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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for ALOX15B
check button Gene summary
Basic gene informationGene symbolALOX15B
Gene namearachidonate 15-lipoxygenase, type B
Synonyms15-LOX-2
CytomapUCSC genome browser: 17p13.1
Type of geneprotein-coding
RefGenesNM_001039130.1,
NM_001039131.1,NM_001141.2,
Description15-LOX-B15S-lipoxygenasearachidonate 15-lipoxygenase 2arachidonate 15-lipoxygenase Barachidonate 15-lipoxygenase type IIarachidonate 15-lipoxygenase, second typearachidonate omega(6) lipoxygenaselinoleate 13-lipoxygenase 15-LOb
Modification date20141207
dbXrefs MIM : 603697
HGNC : HGNC
Ensembl : ENSG00000179593
HPRD : 04739
Vega : OTTHUMG00000108181
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ALOX15B
BioGPS: 247
PathwayNCI Pathway Interaction Database: ALOX15B
KEGG: ALOX15B
REACTOME: ALOX15B
Pathway Commons: ALOX15B
ContextiHOP: ALOX15B
ligand binding site mutation search in PubMed: ALOX15B
UCL Cancer Institute: ALOX15B
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)ProstateSkin
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PRADSKCM
Reference showing the relevant tissue of ALOX15B
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0008285negative regulation of cell proliferation11839751
GO:0019369arachidonic acid metabolic process10542053
GO:0045786negative regulation of cell cycle11839751
GO:0045926negative regulation of growth11839751
GO:0008285negative regulation of cell proliferation11839751
GO:0019369arachidonic acid metabolic process10542053
GO:0045786negative regulation of cell cycle11839751
GO:0045926negative regulation of growth11839751


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TissGeneExp for ALOX15B

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRP0.149007361-3.3778707643.5268781256.47E-095.12E-08
LUAD4.0571685675.917909947-1.8607413796.80E-082.72E-07
LUSC2.7247343216.03135589-3.3066215694.38E-142.37E-13
THCA4.283935751.3803865982.9035491531.88E-121.59E-11
KIRC0.218157361-3.4378245843.6559819448.04E-261.04E-24
BRCA1.8261963963.002931483-1.1767350880.002890.005348161
KICH-1.626983639-3.4376556391.8106720.001280.002720463


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TissGene-miRNA for ALOX15B

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for ALOX15B
TissGeneSNV for ALOX15B

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E601KSKCM2
p.K180NSARC2
p.E630KSKCM2
p.D447NSKCM1
p.T10AKIRC1
p.R252CMESO1
p.D163NLUAD1
p.S277GUCEC1
p.P579LSKCM1
p.S190FLUSC1
p.R361CKIRP1
p.I670MBLCA1
p.D459NSKCM1
p.D505NLUAD1
p.W566*HNSC1
p.A239TGBM1
p.D476NSKCM1
p.G205EUCEC1
p.W19SESCA1
p.Q612XSKCM1
p.V6ISKCM1
p.E653KSKCM1
p.A311VREAD1
p.E514QCESC1
p.P77ADLBC1
p.Y408XDLBC1
p.D430NSKCM1
p.A153TSKCM1
p.P572LLUAD1
p.T372MCOAD1
p.N247ICOAD1
p.E382DSTAD1
p.I676MHNSC1
p.E588QBLCA1
p.S341ISARC1
p.V69MSTAD1
p.P393LKIRP1
p.G17DBRCA1
p.S310YCOAD1
p.N522IUCS1
p.F288LBLCA1
p.R463QHNSC1
p.F438LUCEC1
p.V674IHNSC1
p.Q641*SKCM1
p.D499NSKCM1
p.E147KSKCM1
p.R252CSKCM1
p.S489CLUAD1
p.P624LLIHC1
p.L41FLUAD1
p.Q646HLIHC1
p.I294MCESC1
p.D169VBRCA1
p.R138LHNSC1
p.Q146KLUAD1
p.G205WCOAD1
p.R457CCOAD1
p.R98WUCEC1
p.R361CUCEC1
p.N218ILIHC1
p.A363VOV1
p.S452FSKCM1
p.R654QSTAD1
p.A191VUCEC1
p.G42VHNSC1
p.N445SSTAD1
p.H292YSKCM1
p.S550FSKCM1


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TissGeneCNV for ALOX15B

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for ALOX15B

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABF737723ALOX15B-CAPNS1chr17:7952039chr19:36640996
Chimerdb3.0FusionScanUCECTCGA-E6-A8L9-01APPP1R37-ALOX15BOut-of-Framechr19:45596785chr17:7945686


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TissGeneNet for ALOX15B

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for ALOX15B

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for ALOX15B
TissGeneDrug for ALOX15B

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for ALOX15B

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0600139Prostate carcinoma7BeFree
umls:C0376358Malignant neoplasm of prostate5BeFree
umls:C0596263Carcinogenesis4BeFree
umls:C0003850Arteriosclerosis3BeFree
umls:C0004153Atherosclerosis3BeFree
umls:C0033578Prostatic Neoplasms3BeFree,LHGDN
umls:C0001430Adenoma1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0009404Colorectal Neoplasms1BeFree
umls:C0014859Esophageal Neoplasms1BeFree,LHGDN
umls:C0020542Pulmonary Hypertension1BeFree
umls:C0027404Narcolepsy1GAD
umls:C0032927Precancerous Conditions1BeFree
umls:C0033860Psoriasis1BeFree
umls:C0152018Esophageal carcinoma1BeFree
umls:C0206667Adrenal Cortical Adenoma1BeFree,LHGDN
umls:C0206686Adrenocortical carcinoma1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0278996Cancer of Head and Neck1BeFree
umls:C0546837Malignant neoplasm of esophagus1BeFree
umls:C0677886Epithelial ovarian cancer1GAD
umls:C0684249Carcinoma of lung1BeFree
umls:C0949059Polyp of large intestine1BeFree
umls:C1168401Squamous cell carcinoma of the head and neck1BeFree
umls:C1458155Mammary Neoplasms1LHGDN
umls:C1527249Colorectal Cancer1BeFree
umls:C2937421Prostatic Hyperplasia1BeFree