TissGeneSummary for SLC24A2 |
Gene summary |
Basic gene information | Gene symbol | SLC24A2 |
Gene name | solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 | |
Synonyms | NCKX2 | |
Cytomap | UCSC genome browser: 9p22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001193288.2, NM_020344.3, | |
Description | Na(+)/K(+)/Ca(2+)-exchange protein 2retinal cone Na-Ca+K exchangersodium/potassium/calcium exchanger 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609838 | |
HGNC : HGNC | ||
Ensembl : ENSG00000155886 | ||
HPRD : 15351 | ||
Vega : OTTHUMG00000019646 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC24A2 | |
BioGPS: 25769 | ||
Pathway | NCI Pathway Interaction Database: SLC24A2 | |
KEGG: SLC24A2 | ||
REACTOME: SLC24A2 | ||
Pathway Commons: SLC24A2 | ||
Context | iHOP: SLC24A2 | |
ligand binding site mutation search in PubMed: SLC24A2 | ||
UCL Cancer Institute: SLC24A2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of SLC24A2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0034220 | ion transmembrane transport | 18166528 | GO:0034220 | ion transmembrane transport | 18166528 |
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TissGeneExp for SLC24A2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -2.091749181 | -0.210585293 | -1.881163889 | 5.43E-24 | 5.94E-23 |
LUSC | 0.03087541 | -2.107644198 | 2.138519608 | 1.13E-13 | 5.84E-13 |
LUAD | -0.590010628 | -2.194317524 | 1.604306897 | 4.22E-11 | 2.68E-10 |
HNSC | 0.273767841 | -1.598332159 | 1.8721 | 9.53E-12 | 2.52E-10 |
BRCA | 1.684313026 | -1.847989605 | 3.532302632 | 5.67E-41 | 1.85E-39 |
BLCA | -0.495298377 | -2.034035219 | 1.538736842 | 5.08E-06 | 0.000115019 |
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TissGene-miRNA for SLC24A2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-526b-3p | MIMAT0002836 | 0.02 | -0.26 | 78 |
ACC | hsa-miR-526b-3p | MIMAT0002836 | 0.02 | -0.26 | 78 |
ACC | hsa-miR-125b-5p | MIMAT0000423 | 0.022 | -0.27 | 78 |
ACC | hsa-miR-125b-5p | MIMAT0000423 | 0.022 | -0.27 | 78 |
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TissGeneMut for SLC24A2 |
TissGeneSNV for SLC24A2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R557W | UCEC | 2 |
p.E455D | SKCM | 1 |
p.M613V | STAD | 1 |
p.Y515H | LGG | 1 |
p.E533D | BLCA | 1 |
p.R378K | SKCM | 1 |
p.L217I | CHOL | 1 |
p.E466V | KIRC | 1 |
p.F637C | COAD | 1 |
p.E110Q | BLCA | 1 |
p.V659I | STAD | 1 |
p.I573F | ACC | 1 |
p.S71T | LUAD | 1 |
p.S431L | STAD | 1 |
p.P458L | LUSC | 1 |
p.L231V | STAD | 1 |
p.F593L | STAD | 1 |
p.L269F | HNSC | 1 |
p.M180V | LUAD | 1 |
p.M563I | SKCM | 1 |
p.K93N | BLCA | 1 |
p.R240* | SKCM | 1 |
p.S243Y | COAD | 1 |
p.L386I | UCS | 1 |
p.L386I | UCEC | 1 |
p.M628I | SKCM | 1 |
p.A304E | LUAD | 1 |
p.C605F | LUAD | 1 |
p.R627* | STAD | 1 |
p.S104Y | BRCA | 1 |
p.L655I | READ | 1 |
p.I346M | HNSC | 1 |
p.E265K | SKCM | 1 |
p.N283S | UCEC | 1 |
p.M142I | UCEC | 1 |
p.P583L | OV | 1 |
p.S126F | LUAD | 1 |
p.A405S | LUSC | 1 |
p.G332E | BLCA | 1 |
p.P488T | OV | 1 |
p.R627Q | COAD | 1 |
p.Y273D | LUAD | 1 |
p.E455K | SKCM | 1 |
p.L137P | ACC | 1 |
p.R240P | LGG | 1 |
p.T374A | LUAD | 1 |
p.F197C | READ | 1 |
p.D123N | COAD | 1 |
p.V278I | LIHC | 1 |
p.D318E | STAD | 1 |
p.Y370C | TGCT | 1 |
p.A521V | COAD | 1 |
p.A307T | LUAD | 1 |
p.E533Q | UCEC | 1 |
p.R380I | LUAD | 1 |
p.R38X | SKCM | 1 |
p.K310N | STAD | 1 |
p.I573T | LUAD | 1 |
p.L249F | BLCA | 1 |
p.V196L | LIHC | 1 |
p.E651X | COAD | 1 |
p.G81S | SKCM | 1 |
p.D371G | UCEC | 1 |
p.L137M | LUAD | 1 |
p.W236L | READ | 1 |
p.A79S | STAD | 1 |
p.M628I | PAAD | 1 |
p.D241G | LUSC | 1 |
p.H200Q | COAD | 1 |
p.C153F | BLCA | 1 |
p.L341V | HNSC | 1 |
p.R330G | LUAD | 1 |
p.F604L | UCEC | 1 |
p.R491C | READ | 1 |
p.R240* | PAAD | 1 |
p.V152I | LGG | 1 |
p.S427Y | LUAD | 1 |
p.A58S | LUSC | 1 |
p.V219D | COAD | 1 |
p.L149* | SKCM | 1 |
p.R240X | PAAD | 1 |
p.S243Y | STAD | 1 |
p.D421N | BLCA | 1 |
p.V396L | LUAD | 1 |
p.P433S | SKCM | 1 |
p.D371N | SKCM | 1 |
p.L149F | LIHC | 1 |
p.Q292K | THYM | 1 |
p.D421N | SKCM | 1 |
p.P187L | COAD | 1 |
p.A542P | LUAD | 1 |
p.D63E | COAD | 1 |
p.P488S | UCEC | 1 |
p.L268H | STAD | 1 |
p.Y515S | OV | 1 |
p.E453K | LGG | 1 |
p.R627X | STAD | 1 |
p.E13K | CESC | 1 |
p.V659I | ESCA | 1 |
p.G437E | SKCM | 1 |
p.R38* | SKCM | 1 |
p.H200Q | LUAD | 1 |
p.M636K | LIHC | 1 |
p.N259S | LIHC | 1 |
p.I618F | LUAD | 1 |
p.L40* | GBM | 1 |
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TissGeneCNV for SLC24A2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC24A2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE765952 | GLUL-SLC24A2 | chr1:182352556 | chr9:19509220 | |
Chimerdb3.0 | ChiTaRs | NA | AV723197 | SLC24A2-SPIDR | chr9:19508673 | chr8:48649475 | |
Chimerdb3.0 | ChiTaRs | NA | BI034953 | ADD1-SLC24A2 | chr4:2896414 | chr9:19725743 |
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TissGeneNet for SLC24A2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC24A2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC24A2 |
TissGeneDrug for SLC24A2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC24A2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004096 | Asthma | 1 | GAD |
umls:C0035309 | Retinal Diseases | 1 | BeFree |