TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for ALDH3B2

Gene summary

Basic gene information	Gene symbol	ALDH3B2
	Gene name	aldehyde dehydrogenase 3 family, member B2
	Synonyms	ALDH8
	Cytomap	UCSC genome browser: 11q13
	Type of gene	protein-coding
	RefGenes	NM_000695.3, NM_001031615.1,
	Description	acetaldehyde dehydrogenase 8aldehyde dehydrogenase 8aldehyde dehydrogenase family 3 member B2
	Modification date	20141207
dbXrefs	MIM : 601917
	HGNC : HGNC
	Ensembl : ENSG00000132746
	HPRD : 03559
	Vega : OTTHUMG00000167284
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ALDH3B2
	BioGPS: 222
Pathway	NCI Pathway Interaction Database: ALDH3B2
	KEGG: ALDH3B2
	REACTOME: ALDH3B2
	Pathway Commons: ALDH3B2
Context	iHOP: ALDH3B2
	ligand binding site mutation search in PubMed: ALDH3B2
	UCL Cancer Institute: ALDH3B2
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	BladderSkin
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	BLCASKCM
Reference showing the relevant tissue of ALDH3B2
Description by TissGene annotations

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO term

PubMed ID

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TissGeneExp for ALDH3B2

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
THCA	-3.877538435	-6.11983674	2.242298305	2.38E-17	4.75E-16
LUAD	0.387803879	-1.461089224	1.848893103	4.35E-11	2.76E-10
KIRC	-4.863834339	-1.615517673	-3.248316667	8.55E-37	2.70E-35
KIRP	-4.625877048	-1.582398923	-3.043478125	3.54E-21	2.48E-19
LUSC	2.682168112	-1.439376986	4.121545098	1.97E-20	2.45E-19
PRAD	2.708353481	1.260518866	1.447834615	2.82E-06	1.82E-05
BRCA	3.636282766	2.527679257	1.108603509	0.00187	0.003544979
KICH	-3.441216673	-1.486760673	-1.954456	0.000776	0.00170689
COAD	-2.238581134	-4.604804211	2.366223077	3.84E-05	0.00015353

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TissGene-miRNA for ALDH3B2

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for ALDH3B2

TissGeneSNV for ALDH3B2

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.E269K	SKCM	2
p.I114V	LIHC	1
p.G88E	HNSC	1
p.A182T	UCEC	1
p.I254M	STAD	1
p.E269K	BLCA	1
p.P58S	UCEC	1
p.H344Y	SKCM	1
p.G160S	STAD	1
p.K113N	BLCA	1
p.F341V	COAD	1
p.T8K	BLCA	1
p.R214Q	LGG	1
p.K67E	KIRC	1
p.V262M	STAD	1
p.R331W	COAD	1
p.M377I	STAD	1
p.N288K	BRCA	1
p.I204T	UCEC	1
p.A285T	HNSC	1
p.I271M	STAD	1
p.I254M	BRCA	1
p.L348P	LGG	1
p.Q196X	SKCM	1
p.F18L	BLCA	1
p.G88R	SKCM	1
p.E247D	LUAD	1
p.E245D	LUAD	1
p.E355D	UCEC	1
p.D143N	GBM	1
p.P125H	UCEC	1
p.T8R	LUSC	1
p.W375C	COAD	1
p.D193N	STAD	1
p.V243L	LUAD	1
p.R233S	LUAD	1
p.L86M	PAAD	1
p.G323R	HNSC	1
p.L14P	UCEC	1
p.R212W	COAD	1
p.Q196*	SKCM	1
p.A47T	STAD	1
p.R150C	LGG	1
p.P58S	SKCM	1
p.L357F	COAD	1
p.R299Q	HNSC	1
p.A285V	UCEC	1
p.D143N	SKCM	1
p.M1R	SKCM	1
p.E298D	LUAD	1
p.A31T	UCEC	1

