TissGeneSummary for FRMPD1 |
Gene summary |
Basic gene information | Gene symbol | FRMPD1 |
Gene name | FERM and PDZ domain containing 1 | |
Synonyms | FRMD2 | |
Cytomap | UCSC genome browser: 9p13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_014907.2, | |
Description | FERM and PDZ domain-containing protein 1FERM domain-containing protein 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000070601 | ||
HPRD : 17018 | ||
Vega : OTTHUMG00000019927 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FRMPD1 | |
BioGPS: 22844 | ||
Pathway | NCI Pathway Interaction Database: FRMPD1 | |
KEGG: FRMPD1 | ||
REACTOME: FRMPD1 | ||
Pathway Commons: FRMPD1 | ||
Context | iHOP: FRMPD1 | |
ligand binding site mutation search in PubMed: FRMPD1 | ||
UCL Cancer Institute: FRMPD1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
Reference showing the relevant tissue of FRMPD1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FRMPD1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -1.162985863 | 0.667458965 | -1.830444828 | 8.24E-12 | 5.83E-11 |
KIRC | 0.922978792 | 2.244467681 | -1.321488889 | 1.97E-08 | 5.80E-08 |
BRCA | 0.417459933 | 2.409858178 | -1.992398246 | 4.22E-25 | 4.27E-24 |
THCA | -0.939474174 | 0.955341081 | -1.894815254 | 3.12E-15 | 4.11E-14 |
KIRP | 1.141522542 | 2.432410042 | -1.2908875 | 0.000591 | 0.001709706 |
LUSC | -0.626004051 | 0.584241047 | -1.210245098 | 9.00E-05 | 0.00018732 |
HNSC | -0.146710161 | 1.724341002 | -1.871051163 | 2.07E-05 | 0.00010882 |
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TissGene-miRNA for FRMPD1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FRMPD1 |
TissGeneSNV for FRMPD1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P559L | SKCM | 2 |
p.E1292D | UCEC | 2 |
p.E537K | UCEC | 2 |
p.D334Y | UCEC | 1 |
p.G819R | SKCM | 1 |
p.S1037F | BLCA | 1 |
p.E1352V | LUAD | 1 |
p.S175Y | UCEC | 1 |
p.T6P | COAD | 1 |
p.D1180G | LIHC | 1 |
p.D1040Y | STAD | 1 |
p.R217Q | UCEC | 1 |
p.A44T | PAAD | 1 |
p.V568E | BRCA | 1 |
p.E1093* | UCEC | 1 |
p.E3K | COAD | 1 |
p.T1562M | UVM | 1 |
p.G419R | LUAD | 1 |
p.S791T | LUAD | 1 |
p.L369M | COAD | 1 |
p.R1512H | READ | 1 |
p.L387I | UCEC | 1 |
p.P1022S | UCEC | 1 |
p.V535I | STAD | 1 |
p.R1478K | CESC | 1 |
p.Q849E | LUAD | 1 |
p.V458I | BRCA | 1 |
p.A420T | UCEC | 1 |
p.P969L | SKCM | 1 |
p.R55Q | SKCM | 1 |
p.P1304L | UCEC | 1 |
p.V278M | BRCA | 1 |
p.D935H | LUSC | 1 |
p.A611V | THCA | 1 |
