TissGeneSummary for GAD2 |
Gene summary |
Basic gene information | Gene symbol | GAD2 |
Gene name | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | |
Synonyms | GAD65 | |
Cytomap | UCSC genome browser: 10p11.23 | |
Type of gene | protein-coding | |
RefGenes | NM_000818.2, NM_001134366.1, | |
Description | 65 kDa glutamic acid decarboxylaseGAD-65Glutamate decarboxylase-2 (pancreas)glutamate decarboxylase 2glutamate decarboxylase 65 kDa isoform | |
Modification date | 20141222 | |
dbXrefs | MIM : 138275 | |
HGNC : HGNC | ||
Ensembl : ENSG00000136750 | ||
HPRD : 11817 | ||
Vega : OTTHUMG00000017836 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GAD2 | |
BioGPS: 2572 | ||
Pathway | NCI Pathway Interaction Database: GAD2 | |
KEGG: GAD2 | ||
REACTOME: GAD2 | ||
Pathway Commons: GAD2 | ||
Context | iHOP: GAD2 | |
ligand binding site mutation search in PubMed: GAD2 | ||
UCL Cancer Institute: GAD2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainPancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGPAAD | |
Reference showing the relevant tissue of GAD2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GAD2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for GAD2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GAD2 |
TissGeneSNV for GAD2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R375Q | SKCM | 2 |
p.A100V | COAD | 2 |
p.R448H | COAD | 2 |
p.E576K | SKCM | 2 |
p.K358E | LUAD | 1 |
p.S198* | HNSC | 1 |
p.E21D | BLCA | 1 |
p.P211T | LUAD | 1 |
p.N388I | LUSC | 1 |
p.L426F | SKCM | 1 |
p.A66D | LUAD | 1 |
p.F506L | SARC | 1 |
p.L141F | THCA | 1 |
p.A28T | COAD | 1 |
p.E479D | LUAD | 1 |
p.A469V | BLCA | 1 |
p.Q181* | BLCA | 1 |
p.E14X | KIRP | 1 |
p.S546N | SKCM | 1 |
p.A94V | KIRP | 1 |
p.R522K | LIHC | 1 |
p.A46T | STAD | 1 |
p.R558C | PRAD | 1 |
p.A478T | ESCA | 1 |
p.L142F | DLBC | 1 |
p.S129L | SKCM | 1 |
p.C304F | BRCA | 1 |
p.D297N | SKCM | 1 |
p.Y207F | LIHC | 1 |
p.A33D | READ | 1 |
p.A100G | HNSC | 1 |
p.A72T | PRAD | 1 |
p.D76N | HNSC | 1 |
p.F330V | OV | 1 |
p.E306Q | LUSC | 1 |
p.W230* | UCEC | 1 |
p.F556L | COAD | 1 |
p.D96G | UCEC | 1 |
p.Y249H | UCEC | 1 |
p.L285F | LUAD | 1 |
p.S129* | LUAD | 1 |
p.G463E | LUAD | 1 |
p.G24V | LUAD | 1 |
p.G326E | STAD | 1 |
p.W195* | UCEC | 1 |
p.C45F | LUSC | 1 |
p.E576K | PAAD | 1 |
p.A109E | LUAD | 1 |
p.E279K | SKCM | 1 |
p.G466W | UCEC | 1 |
p.G582E | SKCM | 1 |
p.S389Y | PAAD | 1 |
p.G16D | PRAD | 1 |
p.P510S | HNSC | 1 |
p.I302L | UCEC | 1 |
p.Y178* | LUAD | 1 |
p.P260S | SKCM | 1 |
p.D127N | PAAD | 1 |
p.Y482C | UCEC | 1 |
p.I228T | LGG | 1 |
p.A351T | PRAD | 1 |
p.S13L | UCEC | 1 |
p.L119P | SKCM | 1 |
p.R318M | UCEC | 1 |
p.R225K | SKCM | 1 |
p.A68T | STAD | 1 |
p.P312S | STAD | 1 |
p.A26V | STAD | 1 |
p.I228F | BLCA | 1 |
p.D345Y | LUAD | 1 |
p.P211K | LUAD | 1 |
p.D314N | SKCM | 1 |
p.G447R | PAAD | 1 |
p.A469V | STAD | 1 |
p.W230C | LUAD | 1 |
p.G41R | PRAD | 1 |
p.V452L | LUAD | 1 |
p.G288E | SKCM | 1 |
p.A334V | PAAD | 1 |
p.A530V | SKCM | 1 |
p.A72D | LUAD | 1 |
p.I509F | PRAD | 1 |
p.S527W | LUAD | 1 |
p.K486N | UCEC | 1 |
p.Q143L | LUAD | 1 |
p.A150E | LUSC | 1 |
p.S61G | THCA | 1 |
p.A170E | UCEC | 1 |
p.G413* | OV | 1 |
p.E412D | STAD | 1 |
p.G60R | STAD | 1 |
p.F135S | STAD | 1 |
p.G18V | COAD | 1 |
p.D134N | LUAD | 1 |
p.K286N | BRCA | 1 |
p.N42T | STAD | 1 |
p.P499H | UCEC | 1 |
p.R580C | BRCA | 1 |
p.E208K | HNSC | 1 |
p.R318S | LUSC | 1 |
p.H568N | LUAD | 1 |
p.A334V | THYM | 1 |
p.R525H | COAD | 1 |
p.F330L | LUSC | 1 |
p.Y425* | PRAD | 1 |
p.L108F | LUAD | 1 |
p.I578T | LUAD | 1 |
p.R558H | LGG | 1 |
p.P106H | LUAD | 1 |
p.Y425X | PRAD | 1 |
p.K222N | PRAD | 1 |
p.S3F | SKCM | 1 |
p.G308E | SKCM | 1 |
p.Q420K | BLCA | 1 |
p.G242S | STAD | 1 |
p.G266R | SKCM | 1 |
p.A461T | SKCM | 1 |
p.R375* | UCEC | 1 |
p.D127N | SKCM | 1 |
p.L585I | SKCM | 1 |
p.V409L | LUAD | 1 |
p.V450I | STAD | 1 |
p.P211Q | LUAD | 1 |
p.A443T | HNSC | 1 |
