TissGeneSummary for GABRG1 |
Gene summary |
Basic gene information | Gene symbol | GABRG1 |
Gene name | gamma-aminobutyric acid (GABA) A receptor, gamma 1 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 4p12 | |
Type of gene | protein-coding | |
RefGenes | NM_173536.3, | |
Description | GABA(A) receptor subunit gamma-1GABA(A) receptor, gammagamma-1 polypeptidegamma-aminobutyric acid receptor subunit gamma-1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 137166 | |
HGNC : HGNC | ||
Ensembl : ENSG00000163285 | ||
HPRD : 15923 | ||
Vega : OTTHUMG00000128609 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GABRG1 | |
BioGPS: 2565 | ||
Pathway | NCI Pathway Interaction Database: GABRG1 | |
KEGG: GABRG1 | ||
REACTOME: GABRG1 | ||
Pathway Commons: GABRG1 | ||
Context | iHOP: GABRG1 | |
ligand binding site mutation search in PubMed: GABRG1 | ||
UCL Cancer Institute: GABRG1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of GABRG1 | ||
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GABRG1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | -2.639732223 | -0.649716598 | -1.990015625 | 2.78E-11 | 3.52E-10 |
COAD | -2.632512752 | -1.357231982 | -1.275280769 | 3.82E-07 | 2.35E-06 |
BRCA | -2.247628878 | -0.91502537 | -1.332603509 | 1.62E-18 | 1.04E-17 |
THCA | -0.785723377 | 0.227596962 | -1.013320339 | 0.000169 | 0.000449719 |
BLCA | -2.583732387 | -0.984279756 | -1.599452632 | 7.49E-06 | 0.000151434 |
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TissGene-miRNA for GABRG1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GABRG1 |
TissGeneSNV for GABRG1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E205K | SKCM | 4 |
p.P196S | SKCM | 3 |
p.R80C | SKCM | 3 |
p.H60Y | SKCM | 3 |
p.S304L | SKCM | 3 |
p.W220* | SKCM | 2 |
p.R169Q | SKCM | 2 |
p.Q405H | LUAD | 2 |
p.G425E | SKCM | 2 |
p.T110K | HNSC | 2 |
p.D256N | SKCM | 2 |
p.A346E | LUAD | 2 |
p.S70L | SKCM | 2 |
p.G385* | BLCA | 2 |
p.G33E | SKCM | 2 |
p.G271V | CESC | 1 |
p.P146T | LUSC | 1 |
p.R435C | GBM | 1 |
p.P11S | SKCM | 1 |
p.Y236S | STAD | 1 |
p.V49E | LUAD | 1 |
p.R169Q | PRAD | 1 |
p.T252M | BLCA | 1 |
p.D46N | SKCM | 1 |
p.R80C | COAD | 1 |
p.E91K | SARC | 1 |
p.D121E | PRAD | 1 |
p.P397Q | ESCA | 1 |
p.R244Q | LUAD | 1 |
p.S377_splice | LUSC | 1 |
p.D401Y | LUAD | 1 |
p.A301S | HNSC | 1 |
p.R169X | SKCM | 1 |
p.M333T | LUAD | 1 |
p.Q237E | BLCA | 1 |
p.E205Q | LIHC | 1 |
p.F195I | STAD | 1 |
p.E215K | READ | 1 |
p.A346V | BLCA | 1 |
p.H383N | LUSC | 1 |
p.D37Y | COAD | 1 |
p.D265_L266delinsX | COAD | 1 |
p.R435H | GBM | 1 |
p.P146T | LIHC | 1 |
p.A298V | ESCA | 1 |
p.P104S | SKCM | 1 |
p.G271R | SKCM | 1 |
p.V225I | UCEC | 1 |
p.L28P | LUAD | 1 |
p.R123C | PRAD | 1 |
p.W144C | LUAD | 1 |
p.M130I | SKCM | 1 |
p.P280S | SKCM | 1 |
p.P203T | LUAD | 1 |
p.P380H | KIRC | 1 |
p.Q237* | LUAD | 1 |
p.G255E | KIRC | 1 |
p.G403R | SKCM | 1 |
p.L180V | LUAD | 1 |
p.D334N | SKCM | 1 |
p.R15Q | STAD | 1 |
p.T48M | PRAD | 1 |
p.E215K | SKCM | 1 |
p.L133I | UCEC | 1 |
p.R166H | LUSC | 1 |
p.V339A | UCEC | 1 |
p.S267N | SKCM | 1 |
p.R169* | SKCM | 1 |
p.P280L | SKCM | 1 |
p.G141E | UCEC | 1 |
p.G62* | LIHC | 1 |
p.S377X | READ | 1 |
p.L79R | ESCA | 1 |
p.P230S | SKCM | 1 |