p.H1398Y | SKCM | 1 |
p.S675F | SKCM | 1 |
p.A1391T | PRAD | 1 |
p.G998E | LUAD | 1 |
p.A509V | BLCA | 1 |
p.D865N | PAAD | 1 |
p.L65P | LIHC | 1 |
p.R27H | LUAD | 1 |
p.D276Y | READ | 1 |
p.R664I | UCEC | 1 |
p.S993Y | COAD | 1 |
p.Q558H | LUAD | 1 |
p.D818N | BLCA | 1 |
p.L1568V | LIHC | 1 |
p.R257L | LUSC | 1 |
p.R729Q | STAD | 1 |
p.P853T | SKCM | 1 |
p.E1103* | LUAD | 1 |
p.S1307Y | LUAD | 1 |
p.R372X | COAD | 1 |
p.A1407T | TGCT | 1 |
p.Q314H | LUAD | 1 |
p.R647I | UCEC | 1 |
p.Q1194X | UCS | 1 |
p.F1338L | COAD | 1 |
p.A1364G | UCEC | 1 |
p.L390F | BLCA | 1 |
p.R295H | COAD | 1 |
p.A309P | OV | 1 |
p.A774T | BLCA | 1 |
p.R234W | STAD | 1 |
p.K777E | HNSC | 1 |
p.A1391T | PAAD | 1 |
p.L25V | LUAD | 1 |
p.A1313D | HNSC | 1 |
p.Q1570K | PRAD | 1 |
p.S748N | UCEC | 1 |
p.L689P | UCEC | 1 |
p.V1116G | READ | 1 |
p.H1496Q | LUAD | 1 |
p.P1327A | CESC | 1 |
p.Y718N | PRAD | 1 |
p.E1066* | UCEC | 1 |
p.Q1194K | LUAD | 1 |
p.A1028S | ESCA | 1 |
p.E241K | KIRP | 1 |
p.Q1533E | LUSC | 1 |
p.P1031T | LUSC | 1 |
p.E1127* | LUAD | 1 |
p.G599S | LUAD | 1 |
p.S552L | SKCM | 1 |
p.I341V | LUAD | 1 |
p.D1085G | ACC | 1 |
p.S1244T | LUAD | 1 |
p.R1079I | READ | 1 |
p.V1221I | STAD | 1 |
p.R446S | LUAD | 1 |
p.K829N | UCEC | 1 |
p.Q1333P | READ | 1 |
p.D1434Y | STAD | 1 |
p.S141L | SKCM | 1 |
p.D110G | KIRC | 1 |
p.R551I | UCEC | 1 |
p.S359G | OV | 1 |
p.Q1194* | UCS | 1 |
p.E275K | HNSC | 1 |
p.D1243Y | UCS | 1 |
p.G782C | LUAD | 1 |
p.S1272L | SKCM | 1 |
p.P78S | SKCM | 1 |
p.S1286I | UCEC | 1 |
p.E609K | SKCM | 1 |
p.G1183* | PAAD | 1 |
p.V1325A | UCEC | 1 |
p.G92D | LUAD | 1 |
p.P817S | SKCM | 1 |
p.G1138S | LIHC | 1 |
p.D118N | PAAD | 1 |
p.R1556H | COAD | 1 |
p.K1227N | PRAD | 1 |
p.G1183X | PAAD | 1 |
p.G1183E | SKCM | 1 |
p.Y413C | PAAD | 1 |
p.V1442A | SKCM | 1 |
p.A1383D | LIHC | 1 |
p.A1521V | STAD | 1 |
p.D271N | UCEC | 1 |
p.Q286* | LUAD | 1 |
p.V117L | SKCM | 1 |
p.G978D | PAAD | 1 |
p.R372* | UCEC | 1 |
p.E1359X | THYM | 1 |
p.A1028T | STAD | 1 |
p.P1178L | DLBC | 1 |
p.D591G | BLCA | 1 |
p.P780S | STAD | 1 |
p.A44S | LIHC | 1 |
p.R1556H | LUAD | 1 |
p.P747L | SKCM | 1 |
p.E794* | HNSC | 1 |
p.L501I | ESCA | 1 |
p.E613K | SKCM | 1 |
p.D271N | COAD | 1 |
p.E1485K | SKCM | 1 |
p.P1177S | COAD | 1 |
p.V1167L | COAD | 1 |
p.D721Y | READ | 1 |
p.P734L | LUSC | 1 |
p.A90V | SKCM | 1 |
p.E1093Q | LUAD | 1 |
p.R115X | SKCM | 1 |
p.R1384Q | SKCM | 1 |
p.G1039E | KIRP | 1 |
p.I424T | UCEC | 1 |
p.E109D | LIHC | 1 |
