TissGeneSummary for C8orf46 |
Gene summary |
Basic gene information | Gene symbol | C8orf46 |
Gene name | chromosome 8 open reading frame 46 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 8q13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_152765.3, | |
Description | uncharacterized protein C8orf46 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000169085 | ||
HPRD : 14565 | ||
Vega : OTTHUMG00000156998 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C8orf46 | |
BioGPS: 254778 | ||
Pathway | NCI Pathway Interaction Database: C8orf46 | |
KEGG: C8orf46 | ||
REACTOME: C8orf46 | ||
Pathway Commons: C8orf46 | ||
Context | iHOP: C8orf46 | |
ligand binding site mutation search in PubMed: C8orf46 | ||
UCL Cancer Institute: C8orf46 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of C8orf46 | ||
Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C8orf46 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 2.672925171 | 1.232219615 | 1.440705556 | 9.79E-10 | 3.21E-09 |
PRAD | 1.433533825 | 2.523204978 | -1.089671154 | 1.76E-09 | 2.54E-08 |
COAD | -2.47793156 | -0.436273868 | -2.041657692 | 3.08E-07 | 1.96E-06 |
LUSC | -1.701686839 | 0.578928847 | -2.280615686 | 1.51E-17 | 1.29E-16 |
BLCA | -1.705907066 | -0.224628119 | -1.481278947 | 0.0023 | 0.014328291 |
ESCA | -1.901239602 | 0.926351307 | -2.827590909 | 0.000466 | 0.008952067 |
STAD | -1.665674829 | 0.384047046 | -2.049721875 | 0.000162 | 0.001174958 |
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TissGene-miRNA for C8orf46 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
THYM | hsa-miR-186-5p | MIMAT0000456 | 0.0046 | -0.26 | 122 |
UCS | hsa-miR-186-5p | MIMAT0000456 | 0.0023 | -0.4 | 56 |
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TissGeneMut for C8orf46 |
TissGeneSNV for C8orf46 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A206S | PAAD | 2 |
p.A133V | UCEC | 2 |
p.A79S | COAD | 2 |
p.E11K | UCEC | 1 |
p.V24I | STAD | 1 |
p.P116L | UCEC | 1 |
p.P67L | SKCM | 1 |
p.E156K | CESC | 1 |
p.R146T | ESCA | 1 |
p.K153N | CESC | 1 |
p.E195K | HNSC | 1 |
p.S7I | STAD | 1 |
p.M154I | STAD | 1 |
p.K23N | STAD | 1 |
p.V19A | STAD | 1 |
p.G147X | STAD | 1 |
p.G62R | UCEC | 1 |
p.Q36* | HNSC | 1 |
p.Q4H | PAAD | 1 |
p.P116L | STAD | 1 |
p.L161F | TGCT | 1 |
p.K193* | LGG | 1 |
p.T51M | UCEC | 1 |
p.D69N | COAD | 1 |
p.Q131E | CESC | 1 |
p.R71H | STAD | 1 |
p.K41N | LUAD | 1 |
p.S130L | SKCM | 1 |
p.S97Y | UCEC | 1 |
p.Q36E | CESC | 1 |
p.R64H | ESCA | 1 |
p.E166K | ACC | 1 |
p.R120Q | UCEC | 1 |
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TissGeneCNV for C8orf46 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C8orf46 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for C8orf46 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C8orf46 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C8orf46 |
TissGeneDrug for C8orf46 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C8orf46 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0022658 | Kidney Diseases | 1 | GAD |