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| TissGeneSummary for UNC5CL |
 Gene summary |
| Basic gene information | Gene symbol | UNC5CL |
| Gene name | unc-5 homolog C (C. elegans)-like | |
| Synonyms | MUXA|ZUD | |
| Cytomap | UCSC genome browser: 6p21.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_173561.2, | |
| Description | UNC5C-like proteinZU5 and death domain containingprotein unc-5 homolog C-like | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000124602 | ||
| HPRD : 09844 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_UNC5CL | |
| BioGPS: 222643 | ||
| Pathway | NCI Pathway Interaction Database: UNC5CL | |
| KEGG: UNC5CL | ||
| REACTOME: UNC5CL | ||
| Pathway Commons: UNC5CL | ||
| Context | iHOP: UNC5CL | |
| ligand binding site mutation search in PubMed: UNC5CL | ||
| UCL Cancer Institute: UNC5CL | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
| Reference showing the relevant tissue of UNC5CL | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006508 | proteolysis | 22158417 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 22158417 | GO:0046330 | positive regulation of JNK cascade | 22158417 | GO:0006508 | proteolysis | 22158417 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 22158417 | GO:0046330 | positive regulation of JNK cascade | 22158417 |
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| TissGeneExp for UNC5CL |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 0.430408617 | -2.018384487 | 2.448793103 | 4.96E-19 | 8.36E-18 |
| KICH | -2.210806762 | 1.440053238 | -3.65086 | 1.82E-14 | 3.13E-13 |
| THCA | -0.194909881 | -2.546735305 | 2.351825424 | 1.13E-17 | 2.48E-16 |
| COAD | 1.027713391 | -1.011798147 | 2.039511538 | 1.73E-10 | 2.28E-09 |
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| TissGene-miRNA for UNC5CL |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for UNC5CL |
| TissGeneSNV for UNC5CL |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E51K | SKCM | 2 |
| p.T57P | ACC | 1 |
| p.P258S | COAD | 1 |
| p.R94C | COAD | 1 |
| p.D149N | SKCM | 1 |
| p.Q157E | STAD | 1 |
| p.S104L | STAD | 1 |
| p.R241C | BRCA | 1 |
| p.Y313H | KIRP | 1 |
| p.W33R | OV | 1 |
| p.R106* | UCEC | 1 |
| p.F79I | KIRC | 1 |
| p.R432K | LIHC | 1 |
| p.S123F | SKCM | 1 |
| p.S6G | OV | 1 |
| p.T180M | UCEC | 1 |
| p.V53M | PAAD | 1 |
| p.D219E | HNSC | 1 |
| p.E50* | LUSC | 1 |
| p.L225F | SKCM | 1 |
| p.P453H | LGG | 1 |
| p.E61* | UCEC | 1 |
| p.R138W | UCEC | 1 |
| p.G500D | BRCA | 1 |
| p.A78D | THYM | 1 |
| p.M368I | LGG | 1 |
| p.G511S | GBM | 1 |
| p.R445W | UCEC | 1 |
| p.G427D | LGG | 1 |
| p.G240R | SKCM | 1 |
| p.R244C | SKCM | 1 |
| p.R66M | UCEC | 1 |
| p.A203T | LUAD | 1 |
| p.T494S | STAD | 1 |
| p.R106* | SKCM | 1 |
| p.G466D | STAD | 1 |
| p.S65* | CESC | 1 |
| p.A216T | PRAD | 1 |
| p.Y490C | GBM | 1 |
| p.E502D | PAAD | 1 |
| p.N362S | OV | 1 |
| p.E242K | UVM | 1 |
| p.M1I | STAD | 1 |
| p.I334M | BLCA | 1 |
| p.P212S | SKCM | 1 |
| p.S485F | LUAD | 1 |
| p.N362I | KIRP | 1 |
| p.N406T | UCEC | 1 |
| p.R106X | READ | 1 |
| p.E242K | STAD | 1 |
| p.E502K | CESC | 1 |
| p.S65* | BLCA | 1 |
| p.R241C | CESC | 1 |
| p.R138Q | COAD | 1 |
| p.R32Q | LGG | 1 |
| p.H110Y | SKCM | 1 |
| p.Q278L | LUAD | 1 |
| p.L375S | PAAD | 1 |
| p.P499S | SKCM | 1 |
| p.R432G | COAD | 1 |
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| TissGeneCNV for UNC5CL |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for UNC5CL |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AA496229 | CALM1-UNC5CL | chr14:90872653 | chr6:41029533 |
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| TissGeneNet for UNC5CL |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (tumor) | UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (normal) |
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| COAD (tumor) | COAD (normal) |
| UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (tumor) | UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (tumor) | UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (normal) |
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| KICH (tumor) | KICH (normal) |
| UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (tumor) | UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (tumor) | UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (tumor) | UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (tumor) | UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (tumor) | UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (tumor) | UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (tumor) | UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (normal) |
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| STAD (tumor) | STAD (normal) |
| UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (tumor) | UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (normal) |
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| THCA (tumor) | THCA (normal) |
| UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (tumor) | UNC5CL, RELA, NFKB1, IRAK1, IRAK4 (normal) |
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| TissGeneProg for UNC5CL |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for UNC5CL |
| TissGeneDrug for UNC5CL |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for UNC5CL |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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