p.S378F | ACC | 1 |
p.V1490M | STAD | 1 |
p.D1548N | STAD | 1 |
p.D1238Y | OV | 1 |
p.A482S | LUAD | 1 |
p.K671N | UCEC | 1 |
p.C657G | COAD | 1 |
p.E1229Q | HNSC | 1 |
p.P1078L | SKCM | 1 |
p.R1512L | LUAD | 1 |
p.A442V | UCEC | 1 |
p.P809H | STAD | 1 |
p.R383H | DLBC | 1 |
p.S1037Y | READ | 1 |
p.G1190W | LUAD | 1 |
p.G1055* | UCEC | 1 |
p.P1031L | THYM | 1 |
p.R838I | UCEC | 1 |
p.R543C | LGG | 1 |
p.E251* | LUAD | 1 |
p.F683C | STAD | 1 |
p.K333E | LGG | 1 |
p.C1567S | LUAD | 1 |
p.V138F | LUAD | 1 |
p.N1322K | STAD | 1 |
p.G1502S | UCEC | 1 |
p.I1098N | LUAD | 1 |
p.R115* | SKCM | 1 |
p.G92D | BLCA | 1 |
p.R543C | COAD | 1 |
p.S1405F | SKCM | 1 |
p.E454K | BLCA | 1 |
p.E910K | SKCM | 1 |
p.R1491H | PRAD | 1 |
p.G92S | SKCM | 1 |
p.E794Q | BLCA | 1 |
p.L904R | BLCA | 1 |
p.Q1196E | BLCA | 1 |
p.G1441E | COAD | 1 |
p.V459I | HNSC | 1 |
p.D1238H | DLBC | 1 |
p.R839S | LUAD | 1 |
p.G649R | READ | 1 |
p.S1136F | LUAD | 1 |
p.R16I | UCEC | 1 |
p.P853L | SKCM | 1 |
p.H91Q | SKCM | 1 |
p.Y846C | STAD | 1 |
p.G1441E | LUSC | 1 |
p.L208I | LUSC | 1 |
p.R543H | COAD | 1 |
p.R838I | SKCM | 1 |
p.D865N | STAD | 1 |
p.S136L | STAD | 1 |
p.E519K | SKCM | 1 |
p.R16K | SKCM | 1 |
p.V278M | COAD | 1 |
p.E872K | SKCM | 1 |
p.D98N | SKCM | 1 |
p.S32L | SKCM | 1 |
p.R598H | LUSC | 1 |
p.W685* | SKCM | 1 |
p.P139S | SKCM | 1 |
p.E794G | UCEC | 1 |
p.E926K | UCEC | 1 |
p.R937* | UCEC | 1 |
p.R1512H | COAD | 1 |
p.Q10H | LUAD | 1 |
p.S475F | UCS | 1 |
p.G1106R | UCEC | 1 |
p.H757Y | THYM | 1 |
p.D255N | SKCM | 1 |
p.R1461C | DLBC | 1 |
p.S1394L | UCEC | 1 |
p.A225V | COAD | 1 |
p.E147D | UCEC | 1 |
p.Q558H | ESCA | 1 |
p.S1335C | LUAD | 1 |
p.S1285F | CESC | 1 |
p.P53T | LUAD | 1 |
p.E1485Q | BLCA | 1 |
p.A593T | HNSC | 1 |
p.R729Q | SKCM | 1 |
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TissGeneCNV for FRMPD1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FRMPD1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF091851 | RCOR3-FRMPD1 | chr1:211486319 | chr9:37741487 |
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TissGeneNet for FRMPD1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FRMPD1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FRMPD1 |
TissGeneDrug for FRMPD1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FRMPD1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0024668 | Mammary Neoplasms, Experimental | 1 | RGD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |