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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for FGFR3
check button Gene summary
Basic gene informationGene symbolFGFR3
Gene namefibroblast growth factor receptor 3
SynonymsACH|CD333|CEK2|HSFGFR3EX|JTK4
CytomapUCSC genome browser: 4p16.3
Type of geneprotein-coding
RefGenesNM_000142.4,
NM_001163213.1,NM_022965.3,
DescriptionFGFR-3fibroblast growth factor receptor 3 variant 4hydroxyaryl-protein kinasetyrosine kinase JTK4
Modification date20141219
dbXrefs MIM : 134934
HGNC : HGNC
Ensembl : ENSG00000068078
HPRD : 00624
Vega : OTTHUMG00000121148
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FGFR3
BioGPS: 2261
PathwayNCI Pathway Interaction Database: FGFR3
KEGG: FGFR3
REACTOME: FGFR3
Pathway Commons: FGFR3
ContextiHOP: FGFR3
ligand binding site mutation search in PubMed: FGFR3
UCL Cancer Institute: FGFR3
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Skin
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)SKCM
Reference showing the relevant tissue of FGFR3
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0008543fibroblast growth factor receptor signaling pathway8663044
GO:0018108peptidyl-tyrosine phosphorylation11294897
GO:0046777protein autophosphorylation11294897
GO:0008543fibroblast growth factor receptor signaling pathway8663044
GO:0018108peptidyl-tyrosine phosphorylation11294897
GO:0046777protein autophosphorylation11294897


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TissGeneExp for FGFR3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUAD0.8497645332.44813005-1.5983655172.71E-079.95E-07
KICH-3.671068643.34406736-7.0151363.01E-168.45E-15
BRCA0.37358743-0.9017397631.2753271932.33E-087.43E-08
KIRP1.246028113.227581235-1.9815531259.05E-063.82E-05
KIRC1.5370621382.623037138-1.0859754.87E-091.52E-08
COAD0.9666016682.241478591-1.2748769235.89E-050.000228812


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TissGene-miRNA for FGFR3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for FGFR3
TissGeneSNV for FGFR3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.S249CBLCA29
p.Y375CBLCA8
p.G372CBLCA5
p.S249CHNSC4
p.R248CBLCA3
p.S373CBLCA2
p.Y375CKIRP2
p.G380RBLCA2
p.K652EBLCA2
p.P420QSKCM2
p.S249CLUSC2
p.G382RBLCA2
p.R324CSTAD1
p.A431VCOAD1
p.E688KSKCM1
p.V733IUCEC1
p.A99VSKCM1
p.P63SSKCM1
p.K478NTHYM1
p.H274YSKCM1
p.M725IKIRP1
p.P358LBLCA1
p.P738LSKCM1
p.D762HHNSC1
p.V632MPRAD1
p.H349DBLCA1
p.P250SHNSC1
p.D764HHNSC1
p.V702APAAD1
p.P701LSKCM1
p.G334SSKCM1
p.S681FSKCM1
p.G639WKIRC1
p.R421QUCEC1
p.D788NHNSC1
p.D318NPAAD1
p.G753RLIHC1
p.S329*KIRC1
p.P738SSKCM1
p.V306IBLCA1
p.A36TCOAD1
p.S779RLUAD1
p.S417FSARC1
p.R671QCOAD1
p.V329ASTAD1
p.R418SSKCM1
