TissGeneSummary for DAPK2 |
Gene summary |
Basic gene information | Gene symbol | DAPK2 |
Gene name | death-associated protein kinase 2 | |
Synonyms | DRP-1|DRP1 | |
Cytomap | UCSC genome browser: 15q22.31 | |
Type of gene | protein-coding | |
RefGenes | NM_014326.3, | |
Description | DAP kinase 2DAP-kinase-related protein 1 beta isoform | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000035664 | ||
HPRD : 09905 | ||
Vega : OTTHUMG00000132947 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DAPK2 | |
BioGPS: 23604 | ||
Pathway | NCI Pathway Interaction Database: DAPK2 | |
KEGG: DAPK2 | ||
REACTOME: DAPK2 | ||
Pathway Commons: DAPK2 | ||
Context | iHOP: DAPK2 | |
ligand binding site mutation search in PubMed: DAPK2 | ||
UCL Cancer Institute: DAPK2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonThyroid gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADTHCA | |
Reference showing the relevant tissue of DAPK2 | ||
Description by TissGene annotations | Cancer gene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006468 | protein phosphorylation | 10376525 | GO:0035556 | intracellular signal transduction | 10376525 | GO:0006468 | protein phosphorylation | 10376525 | GO:0035556 | intracellular signal transduction | 10376525 |
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TissGeneExp for DAPK2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -0.078379596 | 2.521011783 | -2.599391379 | 1.55E-27 | 9.93E-26 |
BRCA | -0.202039124 | 1.07621263 | -1.278251754 | 8.03E-23 | 6.96E-22 |
LIHC | -0.089894492 | -1.488228492 | 1.398334 | 7.01E-09 | 6.38E-08 |
LUSC | -0.810470806 | 2.217878213 | -3.02834902 | 2.31E-24 | 4.60E-23 |
THCA | 4.217167745 | 2.842560965 | 1.37460678 | 1.62E-11 | 1.20E-10 |
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TissGene-miRNA for DAPK2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DAPK2 |
TissGeneSNV for DAPK2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R366K | SKCM | 2 |
p.D91N | SKCM | 1 |
p.E451Q | CESC | 1 |
p.Y49N | ESCA | 1 |
p.R345M | KIRC | 1 |
p.R79W | LGG | 1 |
p.R57W | LIHC | 1 |
p.E248* | KIRC | 1 |
p.R41Q | SKCM | 1 |
p.Y49H | STAD | 1 |
p.I130V | LUAD | 1 |
p.S5* | BLCA | 1 |
p.F112L | LIHC | 1 |
p.Q291L | LUAD | 1 |
p.R313S | KIRP | 1 |
p.V199A | STAD | 1 |
p.V300E | BRCA | 1 |
p.S59R | ACC | 1 |
p.R96H | UCEC | 1 |
p.K18N | COAD | 1 |
p.P363S | KIRP | 1 |
p.I276V | KIRP | 1 |
p.L220I | UCEC | 1 |
p.D113N | COAD | 1 |
p.H166P | SKCM | 1 |
p.E177K | UCEC | 1 |
p.T329S | STAD | 1 |
p.H147Y | LUAD | 1 |
p.E202K | SKCM | 1 |
p.W315R | LIHC | 1 |
p.K308E | SARC | 1 |
p.R263Q | COAD | 1 |
p.G205D | SKCM | 1 |
p.A61E | LIHC | 1 |
p.T88A | BLCA | 1 |
p.E248X | KIRC | 1 |
p.P13S | COAD | 1 |
p.I170F | COAD | 1 |
p.L174M | LGG | 1 |
p.H141Y | SKCM | 1 |
p.R96S | BLCA | 1 |
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TissGeneCNV for DAPK2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DAPK2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BQ359645 | TMOD1-DAPK2 | chr9:100363524 | chr15:64199416 | |
Chimerdb3.0 | ChiTaRs | NA | AI692764 | DAPK2-MAP2K5 | chr15:64332457 | chr15:68098982 | |
Chimerdb3.0 | ChiTaRs | NA | BQ330581 | DAPK2-RPL8 | chr15:64241410 | chr8:146015269 | |
Chimerdb3.0 | ChiTaRs | NA | AW013877 | DAPK2-MAP2K5 | chr15:64338528 | chr15:68098982 | |
Chimerdb3.0 | ChiTaRs | NA | BI035829 | DAPK2-DAPK2 | chr15:64204020 | chr15:64203809 | |
TCGAfusionPortal | PRADA | BLCA | TCGA-DK-A3X2-01A | HERC1-DAPK2 | 5UTR-CDS | Chr15:64126026 | Chr15:64231560 |
TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A1JK-01A | HERC1-DAPK2 | 5UTR-CDS | Chr15:64126026 | Chr15:64204396 |
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TissGeneNet for DAPK2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DAPK2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DAPK2 |
TissGeneDrug for DAPK2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DAPK2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C0030567 | Parkinson Disease | 2 | BeFree |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
umls:C0005695 | Bladder Neoplasm | 1 | LHGDN |
umls:C0018801 | Heart failure | 1 | BeFree |
umls:C0018802 | Congestive heart failure | 1 | BeFree |
umls:C0020456 | Hyperglycemia | 1 | BeFree |
umls:C0022116 | Ischemia | 1 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
umls:C0023487 | Acute Promyelocytic Leukemia | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0026764 | Multiple Myeloma | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C0029463 | Osteosarcoma | 1 | BeFree |
umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
umls:C0152171 | Idiopathic pulmonary hypertension | 1 | BeFree |
umls:C0234958 | Muscle degeneration | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0338656 | Impaired cognition | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0524851 | Neurodegenerative Disorders | 1 | BeFree |
umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C0751955 | Brain Infarction | 1 | BeFree |
umls:C2973725 | Pulmonary arterial hypertension | 1 | BeFree |
umls:C3714844 | Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 1 | BeFree |