TissGeneSummary for CNIH2 |
Gene summary |
Basic gene information | Gene symbol | CNIH2 |
Gene name | cornichon family AMPA receptor auxiliary protein 2 | |
Synonyms | CNIH-2|Cnil | |
Cytomap | UCSC genome browser: 11q13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_182553.2, NR_073078.1,NR_073079.1, | |
Description | cornichon homolog 2protein cornichon homolog 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 611288 | |
HGNC : HGNC | ||
Ensembl : ENSG00000174871 | ||
HPRD : 13078 | ||
Vega : OTTHUMG00000166919 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CNIH2 | |
BioGPS: 254263 | ||
Pathway | NCI Pathway Interaction Database: CNIH2 | |
KEGG: CNIH2 | ||
REACTOME: CNIH2 | ||
Pathway Commons: CNIH2 | ||
Context | iHOP: CNIH2 | |
ligand binding site mutation search in PubMed: CNIH2 | ||
UCL Cancer Institute: CNIH2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainPancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGPAAD | |
Reference showing the relevant tissue of CNIH2 | ||
Description by TissGene annotations | Protective TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity | 20805473 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity | 20805473 |
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TissGeneExp for CNIH2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -1.754828552 | -0.730151629 | -1.024676923 | 1.13E-05 | 5.12E-05 |
LUSC | 1.015997542 | -0.665865203 | 1.681862745 | 1.37E-08 | 4.25E-08 |
BRCA | 1.386303837 | -1.523036514 | 2.909340351 | 9.70E-42 | 3.36E-40 |
BLCA | 0.573445942 | -1.229185637 | 1.802631579 | 0.00267 | 0.016180054 |
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TissGene-miRNA for CNIH2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CNIH2 |
TissGeneSNV for CNIH2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.T156M | COAD | 1 |
p.C62F | LIHC | 1 |
p.A119V | ESCA | 1 |
p.F78L | BLCA | 1 |
p.Y117X | LIHC | 1 |
p.A119V | STAD | 1 |
p.A119V | UCEC | 1 |
p.E71Q | THCA | 1 |
p.I29M | KIRP | 1 |
p.Y100H | LUSC | 1 |
p.D32H | HNSC | 1 |
p.Y117* | LIHC | 1 |
p.C62R | LIHC | 1 |
p.E71K | LUAD | 1 |
p.M123V | UCEC | 1 |
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TissGeneCNV for CNIH2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CNIH2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BI912966 | KAT2B-CNIH2 | chr3:20120316 | chr11:66051619 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A0H6-01A | ARFGEF2-CNIH2 | In-Frame | chr20:47558524 | chr11:66049729 |
TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A0H6-01A | ARFGEF2-CNIH2 | In-frame | Chr20:47558524 | Chr11:66049730 |
TCGAfusionPortal | PRADA | SKCM | TCGA-D9-A4Z5-01A | CNIH2-MS4A4A | Out-of-frame | Chr11:66046008 | Chr11:60059698 |
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TissGeneNet for CNIH2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CNIH2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CNIH2 |
TissGeneDrug for CNIH2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CNIH2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0018099 | Gout | 1 | GWASCAT |