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TissGeneCNV for GAD2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GAD2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for GAD2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GAD2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GAD2 |
TissGeneDrug for GAD2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GAD2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 109 | BeFree,GAD,LHGDN,MGD |
umls:C0011849 | Diabetes Mellitus | 45 | BeFree,LHGDN |
umls:C0011847 | Diabetes | 41 | BeFree |
umls:C0028754 | Obesity | 10 | BeFree,GAD |
umls:C0205734 | Diabetes, Autoimmune | 10 | BeFree |
umls:C0085292 | Stiff-Person Syndrome | 8 | BeFree,LHGDN |
umls:C0036341 | Schizophrenia | 6 | BeFree,CTD_human,GAD,LHGDN |
umls:C0004364 | Autoimmune Diseases | 5 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 5 | BeFree |
umls:C0028756 | Obesity, Morbid | 5 | BeFree |
umls:C0362046 | Prediabetes syndrome | 4 | BeFree |
umls:C0001973 | Alcoholic Intoxication, Chronic | 3 | BeFree,GAD |
umls:C0003469 | Anxiety Disorders | 3 | BeFree |
umls:C0036572 | Seizures | 3 | BeFree,CTD_human |
umls:C0751383 | Juvenile Neuronal Ceroid Lipofuscinosis | 3 | BeFree |
umls:C0004352 | Autistic Disorder | 2 | BeFree |
umls:C0010246 | Coxsackievirus Infections | 2 | BeFree |
umls:C0011570 | Mental Depression | 2 | BeFree,GAD |
umls:C0014378 | Enterovirus Infections | 2 | BeFree |
umls:C0018213 | Graves Disease | 2 | BeFree |
umls:C0027796 | Neuralgia | 2 | BeFree |
umls:C0030193 | Pain | 2 | BeFree |
umls:C0041696 | Unipolar Depression | 2 | BeFree |
umls:C0043094 | Weight Gain | 2 | GAD |
umls:C0150055 | Chronic pain | 2 | BeFree |
umls:C0270549 | Generalized Anxiety Disorder | 2 | BeFree |
umls:C0344307 | Absence of pain sensation | 2 | BeFree |
umls:C2911647 | Weight Gain Adverse Event | 2 | GAD |
umls:C0001430 | Adenoma | 1 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | GAD |
umls:C0004153 | Atherosclerosis | 1 | GAD |
umls:C0006012 | Borderline Personality Disorder | 1 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0006287 | Bronchopulmonary Dysplasia | 1 | BeFree |
umls:C0007758 | Cerebellar Ataxia | 1 | LHGDN |
umls:C0011581 | Depressive disorder | 1 | BeFree |
umls:C0011875 | Diabetic Angiopathies | 1 | GAD |
umls:C0011884 | Diabetic Retinopathy | 1 | CTD_human |
umls:C0014548 | Epilepsy, Generalized | 1 | LHGDN |
umls:C0020615 | Hypoglycemia | 1 | BeFree |
umls:C0021670 | insulinoma | 1 | BeFree |
umls:C0022658 | Kidney Diseases | 1 | BeFree |
umls:C0025517 | Metabolic Diseases | 1 | BeFree |
umls:C0027404 | Narcolepsy | 1 | BeFree |
umls:C0027877 | Neuronal Ceroid-Lipofuscinoses | 1 | LHGDN |
umls:C0030319 | Panic Disorder | 1 | BeFree |
umls:C0030567 | Parkinson Disease | 1 | LHGDN |
umls:C0032002 | Pituitary Diseases | 1 | BeFree |
umls:C0034013 | Precocious Puberty | 1 | GAD |
umls:C0035309 | Retinal Diseases | 1 | BeFree |
umls:C0036337 | Schizoaffective Disorder | 1 | BeFree |
umls:C0040128 | Thyroid Diseases | 1 | BeFree |
umls:C0040156 | Thyrotoxicosis | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0085207 | Gestational Diabetes | 1 | BeFree |
umls:C0085648 | Synovial Cyst | 1 | BeFree |
umls:C0162429 | Malnutrition | 1 | BeFree |
umls:C0206081 | Hyperandrogenism | 1 | GAD |
umls:C0221170 | Muscular stiffness | 1 | BeFree |
umls:C0221765 | Chronic schizophrenia | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
umls:C0338656 | Impaired cognition | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0376338 | Diagnosis, Psychiatric | 1 | BeFree |
umls:C0525045 | Mood Disorders | 1 | BeFree |
umls:C0600327 | Toxic Shock Syndrome | 1 | BeFree |
umls:C0677607 | Hashimoto Disease | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0751214 | Hyperalgesia, Thermal | 1 | BeFree |
umls:C1096184 | West Nile viral infection | 1 | BeFree |
umls:C1258666 | Myxoid cyst | 1 | BeFree |
umls:C1269683 | Major Depressive Disorder | 1 | BeFree |
umls:C1842981 | NEUROTICISM | 1 | BeFree |
umls:C1868649 | PANIC DISORDER 1 | 1 | BeFree |
umls:C1960272 | Latent autoimmune diabetes mellitus in adult | 1 | BeFree |