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| TissGeneSummary for FGG |
 Gene summary |
| Basic gene information | Gene symbol | FGG |
| Gene name | fibrinogen gamma chain | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 4q28 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000509.4, NM_021870.2, | |
| Description | fibrinogen, gamma polypeptide | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 134850 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000171557 | ||
| HPRD : 00621 | ||
| Vega : OTTHUMG00000150329 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FGG | |
| BioGPS: 2266 | ||
| Pathway | NCI Pathway Interaction Database: FGG | |
| KEGG: FGG | ||
| REACTOME: FGG | ||
| Pathway Commons: FGG | ||
| Context | iHOP: FGG | |
| ligand binding site mutation search in PubMed: FGG | ||
| UCL Cancer Institute: FGG | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of FGG | DNA methylation profiling of the fibrinogen gene landscape in human cells and during mouse and zebrafish development. Vorjohann S, Pitetti JL, Nef S, Gonelle-Gispert C, Buhler L, Fish RJ, Neerman-Arbez M. PLoS One. 2013 Aug 21;8(8):e73089. doi: 10.1371/journal.pone.0073089. eCollection 2013. (pmid:23991173) go to article | |
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0007160 | cell-matrix adhesion | 10903502 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 8100742 | GO:0043623 | cellular protein complex assembly | 8910396 | GO:0045907 | positive regulation of vasoconstriction | 15739255 | GO:0045921 | positive regulation of exocytosis | 19193866 | GO:0050714 | positive regulation of protein secretion | 19193866 | GO:0051592 | response to calcium ion | 6777381 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10903502 | GO:0070527 | platelet aggregation | 6281794 | GO:0090277 | positive regulation of peptide hormone secretion | 19193866 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 | GO:0007160 | cell-matrix adhesion | 10903502 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 8100742 | GO:0043623 | cellular protein complex assembly | 8910396 | GO:0045907 | positive regulation of vasoconstriction | 15739255 | GO:0045921 | positive regulation of exocytosis | 19193866 | GO:0050714 | positive regulation of protein secretion | 19193866 | GO:0051592 | response to calcium ion | 6777381 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10903502 | GO:0070527 | platelet aggregation | 6281794 | GO:0090277 | positive regulation of peptide hormone secretion | 19193866 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 |
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| TissGeneExp for FGG |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 12.85238439 | 14.95392439 | -2.10154 | 1.17E-07 | 8.10E-07 |
| LUSC | 1.726512 | 7.149510039 | -5.422998039 | 1.12E-12 | 5.11E-12 |
| KIRC | 2.055575725 | -0.976340942 | 3.031916667 | 8.61E-07 | 2.22E-06 |
| LUAD | 5.380237219 | 6.913428599 | -1.533191379 | 0.0185 | 0.031059506 |
| KICH | -2.990963608 | -1.362471608 | -1.628492 | 0.00401 | 0.007725559 |
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| TissGene-miRNA for FGG |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FGG |
| TissGeneSNV for FGG |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.L12I | UCEC | 2 |
| p.Y389* | SARC | 1 |
| p.S190N | BLCA | 1 |
| p.N201I | LGG | 1 |
| p.D211N | LUAD | 1 |
| p.L12F | HNSC | 1 |
| p.G429E | SKCM | 1 |
| p.I90V | GBM | 1 |
| p.T247A | BLCA | 1 |
| p.P325S | ESCA | 1 |
| p.R301C | SKCM | 1 |
| p.D32N | SKCM | 1 |
| p.K146T | COAD | 1 |
| p.C352G | STAD | 1 |
| p.L18* | KIRC | 1 |
| p.E349V | LUAD | 1 |
| p.D71N | COAD | 1 |
| p.S99L | BLCA | 1 |
| p.E117Q | BRCA | 1 |
| p.K185* | LUSC | 1 |
| p.G318D | UCEC | 1 |
| p.N334T | SKCM | 1 |
| p.S184Y | UCEC | 1 |
| p.D167N | BLCA | 1 |
| p.G255E | COAD | 1 |
| p.V293M | GBM | 1 |
| p.N363S | SKCM | 1 |
| p.Q337H | GBM | 1 |
| p.D320H | BLCA | 1 |
| p.D181N | THCA | 1 |
| p.G50D | BRCA | 1 |
| p.S182Y | UCEC | 1 |
| p.L20I | UCEC | 1 |
| p.L302I | HNSC | 1 |
| p.S2N | HNSC | 1 |
| p.R301G | SKCM | 1 |
| p.E138* | UCEC | 1 |
| p.T400P | PAAD | 1 |
| p.T408I | SKCM | 1 |
| p.A440V | SARC | 1 |
| p.D346H | UCEC | 1 |
| p.I171N | HNSC | 1 |
| p.R8Q | COAD | 1 |
| p.I210M | SKCM | 1 |
| p.D178H | THYM | 1 |
| p.G216V | LUAD | 1 |
| p.K231N | UCS | 1 |
| p.V28A | UCEC | 1 |
| p.E209K | SKCM | 1 |
| p.E82* | BRCA | 1 |
| p.G176E | CESC | 1 |
| p.D445N | SKCM | 1 |
| p.D323N | GBM | 1 |
| p.V293M | COAD | 1 |
| p.A289V | HNSC | 1 |
| p.G186R | STAD | 1 |
| p.W234C | UCEC | 1 |
| p.D320A | PAAD | 1 |
| p.A108G | DLBC | 1 |
| p.D323N | PRAD | 1 |
| p.D167E | LUSC | 1 |
| p.G216R | SKCM | 1 |
| p.A52T | STAD | 1 |
| p.D320N | BLCA | 1 |
| p.G318S | SKCM | 1 |
| p.L261F | BLCA | 1 |
| p.V228I | GBM | 1 |
| p.P269L | KICH | 1 |
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| TissGeneCNV for FGG |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FGG |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI133452 | OSMR-FGG | chr5:38935743 | chr4:155531313 | |
| Chimerdb3.0 | ChiTaRs | NA | AI174865 | CRTAP-FGG | chr3:33174186 | chr4:155528018 | |
| Chimerdb3.0 | ChiTaRs | NA | AV655197 | FGG-SLC47A1 | chr4:155527904 | chr17:19480676 | |
| Chimerdb3.0 | ChiTaRs | NA | AI207493 | FGG-TSPAN5 | chr4:155533776 | chr4:99496210 | |
