TissGeneSummary for MORN5 |
Gene summary |
Basic gene information | Gene symbol | MORN5 |
Gene name | MORN repeat containing 5 | |
Synonyms | C9orf113|C9orf18 | |
Cytomap | UCSC genome browser: 9q33.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001286828.1, NM_198469.3, | |
Description | MORN repeat-containing protein 5 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000185681 | ||
HPRD : 12947 | ||
Vega : OTTHUMG00000020599 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MORN5 | |
BioGPS: 254956 | ||
Pathway | NCI Pathway Interaction Database: MORN5 | |
KEGG: MORN5 | ||
REACTOME: MORN5 | ||
Pathway Commons: MORN5 | ||
Context | iHOP: MORN5 | |
ligand binding site mutation search in PubMed: MORN5 | ||
UCL Cancer Institute: MORN5 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of MORN5 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MORN5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -0.547132636 | 2.226377708 | -2.773510345 | 1.43E-08 | 6.25E-08 |
COAD | -2.336783167 | 1.188262987 | -3.525046154 | 9.57E-06 | 4.42E-05 |
LUSC | -1.665303529 | 2.03752 | -3.702823529 | 7.11E-13 | 3.34E-12 |
KIRC | -1.233858594 | 0.444652517 | -1.678511111 | 6.48E-15 | 3.23E-14 |
KICH | -3.055788705 | 0.787435295 | -3.843224 | 6.53E-26 | 1.60E-23 |
BLCA | -2.782807863 | 0.26628161 | -3.049089474 | 0.000134 | 0.001379704 |
STAD | -2.20419783 | 0.686705295 | -2.890903125 | 9.73E-05 | 0.000751985 |
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TissGene-miRNA for MORN5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MORN5 |
TissGeneSNV for MORN5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G119C | LUAD | 1 |
p.R141H | LIHC | 1 |
p.D125E | ACC | 1 |
p.A63T | LGG | 1 |
p.P112T | LUAD | 1 |
p.D122N | GBM | 1 |
p.Y121X | ACC | 1 |
p.D55N | SKCM | 1 |
p.E11K | BLCA | 1 |
p.R114I | UCEC | 1 |
p.G86C | HNSC | 1 |
p.F70L | COAD | 1 |
p.D122N | SKCM | 1 |
p.D14G | UCEC | 1 |
p.Y23H | UCEC | 1 |
p.M17I | SKCM | 1 |
p.T29A | KIRP | 1 |
p.G44E | HNSC | 1 |
p.R141H | KIRC | 1 |
p.G51R | SKCM | 1 |
p.L167M | KICH | 1 |
p.E2* | SKCM | 1 |
p.G61E | SKCM | 1 |
p.W58R | HNSC | 1 |
p.T157A | COAD | 1 |
p.R141H | STAD | 1 |
p.G19D | UCEC | 1 |
p.G19D | LUAD | 1 |
p.R133S | THCA | 1 |
p.T152R | LUAD | 1 |
p.G19D | KICH | 1 |
p.Y121* | ACC | 1 |
p.G44E | SKCM | 1 |
p.E2X | SKCM | 1 |
p.D55N | COAD | 1 |
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TissGeneCNV for MORN5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MORN5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for MORN5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MORN5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MORN5 |
TissGeneDrug for MORN5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MORN5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0008924 | Cleft Lip | 1 | GAD |
umls:C0008925 | Cleft Palate | 1 | GAD |