TissGeneSummary for MS4A6E |
Gene summary |
Basic gene information | Gene symbol | MS4A6E |
Gene name | membrane-spanning 4-domains, subfamily A, member 6E | |
Synonyms | - | |
Cytomap | UCSC genome browser: 11q12.2 | |
Type of gene | protein-coding | |
RefGenes | NM_139249.2, | |
Description | membrane-spanning 4-domains subfamily A member 6E | |
Modification date | 20141207 | |
dbXrefs | MIM : 608402 | |
HGNC : HGNC | ||
Ensembl : ENSG00000166926 | ||
HPRD : 12227 | ||
Vega : OTTHUMG00000167355 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MS4A6E | |
BioGPS: 245802 | ||
Pathway | NCI Pathway Interaction Database: MS4A6E | |
KEGG: MS4A6E | ||
REACTOME: MS4A6E | ||
Pathway Commons: MS4A6E | ||
Context | iHOP: MS4A6E | |
ligand binding site mutation search in PubMed: MS4A6E | ||
UCL Cancer Institute: MS4A6E | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of MS4A6E | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MS4A6E |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for MS4A6E |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MS4A6E |
TissGeneSNV for MS4A6E |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E89K | SKCM | 4 |
p.L117M | LUAD | 1 |
p.T10A | COAD | 1 |
p.R112K | BLCA | 1 |
p.A64D | LUSC | 1 |
p.S122F | READ | 1 |
p.E89K | LUSC | 1 |
p.E89K | PAAD | 1 |
p.A118D | UCEC | 1 |
p.E28K | GBM | 1 |
p.Q84* | STAD | 1 |
p.V47F | COAD | 1 |
p.P27H | LUAD | 1 |
p.I6V | COAD | 1 |
p.G33R | LUAD | 1 |
p.P29H | LUSC | 1 |
p.E9D | COAD | 1 |
p.P80S | SKCM | 1 |
p.D91N | SKCM | 1 |
p.T120I | UCEC | 1 |
p.Q84X | STAD | 1 |
p.V45D | LUAD | 1 |
p.A139G | LUAD | 1 |
p.C110F | UCEC | 1 |
p.V136L | LUAD | 1 |
p.D101N | SKCM | 1 |
p.R40H | UCEC | 1 |
p.V140L | LIHC | 1 |
p.G67S | ESCA | 1 |
p.Q23L | LUSC | 1 |
p.P105S | SKCM | 1 |
p.L98F | SKCM | 1 |
p.G67V | UCEC | 1 |
p.D101Y | LGG | 1 |
p.E28* | LUSC | 1 |
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TissGeneCNV for MS4A6E |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MS4A6E |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-91-8496-01A | MS4A6E-MS4A6A | In-Frame | chr11:60105318 | chr11:59940601 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-E9-A1RB-11A | MS4A6E-MS4A6A | In-Frame | chr11:60102514 | chr11:59947437 |
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TissGeneNet for MS4A6E |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MS4A6E |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MS4A6E |
TissGeneDrug for MS4A6E |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MS4A6E |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |