TissGeneSummary for NUTM1 |
Gene summary |
Basic gene information | Gene symbol | NUTM1 |
Gene name | NUT midline carcinoma, family member 1 | |
Synonyms | C15orf55|FAM22H|NUT | |
Cytomap | UCSC genome browser: 15q14 | |
Type of gene | protein-coding | |
RefGenes | NM_001284292.1, NM_001284293.1,NM_175741.2, | |
Description | NUT family member 1nuclear protein in testis | |
Modification date | 20141222 | |
dbXrefs | MIM : 608963 | |
HGNC : HGNC | ||
Ensembl : ENSG00000184507 | ||
HPRD : 10606 | ||
Vega : OTTHUMG00000172348 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NUTM1 | |
BioGPS: 256646 | ||
Pathway | NCI Pathway Interaction Database: NUTM1 | |
KEGG: NUTM1 | ||
REACTOME: NUTM1 | ||
Pathway Commons: NUTM1 | ||
Context | iHOP: NUTM1 | |
ligand binding site mutation search in PubMed: NUTM1 | ||
UCL Cancer Institute: NUTM1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of NUTM1 | ||
Description by TissGene annotations | Cancer gene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for NUTM1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for NUTM1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NUTM1 |
TissGeneSNV for NUTM1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G544E | SKCM | 2 |
p.E670K | SKCM | 1 |
p.P40Q | LUAD | 1 |
p.G104R | SKCM | 1 |
p.G104R | HNSC | 1 |
p.M315I | SKCM | 1 |
p.T985I | PRAD | 1 |
p.D533N | BLCA | 1 |
p.Y248F | HNSC | 1 |
p.T1007A | SKCM | 1 |
p.K472E | SKCM | 1 |
p.L265V | BLCA | 1 |
p.P385T | LUAD | 1 |
p.G8V | HNSC | 1 |
p.Q727E | HNSC | 1 |
p.E782* | BLCA | 1 |
p.S130F | SKCM | 1 |
p.L551F | SKCM | 1 |
p.G414R | LUAD | 1 |
p.R1136Q | SKCM | 1 |
p.W864* | BLCA | 1 |
p.P199L | SKCM | 1 |
p.L572I | LUAD | 1 |
p.Q518* | BLCA | 1 |
p.G105S | LGG | 1 |
p.S63Y | LUAD | 1 |
p.S235F | SKCM | 1 |
p.G685R | SKCM | 1 |
p.L895I | LUAD | 1 |
p.E422K | SKCM | 1 |
p.A371P | STAD | 1 |
p.G818S | LUAD | 1 |
p.S469F | SKCM | 1 |
p.E482K | SKCM | 1 |
p.G613R | PAAD | 1 |
p.E505* | KIRC | 1 |
p.Q258* | SKCM | 1 |
p.L276P | LUAD | 1 |
p.P989R | SARC | 1 |
p.S993F | BLCA | 1 |
p.A164V | LIHC | 1 |
p.P85S | SKCM | 1 |
p.P54S | SKCM | 1 |
p.P187S | HNSC | 1 |
p.G125W | LUAD | 1 |
p.L347P | SKCM | 1 |
p.P976H | BLCA | 1 |
p.E72K | SKCM | 1 |
p.S1066G | SKCM | 1 |
p.E1015D | SKCM | 1 |
p.G786S | SKCM | 1 |
p.P219S | SKCM | 1 |
p.M90I | LUAD | 1 |
p.G177V | LUAD | 1 |
p.L137F | SKCM | 1 |
p.G114D | SKCM | 1 |
p.D876N | BLCA | 1 |
p.W207C | LUAD | 1 |
p.P436S | SKCM | 1 |
p.S232F | LGG | 1 |
p.H1081Y | SKCM | 1 |
p.G546E | SKCM | 1 |
p.G125V | HNSC | 1 |
p.R243C | SKCM | 1 |
p.E484K | BLCA | 1 |
p.I200S | BLCA | 1 |
p.G987W | HNSC | 1 |
p.P46S | SKCM | 1 |
p.P338S | SKCM | 1 |
p.P202L | BLCA | 1 |
p.G676E | SKCM | 1 |
p.R1143K | SKCM | 1 |
p.G552R | SKCM | 1 |
p.R274C | SKCM | 1 |
p.S144L | PAAD | 1 |
p.S227F | SKCM | 1 |
p.E95Q | CESC | 1 |
p.P476H | LUAD | 1 |
p.M29I | LUAD | 1 |
p.I402M | HNSC | 1 |
p.R254K | BLCA | 1 |
p.D862N | SKCM | 1 |
p.Q334H | PRAD | 1 |
p.P183S | SKCM | 1 |
p.R274C | BLCA | 1 |
p.P60S | SKCM | 1 |
p.K1036N | PAAD | 1 |
p.S590R | LGG | 1 |
p.S645L | ESCA | 1 |
p.P476T | LUAD | 1 |
p.A824T | ESCA | 1 |
p.L1132M | LUAD | 1 |
p.P733L | SKCM | 1 |
p.E27K | SKCM | 1 |
p.P219L | SKCM | 1 |
p.Q325K | BLCA | 1 |
p.D520N | SKCM | 1 |
p.E428K | SKCM | 1 |
p.A164S | PAAD | 1 |
p.P887S | HNSC | 1 |
p.V238I | LUAD | 1 |
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TissGeneCNV for NUTM1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NUTM1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | carcinoma | AY166680 | BRD4-NUTM1 | chr19:15391262 | chr15:34640165 | |
Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-60-2716-01A | WHSC1L1-NUTM1 | Out-of-Frame | chr8:38184247 | chr15:34640169 |
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TissGeneNet for NUTM1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NUTM1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NUTM1 |
TissGeneDrug for NUTM1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NUTM1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1707291 | NUT Midline Carcinoma | 20 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 5 | BeFree |
umls:C0205698 | Undifferentiated carcinoma | 2 | BeFree |
umls:C0496915 | Neoplasm of uncertain or unknown behavior of mediastinum | 2 | BeFree |
umls:C0596263 | Carcinogenesis | 2 | BeFree |
umls:C0013377 | Dysgerminoma | 1 | BeFree |
umls:C0040100 | Thymoma | 1 | BeFree |
umls:C0205851 | Germ cell tumor | 1 | BeFree |
umls:C0205969 | Thymic Carcinoma | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0334244 | Papillary squamous cell carcinoma | 1 | BeFree |
umls:C1322286 | Thymoma, type C | 1 | BeFree |
umls:C1368683 | Epithelioma | 1 | BeFree |