TissGeneSummary for RFX6 |
Gene summary |
Basic gene information | Gene symbol | RFX6 |
Gene name | regulatory factor X, 6 | |
Synonyms | MTCHRS|MTFS|RFXDC1|dJ955L16.1 | |
Cytomap | UCSC genome browser: 6q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_173560.3, | |
Description | DNA-binding protein RFX6regulatory factor X domain-containing protein 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 612659 | |
HGNC : HGNC | ||
Ensembl : ENSG00000185002 | ||
HPRD : 11490 | ||
Vega : OTTHUMG00000015449 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RFX6 | |
BioGPS: 222546 | ||
Pathway | NCI Pathway Interaction Database: RFX6 | |
KEGG: RFX6 | ||
REACTOME: RFX6 | ||
Pathway Commons: RFX6 | ||
Context | iHOP: RFX6 | |
ligand binding site mutation search in PubMed: RFX6 | ||
UCL Cancer Institute: RFX6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasStomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADSTAD | |
Reference showing the relevant tissue of RFX6 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0045893 | positive regulation of transcription, DNA-templated | 20148032 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 20148032 | GO:0045893 | positive regulation of transcription, DNA-templated | 20148032 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 20148032 |
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TissGeneExp for RFX6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -0.552416947 | 1.560688316 | -2.113105263 | 7.24E-15 | 3.72E-14 |
PRAD | 2.245960752 | 0.973354982 | 1.272605769 | 0.000186 | 0.000741683 |
COAD | 0.213485752 | 2.135731906 | -1.922246154 | 3.36E-05 | 0.000136582 |
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TissGene-miRNA for RFX6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for RFX6 |
TissGeneSNV for RFX6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R525Q | SKCM | 3 |
p.S232L | SKCM | 3 |
p.N348K | ESCA | 2 |
p.G888E | SKCM | 2 |
p.P242S | SKCM | 2 |
p.P687L | SKCM | 2 |
p.R866Q | READ | 2 |
p.E307K | SKCM | 2 |
p.R829C | SKCM | 2 |
p.R476I | UCEC | 2 |
p.P687S | SKCM | 2 |
p.A247T | UCEC | 1 |
p.S700R | UCEC | 1 |
p.N542K | KIRP | 1 |
p.C885R | BRCA | 1 |
p.D494Y | COAD | 1 |
p.R347K | HNSC | 1 |
p.A464D | GBM | 1 |
p.D454N | SKCM | 1 |
p.H838Y | SKCM | 1 |
p.K557N | UCEC | 1 |
p.R171C | PAAD | 1 |
p.T124M | PAAD | 1 |
p.P670Q | BRCA | 1 |
p.A745V | COAD | 1 |
p.G503S | SKCM | 1 |
p.L250F | SKCM | 1 |
p.H821N | SARC | 1 |
p.G815R | SKCM | 1 |
p.Q606K | ESCA | 1 |
p.D300Y | LUAD | 1 |
p.P332T | STAD | 1 |
p.P690L | SKCM | 1 |
p.A561V | GBM | 1 |
p.E474* | UCEC | 1 |
p.R866* | BLCA | 1 |
p.E436K | SKCM | 1 |
p.Q704X | DLBC | 1 |
p.R525* | SKCM | 1 |
p.V410M | LUSC | 1 |
p.D470N | SKCM | 1 |
p.R866X | COAD | 1 |
p.S912Y | UCEC | 1 |
p.D846Y | ESCA | 1 |
p.D319Y | LUSC | 1 |
p.T441I | LUSC | 1 |
p.G167E | SKCM | 1 |
p.I395V | SKCM | 1 |
p.G503V | LUAD | 1 |
p.L575P | KIRP | 1 |
p.A561V | LGG | 1 |
p.C744S | HNSC | 1 |
p.Q789* | KIRC | 1 |
p.Y46C | LIHC | 1 |
p.E224K | HNSC | 1 |
p.W730* | SKCM | 1 |
p.G888V | ESCA | 1 |
p.L240R | STAD | 1 |
p.R726Q | SKCM | 1 |
p.L527R | STAD | 1 |
p.S219R | LUAD | 1 |
p.K230N | READ | 1 |
p.A333S | LUAD | 1 |
p.S823F | ESCA | 1 |
p.L390V | STAD | 1 |
p.L551V | SKCM | 1 |
p.W499* | SKCM | 1 |
p.N624K | LUSC | 1 |
p.G848S | SKCM | 1 |
p.P304S | SKCM | 1 |
p.C744F | KIRC | 1 |
p.S881F | SKCM | 1 |
p.L383V | CESC | 1 |
p.P868Q | PRAD | 1 |
p.Q288R | LUSC | 1 |
p.R525* | PRAD | 1 |
p.S432I | ESCA | 1 |
p.W353X | STAD | 1 |
p.M409L | LUSC | 1 |
p.P607H | LUAD | 1 |
p.K590N | THYM | 1 |
