | UCEC | 1 |
p.G5R | TGCT | 1 |
p.E57* | BRCA | 1 |
p.R72L | KIRC | 1 |
p.D91N | SKCM | 1 |
p.G9R | SKCM | 1 |
p.R12C | UCEC | 1 |
p.L94P | BRCA | 1 |
p.R36H | COAD | 1 |
p.T102S | LUAD | 1 |
p.T60A | LUSC | 1 |
p.D73N | LGG | 1 |
p.Q105H | LUAD | 1 |
p.R12H | HNSC | 1 |
p.R36H | SKCM | 1 |
p.R43P | SKCM | 1 |
p.R4X | COAD | 1 |
p.I79N | SKCM | 1 |
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TissGeneCNV for HIST1H2AA |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for HIST1H2AA |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for HIST1H2AA |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for HIST1H2AA |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for HIST1H2AA |
TissGeneDrug for HIST1H2AA |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for HIST1H2AA |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |