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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for DAPK2
check button Gene summary
Basic gene informationGene symbolDAPK2
Gene namedeath-associated protein kinase 2
SynonymsDRP-1|DRP1
CytomapUCSC genome browser: 15q22.31
Type of geneprotein-coding
RefGenesNM_014326.3,
DescriptionDAP kinase 2DAP-kinase-related protein 1 beta isoform
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000035664
HPRD : 09905
Vega : OTTHUMG00000132947
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DAPK2
BioGPS: 23604
PathwayNCI Pathway Interaction Database: DAPK2
KEGG: DAPK2
REACTOME: DAPK2
Pathway Commons: DAPK2
ContextiHOP: DAPK2
ligand binding site mutation search in PubMed: DAPK2
UCL Cancer Institute: DAPK2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)ColonThyroid gland
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)COADTHCA
Reference showing the relevant tissue of DAPK2
Description by TissGene annotationsCancer gene
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006468protein phosphorylation10376525
GO:0035556intracellular signal transduction10376525
GO:0006468protein phosphorylation10376525
GO:0035556intracellular signal transduction10376525


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TissGeneExp for DAPK2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUAD-0.0783795962.521011783-2.5993913791.55E-279.93E-26
BRCA-0.2020391241.07621263-1.2782517548.03E-236.96E-22
LIHC-0.089894492-1.4882284921.3983347.01E-096.38E-08
LUSC-0.8104708062.217878213-3.028349022.31E-244.60E-23
THCA4.2171677452.8425609651.374606781.62E-111.20E-10


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TissGene-miRNA for DAPK2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for DAPK2
TissGeneSNV for DAPK2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R366KSKCM2
p.D91NSKCM1
p.E451QCESC1
p.Y49NESCA1
p.R345MKIRC1
p.R79WLGG1
p.R57WLIHC1
p.E248*KIRC1
p.R41QSKCM1
p.Y49HSTAD1
p.I130VLUAD1
p.S5*BLCA1
p.F112LLIHC1
p.Q291LLUAD1
p.R313SKIRP1
p.V199ASTAD1
p.V300EBRCA1
p.S59RACC1
p.R96HUCEC1
p.K18NCOAD1
p.P363SKIRP1
p.I276VKIRP1
p.L220IUCEC1
p.D113NCOAD1
p.H166PSKCM1
p.E177KUCEC1
p.T329SSTAD1
p.H147YLUAD1
p.E202KSKCM1
p.W315RLIHC1
p.K308ESARC1
p.R263QCOAD1
p.G205DSKCM1
p.A61ELIHC1
p.T88ABLCA1
p.E248XKIRC1
p.P13SCOAD1
p.I170FCOAD1
p.L174MLGG1
p.H141YSKCM1
p.R96SBLCA1


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TissGeneCNV for DAPK2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for DAPK2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABQ359645TMOD1-DAPK2chr9:100363524chr15:64199416
Chimerdb3.0ChiTaRsNAAI692764DAPK2-MAP2K5chr15:64332457chr15:68098982
Chimerdb3.0ChiTaRsNABQ330581DAPK2-RPL8chr15:64241410chr8:146015269
Chimerdb3.0ChiTaRsNAAW013877DAPK2-MAP2K5chr15:64338528chr15:68098982
Chimerdb3.0ChiTaRsNABI035829DAPK2-DAPK2chr15:64204020chr15:64203809
TCGAfusionPortalPRADABLCATCGA-DK-A3X2-01AHERC1-DAPK25UTR-CDSChr15:64126026Chr15:64231560
TCGAfusionPortalPRADABRCATCGA-D8-A1JK-01AHERC1-DAPK25UTR-CDSChr15:64126026Chr15:64204396


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TissGeneNet for DAPK2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
DAPK2, CAMK2A, MLC1 (tumor)DAPK2, CAMK2A, MLC1 (normal)
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COAD (tumor)COAD (normal)
DAPK2, CAMK2A, MLC1 (tumor)DAPK2, CAMK2A, MLC1 (normal)
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HNSC (tumor)HNSC (normal)
DAPK2, CAMK2A, MLC1 (tumor)DAPK2, CAMK2A, MLC1 (normal)
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KICH (tumor)KICH (normal)
DAPK2, CAMK2A, MLC1 (tumor)DAPK2, CAMK2A, MLC1 (normal)
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KIRC (tumor)KIRC (normal)
DAPK2, CAMK2A, MLC1 (tumor)DAPK2, CAMK2A, MLC1 (normal)
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KIRP (tumor)KIRP (normal)
DAPK2, CAMK2A, MLC1 (tumor)DAPK2, CAMK2A, MLC1 (normal)
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LIHC (tumor)LIHC (normal)
DAPK2, CAMK2A, MLC1 (tumor)DAPK2, CAMK2A, MLC1 (normal)
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LUAD (tumor)LUAD (normal)
DAPK2, CAMK2A, MLC1 (tumor)DAPK2, CAMK2A, MLC1 (normal)
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LUSC (tumor)LUSC (normal)
DAPK2, CAMK2A, MLC1 (tumor)DAPK2, CAMK2A, MLC1 (normal)
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PRAD (tumor)PRAD (normal)
DAPK2, CAMK2A, MLC1 (tumor)DAPK2, CAMK2A, MLC1 (normal)
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STAD (tumor)STAD (normal)
DAPK2, CAMK2A, MLC1 (tumor)DAPK2, CAMK2A, MLC1 (normal)
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THCA (tumor)THCA (normal)
DAPK2, CAMK2A, MLC1 (tumor)DAPK2, CAMK2A, MLC1 (normal)
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TissGeneProg for DAPK2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for DAPK2
TissGeneDrug for DAPK2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for DAPK2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0006142Malignant neoplasm of breast3BeFree
umls:C0678222Breast Carcinoma3BeFree
umls:C0030567Parkinson Disease2BeFree
umls:C0002736Amyotrophic Lateral Sclerosis1BeFree
umls:C0005695Bladder Neoplasm1LHGDN
umls:C0018801Heart failure1BeFree
umls:C0018802Congestive heart failure1BeFree
umls:C0020456Hyperglycemia1BeFree
umls:C0022116Ischemia1BeFree
umls:C0023467Leukemia, Myelocytic, Acute1BeFree
umls:C0023487Acute Promyelocytic Leukemia1BeFree
umls:C0025202melanoma1BeFree
umls:C0026764Multiple Myeloma1BeFree
umls:C0027819Neuroblastoma1BeFree
umls:C0028754Obesity1BeFree
umls:C0029463Osteosarcoma1BeFree
umls:C0038356Stomach Neoplasms1LHGDN
umls:C0152171Idiopathic pulmonary hypertension1BeFree
umls:C0234958Muscle degeneration1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0338656Impaired cognition1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0524851Neurodegenerative Disorders1BeFree
umls:C0585442Osteosarcoma of bone1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0751955Brain Infarction1BeFree
umls:C2973725Pulmonary arterial hypertension1BeFree
umls:C3714844Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia1BeFree