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| TissGeneSummary for G6PC |
 Gene summary |
| Basic gene information | Gene symbol | G6PC |
| Gene name | glucose-6-phosphatase, catalytic subunit | |
| Synonyms | G6PC1|G6PT|GSD1|GSD1a | |
| Cytomap | UCSC genome browser: 17q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000151.3, NM_001270397.1, | |
| Description | G-6-PaseG6PaseG6Pase-alphaglucose-6-phosphataseglucose-6-phosphatase alpha | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 613742 | |
| HGNC : HGNC | ||
| HPRD : 01983 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_G6PC | |
| BioGPS: 2538 | ||
| Pathway | NCI Pathway Interaction Database: G6PC | |
| KEGG: G6PC | ||
| REACTOME: G6PC | ||
| Pathway Commons: G6PC | ||
| Context | iHOP: G6PC | |
| ligand binding site mutation search in PubMed: G6PC | ||
| UCL Cancer Institute: G6PC | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of G6PC | ||
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for G6PC |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | 1.762867487 | 8.463426862 | -6.700559375 | 5.64E-13 | 9.58E-12 |
| KICH | -0.602311638 | 6.444304362 | -7.046616 | 5.37E-11 | 4.43E-10 |
| LIHC | 11.31140636 | 13.17500836 | -1.863602 | 7.50E-06 | 3.26E-05 |
| KIRC | 4.408636584 | 7.268657418 | -2.860020833 | 6.01E-07 | 1.57E-06 |
| STAD | -0.385807513 | 1.577070612 | -1.962878125 | 0.0056 | 0.021346441 |
| COAD | -1.076485638 | 1.005398977 | -2.081884615 | 7.63E-05 | 0.000286256 |
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| TissGene-miRNA for G6PC |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for G6PC |
| TissGeneSNV for G6PC |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R170Q | SKCM | 2 |
| p.V251A | GBM | 1 |
| p.G112E | BLCA | 1 |
| p.F210V | READ | 1 |
| p.P160L | SKCM | 1 |
| p.S98F | PRAD | 1 |
| p.L157F | UCEC | 1 |
| p.P144L | LGG | 1 |
| p.A37T | STAD | 1 |
| p.A259D | LUAD | 1 |
| p.S187L | CESC | 1 |
| p.L230M | LGG | 1 |
| p.S283N | UCEC | 1 |
| p.D38N | BRCA | 1 |
| p.T108I | LIHC | 1 |
| p.Q170* | CESC | 1 |
| p.T255N | LUAD | 1 |
| p.P84S | SKCM | 1 |
| p.W63C | LUSC | 1 |
| p.K354N | UCEC | 1 |
| p.C344F | LUSC | 1 |
| p.K285E | LIHC | 1 |
| p.G4* | LGG | 1 |
| p.T91I | SKCM | 1 |
| p.S187P | UCEC | 1 |
| p.I171F | LUAD | 1 |
| p.A331V | LGG | 1 |
| p.P178S | SKCM | 1 |
| p.E282D | CESC | 1 |
| p.L238P | LUAD | 1 |
| p.Q20* | LUSC | 1 |
| p.V304I | OV | 1 |
| p.V74I | UCEC | 1 |
| p.L135F | SKCM | 1 |
| p.G4E | HNSC | 1 |
| p.T267M | LGG | 1 |
| p.L39F | SKCM | 1 |
| p.V131I | LGG | 1 |
| p.Y23N | KIRC | 1 |
| p.D119N | SKCM | 1 |
| p.L305F | SKCM | 1 |
| p.S117T | KIRP | 1 |
| p.A204V | LGG | 1 |
| p.P257L | LUAD | 1 |
| p.G286R | SKCM | 1 |
| p.Y280* | LUAD | 1 |
| p.W158* | SKCM | 1 |
| p.Q20* | SKCM | 1 |
| p.K207N | UCEC | 1 |
| p.H307Y | LUAD | 1 |
| p.A124T | SKCM | 1 |
| p.A259V | ESCA | 1 |
| p.F105L | LIHC | 1 |
| p.Q20X | SKCM | 1 |
| p.L211R | LAML | 1 |
| p.P342S | SKCM | 1 |
| p.G222R | UCEC | 1 |
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| TissGeneCNV for G6PC |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for G6PC |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BC020700 | G6PC-TXNL4B | chr17:41063045 | chr16:72094645 |
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| TissGeneNet for G6PC |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (tumor) | G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (normal) |
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| COAD (tumor) | COAD (normal) |
| G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (tumor) | G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (tumor) | G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (normal) |
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| KICH (tumor) | KICH (normal) |