p.R616GKIRP1
p.P62LSKCM1
p.L610MKIRP1
p.A569VSTAD1
p.V700APAAD1
p.K650NKIRP1
p.A571VSTAD1
p.P451SCOAD1
p.G382RHNSC1
p.P689SBRCA1
p.E216KBLCA1
p.E140KCOAD1
p.V271MLUAD1
p.G370CBLCA1
p.A719THNSC1
p.G235DBLCA1
p.Q115*PAAD1
p.S402NMESO1
p.D760VUCS1
p.Q676*BLCA1
p.G382RSTAD1
p.R248CLUSC1
p.E456KUCEC1
p.R471QCOAD1
p.T808MCOAD1
p.D582HSKCM1
p.R200CLIHC1
p.H349YBLCA1
p.G180DCOAD1
p.A265VSTAD1
p.T311ALIHC1
p.R765CUCEC1
p.K652NKIRP1
p.P698LSKCM1
p.R603QGBM1
p.R618GKIRP1
p.D578NSKCM1
p.P39TLGG1
p.L608MKIRP1
p.P688SBRCA1
p.D786NHNSC1
p.M727IKIRP1
p.S344YBLCA1
p.Y373CBLCA1
p.R671GHNSC1
p.D648NCOAD1
p.G380RSTAD1
p.S789FSKCM1
p.D222NBLCA1
p.L385MUCEC1
p.S329XKIRC1
p.Y373CKIRP1
p.R248CHNSC1
p.G137ESKCM1
p.S131LHNSC1
p.K715MLUSC1
p.D582NSTAD1
p.S695CLUAD1
p.A312VPRAD1
p.S130FSKCM1
p.S249CKIRP1
p.V321MUCEC1
p.E194KCOAD1
p.V50IHNSC1
p.V507ICOAD1
p.S351FBLCA1
p.S351CBLCA1
p.E135KSKCM1
p.F386LLUAD1
p.K650EGBM1


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TissGeneCNV for FGFR3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for FGFR3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABF842660BBS10-FGFR3chr12:76740240chr4:1810437
Chimerdb3.0FusionScanLUSCTCGA-39-5024-01AFGFR3-TACC3In-Framechr4:1808661chr4:1741428
Chimerdb3.0FusionScanLGGTCGA-TM-A84B-01AFGFR3-FBXO28In-Framechr4:1808661chr1:224340843
Chimerdb3.0FusionScanPRADTCGA-EJ-A7NM-01AFGFR3-AESIn-Framechr4:1808661chr19:3061255
Chimerdb3.0FusionScanLGGTCGA-CS-6186-01AFGFR3-ELAVL3In-Framechr4:1808661chr19:11577642
Chimerdb3.0TopHat-FusionLGGTCGA-P5-A72U-01AFGFR3-TACC3In-Framechr4:1808660chr4:1732898
Chimerdb3.0TopHat-FusionLGGTCGA-FG-7643-01AFGFR3-TACC3In-Framechr4:1808660chr4:1741428
Chimerdb3.0TopHat-FusionCESCTCGA-WL-A834-01AFGFR3-TACC3In-Framechr4:1808660chr4:1737457
Chimerdb3.0TopHat-FusionBLCATCGA-E7-A5KE-01AFGFR3-TACC3In-Framechr4:1808660chr4:1741428
Chimerdb3.0TopHat-FusionBLCATCGA-CF-A8HY-01AFGFR3-TACC3In-Framechr4:1808660chr4:1737457
Chimerdb3.0TopHat-FusionLUSCTCGA-39-5024-01AFGFR3-TACC3In-Framechr4:1808650chr4:1737483
Chimerdb3.0TopHat-FusionLUSCTCGA-39-5024-01AFGFR3-TACC3In-Framechr4:1808660chr4:1741428
Chimerdb3.0TopHat-FusionLUSCTCGA-66-2786-01AFGFR3-TACC3In-Framechr4:1808660chr4:1741428
Chimerdb3.0TopHat-FusionLGGTCGA-TM-A84B-01AFGFR3-FBXO283'UTR-CDSchr4:1809431chr1:224336031
Chimerdb3.0TopHat-FusionLGGTCGA-CS-6186-01AFGFR3-ELAVL3In-Framechr4:1808660chr19:11577641
Chimerdb3.0TopHat-FusionLGGTCGA-TM-A84B-01AFGFR3-FBXO28In-Framechr4:1808660chr1:224340843
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-A7NM-01AFGFR3-AESIn-Framechr4:1808660chr19:3061254
Chimerdb3.0TopHat-FusionBRCATCGA-D8-A1JG-01BCTBP1-FGFR3Out-of-Framechr4:1225500chr4:1803203
