TissGeneSummary for NKAPL |
Gene summary |
Basic gene information | Gene symbol | NKAPL |
Gene name | NFKB activating protein-like | |
Synonyms | C6orf194|bA424I5.1 | |
Cytomap | UCSC genome browser: 6p22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001007531.2, | |
Description | NKAP-like protein | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000189134 | ||
HPRD : 16664 | ||
Vega : OTTHUMG00000014517 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NKAPL | |
BioGPS: 222698 | ||
Pathway | NCI Pathway Interaction Database: NKAPL | |
KEGG: NKAPL | ||
REACTOME: NKAPL | ||
Pathway Commons: NKAPL | ||
Context | iHOP: NKAPL | |
ligand binding site mutation search in PubMed: NKAPL | ||
UCL Cancer Institute: NKAPL | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
Reference showing the relevant tissue of NKAPL | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for NKAPL |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | -0.843555236 | 0.840651014 | -1.68420625 | 6.73E-06 | 8.27E-05 |
LIHC | -1.015790111 | 0.302219889 | -1.31801 | 1.58E-05 | 6.39E-05 |
LUSC | -1.453297209 | 0.781951811 | -2.23524902 | 2.19E-26 | 5.73E-25 |
HNSC | -1.58056839 | 0.455050215 | -2.035618605 | 2.30E-11 | 5.45E-10 |
KIRC | 0.168657611 | 1.393129834 | -1.224472222 | 6.73E-18 | 4.36E-17 |
KIRP | -0.804198986 | 0.995741639 | -1.799940625 | 5.49E-08 | 3.52E-07 |
LUAD | -0.72214349 | 0.881558234 | -1.603701724 | 2.77E-15 | 2.90E-14 |
PRAD | -0.226827111 | 1.303078658 | -1.529905769 | 1.12E-15 | 1.61E-13 |
BRCA | -0.78669597 | 1.776423328 | -2.563119298 | 5.09E-66 | 1.15E-62 |
KICH | 0.367691889 | 1.654063889 | -1.286372 | 0.00612 | 0.011528615 |
ESCA | -1.935852111 | 0.083229707 | -2.019081818 | 0.000214 | 0.005598345 |
COAD | -1.73363288 | -0.283479034 | -1.450153846 | 8.12E-05 | 0.000303599 |
BLCA | -1.503052111 | 0.774900521 | -2.277952632 | 1.36E-05 | 0.00024375 |
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TissGene-miRNA for NKAPL |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NKAPL |
TissGeneSNV for NKAPL |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S71L | SKCM | 2 |
p.R105W | READ | 1 |
p.S90L | UCEC | 1 |
p.T212K | LUSC | 1 |
p.K142R | COAD | 1 |
p.G15S | ACC | 1 |
p.A62T | DLBC | 1 |
p.E258D | ESCA | 1 |
p.R21H | HNSC | 1 |
p.R68C | STAD | 1 |
p.E11K | COAD | 1 |
p.H162Y | COAD | 1 |
p.K190R | OV | 1 |
p.R196K | SKCM | 1 |
p.R378* | UCEC | 1 |
p.R105W | STAD | 1 |
p.K397Q | UCEC | 1 |
p.E247K | GBM | 1 |
p.G132A | BLCA | 1 |
p.D203H | HNSC | 1 |
p.W55C | LUAD | 1 |
p.A299V | COAD | 1 |
p.K383N | BLCA | 1 |
p.S24L | SKCM | 1 |
p.G25W | LUSC | 1 |
p.R42H | SARC | 1 |
p.E103K | BRCA | 1 |
p.A133V | PAAD | 1 |
p.R21H | ESCA | 1 |
p.R98H | ESCA | 1 |
p.E130K | SKCM | 1 |
p.Q31X | ESCA | 1 |
p.K142N | LUAD | 1 |
p.R79H | UCEC | 1 |
p.S249N | BLCA | 1 |
p.P54L | SKCM | 1 |
p.N207D | UCEC | 1 |
p.P28L | SKCM | 1 |
p.H346Y | UCEC | 1 |
p.R378Q | COAD | 1 |
p.P30T | BLCA | 1 |
p.R72Q | SKCM | 1 |
p.L51F | BLCA | 1 |
p.R222G | GBM | 1 |
p.R74W | UCS | 1 |
p.S167I | LIHC | 1 |
p.Q31* | ESCA | 1 |
p.R389* | LGG | 1 |
p.R68C | LUAD | 1 |
p.S193L | UCEC | 1 |
p.R199K | SKCM | 1 |
p.Y96C | COAD | 1 |
p.S371F | SKCM | 1 |
p.A299T | HNSC | 1 |
p.T161M | STAD | 1 |
p.S41F | KIRC | 1 |
p.S194T | LUAD | 1 |
p.K186N | BLCA | 1 |
p.K232R | ESCA | 1 |
p.K366N | CESC | 1 |
p.D59E | LUAD | 1 |
p.E262Q | BLCA | 1 |
p.K187E | CESC | 1 |
p.G332S | UCEC | 1 |
p.C34S | LUAD | 1 |
p.S333Y | CESC | 1 |
p.P54S | SKCM | 1 |
p.E365K | BLCA | 1 |
p.R317X | COAD | 1 |
p.E365D | UCEC | 1 |
p.S85Y | SKCM | 1 |
p.G303S | SKCM | 1 |
p.R355H | COAD | 1 |
p.R95H | STAD | 1 |
p.S251X | STAD | 1 |
p.P144S | SKCM | 1 |
p.R74Q | BRCA | 1 |
p.K379N | CESC | 1 |
p.P139L | PAAD | 1 |
p.S193L | READ | 1 |
p.I284T | STAD | 1 |
p.E291K | SKCM | 1 |
p.A225T | SKCM | 1 |
p.L369I | PAAD | 1 |
p.V392A | HNSC | 1 |
p.E150D | LUAD | 1 |
p.E150K | BRCA | 1 |
p.R353Q | STAD | 1 |
p.R355C | HNSC | 1 |
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TissGeneCNV for NKAPL |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NKAPL |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for NKAPL |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NKAPL |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NKAPL |
TissGeneDrug for NKAPL |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NKAPL |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0036341 | Schizophrenia | 3 | BeFree,CTD_human,GAD,GWASCAT |