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| TissGeneSummary for ALDOB |
 Gene summary |
| Basic gene information | Gene symbol | ALDOB |
| Gene name | aldolase B, fructose-bisphosphate | |
| Synonyms | ALDB|ALDO2 | |
| Cytomap | UCSC genome browser: 9q21.3-q22.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000035.3, | |
| Description | aldolase 2aldolase B, fructose-bisphosphatasefructose-bisphosphate aldolase Bliver-type aldolase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612724 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000136872 | ||
| HPRD : 01972 | ||
| Vega : OTTHUMG00000020378 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ALDOB | |
| BioGPS: 229 | ||
| Pathway | NCI Pathway Interaction Database: ALDOB | |
| KEGG: ALDOB | ||
| REACTOME: ALDOB | ||
| Pathway Commons: ALDOB | ||
| Context | iHOP: ALDOB | |
| ligand binding site mutation search in PubMed: ALDOB | ||
| UCL Cancer Institute: ALDOB | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of ALDOB | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006096 | glycolytic process | 10625657 | GO:0006116 | NADH oxidation | 17576770 | GO:0030388 | fructose 1,6-bisphosphate metabolic process | 10625657 | GO:0006096 | glycolytic process | 10625657 | GO:0006116 | NADH oxidation | 17576770 | GO:0030388 | fructose 1,6-bisphosphate metabolic process | 10625657 |
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| TissGeneExp for ALDOB |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -0.853020545 | 8.620375455 | -9.473396 | 1.69E-13 | 2.33E-12 |
| KIRC | 4.528343955 | 9.269228678 | -4.740884722 | 3.13E-12 | 1.29E-11 |
| LIHC | 10.51871946 | 13.44697346 | -2.928254 | 1.48E-08 | 1.26E-07 |
| KIRP | 1.89095333 | 10.62826271 | -8.737309375 | 2.65E-17 | 1.19E-15 |
| BRCA | -3.228069422 | -2.146536089 | -1.081533333 | 2.06E-15 | 1.10E-14 |
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| TissGene-miRNA for ALDOB |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ALDOB |
| TissGeneSNV for ALDOB |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E100K | SKCM | 3 |
| p.R4Q | UCEC | 2 |
| p.G29R | SKCM | 2 |
| p.L128H | LUAD | 1 |
| p.G102E | SKCM | 1 |
| p.D110N | SKCM | 1 |
| p.F328V | TGCT | 1 |
| p.K28N | STAD | 1 |
| p.S65F | HNSC | 1 |
| p.Q90H | COAD | 1 |
| p.Q248K | LUAD | 1 |
| p.F300L | UCEC | 1 |
| p.A211V | STAD | 1 |
| p.T9A | UCEC | 1 |
| p.L284H | GBM | 1 |
| p.R259C | SKCM | 1 |
| p.T260N | ESCA | 1 |
| p.R331Q | CESC | 1 |
| p.R259H | SARC | 1 |
| p.W296* | UCEC | 1 |
| p.I70T | LUSC | 1 |
| p.R331W | OV | 1 |
| p.C290F | STAD | 1 |
| p.P115S | SKCM | 1 |
| p.N55K | LUAD | 1 |
| p.S132* | LUAD | 1 |
| p.W148* | UCEC | 1 |
| p.V66M | LUAD | 1 |
| p.T206P | HNSC | 1 |
| p.G341R | SKCM | 1 |
| p.A280V | STAD | 1 |
| p.V105M | THCA | 1 |
| p.T253I | SKCM | 1 |
| p.G29E | SKCM | 1 |
| p.A239S | COAD | 1 |
| p.A319T | STAD | 1 |
| p.K13T | STAD | 1 |
| p.L79P | THYM | 1 |
| p.R56C | UCEC | 1 |
| p.A2T | LGG | 1 |
| p.G195E | COAD | 1 |
| p.P231R | BLCA | 1 |
| p.E54D | COAD | 1 |
| p.A163T | COAD | 1 |
| p.A172T | SKCM | 1 |
| p.S348F | BRCA | 1 |
| p.P6L | SKCM | 1 |
| p.Y204H | ESCA | 1 |
| p.R173C | BLCA | 1 |
| p.A25T | STAD | 1 |
| p.R56H | COAD | 1 |
| p.Y174C | STAD | 1 |
| p.I164T | DLBC | 1 |
| p.G182R | SKCM | 1 |
| p.A32T | PAAD | 1 |
| p.L31M | LUSC | 1 |
| p.K230T | UCEC | 1 |
| p.L63F | SKCM | 1 |
| p.Q179K | LUAD | 1 |
| p.E322* | SKCM | 1 |
| p.T245S | HNSC | 1 |
| p.S301P | UCEC | 1 |
| p.D141Y | BLCA | 1 |
