TissGeneSummary for NPAP1 |
Gene summary |
Basic gene information | Gene symbol | NPAP1 |
Gene name | nuclear pore associated protein 1 | |
Synonyms | C15orf2 | |
Cytomap | UCSC genome browser: 15q11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_018958.2, | |
Description | nuclear pore-associated protein 1protein C15orf2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610922 | |
HGNC : HGNC | ||
Ensembl : ENSG00000185823 | ||
HPRD : 08506 | ||
Vega : OTTHUMG00000129179 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NPAP1 | |
BioGPS: 23742 | ||
Pathway | NCI Pathway Interaction Database: NPAP1 | |
KEGG: NPAP1 | ||
REACTOME: NPAP1 | ||
Pathway Commons: NPAP1 | ||
Context | iHOP: NPAP1 | |
ligand binding site mutation search in PubMed: NPAP1 | ||
UCL Cancer Institute: NPAP1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of NPAP1 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for NPAP1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for NPAP1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NPAP1 |
TissGeneSNV for NPAP1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G210E | SKCM | 7 |
p.S528F | SKCM | 5 |
p.S887F | SKCM | 4 |
p.G481R | SKCM | 3 |
p.G1080E | SKCM | 2 |
p.E170K | SKCM | 2 |
p.P333L | SKCM | 2 |
p.R56L | LUAD | 2 |
p.D791N | SKCM | 2 |
p.P573S | SKCM | 2 |
p.P166S | SKCM | 2 |
p.D347N | SKCM | 2 |
p.G615E | SKCM | 2 |
p.P86T | LUAD | 2 |
p.P166L | SKCM | 2 |
p.P27L | SKCM | 2 |
p.S1098L | SKCM | 2 |
p.P459S | SKCM | 2 |
p.R95K | SKCM | 2 |
p.D384N | SKCM | 2 |
p.Q1120* | SKCM | 2 |
p.D173N | SKCM | 2 |
p.L437I | HNSC | 1 |
p.N391K | SARC | 1 |
p.G938C | LUAD | 1 |
p.P536S | SKCM | 1 |
p.P614Q | ESCA | 1 |
p.P27S | SKCM | 1 |
p.W152X | SKCM | 1 |
p.A1085V | SKCM | 1 |
p.S204N | SKCM | 1 |
p.P71Q | LUAD | 1 |
p.T446I | SKCM | 1 |
p.E150K | SKCM | 1 |
p.T407A | HNSC | 1 |
p.P303T | LUAD | 1 |
p.E452D | BLCA | 1 |
p.R328S | STAD | 1 |
p.P119L | HNSC | 1 |
p.S970R | LUAD | 1 |
p.R513K | SKCM | 1 |
p.P800S | SKCM | 1 |
p.G247E | SKCM | 1 |
p.T551M | CESC | 1 |
p.S599F | SKCM | 1 |
p.S120G | STAD | 1 |
p.P466H | LUAD | 1 |
p.D579V | LIHC | 1 |
p.P295L | STAD | 1 |
p.L180P | LIHC | 1 |
p.A491S | LUAD | 1 |
p.L786F | BLCA | 1 |
p.P240T | LUAD | 1 |
p.P471S | SKCM | 1 |
p.G49S | SKCM | 1 |
p.E387K | SKCM | 1 |
p.H629Q | LUAD | 1 |
p.A61E | LUAD | 1 |
p.K1132N | PAAD | 1 |
p.S594I | LUAD | 1 |
p.K648R | SKCM | 1 |
p.P931L | BLCA | 1 |
p.W1128S | LGG | 1 |
p.P358H | CESC | 1 |
p.P931S | LUAD | 1 |
p.R131S | LIHC | 1 |
p.W152* | SKCM | 1 |
p.S706T | LUAD | 1 |
p.S785Y | LUAD | 1 |
p.P876L | SKCM | 1 |
p.G11R | UCS | 1 |
p.P601S | SKCM | 1 |
p.G992E | SKCM | 1 |
p.R45C | PRAD | 1 |
p.A985V | THYM | 1 |
p.R348* | SKCM | 1 |
p.R849Q | BLCA | 1 |
p.L444F | SKCM | 1 |
p.L861Q | LUAD | 1 |
p.A430D | LUAD | 1 |
p.R250W | LGG | 1 |
p.G489E | LUAD | 1 |
p.I941F | SKCM | 1 |
p.S372N | SKCM | 1 |
p.M122L | BLCA | 1 |
p.E845* | LUAD | 1 |
p.S741* | LUAD | 1 |
p.P829L | LUAD | 1 |
p.M548T | PAAD | 1 |
p.C1099F | PRAD | 1 |
p.S537F | SKCM | 1 |
p.G1044E | SKCM | 1 |
p.E283K | SKCM | 1 |
p.S331L | LGG | 1 |
p.S528F | HNSC | 1 |
p.S591F | SKCM | 1 |
p.R15W | LGG | 1 |
p.E514V | LUAD | 1 |
p.P27T | LGG | 1 |
p.R57H | LIHC | 1 |
p.P536H | PAAD | 1 |
p.V198L | LUAD | 1 |
p.S663T | LUAD | 1 |
p.P73H | LUAD | 1 |
p.S562F | ESCA | 1 |
p.Q781H | LUAD | 1 |
p.S113F | SKCM | 1 |
p.P573L | SKCM | 1 |
p.A67V | BLCA | 1 |
p.L465F | DLBC | 1 |
p.P73T | LUAD | 1 |
p.Y952C | LUAD | 1 |
p.P829S | SKCM | 1 |
p.S809I | LUAD | 1 |
p.R131C | KIRP | 1 |
p.R30W | SKCM | 1 |
p.S804F | SKCM | 1 |
p.A961V | HNSC | 1 |
p.G253E | SKCM | 1 |
p.P427A | MESO | 1 |
p.D496E | SKCM | 1 |
p.G779E | SKCM | 1 |
p.D173N | ACC | 1 |
p.P919S | SARC | 1 |
p.A433V | SKCM | 1 |
p.S1033L | BLCA | 1 |
p.G23D | ACC | 1 |
p.A561T | PAAD | 1 |
p.E164K | SKCM | 1 |
p.P647L | SKCM | 1 |
p.P500R | HNSC | 1 |
p.E155D | LGG | 1 |
p.L565I | LUAD | 1 |
p.A238P | HNSC | 1 |
p.A903D | HNSC | 1 |
p.E363D | LUAD | 1 |
p.P462S | SKCM | 1 |
p.R158K | SKCM | 1 |
p.R22H | SARC | 1 |
p.P763S | LGG | 1 |
p.R52H | STAD | 1 |
p.D1105N | LUAD | 1 |
p.F8L | SKCM | 1 |
p.S939N | SKCM | 1 |
p.P295T | LUAD | 1 |
p.R513T | LUAD | 1 |
p.P352L | SKCM | 1 |
p.H629Q | BLCA | 1 |
p.S634C | STAD | 1 |
p.N104T | HNSC | 1 |
p.Q870K | THYM | 1 |
p.P307S | SKCM | 1 |
p.V487F | BLCA | 1 |
p.A467V | SKCM | 1 |
p.P237S | LGG | 1 |
p.I820F | PRAD | 1 |
p.S634R | STAD | 1 |
p.P307H | LUAD | 1 |
p.S562F | SKCM | 1 |
p.S584P | SARC | 1 |
p.S518Y | LUAD | 1 |
p.R52C | SKCM | 1 |
p.I820V | BLCA | 1 |
p.R70S | LIHC | 1 |
p.V1116A | LUAD | 1 |
p.H629N | LUAD | 1 |
p.V167L | LUAD | 1 |
p.A490T | HNSC | 1 |
p.P524R | HNSC | 1 |
p.R76W | SKCM | 1 |
p.P75H | HNSC | 1 |
p.P293S | SKCM | 1 |
p.M450I | SKCM | 1 |
p.D824V | STAD | 1 |
p.P1117L | SKCM | 1 |
p.L92M | CESC | 1 |
p.M1024T | LIHC | 1 |
p.P922R | LUAD | 1 |
p.H39Q | LUAD | 1 |
p.A971G | HNSC | 1 |
p.P466S | HNSC | 1 |
p.P105S | SKCM | 1 |
p.T388I | SKCM | 1 |
p.G615R | SKCM | 1 |
p.P749S | STAD | 1 |
p.G183R | LGG | 1 |
p.S831F | SKCM | 1 |
p.P442S | SKCM | 1 |
p.T447P | HNSC | 1 |
p.D163N | SKCM | 1 |
p.V1111F | LUAD | 1 |
p.P601Q | SKCM | 1 |
p.Q743H | LUAD | 1 |
p.G1112R | SKCM | 1 |
p.T957I | STAD | 1 |
p.G1090D | LGG | 1 |
p.K329* | SKCM | 1 |
p.H898Y | SKCM | 1 |
p.G1012E | SKCM | 1 |
p.P674A | LUAD | 1 |
p.E1144Q | LUAD | 1 |
p.D431E | LUAD | 1 |
p.G906W | LUAD | 1 |
p.G539W | BLCA | 1 |
p.P75S | SKCM | 1 |
p.S1031F | SKCM | 1 |
p.R58K | SKCM | 1 |
p.L145F | SKCM | 1 |
p.K719N | BLCA | 1 |
p.E452G | STAD | 1 |
p.H1126N | LUAD | 1 |
p.E387D | LUAD | 1 |
p.P166Q | LUAD | 1 |
p.A490S | PAAD | 1 |
p.G917E | HNSC | 1 |
p.R849Q | SKCM | 1 |
p.G1017D | SKCM | 1 |
p.L527F | SKCM | 1 |
p.G193V | LUAD | 1 |
p.A67S | LUAD | 1 |
p.P207S | SKCM | 1 |
p.H564Y | SKCM | 1 |
p.G906E | SKCM | 1 |
p.S713F | CESC | 1 |
p.A810D | LUAD | 1 |
p.P876S | SKCM | 1 |
p.M548I | SKCM | 1 |
p.T929K | LIHC | 1 |
p.A87V | SKCM | 1 |
p.P625S | SKCM | 1 |
p.S518Y | STAD | 1 |
p.S112I | LUAD | 1 |
p.D174E | LUAD | 1 |
p.S939R | LUAD | 1 |
p.P255H | LUAD | 1 |
p.S400F | SKCM | 1 |
p.G917E | SKCM | 1 |
p.A67T | STAD | 1 |
p.G91R | LUAD | 1 |
p.V753F | LUAD | 1 |
p.A776D | LIHC | 1 |
p.P27R | KIRP | 1 |
p.D197Y | LUAD | 1 |
p.S1023R | ESCA | 1 |
p.S663C | LUAD | 1 |
p.G481E | SKCM | 1 |
p.P443L | SKCM | 1 |
p.G1142E | SKCM | 1 |
p.H251L | SKCM | 1 |
p.D409N | HNSC | 1 |
p.H613Q | LUAD | 1 |
p.P318L | SKCM | 1 |
p.R159G | STAD | 1 |
p.T538N | LUAD | 1 |
p.P1089T | LUAD | 1 |
p.P436L | SKCM | 1 |
p.T512A | LGG | 1 |
p.V267I | LIHC | 1 |
p.S663I | LUAD | 1 |
p.C1122S | SKCM | 1 |
p.T702I | LUAD | 1 |
p.I294L | STAD | 1 |
p.R348Q | SKCM | 1 |
p.S660F | SKCM | 1 |
p.P1156R | KIRP | 1 |
p.S736C | KIRC | 1 |
p.S200F | SKCM | 1 |
p.A227V | STAD | 1 |
p.A77V | SKCM | 1 |
p.P509H | LUAD | 1 |
p.K641T | STAD | 1 |
p.P501S | SKCM | 1 |
p.A740D | PAAD | 1 |
p.P340L | SKCM | 1 |
p.P951S | SKCM | 1 |
p.P166L | STAD | 1 |
p.A246P | HNSC | 1 |
p.T1013A | SKCM | 1 |
p.P34Q | KIRP | 1 |
p.C1152* | LGG | 1 |
p.G1072E | SKCM | 1 |
p.F840V | STAD | 1 |
p.G853E | SKCM | 1 |
p.T395N | HNSC | 1 |
p.G364E | SKCM | 1 |
p.E264K | PAAD | 1 |
p.S899F | SKCM | 1 |
p.L661F | SKCM | 1 |
p.P436T | HNSC | 1 |
p.R13C | HNSC | 1 |
p.W1128* | SKCM | 1 |
p.Y724* | LUAD | 1 |
p.T953N | LIHC | 1 |
p.P285S | THYM | 1 |
p.R301K | SKCM | 1 |
p.T390A | SKCM | 1 |
p.D31N | SKCM | 1 |
p.P958T | PRAD | 1 |
p.K139M | LUAD | 1 |
p.P471L | SKCM | 1 |
p.G291V | LUAD | 1 |
p.V871F | HNSC | 1 |
p.A227G | SKCM | 1 |
p.S913C | LUAD | 1 |
p.G210R | SKCM | 1 |