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TissGeneCNV for ALDH3B2

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for ALDH3B2

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	FusionScan	BRCA	TCGA-A8-A09C-01A	TMEM135-ALDH3B2	5'UTR-5'UTR	chr11:86749228	chr11:67435106
Chimerdb3.0	FusionScan	BRCA	TCGA-A8-A09C-01A	TMEM135-ALDH3B2	5'UTR-5'UTR	chr11:86749228	chr11:67434487
Chimerdb3.0	TopHat-Fusion	BRCA	TCGA-A8-A09C-01A	TMEM135-ALDH3B2	5'UTR-5'UTR	chr11:86749227	chr11:67434486
Chimerdb3.0	TopHat-Fusion	BRCA	TCGA-A8-A09C-01A	TMEM135-ALDH3B2	5'UTR-5'UTR	chr11:86749227	chr11:67435105
Chimerdb3.0	TopHat-Fusion	UCEC	TCGA-AX-A3G4-01A	ALDH3B2-ALDH3B1	Out-of-Frame	chr11:67434044	chr11:67786638
Chimerdb3.0	TopHat-Fusion	BRCA	TCGA-A1-A0SD-01A	ALDH3B2-ALDH3B1	Out-of-Frame	chr11:67434044	chr11:67786638
Chimerdb3.0	TopHat-Fusion	BRCA	TCGA-D8-A1JH-01A	ALDH3B2-ALDH3B1	Out-of-Frame	chr11:67434044	chr11:67786638
Chimerdb3.0	TopHat-Fusion	BRCA	TCGA-A2-A25C-01A	ALDH3B2-ALDH3B1	Out-of-Frame	chr11:67434044	chr11:67786638
Chimerdb3.0	TopHat-Fusion	BRCA	TCGA-A2-A0SW-01A	ALDH3B2-ALDH3B1	Out-of-Frame	chr11:67434044	chr11:67786638
Chimerdb3.0	TopHat-Fusion	BRCA	TCGA-E2-A15A-06A	ALDH3B2-ALDH3B1	Out-of-Frame	chr11:67434044	chr11:67786638
Chimerdb3.0	TopHat-Fusion	BRCA	TCGA-A2-A0ER-01A	ALDH3B2-ALDH3B1	Out-of-Frame	chr11:67434044	chr11:67786638
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-22-5472-01A	ALDH3B2-ALDH3B1	Out-of-Frame	chr11:67434044	chr11:67786638
TCGAfusionPortal	PRADA	BRCA	TCGA-A8-A09C-01A	TMEM135-ALDH3B2	CDS-5UTR	Chr11:86749228	Chr11:67435106
TCGAfusionPortal	PRADA	LUAD	TCGA-91-6840-01A	KCNMB4-ALDH3B2	CDS-5UTR	Chr12:70760850	Chr11:67435106

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TissGeneNet for ALDH3B2

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
ALDH3B2, UBC (tumor)	ALDH3B2, UBC (normal)

COAD (tumor)	COAD (normal)
ALDH3B2, UBC (tumor)	ALDH3B2, UBC (normal)

HNSC (tumor)	HNSC (normal)
ALDH3B2, UBC (tumor)	ALDH3B2, UBC (normal)

KICH (tumor)	KICH (normal)
ALDH3B2, UBC (tumor)	ALDH3B2, UBC (normal)

KIRC (tumor)	KIRC (normal)
ALDH3B2, UBC (tumor)	ALDH3B2, UBC (normal)

KIRP (tumor)	KIRP (normal)
ALDH3B2, UBC (tumor)	ALDH3B2, UBC (normal)

LIHC (tumor)	LIHC (normal)
ALDH3B2, UBC (tumor)	ALDH3B2, UBC (normal)

LUAD (tumor)	LUAD (normal)
ALDH3B2, UBC (tumor)	ALDH3B2, UBC (normal)

LUSC (tumor)	LUSC (normal)
ALDH3B2, UBC (tumor)	ALDH3B2, UBC (normal)

PRAD (tumor)	PRAD (normal)
ALDH3B2, UBC (tumor)	ALDH3B2, UBC (normal)

STAD (tumor)	STAD (normal)
ALDH3B2, UBC (tumor)	ALDH3B2, UBC (normal)

THCA (tumor)	THCA (normal)
ALDH3B2, UBC (tumor)	ALDH3B2, UBC (normal)

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TissGeneProg for ALDH3B2

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for ALDH3B2

TissGeneDrug for ALDH3B2

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for ALDH3B2

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0001973	Alcoholic Intoxication, Chronic	1	BeFree