Chimerdb3.0TopHat-FusionBRCATCGA-D8-A1JG-01BCTBP1-FGFR3Out-of-Framechr4:1225866chr4:1801538
Chimerdb3.0TopHat-FusionBRCATCGA-D8-A1JG-01BCTBP1-FGFR3Out-of-Framechr4:1231970chr4:1802494
TCGAfusionPortalPRADABLCATCGA-CF-A3MF-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1741429
TCGAfusionPortalPRADABLCATCGA-CF-A3MG-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1741429
TCGAfusionPortalPRADABLCATCGA-CF-A3MH-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1741429
TCGAfusionPortalPRADAGBMTCGA-06-2567-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1741429
TCGAfusionPortalPRADAGBMTCGA-14-0789-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1741429
TCGAfusionPortalPRADAGBMTCGA-14-1823-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1741429
TCGAfusionPortalPRADAGBMTCGA-14-1829-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1741429
TCGAfusionPortalPRADAGBMTCGA-27-1835-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1741429
TCGAfusionPortalPRADAGBMTCGA-76-4925-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1739325
TCGAfusionPortalPRADAHNSCTCGA-CR-6473-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1739325
TCGAfusionPortalPRADAHNSCTCGA-CV-7100-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1741429
TCGAfusionPortalPRADAHNSCTCGA-CV-7177-01AFGFR3-TPRG1Out-of-frameChr4:1795770Chr3:189028175
TCGAfusionPortalPRADALGGTCGA-CS-6186-01AFGFR3-ELAVL3In-frameChr4:1808661Chr19:11577642
TCGAfusionPortalPRADALGGTCGA-FG-7643-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1741429
TCGAfusionPortalPRADALUSCTCGA-22-4607-01AFGFR3-TACC3Out-of-frameChr4:1808661Chr4:1737000
TCGAfusionPortalPRADALUSCTCGA-34-2608-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1741429
TCGAfusionPortalPRADALUSCTCGA-39-5024-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1741429
TCGAfusionPortalPRADALUSCTCGA-63-7022-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1746245
TCGAfusionPortalPRADALUSCTCGA-66-2786-01AFGFR3-TACC3In-frameChr4:1808661Chr4:1741429
TCGAfusionPortalPRADAPRADTCGA-EJ-A7NM-01AFGFR3-AESIn-frameChr4:1808661Chr19:3061255


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TissGeneNet for FGFR3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
FGFR3, GRB2, ATF3, HSPA4, RPL8, RNF130, FGF2, KRT8, PTK2B, FGF7, KIAA1377, FGF23, CHGB, GUSB, FGF6, SH2B1, RADIL, HNRNPL, C6orf47, FGF9, CCDC17 (tumor)FGFR3, GRB2, ATF3, STAT3, HSPA8, STAT1, RNF130, HSPA1B, KRT8, PTK2B, GTF3C1, FGF7, EPHA4, CHGB, SH2B1, RADIL, ARAP1, C6orf47, FGF18, FGF9, FGF5 (normal)
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COAD (tumor)COAD (normal)
