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| TissGeneSummary for ZNF365 |
 Gene summary |
| Basic gene information | Gene symbol | ZNF365 |
| Gene name | zinc finger protein 365 | |
| Synonyms | Su48|UAN|ZNF365D | |
| Cytomap | UCSC genome browser: 10q21.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014951.2, NM_199450.2,NM_199451.2,NM_199452.3, | |
| Description | protein ZNF365protein su48talanin | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607818 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000138311 | ||
| HPRD : 06380 | ||
| Vega : OTTHUMG00000018302 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZNF365 | |
| BioGPS: 22891 | ||
| Pathway | NCI Pathway Interaction Database: ZNF365 | |
| KEGG: ZNF365 | ||
| REACTOME: ZNF365 | ||
| Pathway Commons: ZNF365 | ||
| Context | iHOP: ZNF365 | |
| ligand binding site mutation search in PubMed: ZNF365 | ||
| UCL Cancer Institute: ZNF365 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of ZNF365 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ZNF365 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | -0.652551238 | 1.369510831 | -2.022062069 | 1.15E-18 | 1.75E-17 |
| KICH | -2.970907652 | -1.729951652 | -1.240956 | 0.00388 | 0.007514517 |
| KIRP | -0.308320527 | -1.938264277 | 1.62994375 | 7.35E-05 | 0.000261863 |
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| TissGene-miRNA for ZNF365 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ZNF365 |
| TissGeneSNV for ZNF365 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.M51I | BLCA | 2 |
| p.S328L | SKCM | 2 |
| p.S337L | SKCM | 1 |
| p.T62I | LIHC | 1 |
| p.E238K | HNSC | 1 |
| p.I180T | BLCA | 1 |
| p.S167R | STAD | 1 |
| p.E120K | LUAD | 1 |
| p.A367V | COAD | 1 |
| p.T8I | STAD | 1 |
| p.L284V | LIHC | 1 |
| p.V222A | LGG | 1 |
| p.G401V | ESCA | 1 |
| p.A330V | CESC | 1 |
| p.R270Q | STAD | 1 |
| p.V265F | LIHC | 1 |
| p.S41L | LUAD | 1 |
| p.L421P | BRCA | 1 |
| p.A31S | THYM | 1 |
| p.R302C | SKCM | 1 |
| p.G30R | BLCA | 1 |
| p.H334Y | SKCM | 1 |
| p.P96T | LUAD | 1 |
| p.E54K | SKCM | 1 |
| p.E55K | LUAD | 1 |
| p.K342N | PRAD | 1 |
| p.R216L | STAD | 1 |
| p.Q427H | LIHC | 1 |
| p.N20D | COAD | 1 |
| p.S342Y | LUAD | 1 |
| p.S9R | STAD | 1 |
| p.A45V | LUAD | 1 |
| p.L434* | LUAD | 1 |
| p.R233W | BLCA | 1 |
| p.L336I | COAD | 1 |
| p.I436M | CESC | 1 |
| p.G343R | SKCM | 1 |
| p.S93P | PRAD | 1 |
| p.M228I | UCEC | 1 |
| p.K84T | UCS | 1 |
| p.S103C | PAAD | 1 |
| p.Q403* | HNSC | 1 |
| p.N171H | STAD | 1 |
| p.S116Y | LUAD | 1 |
| p.T73P | STAD | 1 |
| p.S77* | LUAD | 1 |
| p.K398R | HNSC | 1 |
| p.G145S | SKCM | 1 |
| p.K182E | UCEC | 1 |
| p.R167* | HNSC | 1 |
| p.K413R | HNSC | 1 |
| p.E18K | READ | 1 |
| p.D173N | SKCM | 1 |
| p.H335L | HNSC | 1 |
| p.S83L | HNSC | 1 |
| p.L188* | LUAD | 1 |
| p.I391T | LUAD | 1 |
| p.W310* | SKCM | 1 |
| p.P26S | SKCM | 1 |
| p.D438N | ESCA | 1 |
| p.V127A | LIHC | 1 |
| p.Q414E | BLCA | 1 |
| p.L73I | BRCA | 1 |
| p.T370M | BLCA | 1 |
| p.Y102H | OV | 1 |
| p.A200V | UCEC | 1 |
| p.S413R | STAD | 1 |
| p.M132I | SKCM | 1 |
| p.R167Q | UCEC | 1 |
| p.Q86H | UCEC | 1 |
| p.N417H | STAD | 1 |
| p.K378N | READ | 1 |
| p.C374X | LIHC | 1 |
| p.S305C | LIHC | 1 |
| p.E327Q | LUAD | 1 |
| p.S2T | PRAD | 1 |
| p.E210K | SKCM | 1 |
| p.P25Q | COAD | 1 |
| p.R235C | PRAD | 1 |
| p.P29T | LUAD | 1 |
| p.A217V | STAD | 1 |
| p.W456* | SKCM | 1 |
| p.Q295H | UCEC | 1 |
| p.R387C | PAAD | 1 |
| p.Q157* | HNSC | 1 |
| p.S84L | HNSC | 1 |
| p.R270Q | LUAD | 1 |
| p.S43L | BLCA | 1 |
| p.S39N | LUAD | 1 |
| p.E365K | SKCM | 1 |
| p.Y124C | LUAD | 1 |
| p.R323Q | BLCA | 1 |
| p.E406Q | CESC | 1 |
| p.D438Y | ESCA | 1 |