| Chimerdb3.0 | ChiTaRs | NA | CB154699 | CPT1A-FGG | chr11:68523409 | chr4:155525288 | |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-49-6743-01A | DCHS2-FGG | In-Frame | chr4:155410455 | chr4:155533353 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-49-6743-01A | DCHS2-FGG | In-frame | Chr4:155410456 | Chr4:155533353 |
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| TissGeneNet for FGG |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor) | FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal) |
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| COAD (tumor) | COAD (normal) |
| FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor) | FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor) | FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal) |
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| KICH (tumor) | KICH (normal) |
| FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor) | FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal) |
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| KIRC (tumor) | KIRC (normal) |
| FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor) | FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor) | FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor) | FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal) |
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| LUAD (tumor) | LUAD (normal) |
| FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor) | FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal) |
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| LUSC (tumor) | LUSC (normal) |
| FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor) | FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal) |
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| PRAD (tumor) | PRAD (normal) |
| FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor) | FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal) |
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| STAD (tumor) | STAD (normal) |
| FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor) | FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal) |
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| THCA (tumor) | THCA (normal) |
| FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (tumor) | FGG, STAT3, HRG, PITX3, ICAM1, ITGB3, IL7R, F13A1, KHDRBS2, CDC73, F2, SERPINA5, FGA, VTN, CTR9, LEO1, ITGAM, FGB, F13B (normal) |
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| TissGeneProg for FGG |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FGG |
| TissGeneDrug for FGG |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00364 | Sucralfate | Antagonist | Small molecule | Approved |
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| TissGeneDisease for FGG |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0027051 | Myocardial Infarction | 6 | BeFree,GAD,LHGDN |
| umls:C0038454 | Cerebrovascular accident | 6 | BeFree,GAD,LHGDN |
| umls:C0001733 | Afibrinogenemia | 4 | BeFree,LHGDN |
| umls:C0007222 | Cardiovascular Diseases | 4 | BeFree,GAD,LHGDN |
| umls:C0007786 | Brain Ischemia | 4 | GAD |
| umls:C0019250 | Hereditary factor I deficiency disease | 4 | BeFree |
| umls:C0149871 | Deep Vein Thrombosis | 4 | BeFree,GAD |
| umls:C0272350 | Dysfibrinogenemia, Congenital | 4 | ORPHANET,UNIPROT |
| umls:C0553681 | Hypofibrinogenemia | 4 | BeFree |
| umls:C1260903 | Dysfibrinogenemia | 4 | BeFree |
| umls:C1561955 | Fibrinogen Adverse Event | 4 | GAD |
| umls:C0004153 | Atherosclerosis | 3 | BeFree,GAD |
| umls:C0040053 | Thrombosis | 3 | GAD,LHGDN |
| umls:C0042487 | Venous Thrombosis | 3 | GAD,LHGDN |
| umls:C0002395 | Alzheimer's Disease | 2 | GAD |
| umls:C0042373 | Vascular Diseases | 2 | GAD,LHGDN |
| umls:C0948008 | Ischemic stroke | 2 | BeFree |
| umls:C1861172 | Venous Thromboembolism | 2 | GAD,GWASCAT |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 2 | BeFree |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0007273 | Carotid Artery Diseases | 1 | GAD |
| umls:C0007282 | Carotid Stenosis | 1 | GAD |
| umls:C0007787 | Transient Ischemic Attack | 1 | GAD |
| umls:C0020538 | Hypertensive disease | 1 | GAD |
| umls:C0021368 | Inflammation | 1 | GAD |
| umls:C0022116 | Ischemia | 1 | GAD |
| umls:C0022548 | Keloid | 1 | CTD_human |
| umls:C0022658 | Kidney Diseases | 1 | LHGDN |
| umls:C0023893 | Liver Cirrhosis, Experimental | 1 | RGD |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | BeFree,GAD |
| umls:C0026837 | Muscle Rigidity | 1 | BeFree |
| umls:C0030305 | Pancreatitis | 1 | RGD |
| umls:C0032285 | Pneumonia | 1 | LHGDN |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0034065 | Pulmonary Embolism | 1 | RGD |
| umls:C0038356 | Stomach Neoplasms | 1 | CTD_human |
| umls:C0040038 | Thromboembolism | 1 | GAD |
| umls:C0079745 | Lymphoma, Large-Cell, Follicular | 1 | BeFree |
| umls:C0242383 | Age related macular degeneration | 1 | GAD |
| umls:C0600433 | Activated Protein C Resistance | 1 | BeFree |
| umls:C0948089 | Acute Coronary Syndrome | 1 | GAD |
| umls:C1861171 | THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder) | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree,GAD |
| umls:C2584774 | Congenital hypofibrinogenemia | 1 | MGD,ORPHANET,UNIPROT |
| umls:C2717961 | Thrombotic Microangiopathies | 1 | BeFree |
| umls:C2937358 | Cerebral Hemorrhage | 1 | GAD |
| umls:C0472803 | Hypodysfibrinogenemia | 0 | CLINVAR |
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