| p.F145Y | SKCM | 1 |
| p.L289R | HNSC | 1 |
| p.S17L | BRCA | 1 |
| p.R259C | PAAD | 1 |
| p.F64L | LIHC | 1 |
| p.Q180H | COAD | 1 |
| p.G130S | SKCM | 1 |
| p.P6A | SKCM | 1 |
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| TissGeneCNV for ALDOB |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ALDOB |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI061606 | INS-IGF2-ALDOB | chr11:2153101 | chr9:104188841 | |
| Chimerdb3.0 | ChiTaRs | NA | BC005314 | TXNL4B-ALDOB | chr16:72090495 | chr9:104183658 | |
| TCGAfusionPortal | PRADA | PRAD | TCGA-XQ-A8TA-01A | SNX30-ALDOB | In-frame | Chr9:115626679 | Chr9:104184186 |
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| TissGeneNet for ALDOB |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (tumor) | ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (normal) |
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| COAD (tumor) | COAD (normal) |
| ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (tumor) | ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (tumor) | ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (normal) |
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| KICH (tumor) | KICH (normal) |
| ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (tumor) | ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (tumor) | ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (tumor) | ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (tumor) | ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (tumor) | ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (tumor) | ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (tumor) | ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (normal) |
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| STAD (tumor) | STAD (normal) |
| ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (tumor) | ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (normal) |
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| THCA (tumor) | THCA (normal) |
| ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (tumor) | ALDOB, HSPA8, BBS1, TXN2, BBS2, ALDOA, BBS4, HIVEP1, ATP6V1E1, AGXT2, HUS1, BBS7, MUC20 (normal) |
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| TissGeneProg for ALDOB |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ALDOB |
| TissGeneDrug for ALDOB |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ALDOB |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0016751 | Hereditary fructose intolerance syndrome | 13 | BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD,ORPHANET,UNIPROT |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | GAD,RGD |
| umls:C0003130 | Anoxia | 1 | CTD_human |
| umls:C0009324 | Ulcerative Colitis | 1 | LHGDN |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0014859 | Esophageal Neoplasms | 1 | RGD |
| umls:C0019196 | Hepatitis C | 1 | GAD |
| umls:C0023903 | Liver neoplasms | 1 | RGD |
| umls:C0031154 | Peritonitis | 1 | RGD |
| umls:C0038356 | Stomach Neoplasms | 1 | CTD_human |
| umls:C0086543 | Cataract | 1 | BeFree |
| umls:C0149670 | Disorder of carbohydrate metabolism | 1 | BeFree |
| umls:C0241910 | Hepatitis, Autoimmune | 1 | CTD_human |
| umls:C0521707 | Bilateral cataracts (disorder) | 1 | BeFree |
| umls:C0860207 | Drug-Induced Liver Injury | 1 | CTD_human |
| umls:C1561546 | Alkaline Phosphatase Adverse Event | 1 | GAD |
| umls:C2239176 | Liver carcinoma | 1 | GAD |
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