p.G363E | SKCM | 1 |
p.T261I | CESC | 1 |
p.R423G | LUAD | 1 |
p.L463I | LUSC | 1 |
p.M391I | SKCM | 1 |
p.T314K | LUSC | 1 |
p.F263L | LIHC | 1 |
p.R435C | LUSC | 1 |
p.D93N | SKCM | 1 |
p.R435C | UCEC | 1 |
p.A39E | LUAD | 1 |
p.S441C | LUAD | 1 |
p.L68V | HNSC | 1 |
p.M270I | SKCM | 1 |
p.S338C | LUAD | 1 |
p.L26V | STAD | 1 |
p.D229N | SKCM | 1 |
p.I170M | SKCM | 1 |
p.D112V | LGG | 1 |
p.W289L | LIHC | 1 |
p.R370K | SKCM | 1 |
p.L168F | LUAD | 1 |
p.F419L | LIHC | 1 |
p.W459L | HNSC | 1 |
p.Y329* | HNSC | 1 |
p.D103G | ESCA | 1 |
p.W53C | LUSC | 1 |
p.V241A | LIHC | 1 |
p.G62X | LIHC | 1 |
p.K219Q | SKCM | 1 |
p.D41N | BLCA | 1 |
p.R234I | COAD | 1 |
p.T312S | BRCA | 1 |
p.F357I | LIHC | 1 |
p.G271* | LIHC | 1 |
p.G430* | LUAD | 1 |
p.R154G | THYM | 1 |
p.P390T | BRCA | 1 |
p.K38N | LUAD | 1 |
p.C281* | ACC | 1 |
p.S426Y | ESCA | 1 |
p.T424K | LUSC | 1 |
p.R268I | LGG | 1 |
p.D41G | STAD | 1 |
p.S201Y | LUAD | 1 |
p.D44Y | LUAD | 1 |
p.D411Y | PRAD | 1 |
p.R166S | LUSC | 1 |
p.G141R | SKCM | 1 |
p.R169Q | COAD | 1 |
p.K438N | BLCA | 1 |
p.H60N | HNSC | 1 |
p.S386F | SKCM | 1 |
p.K322* | SARC | 1 |
p.T252M | READ | 1 |
p.W53* | LUAD | 1 |
p.H433D | LUSC | 1 |
p.G271E | SKCM | 1 |
p.R22T | LUAD | 1 |
p.I249T | LUAD | 1 |
p.W220X | SKCM | 1 |
p.R444I | BLCA | 1 |
p.N136K | HNSC | 1 |
p.G271R | CESC | 1 |
p.R15Q | SKCM | 1 |
p.N50I | LUAD | 1 |
p.I64T | READ | 1 |
p.P203L | LUSC | 1 |
p.V337L | TGCT | 1 |
p.N138D | STAD | 1 |
p.F292I | SKCM | 1 |
p.W171G | LUSC | 1 |
p.G271X | LIHC | 1 |
p.E45V | BLCA | 1 |
p.G2V | HNSC | 1 |
p.S18N | LUAD | 1 |
p.I113L | LGG | 1 |
p.P104L | UCEC | 1 |
p.E248K | SKCM | 1 |
p.V24I | UCEC | 1 |
p.D121Y | LIHC | 1 |
p.P390L | LGG | 1 |
p.S224F | BLCA | 1 |
p.C281X | ACC | 1 |
p.C202S | LUAD | 1 |
p.S70L | LUSC | 1 |
p.L68M | UCEC | 1 |
p.G174R | SKCM | 1 |
p.D112Y | UCEC | 1 |
p.V396M | STAD | 1 |
p.P380T | HNSC | 1 |
p.T314A | COAD | 1 |
p.L335I | LUAD | 1 |
p.Y218C | LUSC | 1 |
p.A320V | STAD | 1 |
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TissGeneCNV for GABRG1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GABRG1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for GABRG1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GABRG1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GABRG1 |
TissGeneDrug for GABRG1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GABRG1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0001973 | Alcoholic Intoxication, Chronic | 3 | BeFree,GAD |
umls:C0004352 | Autistic Disorder | 3 | BeFree,GAD |
umls:C0005586 | Bipolar Disorder | 2 | BeFree,GAD |
umls:C0036341 | Schizophrenia | 2 | BeFree,GAD |
umls:C0006012 | Borderline Personality Disorder | 1 | BeFree |
umls:C0006287 | Bronchopulmonary Dysplasia | 1 | BeFree |
umls:C0007273 | Carotid Artery Diseases | 1 | GAD |
umls:C0015625 | Fanconi Anemia | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C1271104 | Blood pressure finding | 1 | GAD |
umls:C1272641 | Systemic arterial pressure | 1 | GAD |
umls:C1510586 | Autism Spectrum Disorders | 1 | BeFree |
umls:C3468041 | FANCONI ANEMIA, COMPLEMENTATION GROUP C | 1 | BeFree |
umls:C3469521 | FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 1 | BeFree |