FGFR3, HSP90AB1, ATF3, RNF130, HSPA1B, FGF2, KRT8, PTK2B, FGF7, KIAA1377, FGF1, EPHA4, CTSK, GUSB, SH2B1, RADIL, HBZ, ARAP1, FGF18, FGF9, FGF5 (tumor)FGFR3, ATF3, STAT1, RNF130, FGF2, FGF4, FGF7, KIAA1377, FGF1, EPHA4, FGF23, CTSK, GUSB, SH2B1, RADIL, SMG7, FGF3, FGF18, GPSM3, FGF5, CCDC17 (normal)
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HNSC (tumor)HNSC (normal)
FGFR3, HSPA4, RNF130, POLA2, FGF2, GTF3C1, FGF7, KIAA1377, FGF1, EPHA4, FGF23, CHGB, CTSK, GUSB, FGF6, SH2B1, RADIL, HNRNPL, C6orf47, FGF18, FGF9 (tumor)FGFR3, HSP90AB1, STAT3, RPL8, HSPA8, RNF130, POLA2, FGF2, GTF3C1, FGF7, KIAA1377, SLC25A6, EPHA4, FGF8, CHGB, CTSK, RADIL, SMG7, FGF9, GPSM3, FGF5 (normal)
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KICH (tumor)KICH (normal)
FGFR3, GRB2, HSP90AB1, STAT1, FGF2, FGF4, HSP90AA1, PTK2B, FGF7, KIAA1377, SLC25A6, EPHA4, NDUFS6, CHGB, CTSK, GUSB, SH2B1, FGF3, FGF9, GPSM3, CCDC17 (tumor)FGFR3, RPL8, CDC37, FGF2, HSP90AA1, FGF7, GUSBP1, EPHA4, FGF23, NDUFS6, FGF8, GUSB, RADIL, SMG7, FGF3, C6orf47, FGF18, FGF9, GPSM3, FGF17, FGF5 (normal)
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KIRC (tumor)KIRC (normal)
FGFR3, GRB2, HSP90AB1, HSPA4, STAT1, RNF130, HSP90AA1, GTF3C1, FGF7, SLC25A6, GUSBP1, NDUFS6, CHGB, GUSB, SH2B1, HNRNPL, SMG7, ARAP1, FGF9, GPSM3, FGF17 (tumor)FGFR3, HSPA4, HSPA8, CDC37, HSPA1B, POLA2, FGF2, HSP90AA1, PTK2B, FGF7, KIAA1377, EPHA4, CHGB, CTSK, RADIL, HNRNPL, SMG7, ARAP1, C6orf47, FGF9, FGF17 (normal)
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KIRP (tumor)KIRP (normal)
FGFR3, GRB2, HSPA4, STAT3, HSPA8, STAT1, CDC37, PTK2B, FGF7, SLC25A6, FGF1, EPHA4, FGF23, NDUFS6, CHGB, SH2B1, HNRNPL, ARAP1, FGF9, GPSM3, CCDC17 (tumor)FGFR3, STAT3, HSPA8, STAT1, RNF130, FGF2, KRT8, PTK2B, FGF7, GUSBP1, CHGB, SH2B1, RADIL, HNRNPL, SMG7, ARAP1, FGF18, FGF9, GPSM3, FGF17, CCDC17 (normal)
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LIHC (tumor)LIHC (normal)
FGFR3, HSP90AB1, ATF3, HSPA4, STAT3, RNF130, CDC37, POLA2, HSP90AA1, PTK2B, FGF1, GUSBP1, FGF23, GUSB, SH2B1, RADIL, HNRNPL, ARAP1, FGF17, FGF5, CCDC17 (tumor)FGFR3, HSP90AB1, ATF3, STAT3, RPL8, STAT1, RNF130, HSPA1B, POLA2, FGF2, KRT8, PTK2B, GTF3C1, FGF7, SLC25A6, GUSBP1, HNRNPL, SMG7, ARAP1, C6orf47, FGF5 (normal)
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LUAD (tumor)LUAD (normal)
FGFR3, HSPA4, RPL8, HSPA8, RNF130, HSP90AA1, PTK2B, GTF3C1, FGF7, SLC25A6, EPHA4, NDUFS6, CTSK, SH2B1, RADIL, SMG7, ARAP1, C6orf47, FGF9, GPSM3, FGF17 (tumor)FGFR3, HSPA4, STAT3, HSPA8, STAT1, POLA2, HSP90AA1, PTK2B, EPHA4, NDUFS6, GUSB, SH2B1, RADIL, HNRNPL, HBZ, ARAP1, C6orf47, FGF18, FGF17, FGF5, CCDC17 (normal)
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LUSC (tumor)LUSC (normal)
