TissGeneSummary for C4orf22 |
Gene summary |
Basic gene information | Gene symbol | C4orf22 |
Gene name | chromosome 4 open reading frame 22 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 4q21.21 | |
Type of gene | protein-coding | |
RefGenes | NM_001206997.1, NM_152770.2, | |
Description | uncharacterized protein C4orf22 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000197826 | ||
HPRD : 14597 | ||
Vega : OTTHUMG00000130289 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C4orf22 | |
BioGPS: 255119 | ||
Pathway | NCI Pathway Interaction Database: C4orf22 | |
KEGG: C4orf22 | ||
REACTOME: C4orf22 | ||
Pathway Commons: C4orf22 | ||
Context | iHOP: C4orf22 | |
ligand binding site mutation search in PubMed: C4orf22 | ||
UCL Cancer Institute: C4orf22 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C4orf22 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C4orf22 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -0.689803387 | 0.94113282 | -1.630936207 | 2.42E-06 | 7.59E-06 |
THCA | -1.531302306 | -0.183715865 | -1.347586441 | 5.25E-18 | 1.24E-16 |
LUSC | -1.232312143 | 0.895297661 | -2.127609804 | 3.14E-09 | 1.03E-08 |
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TissGene-miRNA for C4orf22 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C4orf22 |
TissGeneSNV for C4orf22 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R117C | SKCM | 3 |
p.P153S | SKCM | 2 |
p.T96M | SKCM | 2 |
p.P205T | LUAD | 1 |
p.N137K | PAAD | 1 |
p.R106H | PAAD | 1 |
p.E70Q | LUAD | 1 |
p.R43H | SKCM | 1 |
p.P183S | SKCM | 1 |
p.N208K | SKCM | 1 |
p.D131Y | BLCA | 1 |
p.V46A | LIHC | 1 |
p.A19T | STAD | 1 |
p.L197F | SARC | 1 |
p.D198N | SKCM | 1 |
p.S138F | SKCM | 1 |
p.S26* | BLCA | 1 |
p.Y219C | STAD | 1 |
p.T96M | HNSC | 1 |
p.P170S | SKCM | 1 |
p.D104V | SKCM | 1 |
p.T96M | ESCA | 1 |
p.D118E | SARC | 1 |
p.G52R | SKCM | 1 |
p.Y236C | STAD | 1 |
p.E39K | BLCA | 1 |
p.A119V | THYM | 1 |
p.S121F | SKCM | 1 |
p.E142D | READ | 1 |
p.D131N | SKCM | 1 |
p.R59M | THYM | 1 |
p.T96M | SARC | 1 |
p.R51Q | HNSC | 1 |
p.A72V | ESCA | 1 |
p.D2H | KIRP | 1 |
p.G108E | SKCM | 1 |
p.Q177* | SKCM | 1 |
p.G147E | SKCM | 1 |
p.P200S | SKCM | 1 |
p.D11N | SKCM | 1 |
p.N192H | DLBC | 1 |
p.Y219C | BRCA | 1 |
p.P201T | LUAD | 1 |
p.N120K | PAAD | 1 |
p.E76D | SKCM | 1 |
p.R134C | SKCM | 1 |
p.S121Y | UCEC | 1 |
p.R231K | SKCM | 1 |
p.L197I | LGG | 1 |
p.E21D | LIHC | 1 |
p.D181N | SKCM | 1 |
p.R134C | COAD | 1 |
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TissGeneCNV for C4orf22 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C4orf22 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CA335494 | C4orf22-MYH13 | chr4:81580773 | chr17:10247240 | |
Chimerdb3.0 | ChiTaRs | NA | DA120291 | RBFOX3-C4orf22 | chr17:77478680 | chr4:81550798 | |
Chimerdb3.0 | FusionScan | PRAD | TCGA-XK-AAJT-01A | BANK1-C4orf22 | In-Frame | chr4:102839346 | chr4:81884670 |
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TissGeneNet for C4orf22 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C4orf22 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C4orf22 |
TissGeneDrug for C4orf22 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C4orf22 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 2 | GAD |
umls:C0518014 | Hematocrit level | 1 | GAD |
umls:C1271104 | Blood pressure finding | 1 | GAD |
umls:C1272641 | Systemic arterial pressure | 1 | GAD |