TissGeneSummary for TTLL10 |
Gene summary |
Basic gene information | Gene symbol | TTLL10 |
Gene name | tubulin tyrosine ligase-like family, member 10 | |
Synonyms | TTLL5 | |
Cytomap | UCSC genome browser: 1p36.33 | |
Type of gene | protein-coding | |
RefGenes | NM_001130045.1, NM_153254.2, | |
Description | inactive polyglycylase TTLL10tubulin tyrosine ligase-like family, member 5tubulin--tyrosine ligase-like protein 10 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000162571 | ||
HPRD : 08771 | ||
Vega : OTTHUMG00000000851 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TTLL10 | |
BioGPS: 254173 | ||
Pathway | NCI Pathway Interaction Database: TTLL10 | |
KEGG: TTLL10 | ||
REACTOME: TTLL10 | ||
Pathway Commons: TTLL10 | ||
Context | iHOP: TTLL10 | |
ligand binding site mutation search in PubMed: TTLL10 | ||
UCL Cancer Institute: TTLL10 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TTLL10 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0018094 | protein polyglycylation | 19524510 | GO:0018094 | protein polyglycylation | 19524510 |
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TissGeneExp for TTLL10 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.339326204 | -0.193234204 | -1.146092 | 1.72E-05 | 5.16E-05 |
LUAD | -0.053572411 | 2.601903452 | -2.655475862 | 6.19E-12 | 4.45E-11 |
LUSC | -0.652678361 | 2.58677262 | -3.23945098 | 4.81E-15 | 2.98E-14 |
KIRP | -1.879595579 | -0.639308079 | -1.2402875 | 5.16E-06 | 2.26E-05 |
BRCA | -1.435531818 | 0.445513796 | -1.881045614 | 1.02E-32 | 1.59E-31 |
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TissGene-miRNA for TTLL10 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TTLL10 |
TissGeneSNV for TTLL10 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D412N | SKCM | 3 |
p.E296K | SKCM | 2 |
p.D339N | SKCM | 2 |
p.D387H | THCA | 1 |
p.A517S | SARC | 1 |
p.R396C | COAD | 1 |
p.A358V | PRAD | 1 |
p.Q276H | BLCA | 1 |
p.E223K | SKCM | 1 |
p.H295Q | PRAD | 1 |
p.G320S | HNSC | 1 |
p.R17Q | ESCA | 1 |
p.T153S | LUAD | 1 |
p.P352L | SKCM | 1 |
p.R372H | COAD | 1 |
p.A57T | LGG | 1 |
p.L141F | SKCM | 1 |
p.D345G | STAD | 1 |
p.P572L | COAD | 1 |
p.K255M | HNSC | 1 |
p.G71E | SKCM | 1 |
p.E511Q | CESC | 1 |
p.R12Q | COAD | 1 |
p.P157S | SKCM | 1 |
p.A333V | LUAD | 1 |
p.R280I | UCEC | 1 |
p.E102V | PAAD | 1 |
p.L68F | SKCM | 1 |
p.D460H | BLCA | 1 |
p.R455W | GBM | 1 |
p.M281I | SKCM | 1 |
p.M318I | SKCM | 1 |
p.M391I | SKCM | 1 |
p.G456S | STAD | 1 |
p.E296D | LUAD | 1 |
p.G95R | SKCM | 1 |
p.A261S | ESCA | 1 |
p.R35W | COAD | 1 |
p.R35Q | READ | 1 |
p.T402N | SKCM | 1 |
p.T464I | SKCM | 1 |
p.L344V | SKCM | 1 |
p.D100N | SKCM | 1 |
p.F478L | LIHC | 1 |
p.D27N | SKCM | 1 |
p.G578D | KIRP | 1 |
p.R121W | KIRC | 1 |
p.G144E | SKCM | 1 |
p.R290C | SARC | 1 |
p.V176A | COAD | 1 |
p.L417V | SKCM | 1 |
p.P397S | SKCM | 1 |
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TissGeneCNV for TTLL10 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TTLL10 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | CESC | TCGA-Q1-A73P-01A | TTLL10-CTAG1B | Out-of-Frame | chr1:1120489 | chrX:153814784 |
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TissGeneNet for TTLL10 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TTLL10 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TTLL10 |
TissGeneDrug for TTLL10 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TTLL10 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0854723 | Retinal Dystrophies | 1 | BeFree |