p.P766L | SKCM | 1 |
p.P652L | SKCM | 1 |
p.E209K | CESC | 1 |
p.P501R | STAD | 1 |
p.P293L | SKCM | 1 |
p.D431Y | LUAD | 1 |
p.L429F | HNSC | 1 |
p.N219I | STAD | 1 |
p.P796S | SKCM | 1 |
p.P130L | LUAD | 1 |
p.P614Q | HNSC | 1 |
p.Y1134C | HNSC | 1 |
p.R348X | SKCM | 1 |
p.L493H | STAD | 1 |
p.Q782K | LUAD | 1 |
p.S222I | LUAD | 1 |
p.L252P | SKCM | 1 |
p.S747G | THYM | 1 |
p.H367Q | ESCA | 1 |
p.A321S | ESCA | 1 |
p.A1118S | LUAD | 1 |
p.E374K | LUAD | 1 |
p.Q226H | ESCA | 1 |
p.P883T | HNSC | 1 |
p.S1033* | LUAD | 1 |
p.N974K | STAD | 1 |
p.D496Y | HNSC | 1 |
p.G299R | STAD | 1 |
p.R103Q | LIHC | 1 |
p.P311S | SKCM | 1 |
p.S63C | LUAD | 1 |
p.S523F | SKCM | 1 |
p.E170K | LUAD | 1 |
p.V405L | LUAD | 1 |
p.G894R | SKCM | 1 |
p.F840S | CESC | 1 |
p.L413M | LUAD | 1 |
p.G999* | SKCM | 1 |
p.P81S | LIHC | 1 |
p.G299V | HNSC | 1 |
p.S715Y | HNSC | 1 |
p.P534S | SKCM | 1 |
p.S495Y | BLCA | 1 |
p.V114L | HNSC | 1 |
p.E846K | HNSC | 1 |
p.S562F | LUAD | 1 |
p.S932L | SKCM | 1 |
p.R348G | CESC | 1 |
p.G917R | SKCM | 1 |
p.G938V | LUAD | 1 |
p.F840I | SARC | 1 |
p.P263S | SKCM | 1 |
p.A134V | HNSC | 1 |
p.P694T | LUAD | 1 |
p.A134V | STAD | 1 |
p.T580A | STAD | 1 |
p.I1123M | SKCM | 1 |
p.G1017D | PAAD | 1 |
p.V571L | LUAD | 1 |
p.A563T | STAD | 1 |
p.C1152X | LGG | 1 |
p.R52L | HNSC | 1 |
p.G171R | LUAD | 1 |
p.A813S | LUAD | 1 |
p.M519I | STAD | 1 |
p.P674S | SKCM | 1 |
p.S622F | SKCM | 1 |
p.G1072E | LUAD | 1 |
p.F840I | LIHC | 1 |
p.R13S | ESCA | 1 |
p.G894E | SKCM | 1 |
p.D572N | SKCM | 1 |
p.M1102I | HNSC | 1 |
p.S112R | SARC | 1 |
p.V682L | LUAD | 1 |
p.S794R | STAD | 1 |
p.P922A | LUAD | 1 |
p.P931S | SKCM | 1 |
p.S232F | SKCM | 1 |
p.P240H | LUAD | 1 |
p.S684C | LUAD | 1 |
p.S741L | CESC | 1 |
p.F635S | STAD | 1 |
p.P404T | LUAD | 1 |
p.S314R | LUAD | 1 |
p.S270P | HNSC | 1 |
p.P318H | ACC | 1 |
p.S912I | HNSC | 1 |
p.R131L | LUAD | 1 |
p.A1118D | LUAD | 1 |
p.E947Q | SARC | 1 |
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TissGeneCNV for NPAP1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NPAP1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for NPAP1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NPAP1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NPAP1 |
TissGeneDrug for NPAP1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NPAP1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0032897 | Prader-Willi Syndrome | 5 | BeFree |
umls:C0025202 | melanoma | 1 | CTD_human |
umls:C0162635 | Angelman Syndrome | 1 | BeFree |