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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for GAD2
check button Gene summary
Basic gene informationGene symbolGAD2
Gene nameglutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
SynonymsGAD65
CytomapUCSC genome browser: 10p11.23
Type of geneprotein-coding
RefGenesNM_000818.2,
NM_001134366.1,
Description65 kDa glutamic acid decarboxylaseGAD-65Glutamate decarboxylase-2 (pancreas)glutamate decarboxylase 2glutamate decarboxylase 65 kDa isoform
Modification date20141222
dbXrefs MIM : 138275
HGNC : HGNC
Ensembl : ENSG00000136750
HPRD : 11817
Vega : OTTHUMG00000017836
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GAD2
BioGPS: 2572
PathwayNCI Pathway Interaction Database: GAD2
KEGG: GAD2
REACTOME: GAD2
Pathway Commons: GAD2
ContextiHOP: GAD2
ligand binding site mutation search in PubMed: GAD2
UCL Cancer Institute: GAD2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,TiGER
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BrainPancreas
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)GBM,LGGPAAD
Reference showing the relevant tissue of GAD2
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for GAD2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for GAD2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for GAD2
TissGeneSNV for GAD2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R375QSKCM2
p.A100VCOAD2
p.R448HCOAD2
p.E576KSKCM2
p.K358ELUAD1
p.S198*HNSC1
p.E21DBLCA1
p.P211TLUAD1
p.N388ILUSC1
p.L426FSKCM1
p.A66DLUAD1
p.F506LSARC1
p.L141FTHCA1
p.A28TCOAD1
p.E479DLUAD1
p.A469VBLCA1
p.Q181*BLCA1
p.E14XKIRP1
p.S546NSKCM1
p.A94VKIRP1
p.R522KLIHC1
p.A46TSTAD1
p.R558CPRAD1
p.A478TESCA1
p.L142FDLBC1
p.S129LSKCM1
p.C304FBRCA1
p.D297NSKCM1
p.Y207FLIHC1
p.A33DREAD1
p.A100GHNSC1
p.A72TPRAD1
p.D76NHNSC1
p.F330VOV1
p.E306QLUSC1
p.W230*UCEC1
p.F556LCOAD1
p.D96GUCEC1
p.Y249HUCEC1
p.L285FLUAD1
p.S129*LUAD1
p.G463ELUAD1
p.G24VLUAD1
p.G326ESTAD1
p.W195*UCEC1
p.C45FLUSC1
p.E576KPAAD1
p.A109ELUAD1
p.E279KSKCM1
p.G466WUCEC1
p.G582ESKCM1
p.S389YPAAD1
p.G16DPRAD1
p.P510SHNSC1
p.I302LUCEC1
p.Y178*LUAD1
p.P260SSKCM1
p.D127NPAAD1
p.Y482CUCEC1
p.I228TLGG1
p.A351TPRAD1
p.S13LUCEC1
p.L119PSKCM1
p.R318MUCEC1
p.R225KSKCM1
p.A68TSTAD1
p.P312SSTAD1
p.A26VSTAD1
p.I228FBLCA1
p.D345YLUAD1
p.P211KLUAD1
p.D314NSKCM1
p.G447RPAAD1
p.A469VSTAD1
p.W230CLUAD1
p.G41RPRAD1
p.V452LLUAD1
p.G288ESKCM1
p.A334VPAAD1
p.A530VSKCM1
p.A72DLUAD1
p.I509FPRAD1
p.S527WLUAD1
p.K486NUCEC1
p.Q143LLUAD1
p.A150ELUSC1
p.S61GTHCA1
p.A170EUCEC1
p.G413*OV1
p.E412DSTAD1
p.G60RSTAD1
p.F135SSTAD1
p.G18VCOAD1
p.D134NLUAD1
p.K286NBRCA1
p.N42TSTAD1
p.P499HUCEC1
p.R580CBRCA1
p.E208KHNSC1
p.R318SLUSC1
p.H568NLUAD1
p.A334VTHYM1
p.R525HCOAD1
p.F330LLUSC1
p.Y425*PRAD1
p.L108FLUAD1
p.I578TLUAD1
p.R558HLGG1
p.P106HLUAD1
p.Y425XPRAD1
p.K222NPRAD1
p.S3FSKCM1
p.G308ESKCM1
p.Q420KBLCA1
p.G242SSTAD1
p.G266RSKCM1
p.A461TSKCM1
p.R375*UCEC1
p.D127NSKCM1
p.L585ISKCM1
p.V409LLUAD1
p.V450ISTAD1
p.P211QLUAD1
p.A443THNSC1


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TissGeneCNV for GAD2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for GAD2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for GAD2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (tumor)GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (normal)
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COAD (tumor)COAD (normal)
GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (tumor)GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (normal)
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HNSC (tumor)HNSC (normal)
GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (tumor)GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (normal)
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KICH (tumor)KICH (normal)
GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (tumor)GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (normal)
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KIRC (tumor)KIRC (normal)
GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (tumor)GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (normal)
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KIRP (tumor)KIRP (normal)
GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (tumor)GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (normal)
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LIHC (tumor)LIHC (normal)
GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (tumor)GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (normal)
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LUAD (tumor)LUAD (normal)
GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (tumor)GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (normal)
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LUSC (tumor)LUSC (normal)
GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (tumor)GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (normal)
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PRAD (tumor)PRAD (normal)
GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (tumor)GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (normal)
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STAD (tumor)STAD (normal)
GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (tumor)GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (normal)
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THCA (tumor)THCA (normal)
GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (tumor)GAD2, PRKACA, PRKCE, GAD1, F10, ZDHHC17 (normal)
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TissGeneProg for GAD2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for GAD2
TissGeneDrug for GAD2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for GAD2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0011854Diabetes Mellitus, Insulin-Dependent109BeFree,GAD,LHGDN,MGD
umls:C0011849Diabetes Mellitus45BeFree,LHGDN
umls:C0011847Diabetes41BeFree
umls:C0028754Obesity10BeFree,GAD
umls:C0205734Diabetes, Autoimmune10BeFree
umls:C0085292Stiff-Person Syndrome8BeFree,LHGDN
umls:C0036341Schizophrenia6BeFree,CTD_human,GAD,LHGDN
umls:C0004364Autoimmune Diseases5BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent5BeFree
umls:C0028756Obesity, Morbid5BeFree
umls:C0362046Prediabetes syndrome4BeFree
umls:C0001973Alcoholic Intoxication, Chronic3BeFree,GAD
umls:C0003469Anxiety Disorders3BeFree
umls:C0036572Seizures3BeFree,CTD_human
umls:C0751383Juvenile Neuronal Ceroid Lipofuscinosis3BeFree
umls:C0004352Autistic Disorder2BeFree
umls:C0010246Coxsackievirus Infections2BeFree
umls:C0011570Mental Depression2BeFree,GAD
umls:C0014378Enterovirus Infections2BeFree
umls:C0018213Graves Disease2BeFree
umls:C0027796Neuralgia2BeFree
umls:C0030193Pain2BeFree
umls:C0041696Unipolar Depression2BeFree
umls:C0043094Weight Gain2GAD
umls:C0150055Chronic pain2BeFree
umls:C0270549Generalized Anxiety Disorder2BeFree
umls:C0344307Absence of pain sensation2BeFree
umls:C2911647Weight Gain Adverse Event2GAD
umls:C0001430Adenoma1BeFree
umls:C0002395Alzheimer's Disease1GAD
umls:C0004153Atherosclerosis1GAD
umls:C0006012Borderline Personality Disorder1BeFree
umls:C0006142Malignant neoplasm of breast1BeFree
umls:C0006287Bronchopulmonary Dysplasia1BeFree
umls:C0007758Cerebellar Ataxia1LHGDN
umls:C0011581Depressive disorder1BeFree
umls:C0011875Diabetic Angiopathies1GAD
umls:C0011884Diabetic Retinopathy1CTD_human
umls:C0014548Epilepsy, Generalized1LHGDN
umls:C0020615Hypoglycemia1BeFree
umls:C0021670insulinoma1BeFree
umls:C0022658Kidney Diseases1BeFree
umls:C0025517Metabolic Diseases1BeFree
umls:C0027404Narcolepsy1BeFree
umls:C0027877Neuronal Ceroid-Lipofuscinoses1LHGDN
umls:C0030319Panic Disorder1BeFree
umls:C0030567Parkinson Disease1LHGDN
umls:C0032002Pituitary Diseases1BeFree
umls:C0034013Precocious Puberty1GAD
umls:C0035309Retinal Diseases1BeFree
umls:C0036337Schizoaffective Disorder1BeFree
umls:C0040128Thyroid Diseases1BeFree
umls:C0040156Thyrotoxicosis1BeFree
umls:C0040336Tobacco Use Disorder1GAD
umls:C0085207Gestational Diabetes1BeFree
umls:C0085648Synovial Cyst1BeFree
umls:C0162429Malnutrition1BeFree
umls:C0206081Hyperandrogenism1GAD
umls:C0221170Muscular stiffness1BeFree
umls:C0221765Chronic schizophrenia1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0236736Cocaine-Related Disorders1CTD_human
umls:C0338656Impaired cognition1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0376338Diagnosis, Psychiatric1BeFree
umls:C0525045Mood Disorders1BeFree
umls:C0600327Toxic Shock Syndrome1BeFree
umls:C0677607Hashimoto Disease1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C0751214Hyperalgesia, Thermal1BeFree
umls:C1096184West Nile viral infection1BeFree
umls:C1258666Myxoid cyst1BeFree
umls:C1269683Major Depressive Disorder1BeFree
umls:C1842981NEUROTICISM1BeFree
umls:C1868649PANIC DISORDER 11BeFree
umls:C1960272Latent autoimmune diabetes mellitus in adult1BeFree