FGFR3, HSP90AB1, ATF3, HSPA4, STAT3, HSPA8, STAT1, POLA2, FGF2, HSP90AA1, KRT8, FGF7, SLC25A6, GUSBP1, CHGB, SH2B1, RADIL, HNRNPL, HBZ, ARAP1, CCDC17 (tumor)FGFR3, HSP90AB1, ATF3, HSPA8, STAT1, RNF130, PTK2B, GTF3C1, FGF7, GUSBP1, EPHA4, FGF8, CTSK, SH2B1, RADIL, ARAP1, FGF3, FGF9, GPSM3, FGF5, CCDC17 (normal)
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PRAD (tumor)PRAD (normal)
FGFR3, HSP90AB1, ATF3, HSPA4, STAT3, HSPA8, HSPA1B, FGF2, KRT8, PTK2B, FGF7, KIAA1377, EPHA4, CTSK, GUSB, FGF6, SH2B1, RADIL, ARAP1, FGF18, FGF17 (tumor)FGFR3, HSPA4, STAT3, STAT1, RNF130, CDC37, POLA2, FGF2, KRT8, GTF3C1, FGF7, KIAA1377, FGF1, EPHA4, CTSK, SH2B1, RADIL, FGF18, FGF9, GPSM3, FGF17 (normal)
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STAD (tumor)STAD (normal)
FGFR3, HSPA4, RNF130, FGF2, HSP90AA1, PTK2B, GTF3C1, FGF7, KIAA1377, FGF1, EPHA4, FGF8, CHGB, CTSK, RADIL, SMG7, FGF3, FGF18, FGF9, FGF5, CCDC17 (tumor)FGFR3, HSP90AB1, STAT1, RNF130, HSPA1B, FGF2, FGF4, KRT8, GTF3C1, FGF7, FGF1, EPHA4, FGF23, CTSK, GUSB, SH2B1, SMG7, FGF3, FGF9, GPSM3, FGF5 (normal)
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THCA (tumor)THCA (normal)
FGFR3, STAT3, HSPA8, STAT1, RNF130, POLA2, FGF2, GTF3C1, FGF7, KIAA1377, GUSBP1, EPHA4, GUSB, SH2B1, RADIL, HNRNPL, C6orf47, FGF18, FGF9, FGF17, CCDC17 (tumor)FGFR3, GRB2, ATF3, HSPA8, CDC37, POLA2, FGF4, PTK2B, KIAA1377, SLC25A6, FGF1, EPHA4, NDUFS6, CHGB, GUSB, SH2B1, FGF18, FGF9, FGF17, FGF5, CCDC17 (normal)
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TissGeneProg for FGFR3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for FGFR3
TissGeneDrug for FGFR3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for FGFR3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0001080Achondroplasia115BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD,ORPHANET,UNIPROT
umls:C0005684Malignant neoplasm of urinary bladder71BeFree,CLINVAR,GAD,UNIPROT
umls:C0699885Carcinoma of bladder71BeFree
umls:C0026764Multiple Myeloma70BeFree,CLINVAR,CTD_human,GAD,LHGDN
umls:C1868678THANATOPHORIC DYSPLASIA, TYPE I (disorder)63BeFree,CLINVAR,CTD_human,MGD,UNIPROT
umls:C0410529Hypochondroplasia (disorder)57BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C0039743Thanatophoric Dysplasia55BeFree,CTD_human,GAD,LHGDN
umls:C0010278Craniosynostosis51BeFree,GAD,LHGDN
umls:C0005695Bladder Neoplasm37BeFree,CTD_human,GAD,LHGDN
umls:C0013336Dwarfism34BeFree
umls:C0596263Carcinogenesis27BeFree
umls:C0410528Skeletal dysplasia26BeFree
umls:C0007138Carcinoma, Transitional Cell23BeFree,CTD_human,GAD
umls:C0022603Seborrheic keratosis19BeFree,CLINVAR,LHGDN,UNIPROT
umls:C2145472Urothelial Carcinoma18BeFree
umls:C1864436Muenke Syndrome17BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT
umls:C0343284Chondrodysplasia16BeFree
