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| TissGeneSummary for ALOX15B |
 Gene summary |
| Basic gene information | Gene symbol | ALOX15B |
| Gene name | arachidonate 15-lipoxygenase, type B | |
| Synonyms | 15-LOX-2 | |
| Cytomap | UCSC genome browser: 17p13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001039130.1, NM_001039131.1,NM_001141.2, | |
| Description | 15-LOX-B15S-lipoxygenasearachidonate 15-lipoxygenase 2arachidonate 15-lipoxygenase Barachidonate 15-lipoxygenase type IIarachidonate 15-lipoxygenase, second typearachidonate omega(6) lipoxygenaselinoleate 13-lipoxygenase 15-LOb | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603697 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000179593 | ||
| HPRD : 04739 | ||
| Vega : OTTHUMG00000108181 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ALOX15B | |
| BioGPS: 247 | ||
| Pathway | NCI Pathway Interaction Database: ALOX15B | |
| KEGG: ALOX15B | ||
| REACTOME: ALOX15B | ||
| Pathway Commons: ALOX15B | ||
| Context | iHOP: ALOX15B | |
| ligand binding site mutation search in PubMed: ALOX15B | ||
| UCL Cancer Institute: ALOX15B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ProstateSkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRADSKCM | |
| Reference showing the relevant tissue of ALOX15B | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0008285 | negative regulation of cell proliferation | 11839751 | GO:0019369 | arachidonic acid metabolic process | 10542053 | GO:0045786 | negative regulation of cell cycle | 11839751 | GO:0045926 | negative regulation of growth | 11839751 | GO:0008285 | negative regulation of cell proliferation | 11839751 | GO:0019369 | arachidonic acid metabolic process | 10542053 | GO:0045786 | negative regulation of cell cycle | 11839751 | GO:0045926 | negative regulation of growth | 11839751 |
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| TissGeneExp for ALOX15B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | 0.149007361 | -3.377870764 | 3.526878125 | 6.47E-09 | 5.12E-08 |
| LUAD | 4.057168567 | 5.917909947 | -1.860741379 | 6.80E-08 | 2.72E-07 |
| LUSC | 2.724734321 | 6.03135589 | -3.306621569 | 4.38E-14 | 2.37E-13 |
| THCA | 4.28393575 | 1.380386598 | 2.903549153 | 1.88E-12 | 1.59E-11 |
| KIRC | 0.218157361 | -3.437824584 | 3.655981944 | 8.04E-26 | 1.04E-24 |
| BRCA | 1.826196396 | 3.002931483 | -1.176735088 | 0.00289 | 0.005348161 |
| KICH | -1.626983639 | -3.437655639 | 1.810672 | 0.00128 | 0.002720463 |
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| TissGene-miRNA for ALOX15B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ALOX15B |
| TissGeneSNV for ALOX15B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E601K | SKCM | 2 |
| p.K180N | SARC | 2 |
| p.E630K | SKCM | 2 |
| p.D447N | SKCM | 1 |
| p.T10A | KIRC | 1 |
| p.R252C | MESO | 1 |
| p.D163N | LUAD | 1 |
| p.S277G | UCEC | 1 |
| p.P579L | SKCM | 1 |
| p.S190F | LUSC | 1 |
| p.R361C | KIRP | 1 |
| p.I670M | BLCA | 1 |
| p.D459N | SKCM | 1 |
| p.D505N | LUAD | 1 |
| p.W566* | HNSC | 1 |
| p.A239T | GBM | 1 |
| p.D476N | SKCM | 1 |
| p.G205E | UCEC | 1 |
| p.W19S | ESCA | 1 |
| p.Q612X | SKCM | 1 |
| p.V6I | SKCM | 1 |
| p.E653K | SKCM | 1 |
| p.A311V | READ | 1 |
| p.E514Q | CESC | 1 |
| p.P77A | DLBC | 1 |
| p.Y408X | DLBC | 1 |
| p.D430N | SKCM | 1 |
| p.A153T | SKCM | 1 |
| p.P572L | LUAD | 1 |
| p.T372M | COAD | 1 |
| p.N247I | COAD | 1 |
| p.E382D | STAD | 1 |
| p.I676M | HNSC | 1 |
| p.E588Q | BLCA | 1 |
| p.S341I | SARC | 1 |
| p.V69M | STAD | 1 |
| p.P393L | KIRP | 1 |
| p.G17D | BRCA | 1 |
| p.S310Y | COAD | 1 |
| p.N522I | UCS | 1 |
| p.F288L | BLCA | 1 |
| p.R463Q | HNSC | 1 |
| p.F438L | UCEC | 1 |
| p.V674I | HNSC | 1 |
| p.Q641* | SKCM | 1 |
| p.D499N | SKCM | 1 |
| p.E147K | SKCM | 1 |
| p.R252C | SKCM | 1 |
| p.S489C | LUAD | 1 |
| p.P624L | LIHC | 1 |
| p.L41F | LUAD | 1 |
| p.Q646H | LIHC | 1 |
| p.I294M | CESC | 1 |
| p.D169V | BRCA | 1 |
| p.R138L | HNSC | 1 |
| p.Q146K | LUAD | 1 |
| p.G205W | COAD | 1 |
| p.R457C | COAD | 1 |
| p.R98W | UCEC | 1 |
| p.R361C | UCEC | 1 |
| p.N218I | LIHC | 1 |
| p.A363V | OV | 1 |
| p.S452F | SKCM | 1 |
| p.R654Q | STAD | 1 |
| p.A191V | UCEC | 1 |
| p.G42V | HNSC | 1 |
| p.N445S | STAD | 1 |
| p.H292Y | SKCM | 1 |
| p.S550F | SKCM | 1 |
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| TissGeneCNV for ALOX15B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ALOX15B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF737723 | ALOX15B-CAPNS1 | chr17:7952039 | chr19:36640996 | |
| Chimerdb3.0 | FusionScan | UCEC | TCGA-E6-A8L9-01A | PPP1R37-ALOX15B | Out-of-Frame | chr19:45596785 | chr17:7945686 |
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| TissGeneNet for ALOX15B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for ALOX15B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ALOX15B |
| TissGeneDrug for ALOX15B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ALOX15B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0600139 | Prostate carcinoma | 7 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 5 | BeFree |
| umls:C0596263 | Carcinogenesis | 4 | BeFree |
| umls:C0003850 | Arteriosclerosis | 3 | BeFree |
| umls:C0004153 | Atherosclerosis | 3 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 3 | BeFree,LHGDN |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 1 | BeFree,LHGDN |
| umls:C0020542 | Pulmonary Hypertension | 1 | BeFree |
| umls:C0027404 | Narcolepsy | 1 | GAD |
| umls:C0032927 | Precancerous Conditions | 1 | BeFree |
| umls:C0033860 | Psoriasis | 1 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
| umls:C0206667 | Adrenal Cortical Adenoma | 1 | BeFree,LHGDN |
| umls:C0206686 | Adrenocortical carcinoma | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0278996 | Cancer of Head and Neck | 1 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | GAD |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0949059 | Polyp of large intestine | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C2937421 | Prostatic Hyperplasia | 1 | BeFree |
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