TissGeneSummary for VSIG2 |
Gene summary |
Basic gene information | Gene symbol | VSIG2 |
Gene name | V-set and immunoglobulin domain containing 2 | |
Synonyms | 2210413P10Rik|CTH|CTXL | |
Cytomap | UCSC genome browser: 11q24 | |
Type of gene | protein-coding | |
RefGenes | NM_014312.3, | |
Description | CT-like proteinV-set and immunoglobulin domain-containing protein 2cortical thymocyte receptor (X. laevis CTX) likecortical thymocyte-like protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 606011 | |
HGNC : HGNC | ||
Ensembl : ENSG00000019102 | ||
HPRD : 08390 | ||
Vega : OTTHUMG00000150357 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_VSIG2 | |
BioGPS: 23584 | ||
Pathway | NCI Pathway Interaction Database: VSIG2 | |
KEGG: VSIG2 | ||
REACTOME: VSIG2 | ||
Pathway Commons: VSIG2 | ||
Context | iHOP: VSIG2 | |
ligand binding site mutation search in PubMed: VSIG2 | ||
UCL Cancer Institute: VSIG2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
Reference showing the relevant tissue of VSIG2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for VSIG2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | 1.319230595 | 5.752153672 | -4.432923077 | 8.72E-09 | 7.84E-08 |
KIRC | -3.393471435 | -0.678570046 | -2.714901389 | 3.71E-24 | 4.12E-23 |
HNSC | -2.976244271 | 1.521365031 | -4.497609302 | 8.32E-14 | 4.12E-12 |
LIHC | -2.478777713 | 0.333662287 | -2.81244 | 3.59E-08 | 2.81E-07 |
LUSC | -1.262221517 | 4.080633385 | -5.342854902 | 1.63E-21 | 2.34E-20 |
LUAD | 0.892048632 | 4.340483115 | -3.448434483 | 1.67E-13 | 1.42E-12 |
KIRP | -4.597774213 | -0.242605463 | -4.35516875 | 2.79E-17 | 1.23E-15 |
BRCA | -1.842207327 | 0.807008463 | -2.649215789 | 1.97E-15 | 1.05E-14 |
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TissGene-miRNA for VSIG2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for VSIG2 |
TissGeneSNV for VSIG2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P148S | SKCM | 2 |
p.R181H | STAD | 1 |
p.F55L | CESC | 1 |
p.R241Q | HNSC | 1 |
p.P144S | SKCM | 1 |
p.G200S | THCA | 1 |
p.G279R | LIHC | 1 |
p.E276K | SKCM | 1 |
p.R181C | STAD | 1 |
p.P84L | GBM | 1 |
p.E170K | LUAD | 1 |
p.V327L | LUSC | 1 |
p.R241P | HNSC | 1 |
p.G160D | KIRC | 1 |
p.N178S | STAD | 1 |
p.K27N | LGG | 1 |
p.R241Q | SKCM | 1 |
p.F129L | UCEC | 1 |
p.G244E | LUAD | 1 |
p.L106M | LUSC | 1 |
p.G21E | LUAD | 1 |
p.V123I | STAD | 1 |
p.L256M | PAAD | 1 |
p.A56S | LUAD | 1 |
p.C45Y | UCEC | 1 |
p.G133E | KIRP | 1 |
p.Y76X | READ | 1 |
p.R284Q | SKCM | 1 |
p.Q152H | TGCT | 1 |
p.D53Y | BLCA | 1 |
p.E58D | HNSC | 1 |
p.T235S | LIHC | 1 |
p.R309* | LUSC | 1 |
p.P188L | SKCM | 1 |
p.E197K | LUAD | 1 |
p.P98L | SKCM | 1 |
p.E269K | SKCM | 1 |
p.Q222* | ACC | 1 |
p.R241P | BLCA | 1 |
p.P173S | HNSC | 1 |
p.R181H | LGG | 1 |
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TissGeneCNV for VSIG2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for VSIG2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AW843261 | VSIG2-VSIG2 | chr11:124620476 | chr11:124620147 | |
Chimerdb3.0 | ChiTaRs | NA | BG981989 | VSIG2-VSIG2 | chr11:124618326 | chr11:124617370 |
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TissGeneNet for VSIG2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for VSIG2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for VSIG2 |
TissGeneDrug for VSIG2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for VSIG2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0220993 | Cystathioninuria | 2 | BeFree |
umls:C0268616 | Gamma-cystathionase deficiency | 2 | BeFree |
umls:C0002986 | Fabry Disease | 1 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | BeFree |
umls:C0024141 | Lupus Erythematosus, Systemic | 1 | GAD |
umls:C0699885 | Carcinoma of bladder | 1 | BeFree |