umls:C0000889Acanthosis Nigricans15BeFree,LHGDN
umls:C0334082NEVUS, EPIDERMAL (disorder)12BeFree,CLINVAR,CTD_human,UNIPROT
umls:C1300257Thanatophoric dysplasia, type 210BeFree,CLINVAR,CTD_human,MGD,UNIPROT
umls:C2677099CROUZON SYNDROME WITH ACANTHOSIS NIGRICANS (disorder)10BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C0178874Tumor Progression9BeFree
umls:C0039093Congenital abnormal Synostosis8BeFree,LHGDN
umls:C2674173Achondroplasia, Severe, With Developmental Delay And Acanthosis Nigricans8BeFree,ORPHANET
umls:C0000768Congenital Abnormality7BeFree
umls:C0007137Squamous cell carcinoma7BeFree,GAD
umls:C0302592Cervix carcinoma7BeFree,CLINVAR,UNIPROT
umls:C1300256Thanatophoric dysplasia, type 16BeFree
umls:C0001193Apert syndrome5BeFree
umls:C0010273Craniofacial Dysostosis5BeFree
umls:C0242379Malignant neoplasm of lung5BeFree
umls:C2931196Craniofacial dysostosis type 15BeFree
umls:C0005941Bone Diseases, Developmental4BeFree
umls:C0006142Malignant neoplasm of breast4BeFree
umls:C0007131Non-Small Cell Lung Carcinoma4BeFree
umls:C0009402Colorectal Carcinoma4BeFree
umls:C0220658Pfeiffer Syndrome4BeFree
umls:C0263661Disorder of skeletal system4BeFree
umls:C0265303ACROCEPHALOPOLYSYNDACTYLY TYPE IV4BeFree
umls:C0279680Transitional cell carcinoma of bladder4BeFree
umls:C0376358Malignant neoplasm of prostate4BeFree,GAD
umls:C0600139Prostate carcinoma4BeFree
umls:C0678222Breast Carcinoma4BeFree
umls:C0684249Carcinoma of lung4BeFree
umls:C0004998Benign neoplasm of skin3BeFree
umls:C0007847Malignant tumor of cervix3BeFree
umls:C0017636Glioblastoma3BeFree
umls:C0023418leukemia3BeFree
umls:C0024299Lymphoma3BeFree,LHGDN
umls:C0029422Osteochondrodysplasias3BeFree,GAD
umls:C0029434Osteogenesis Imperfecta3BeFree
umls:C0033578Prostatic Neoplasms3BeFree
umls:C0037286Skin Neoplasms3BeFree
umls:C0079731B-Cell Lymphomas3BeFree
umls:C0079774Peripheral T-Cell Lymphoma3BeFree,LHGDN
umls:C0152013Adenocarcinoma of lung (disorder)3BeFree
umls:C0424605Developmental delay (disorder)3BeFree
umls:C0751571Cancer of Urinary Tract3BeFree
umls:C1520166Xenograft Model3BeFree
umls:C1527249Colorectal Cancer3BeFree
umls:C1956097Wolf-Hirschhorn Syndrome3BeFree
umls:C0005940Bone Diseases2BeFree
umls:C0005967Bone neoplasms2BeFree
umls:C0007134Renal Cell Carcinoma2BeFree
umls:C0007873Uterine Cervical Neoplasm2BeFree,CTD_human
umls:C0013080Down Syndrome2BeFree
umls:C0023434Chronic Lymphocytic Leukemia2BeFree
umls:C0023473Myeloid Leukemia, Chronic2BeFree
umls:C0025202melanoma2BeFree,LHGDN
umls:C0026470Monoclonal Gammopathy of Undetermined Significance2BeFree
umls:C0026707Mucopolysaccharidosis IV2BeFree
umls:C0026896Myasthenia Gravis2BeFree
umls:C0027626Neoplasm Invasiveness2GAD