| p.T130N | KICH | 1 |
| p.R179I | READ | 1 |
| p.D438N | UCEC | 1 |
| p.R198W | SKCM | 1 |
| p.L232P | STAD | 1 |
| p.E238* | UCEC | 1 |
| p.R344K | SKCM | 1 |
| p.Y11F | BLCA | 1 |
| p.A402V | SKCM | 1 |
| p.H343L | LUAD | 1 |
| p.T17I | PAAD | 1 |
| p.A171S | LUAD | 1 |
| p.G141E | LUAD | 1 |
| p.P377S | SKCM | 1 |
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| TissGeneCNV for ZNF365 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ZNF365 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BLCA | TCGA-BT-A2LA-01A | FAM13C-ZNF365 | Out-of-frame | Chr10:61011335 | Chr10:64382863 |
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| TissGeneNet for ZNF365 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ZNF365, DISC1, HNF1A, NDEL1, NDE1 (tumor) | ZNF365, DISC1, HNF1A, NDEL1, NDE1 (normal) |
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| COAD (tumor) | COAD (normal) |
| ZNF365, DISC1, HNF1A, NDEL1, NDE1 (tumor) | ZNF365, DISC1, HNF1A, NDEL1, NDE1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| ZNF365, DISC1, HNF1A, NDEL1, NDE1 (tumor) | ZNF365, DISC1, HNF1A, NDEL1, NDE1 (normal) |
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| KICH (tumor) | KICH (normal) |
| ZNF365, DISC1, HNF1A, NDEL1, NDE1 (tumor) | ZNF365, DISC1, HNF1A, NDEL1, NDE1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| ZNF365, DISC1, HNF1A, NDEL1, NDE1 (tumor) | ZNF365, DISC1, HNF1A, NDEL1, NDE1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ZNF365, DISC1, HNF1A, NDEL1, NDE1 (tumor) | ZNF365, DISC1, HNF1A, NDEL1, NDE1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ZNF365, DISC1, HNF1A, NDEL1, NDE1 (tumor) | ZNF365, DISC1, HNF1A, NDEL1, NDE1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ZNF365, DISC1, HNF1A, NDEL1, NDE1 (tumor) | ZNF365, DISC1, HNF1A, NDEL1, NDE1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ZNF365, DISC1, HNF1A, NDEL1, NDE1 (tumor) | ZNF365, DISC1, HNF1A, NDEL1, NDE1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| ZNF365, DISC1, HNF1A, NDEL1, NDE1 (tumor) | ZNF365, DISC1, HNF1A, NDEL1, NDE1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| ZNF365, DISC1, HNF1A, NDEL1, NDE1 (tumor) | ZNF365, DISC1, HNF1A, NDEL1, NDE1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| ZNF365, DISC1, HNF1A, NDEL1, NDE1 (tumor) | ZNF365, DISC1, HNF1A, NDEL1, NDE1 (normal) |
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| TissGeneProg for ZNF365 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ZNF365 |
| TissGeneDrug for ZNF365 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ZNF365 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 13 | BeFree,GWASCAT |
| umls:C0010346 | Crohn Disease | 10 | BeFree,GAD,GWASCAT |
| umls:C0678222 | Breast Carcinoma | 10 | BeFree |
| umls:C1846502 | Mammographic Density | 3 | BeFree,GWASCAT |
| umls:C0021390 | Inflammatory Bowel Diseases | 2 | GAD |
| umls:C0011615 | Dermatitis, Atopic | 1 | CTD_human,GWASCAT |
| umls:C0020875 | Ileal Diseases | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0025517 | Metabolic Diseases | 1 | BeFree |
| umls:C0027404 | Narcolepsy | 1 | GWASCAT,ORPHANET |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042170 | Uveomeningoencephalitic Syndrome | 1 | BeFree |
| umls:C0425782 | Breast size | 1 | GWASCAT |
| umls:C0451641 | Urolithiasis | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | CTD_human |
| umls:C1510586 | Autism Spectrum Disorders | 1 | GWASCAT |
| umls:C0751362 | Narcolepsy-Cataplexy Syndrome | 0 | ORPHANET |
| umls:C2700426 | NEPHROLITHIASIS, URIC ACID, SUSCEPTIBILITY TO (finding) | 0 | CLINVAR,CTD_human |
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