p.R476I | ESCA | 1 |
p.K220N | UCEC | 1 |
p.G659* | PAAD | 1 |
p.S755F | HNSC | 1 |
p.L182P | SKCM | 1 |
p.E467K | SKCM | 1 |
p.R505* | SKCM | 1 |
p.E61K | SKCM | 1 |
p.P879S | SKCM | 1 |
p.H812Y | SKCM | 1 |
p.F617Y | LGG | 1 |
p.R385* | LUSC | 1 |
p.L455F | LUAD | 1 |
p.Q424E | BLCA | 1 |
p.C865* | LUAD | 1 |
p.H694Y | SKCM | 1 |
p.S520C | BLCA | 1 |
p.K269R | STAD | 1 |
p.M266I | SARC | 1 |
p.G186S | STAD | 1 |
p.S408P | PRAD | 1 |
p.G790R | SKCM | 1 |
p.D839N | SKCM | 1 |
p.S766L | SKCM | 1 |
p.S572A | LUAD | 1 |
p.Y193S | GBM | 1 |
p.P915T | HNSC | 1 |
p.S646Y | COAD | 1 |
p.Q820K | KIRP | 1 |
p.P894L | SKCM | 1 |
p.H639N | HNSC | 1 |
p.Q475H | BLCA | 1 |
p.H191Y | SKCM | 1 |
p.R866* | UCEC | 1 |
p.A588T | STAD | 1 |
p.S432N | UCEC | 1 |
p.Q896E | BLCA | 1 |
p.I311M | BLCA | 1 |
p.L303F | SKCM | 1 |
p.D900N | UCEC | 1 |
p.S516C | BLCA | 1 |
p.S860L | CESC | 1 |
p.G254R | LUSC | 1 |
p.P687L | LUSC | 1 |
p.S854L | SARC | 1 |
p.H812Q | BRCA | 1 |
p.Q15L | OV | 1 |
p.S487L | SKCM | 1 |
p.L177I | PAAD | 1 |
p.S520C | ESCA | 1 |
p.K457T | LUAD | 1 |
p.G23R | SKCM | 1 |
p.L455H | LUAD | 1 |
p.R525X | PRAD | 1 |
p.E362K | SKCM | 1 |
p.S235* | BLCA | 1 |
p.T898I | SKCM | 1 |
p.W499X | SKCM | 1 |
p.D345A | UCEC | 1 |
p.T387K | LUSC | 1 |
p.A100V | STAD | 1 |
p.G254E | LUSC | 1 |
p.W353* | STAD | 1 |
p.G34S | LIHC | 1 |
p.T263M | LIHC | 1 |
p.R476K | SKCM | 1 |
p.E286K | COAD | 1 |
p.A561V | UCEC | 1 |
p.E632K | SKCM | 1 |
p.P833L | SKCM | 1 |
p.G659X | PAAD | 1 |
p.P840L | HNSC | 1 |
p.E56K | SKCM | 1 |
p.E130D | UCEC | 1 |
p.L717F | SKCM | 1 |
p.S715L | SKCM | 1 |
p.G922R | SKCM | 1 |
p.P332L | SKCM | 1 |
p.S360Y | LUAD | 1 |
p.Q52L | LUAD | 1 |
p.H720Y | SKCM | 1 |
p.W295C | ESCA | 1 |
p.Q248* | HNSC | 1 |
p.H271Q | LUAD | 1 |
p.R171C | STAD | 1 |
p.C788Y | STAD | 1 |
p.H205L | HNSC | 1 |
p.P670S | LIHC | 1 |
p.E451K | SKCM | 1 |
p.P644S | SKCM | 1 |
p.A561V | STAD | 1 |
p.R385Q | HNSC | 1 |
p.S235L | BRCA | 1 |
p.G183E | SARC | 1 |
p.G608* | SKCM | 1 |
p.L533I | UCEC | 1 |
p.Q483K | GBM | 1 |
p.G669V | LUAD | 1 |
p.L533F | SKCM | 1 |
p.V405A | PAAD | 1 |
p.A613T | HNSC | 1 |
p.R866Q | UCEC | 1 |
p.G784E | SKCM | 1 |
p.L672Q | LUAD | 1 |
p.E50K | BLCA | 1 |
p.P666L | LUSC | 1 |
p.P690T | SKCM | 1 |
p.T111M | CESC | 1 |
p.S569F | SKCM | 1 |
p.D277E | HNSC | 1 |
p.S890F | SKCM | 1 |
p.S219I | UCEC | 1 |
p.P754L | LGG | 1 |
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TissGeneCNV for RFX6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for RFX6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | ESCA | TCGA-R6-A8W5-01B | DVL3-RFX6 | Out-of-Frame | chr3:183873584 | chr6:117252493 |
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TissGeneNet for RFX6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for RFX6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for RFX6 |
TissGeneDrug for RFX6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for RFX6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0376358 | Malignant neoplasm of prostate | 6 | BeFree,GAD,GWASCAT |
umls:C0600139 | Prostate carcinoma | 6 | BeFree |
umls:C0158981 | Neonatal diabetes mellitus | 4 | BeFree |
umls:C0011849 | Diabetes Mellitus | 3 | BeFree |
umls:C2748662 | Mitchell-Riley Syndrome | 3 | BeFree,CLINVAR,ORPHANET,UNIPROT |
umls:C0011847 | Diabetes | 2 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 2 | BeFree,CTD_human,GAD |
umls:C0000768 | Congenital Abnormality | 1 | BeFree |
umls:C0025202 | melanoma | 1 | CTD_human |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C1704272 | Benign Prostatic Hyperplasia | 1 | BeFree |