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0035335Retinoblastoma2BeFree
umls:C0036651Senile lentigo2BeFree
umls:C0038379Strabismus2BeFree
umls:C0149782Squamous cell carcinoma of lung2BeFree
umls:C0235754Bladder papilloma2BeFree
umls:C0235831Renal Cell Dysplasia2BeFree
umls:C0263641Epithelial hyperplasia of skin2BeFree
umls:C0265269Lacrimoauriculodentodigital syndrome2BeFree,CTD_human,ORPHANET,UNIPROT
umls:C0265329Organoid Nevus Phakomatosis2BeFree
umls:C0265529Plagiocephaly2BeFree
umls:C0265534Scaphycephaly2BeFree
umls:C0278827Bladder cancer recurrent2BeFree
umls:C0362030Verrucous epidermal nevus2BeFree
umls:C0521158Recurrent tumor2BeFree
umls:C0854917Rhabdoid Tumor of the Kidney2BeFree
umls:C1336527Carcinoma of urinary bladder, superficial2BeFree
umls:C1709246Non-Neoplastic Disorder2BeFree
umls:C2931822Nasopharyngeal carcinoma2BeFree
umls:C3536714Renal dysplasia2BeFree
umls:C0001418Adenocarcinoma1BeFree
umls:C0001969Alcoholic Intoxication1BeFree
umls:C0002395Alzheimer's Disease1GAD
umls:C0003706Arachnodactyly1BeFree
umls:C0003803Arnold Chiari Malformation1BeFree
umls:C0004364Autoimmune Diseases1BeFree
umls:C0007114Malignant neoplasm of skin1BeFree
umls:C0007133Carcinoma, Papillary1BeFree
umls:C0007971Cheilitis1GAD
umls:C0008479Chondrosarcoma1BeFree
umls:C0008625Chromosome Aberrations1GAD
umls:C0008924Cleft Lip1CTD_human
umls:C0008925Cleft Palate1CTD_human
umls:C0011645Dermatosis Papulosa Nigra1BeFree
umls:C0015544Failure to Thrive1BeFree
umls:C0017638Glioma1BeFree
umls:C0018784Sensorineural Hearing Loss (disorder)1LHGDN
umls:C0020437Hypercalcemia1BeFree
umls:C0020538Hypertensive disease1GAD
umls:C0022593Keratosis1BeFree
umls:C0022602Actinic keratosis1BeFree
umls:C0022665Kidney Neoplasm1GAD
umls:C0023267Fibroid Tumor1LHGDN
umls:C0023484Leukemia, Plasma Cell1BeFree
umls:C0023761Lip Neoplasms1GAD
umls:C0024419Waldenstrom Macroglobulinemia1BeFree
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0025286Meningioma1BeFree
umls:C0025362Mental Retardation1BeFree
umls:C0026552Morphine Dependence1BeFree
umls:C0027051Myocardial Infarction1BeFree
umls:C0027643Neoplasm Recurrence, Local1GAD
umls:C0027960Nevus1LHGDN
umls:C0029423Cartilaginous exostosis1BeFree
umls:C0030297Pancreatic Neoplasm1GAD
umls:C0030354Papilloma1BeFree
umls:C0030421Paraganglioma1BeFree
umls:C0031511Pheochromocytoma1BeFree
umls:C0032927Precancerous Conditions1BeFree
umls:C0036631Seminoma1BeFree,CTD_human
umls:C0037274Dermatologic disorders1BeFree
umls:C0038015Spondyloepiphyseal Dysplasia1BeFree
umls:C0039590Testicular Neoplasms1BeFree
umls:C0041341Tuberous Sclerosis1BeFree
umls:C0041955Ureteral Neoplasms1GAD
umls:C0042769Virus Diseases1BeFree