| G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (tumor) | G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (tumor) | G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (tumor) | G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (tumor) | G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (tumor) | G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (tumor) | G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (tumor) | G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (normal) |
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| STAD (tumor) | STAD (normal) |
| G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (tumor) | G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (normal) |
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| THCA (tumor) | THCA (normal) |
| G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (tumor) | G6PC, HNF4A, ONECUT1, FOXO1, FOXO3, NSL1, CDH16, ZNF746, SNX13 (normal) |
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| TissGeneProg for G6PC |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for G6PC |
| TissGeneDrug for G6PC |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for G6PC |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0017919 | Glycogen Storage Disease | 55 | BeFree,GAD,LHGDN |
| umls:C0017920 | Glycogen Storage Disease Type I | 48 | BeFree,CTD_human,GAD,LHGDN,MGD,ORPHANET,UNIPROT |
| umls:C2919796 | Glycogen storage disease type Ia | 30 | BeFree,CTD_human |
| umls:C2239176 | Liver carcinoma | 12 | BeFree,LHGDN |
| umls:C0023903 | Liver neoplasms | 11 | BeFree |
| umls:C0025517 | Metabolic Diseases | 11 | BeFree |
| umls:C0268146 | Glucose-6-phosphate transport defect | 10 | BeFree,CLINVAR |
| umls:C0020615 | Hypoglycemia | 6 | BeFree |
| umls:C2711227 | Steatohepatitis | 4 | BeFree |
| umls:C0006118 | Brain Neoplasms | 3 | BeFree |
| umls:C0011847 | Diabetes | 3 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 3 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 3 | BeFree,RGD |
| umls:C0015695 | Fatty Liver | 3 | BeFree |
| umls:C0017922 | Glycogen Storage Disease Type III | 3 | BeFree |
| umls:C0020456 | Hyperglycemia | 3 | BeFree |
| umls:C0206669 | Hepatocellular Adenoma | 3 | BeFree |
| umls:C0271708 | Fasting Hypoglycemia | 3 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | BeFree,GAD |
| umls:C0017636 | Glioblastoma | 2 | BeFree |
| umls:C0019209 | Hepatomegaly | 2 | BeFree |
| umls:C0022658 | Kidney Diseases | 2 | BeFree |
| umls:C0023530 | Leukopenia | 2 | BeFree |
| umls:C0027947 | Neutropenia | 2 | BeFree |
| umls:C0038644 | Sudden infant death syndrome | 2 | BeFree,LHGDN |
| umls:C0271650 | Impaired glucose tolerance | 2 | BeFree |
| umls:C0340970 | Congenital neutropenia | 2 | BeFree |
| umls:C0740394 | Hyperuricemia | 2 | BeFree |
| umls:C1853118 | Severe congenital neutropenia | 2 | BeFree |
| umls:C0001125 | Acidosis, Lactic | 1 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0001916 | Albinism | 1 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0015934 | Fetal Growth Retardation | 1 | RGD |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0017921 | Glycogen storage disease type II | 1 | BeFree |
| umls:C0017927 | Glycogen Storage Disease Type VIII | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0020459 | Hyperinsulinism | 1 | BeFree |
| umls:C0021670 | insulinoma | 1 | BeFree |
| umls:C0021831 | Intestinal Diseases | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0027022 | Myeloproliferative disease | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | BeFree |
| umls:C0035078 | Kidney Failure | 1 | BeFree |
| umls:C0038433 | Streptozotocin Diabetes | 1 | BeFree |
| umls:C0153452 | Malignant neoplasm of gallbladder | 1 | BeFree |
| umls:C0235782 | Gallbladder Carcinoma | 1 | BeFree |
| umls:C0242339 | Dyslipidemias | 1 | BeFree |
| umls:C0268147 | Glycogen storage disease, type IX | 1 | BeFree |
| umls:C0851887 | Adenoviral infections | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1291390 | Deficiency of phosphorylase kinase | 1 | BeFree |
| umls:C1512409 | Hepatocarcinogenesis | 1 | BeFree |
| umls:C1955741 | Glucocorticoid deficiency | 1 | BeFree |
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