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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for FGG
check button Gene summary
Basic gene informationGene symbolFGG
Gene namefibrinogen gamma chain
Synonyms-
CytomapUCSC genome browser: 4q28
Type of geneprotein-coding
RefGenesNM_000509.4,
NM_021870.2,
Descriptionfibrinogen, gamma polypeptide
Modification date20141222
dbXrefs MIM : 134850
HGNC : HGNC
Ensembl : ENSG00000171557
HPRD : 00621
Vega : OTTHUMG00000150329
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FGG
BioGPS: 2266
PathwayNCI Pathway Interaction Database: FGG
KEGG: FGG
REACTOME: FGG
Pathway Commons: FGG
ContextiHOP: FGG
ligand binding site mutation search in PubMed: FGG
UCL Cancer Institute: FGG
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of FGGDNA methylation profiling of the fibrinogen gene landscape in human cells and during mouse and zebrafish development. Vorjohann S, Pitetti JL, Nef S, Gonelle-Gispert C, Buhler L, Fish RJ, Neerman-Arbez M. PLoS One. 2013 Aug 21;8(8):e73089. doi: 10.1371/journal.pone.0073089. eCollection 2013. (pmid:23991173)
go to article
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0007160cell-matrix adhesion10903502
GO:0034116positive regulation of heterotypic cell-cell adhesion8100742
GO:0043623cellular protein complex assembly8910396
GO:0045907positive regulation of vasoconstriction15739255
GO:0045921positive regulation of exocytosis19193866
GO:0050714positive regulation of protein secretion19193866
GO:0051592response to calcium ion6777381
GO:0070374positive regulation of ERK1 and ERK2 cascade10903502
GO:0070527platelet aggregation6281794
GO:0090277positive regulation of peptide hormone secretion19193866
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors10903502
GO:2000352negative regulation of endothelial cell apoptotic process10903502
GO:0007160cell-matrix adhesion10903502
GO:0034116positive regulation of heterotypic cell-cell adhesion8100742
GO:0043623cellular protein complex assembly8910396
GO:0045907positive regulation of vasoconstriction15739255
GO:0045921positive regulation of exocytosis19193866
GO:0050714positive regulation of protein secretion19193866
GO:0051592response to calcium ion6777381
GO:0070374positive regulation of ERK1 and ERK2 cascade10903502
GO:0070527platelet aggregation6281794
GO:0090277positive regulation of peptide hormone secretion19193866
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors10903502
GO:2000352negative regulation of endothelial cell apoptotic process10903502


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TissGeneExp for FGG

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LIHC12.8523843914.95392439-2.101541.17E-078.10E-07
LUSC1.7265127.149510039-5.4229980391.12E-125.11E-12
KIRC2.055575725-0.9763409423.0319166678.61E-072.22E-06
LUAD5.3802372196.913428599-1.5331913790.01850.031059506
KICH-2.990963608-1.362471608-1.6284920.004010.007725559


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TissGene-miRNA for FGG

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for FGG
TissGeneSNV for FGG

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.L12IUCEC2
p.Y389*SARC1
p.S190NBLCA1
p.N201ILGG1
p.D211NLUAD1
p.L12FHNSC1
p.G429ESKCM1
p.I90VGBM1
p.T247ABLCA1
p.P325SESCA1
p.R301CSKCM1
p.D32NSKCM1
p.K146TCOAD1
p.C352GSTAD1
p.L18*KIRC1
p.E349VLUAD1
p.D71NCOAD1
p.S99LBLCA1
p.E117QBRCA1
p.K185*LUSC1
p.G318DUCEC1
p.N334TSKCM1
p.S184YUCEC1
p.D167NBLCA1
p.G255ECOAD1
p.V293MGBM1
p.N363SSKCM1
p.Q337HGBM1
p.D320HBLCA1
p.D181NTHCA1
p.G50DBRCA1
p.S182YUCEC1
p.L20IUCEC1
p.L302IHNSC1
p.S2NHNSC1
p.R301GSKCM1
p.E138*UCEC1
p.T400PPAAD1
p.T408ISKCM1
p.A440VSARC1
p.D346HUCEC1
p.I171NHNSC1
p.R8QCOAD1
p.I210MSKCM1
p.D178HTHYM1
p.G216VLUAD1
p.K231NUCS1
p.V28AUCEC1
p.E209KSKCM1
p.E82*BRCA1
p.G176ECESC1
p.D445NSKCM1
p.D323NGBM1
p.V293MCOAD1
p.A289VHNSC1
p.G186RSTAD1
p.W234CUCEC1
p.D320APAAD1
p.A108GDLBC1
p.D323NPRAD1
p.D167ELUSC1
p.G216RSKCM1
p.A52TSTAD1
p.D320NBLCA1
p.G318SSKCM1
p.L261FBLCA1
p.V228IGBM1
p.P269LKICH1


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TissGeneCNV for FGG

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for FGG

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAAI133452OSMR-FGGchr5:38935743chr4:155531313
Chimerdb3.0ChiTaRsNAAI174865CRTAP-FGGchr3:33174186chr4:155528018
Chimerdb3.0ChiTaRsNAAV655197FGG-SLC47A1chr4:155527904chr17:19480676
Chimerdb3.0ChiTaRsNAAI207493FGG-TSPAN5chr4:155533776chr4:99496210
Chimerdb3.0ChiTaRsNACB154699CPT1A-FGGchr11:68523409chr4:155525288
Chimerdb3.0FusionScanLUADTCGA-49-6743-01ADCHS2-FGGIn-Framechr4:155410455chr4:155533353
TCGAfusionPortalPRADALUADTCGA-49-6743-01ADCHS2-FGGIn-frameChr4:155410456Chr4:155533353


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TissGeneNet for FGG

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor)FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal)
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COAD (tumor)COAD (normal)
FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor)FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal)
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HNSC (tumor)HNSC (normal)
FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor)FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal)
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KICH (tumor)KICH (normal)
FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor)FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal)
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KIRC (tumor)KIRC (normal)
FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor)FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal)
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KIRP (tumor)KIRP (normal)
FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor)FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal)
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LIHC (tumor)LIHC (normal)
FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor)FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal)
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LUAD (tumor)LUAD (normal)
FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor)FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal)
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LUSC (tumor)LUSC (normal)
FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor)FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal)
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PRAD (tumor)PRAD (normal)
FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor)FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal)
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STAD (tumor)STAD (normal)
FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor)FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal)
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THCA (tumor)THCA (normal)
FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor)FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal)
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TissGeneProg for FGG

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for FGG
TissGeneDrug for FGG

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00364SucralfateAntagonistSmall moleculeApproved


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TissGeneDisease for FGG

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0027051Myocardial Infarction6BeFree,GAD,LHGDN
umls:C0038454Cerebrovascular accident6BeFree,GAD,LHGDN
umls:C0001733Afibrinogenemia4BeFree,LHGDN
umls:C0007222Cardiovascular Diseases4BeFree,GAD,LHGDN
umls:C0007786Brain Ischemia4GAD
umls:C0019250Hereditary factor I deficiency disease4BeFree
umls:C0149871Deep Vein Thrombosis4BeFree,GAD
umls:C0272350Dysfibrinogenemia, Congenital4ORPHANET,UNIPROT
umls:C0553681Hypofibrinogenemia4BeFree
umls:C1260903Dysfibrinogenemia4BeFree
umls:C1561955Fibrinogen Adverse Event4GAD
umls:C0004153Atherosclerosis3BeFree,GAD
umls:C0040053Thrombosis3GAD,LHGDN
umls:C0042487Venous Thrombosis3GAD,LHGDN
umls:C0002395Alzheimer's Disease2GAD
umls:C0042373Vascular Diseases2GAD,LHGDN
umls:C0948008Ischemic stroke2BeFree
umls:C1861172Venous Thromboembolism2GAD,GWASCAT
umls:C3272363Ischemic Cerebrovascular Accident2BeFree
umls:C0003850Arteriosclerosis1BeFree
umls:C0007273Carotid Artery Diseases1GAD
umls:C0007282Carotid Stenosis1GAD
umls:C0007787Transient Ischemic Attack1GAD
umls:C0020538Hypertensive disease1GAD
umls:C0021368Inflammation1GAD
umls:C0022116Ischemia1GAD
umls:C0022548Keloid1CTD_human
umls:C0022658Kidney Diseases1LHGDN
umls:C0023893Liver Cirrhosis, Experimental1RGD
umls:C0024305Lymphoma, Non-Hodgkin1BeFree,GAD
umls:C0026837Muscle Rigidity1BeFree
umls:C0030305Pancreatitis1RGD
umls:C0032285Pneumonia1LHGDN
umls:C0033578Prostatic Neoplasms1LHGDN
umls:C0034065Pulmonary Embolism1RGD
umls:C0038356Stomach Neoplasms1CTD_human
umls:C0040038Thromboembolism1GAD
umls:C0079745Lymphoma, Large-Cell, Follicular1BeFree
umls:C0242383Age related macular degeneration1GAD
umls:C0600433Activated Protein C Resistance1BeFree
umls:C0948089Acute Coronary Syndrome1GAD
umls:C1861171THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder)1BeFree
umls:C1956346Coronary Artery Disease1BeFree,GAD
umls:C2584774Congenital hypofibrinogenemia1MGD,ORPHANET,UNIPROT
umls:C2717961Thrombotic Microangiopathies1BeFree
umls:C2937358Cerebral Hemorrhage1GAD
umls:C0472803Hypodysfibrinogenemia0CLINVAR