umls:C0151491Congenital musculoskeletal anomalies1GAD
umls:C0155552Hearing Loss, Mixed Conductive-Sensorineural1BeFree
umls:C0175695Sotos' syndrome1BeFree
umls:C0175699Saethre-Chotzen Syndrome1BeFree,CLINVAR,ORPHANET
umls:C0205851Germ cell tumor1BeFree
umls:C0206721Inverted Papilloma1BeFree
umls:C0220726Diastrophic dysplasia1BeFree
umls:C0221369Acquired Camptodactyly1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0238198Gastrointestinal Stromal Tumors1BeFree
umls:C0243066Atresia1BeFree
umls:C0265309Leri-Weill dyschondrosteosis1BeFree
umls:C0266617Congenital anomaly of face1BeFree
umls:C0268800Simple renal cyst1BeFree
umls:C0278080Physical addiction1BeFree
umls:C0280100Solid tumour1BeFree
umls:C0282529Chondrodysplasia Punctata, Rhizomelic1BeFree
umls:C0302894Stucco keratosis1BeFree
umls:C0333997Lymphoid hyperplasia1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0376545Hematologic Neoplasms1BeFree
umls:C0432283Osteoglophonic dwarfism1BeFree
umls:C0520679Sleep Apnea, Obstructive1GAD
umls:C0553723Squamous cell carcinoma of skin1GAD
umls:C0685409Congenital Camptodactyly1BeFree
umls:C0699791Stomach Carcinoma1BeFree
umls:C0744483growth hormone treatment1BeFree
umls:C0751882Myasthenic Syndromes, Congenital1BeFree
umls:C0870082Hyperkeratosis1BeFree
umls:C0878787Growth failure1BeFree
umls:C1168401Squamous cell carcinoma of the head and neck1BeFree
umls:C1261473Sarcoma1BeFree
umls:C1292769Precursor B-cell lymphoblastic leukemia1BeFree
umls:C1334282Inverted Urothelial Papilloma1BeFree
umls:C1336708Testicular Germ Cell Tumor1UNIPROT
umls:C1458155Mammary Neoplasms1LHGDN
umls:C1516170Cancer Cell Growth1BeFree
umls:C1519346Skin Carcinogenesis1BeFree
umls:C1519670Tumor Angiogenesis1BeFree
umls:C1519840Urothelial Neoplasm1BeFree
umls:C1704272Benign Prostatic Hyperplasia1BeFree
umls:C1737329Dysmorphism1BeFree
umls:C1762616Meningioma, benign, no ICD-O subtype1BeFree
umls:C1861456Stiff Skin Syndrome1BeFree
umls:C1864852CATSHL syndrome1CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C2745959Spondyloepiphyseal dysplasia, congenita1BeFree
umls:C2930792Familial acanthosis nigricans1BeFree
umls:C2931150Synostotic Anterior Plagiocephaly1BeFree
umls:C2986536Bisphosphonate-associated osteonecrosis1BeFree
umls:C2986703Overgrowth Syndrome1BeFree
umls:C3696898Autosomal Dominant Nocturnal Frontal Lobe Epilepsy1BeFree
umls:C3714756Intellectual Disability1BeFree
umls:C3811653Experimental Organism Basal Cell Carcinoma1BeFree
umls:C0009404Colorectal Neoplasms0CTD_human
umls:C0206726gliosarcoma0ORPHANET
umls:C0334517Spermatocytic seminoma0CLINVAR
umls:C0334588Giant Cell Glioblastoma0ORPHANET
umls:C0699790Colon Carcinoma0CLINVAR
umls:C2931282Skeletal dysplasia, San Diego type0ORPHANET